LOCUS       NM_001410498            2347 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus acylpeptide hydrolase (Apeh), transcript variant 2,
            mRNA.
ACCESSION   NM_001410498
VERSION     NM_001410498.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2347)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2347)
  AUTHORS   Tyler,K., Geilman,S., Bell,D.M., Taylor,N., Honeycutt,S.C.,
            Garrett,P.I., Hillhouse,T.M. and Covey,T.M.
  TITLE     Acyl Peptide Enzyme Hydrolase (APEH) activity is inhibited by lipid
            metabolites and peroxidation products
  JOURNAL   Chem Biol Interact 348, 109639 (2021)
   PUBMED   34508712
  REMARK    GeneRIF: Acyl Peptide Enzyme Hydrolase (APEH) activity is inhibited
            by lipid metabolites and peroxidation products.
REFERENCE   3  (bases 1 to 2347)
  AUTHORS   Sasaki,K., Hara,S., Yamakami,R., Sato,Y., Hasegawa,S., Kono,T.,
            Morohaku,K. and Obata,Y.
  TITLE     Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L
            leads to aberrant hypermethylation and postnatal lethality in mice
  JOURNAL   Mol Reprod Dev 86 (6), 614-623 (2019)
   PUBMED   30834655
REFERENCE   4  (bases 1 to 2347)
  AUTHORS   Lahbib-Mansais,Y., Leroux,S., Milan,D., Yerle,M., Robic,A.,
            Jiang,Z., Andre,C. and Gellin,J.
  TITLE     Comparative mapping between humans and pigs: localization of 58
            anchorage markers (TOASTs) by use of porcine somatic cell and
            radiation hybrid panels
  JOURNAL   Mamm Genome 11 (12), 1098-1106 (2000)
   PUBMED   11130978
REFERENCE   5  (bases 1 to 2347)
  AUTHORS   Persons,D.A., Paulson,R.F., Loyd,M.R., Herley,M.T., Bodner,S.M.,
            Bernstein,A., Correll,P.H. and Ney,P.A.
  TITLE     Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
  JOURNAL   Nat Genet 23 (2), 159-165 (1999)
   PUBMED   10508511
REFERENCE   6  (bases 1 to 2347)
  AUTHORS   Naylor,S.L., Carritt,B., Boileau,C., Beroud,C., Alexander,C.,
            Allderdice,P., Alimov,A., Ashworth,T., Bonifas,J., Bugert,P.,
            Buys,C.H., Chipperfield,M.A., Deng,G., Drabkin,H., Gemmill,R.M.,
            Grompe,M., Joensuu,T., Jonasdottir,A., Gizatullin,R., Krols,L.,
            Leach,R.J., Lott,S.T., Killary,A., Martinsson,T., Messiaen,L. et
            al.
  TITLE     Report of the sixth international workshop on human chromosome 3
            mapping 1995
  JOURNAL   Cytogenet Cell Genet 72 (4), 255-270 (1996)
   PUBMED   8641130
REFERENCE   7  (bases 1 to 2347)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (bases 1 to 2347)
  AUTHORS   Degen,S.J., Stuart,L.A., Han,S. and Jamison,C.S.
  TITLE     Characterization of the mouse cDNA and gene coding for a hepatocyte
            growth factor-like protein: expression during development
  JOURNAL   Biochemistry 30 (40), 9781-9791 (1991)
   PUBMED   1832957
REFERENCE   9  (bases 1 to 2347)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137678.11.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC137678.11        106962-107008       c
            48-180              AC137678.11        106754-106886       c
            181-307             AC137678.11        106149-106275       c
            308-401             AC137678.11        105508-105601       c
            402-477             AC137678.11        105334-105409       c
            478-641             AC137678.11        105081-105244       c
            642-779             AC137678.11        104803-104940       c
            780-871             AC137678.11        104615-104706       c
            872-912             AC137678.11        104498-104538       c
            913-1034            AC137678.11        104295-104416       c
            1035-1095           AC137678.11        103770-103830       c
            1096-1193           AC137678.11        102616-102713       c
            1194-1245           AC137678.11        102045-102096       c
            1246-1334           AC137678.11        100788-100876       c
            1335-1473           AC137678.11        100250-100388       c
            1474-1557           AC137678.11        99708-99791         c
            1558-1593           AC137678.11        99550-99585         c
            1594-1682           AC137678.11        98950-99038         c
            1683-1873           AC137678.11        98666-98856         c
            1874-1976           AC137678.11        98477-98579         c
            1977-2083           AC137678.11        98288-98394         c
            2084-2347           AC137678.11        97941-98204         c
FEATURES             Location/Qualifiers
     source          1..2347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..2347
                     /gene="Apeh"
                     /note="acylpeptide hydrolase"
                     /db_xref="GeneID:235606"
                     /db_xref="MGI:MGI:88041"
     exon            1..47
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2189
                     /gene="Apeh"
                     /EC_number="3.4.19.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     acylamino-acid-releasing enzyme; APH; AARE; acyl-peptide
                     hydrolase; acylaminoacyl-peptidase; N-acylaminoacyl
                     peptide hydrolase"
                     /codon_start=1
                     /product="acylamino-acid-releasing enzyme isoform 2"
                     /protein_id="NP_001397427.1"
                     /db_xref="GeneID:235606"
                     /db_xref="MGI:MGI:88041"
                     /translation="MERQVLLSEPQEAAALYRGLSRQPSLSAACLGPEVTTQYGGLYR
                     TVHTEWTQRDLDRMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTM
                     KAVLRKAGGAVSGEEKQFLEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSET
                     HLLYVAEKKRPKAESFFQTKALDVSASDEEMARPKKPDQAIKGDQFVFYEDWGETMVS
                     KSIPVLCVLDIESGNISVLEGVPENVSPGQAFWAPGDTGVVFVGWWHEPFRLGIRYCT
                     NRRSALYYVDLSGGKCELLSDESLAVCSPRLSPDQCRVVYLQYPSLAPHHQCSQLFLY
                     DWYTKVTSLVVDIVPRQLGESFSGIYCSLLPLGCWSADSQRVVFDSVQRSRQDLFAVD
                     TQTGSVTSLTAGGSAGSWKLLTIDRDLMVAQFSTPNLPPSLKVGFLPPAGKEQSVSWV
                     SLEEAEPIPDIHWGIRVLHPPPDQENVQYADLDFEAILLQPSNSPDKSQVPMVVMPHA
                     MLCKMGFAVLLVNYRGSTGFGQDSILSLPGNVGHQDVKDVQFAVQQVLQEEHFDARRV
                     ALMGGSHGGFLSCHLIGQYPETYSACIARNPVINIVSMMGTTDIPDWCMVETGFPYSN
                     DYLPDLNVLEEMLDKSPIKYIPQVKTPVLLMLGQEDRRVPFKQGLEYYHALKARNVPV
                     RLLLYPKSTHALSEVEVESDSFMNTVLWLHTHLGS"
     exon            48..180
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            181..307
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            308..401
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            402..477
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            478..641
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            642..779
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            780..871
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            872..912
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1034
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1095
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1193
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1245
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1334
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1473
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1557
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1593
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1682
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1873
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1976
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2083
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2347
                     /gene="Apeh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2330..2335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apeh"
                     /note="hexamer: AATAAA"
     polyA_site      2347
                     /gene="Apeh"
                     /note="major polyA site"
ORIGIN      
        1 acttccggga cttagctgct accgaaagac cgactatgga gcgtcaggtg ctgctgagtg
       61 agccccagga ggcggcagcg ctgtaccggg gccttagccg ccagccttcg ctgagcgccg
      121 cctgcctggg cccggaggtc accacgcagt atgggggcct ctatcggact gtgcacactg
      181 agtggactca gagggacttg gatcgaatgg agaacatccg attctgccgc cagtacctag
      241 tgttccatga tggagactcg gtggtgtttg ccgggcctgc gggcaacagt gtggaaaccc
      301 ggggggagct gctgagcaga gagtctcctt caggcaccat gaaagcagtg ctgcgcaagg
      361 ctggaggtgc agtctcggga gaggaaaaac agttcttgga ggtctgggag aagaaccgca
      421 agctcaagag tttcaacctg tctgcactgg agaagcatgg gcctgtgtat gaagatgact
      481 gctttggctg cctctcctgg tcacactcag agacgcactt gttgtatgtg gcggagaaga
      541 agcgtcccaa agctgagtcc ttctttcaaa ccaaagcctt ggacgtcagt gccagtgatg
      601 aggagatggc caggccgaag aagccagacc aggccatcaa gggggaccag tttgtatttt
      661 atgaagactg gggagaaact atggtttcca aaagcatccc tgtgctctgc gtgctggata
      721 tcgagagtgg taacatctcc gtgcttgagg gcgtccctga aaatgtgtcc cctggtcagg
      781 ctttctgggc ccctggagac acgggtgtgg tgtttgtggg ctggtggcac gaacccttcc
      841 ggctaggtat ccgctactgc accaatcgca ggtcagccct gtactatgtg gacctgagcg
      901 gggggaagtg tgaactactc tcggatgagt ccctggctgt ctgctctcct cggctgagcc
      961 cagaccagtg tcgcgtcgtc tacctgcagt acccatctct agcccctcat caccagtgca
     1021 gccagctctt cctgtatgac tggtacacca aggtcacctc attggtggtg gacattgtac
     1081 ctcggcagct gggagagagc ttctctggga tctactgcag cctccttcct ttgggatgct
     1141 ggtcagctga cagccagaga gtggtcttcg actcggtcca gcgcagtcgg caggacctgt
     1201 ttgctgtgga cacccagaca ggaagtgtca cctccctgac agctgggggg tcagcgggaa
     1261 gctggaagct gcttacaatt gaccgagacc ttatggtggc ccagttctcc acacccaacc
     1321 tgcccccgag cctgaaagtc gggttcctgc ctcctgctgg gaaggagcag tctgtgtcat
     1381 gggtgtcact ggaggaggct gaacctattc ctgacatcca ctggggcatc cgagtgctgc
     1441 acccacctcc agaccaagag aatgtacaat atgctgacct tgactttgaa gcaatcctcc
     1501 tgcagcccag caactctcca gataagagcc aggtccccat ggtagtcatg ccccatgcca
     1561 tgctttgcaa gatgggcttt gcagtactac tggtgaacta tcgtggttcc acgggctttg
     1621 gccaagacag catcctttcc ctcccaggca atgtgggcca ccaggatgtg aaggatgtcc
     1681 agttcgcagt gcagcaggtg ctccaggagg aacactttga tgcaagacgt gtggccctta
     1741 tgggtggttc ccatggtggg ttcctctcct gccacctgat tggtcaatac ccagaaacct
     1801 acagtgcctg tatagcccgg aacccagtga tcaacattgt ctccatgatg ggcaccactg
     1861 acatccctga ttggtgtatg gtggagactg gcttccctta tagtaatgac tacctgccag
     1921 acctgaatgt gttggaagag atgctggata aatcacccat caagtacatc cctcaggtaa
     1981 agacaccagt gttactgatg ctgggccagg aggaccggcg tgtacccttc aagcagggtc
     2041 tggagtatta ccatgccctc aaggcccgga atgtgcctgt ccggctcctg ctgtatccca
     2101 agagcaccca tgcgctgtca gaggtggagg tggaatcaga cagcttcatg aacactgtgc
     2161 tttggctaca cacacacttg ggcagctgaa gccctgttgc tctttgtgag ctgggcagtc
     2221 cgtctcgaac tttgctcttg gtaagcccca ggatctggca gaactgccta gaggtttcct
     2281 gggctctgga ctccgaatga gtgggcagag gactatggac tctaatcata ataaaggagg
     2341 acacaga
//
