LOCUS       NM_011318                879 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus amyloid P component, serum (Apcs), mRNA.
ACCESSION   NM_011318
VERSION     NM_011318.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 879)
  AUTHORS   Wang,L., Liang,D., Huang,Y., Chen,Y., Yang,X., Huang,Z., Jiang,Y.,
            Su,H., Wang,L., Pathak,J.L. and Ge,L.
  TITLE     SAP deficiency aggravates periodontitis possibly via C5a-C5aR
            signaling-mediated defective macrophage phagocytosis of
            Porphyromonas gingivalis
  JOURNAL   J Adv Res 50, 55-68 (2023)
   PUBMED   36243399
  REMARK    GeneRIF: SAP deficiency aggravates periodontitis possibly via
            C5a-C5aR signaling-mediated defective macrophage phagocytosis of
            Porphyromonas gingivalis.
REFERENCE   2  (bases 1 to 879)
  AUTHORS   Doni,A., Parente,R., Laface,I., Magrini,E., Cunha,C., Colombo,F.S.,
            Lacerda,J.F., Campos,A. Jr., Mapelli,S.N., Petroni,F., Porte,R.,
            Schorn,T., Inforzato,A., Mercier,T., Lagrou,K., Maertens,J.,
            Lambris,J.D., Bottazzi,B., Garlanda,C., Botto,M., Carvalho,A. and
            Mantovani,A.
  TITLE     Serum amyloid P component is an essential element of resistance
            against Aspergillus fumigatus
  JOURNAL   Nat Commun 12 (1), 3739 (2021)
   PUBMED   34145258
  REMARK    GeneRIF: Serum amyloid P component is an essential element of
            resistance against Aspergillus fumigatus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 879)
  AUTHORS   Pilling,D., Cox,N., Thomson,M.A., Karhadkar,T.R. and Gomer,R.H.
  TITLE     Serum Amyloid P and a Dendritic Cell-Specific Intercellular
            Adhesion Molecule-3-Grabbing Nonintegrin Ligand Inhibit High-Fat
            Diet-Induced Adipose Tissue and Liver Inflammation and Steatosis in
            Mice
  JOURNAL   Am J Pathol 189 (12), 2400-2413 (2019)
   PUBMED   31539521
REFERENCE   4  (bases 1 to 879)
  AUTHORS   Tanigaki,K., Sacharidou,A., Peng,J., Chambliss,K.L., Yuhanna,I.S.,
            Ghosh,D., Ahmed,M., Szalai,A.J., Vongpatanasin,W., Mattrey,R.F.,
            Chen,Q., Azadi,P., Lingvay,I., Botto,M., Holland,W.L., Kohler,J.J.,
            Sirsi,S.R., Hoyt,K., Shaul,P.W. and Mineo,C.
  TITLE     Hyposialylated IgG activates endothelial IgG receptor FcgammaRIIB
            to promote obesity-induced insulin resistance
  JOURNAL   J Clin Invest 128 (1), 309-322 (2018)
   PUBMED   29202472
REFERENCE   5  (bases 1 to 879)
  AUTHORS   Zheng,L., Wu,T., Zeng,C., Li,X., Li,X., Wen,D., Ji,T., Lan,T.,
            Xing,L., Li,J., He,X. and Wang,L.
  TITLE     SAP deficiency mitigated atherosclerotic lesions in ApoE(-/-) mice
  JOURNAL   Atherosclerosis 244, 179-187 (2016)
   PUBMED   26649902
  REMARK    GeneRIF: SAP deficiency mitigated foam cell formation and
            atherosclerotic development in apoE(-/-) mice, due to reduction in
            macrophages recruitment, polarization and pro-inflammatory
            cytokines
REFERENCE   6  (bases 1 to 879)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   7  (bases 1 to 879)
  AUTHORS   Murakami,T., Yi,S., Maeda,S., Tashiro,F., Yamamura,K.,
            Takahashi,K., Shimada,K. and Araki,S.
  TITLE     Effect of serum amyloid P component level on transthyretin-derived
            amyloid deposition in a transgenic mouse model of familial
            amyloidotic polyneuropathy
  JOURNAL   Am J Pathol 141 (2), 451-456 (1992)
   PUBMED   1497094
REFERENCE   8  (bases 1 to 879)
  AUTHORS   Itoh,Y., Takeuchi,S., Shigemoto,K., Kubo,S., Handa,S., Ishikawa,N.
            and Maruyama,N.
  TITLE     The strain-dependent constitutive expression of murine serum
            amyloid-P component is regulated at the transcriptional level
  JOURNAL   Biochim Biophys Acta 1131 (3), 261-269 (1992)
   PUBMED   1627642
REFERENCE   9  (bases 1 to 879)
  AUTHORS   Gough,N.M., Lipkowitz,S., Kirsch,I.R. and Begley,C.G.
  TITLE     Localization of murine HLH gene NSCL to chromosome 1 by use of
            recombinant inbred strains
  JOURNAL   Mamm Genome 3 (3), 182-183 (1992)
   PUBMED   1617226
REFERENCE   10 (bases 1 to 879)
  AUTHORS   Wong,Y.W., Williams,A.F., Kingsmore,S.F. and Seldin,M.F.
  TITLE     Structure, expression, and genetic linkage of the mouse BCM1 (OX45
            or Blast-1) antigen. Evidence for genetic duplication giving rise
            to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on
            mouse chromosome 3
  JOURNAL   J Exp Med 171 (6), 2115-2130 (1990)
   PUBMED   1693656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116483.10.
            
            On Oct 11, 2022 this sequence version replaced NM_011318.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061125.1, AI528120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC116483.10        166023-166151       c
            130-879             AC116483.10        165163-165912       c
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.33 cM"
     gene            1..879
                     /gene="Apcs"
                     /gene_synonym="Sap"
                     /note="amyloid P component, serum"
                     /db_xref="GeneID:20219"
                     /db_xref="MGI:MGI:98229"
     exon            1..129
                     /gene="Apcs"
                     /gene_synonym="Sap"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..737
                     /gene="Apcs"
                     /gene_synonym="Sap"
                     /note="APCS amyloid P-component serum protein; serum
                     amyloid P-component"
                     /codon_start=1
                     /product="serum amyloid P-component precursor"
                     /protein_id="NP_035448.2"
                     /db_xref="CCDS:CCDS15520.1"
                     /db_xref="GeneID:20219"
                     /db_xref="MGI:MGI:98229"
                     /translation="MDKLLLWMFVFTSLLSEAFCQTDLKRKVFVFPRESETDHVKLIP
                     HLEKPLQNFTLCFRTYSDLSRSQSLFSYSVKGRDNELLIYKEKVGEYSLYIGQSKVTV
                     RGMEEYLSPVHLCTTWESSSGIVEFWVNGKPWVKKSLQREYTVKAPPSIVLGQEQDNY
                     GGGFQRSQSFVGEFSDLYMWDYVLTPQDILFVYRDSPVNPNILNWQALNYEINGYVVI
                     RPRVWD"
     exon            130..879
                     /gene="Apcs"
                     /gene_synonym="Sap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      857..862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apcs"
                     /gene_synonym="Sap"
                     /note="hexamer: AATAAA"
     polyA_site      879
                     /gene="Apcs"
                     /gene_synonym="Sap"
                     /note="major polyA site"
ORIGIN      
        1 agacaccaca cttttgttcc acacccaagt aacagctgct gctgtcatac cctggaccaa
       61 gcatggacaa gctactgctt tggatgtttg tcttcaccag ccttctttca gaagcctttt
      121 gtcagacaga cctcaagagg aaagtatttg tgttccccag agaatctgaa actgatcatg
      181 tgaagctgat cccacatcta gagaaacctc tgcagaattt tacactgtgt ttccgaacct
      241 acagtgacct ttcccgctct cagagtcttt tctcctacag tgtcaagggc agagacaatg
      301 agctactaat ttataaagaa aaagttggag aatacagcct atacatcgga caatcaaaag
      361 tcacagtccg tggtatggaa gaataccttt ctccagtaca cctatgtacc acttgggagt
      421 cctcctctgg cattgttgaa ttttgggtca atggaaagcc ttgggtaaaa aagtctctgc
      481 agagggaata cactgtgaaa gccccaccca gtatagtcct gggacaggag caggataact
      541 acggaggagg gtttcaaagg tcacagtcct ttgtaggaga gttttcagat ttatacatgt
      601 gggactatgt gctgacccca caagacattc tatttgtgta cagagattcc cctgtcaatc
      661 ctaatatttt gaattggcag gctcttaact atgaaataaa tggctacgta gtcatcaggc
      721 cccgtgtctg ggattgagat cttacaacaa aacctcatgg acatcagatg gccgatgtgt
      781 aagaggtcaa ggcagcagaa ttcactctat ctggagcttt ttcttctttg tgaacatctt
      841 gtatacatat ctgccaaata aaaatcctct ccaattcca
//
