LOCUS       NM_133237               3419 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus adenomatosis polyposis coli down-regulated 1 (Apcdd1),
            mRNA.
ACCESSION   NM_133237 XM_619546 XM_914219 XM_994681
VERSION     NM_133237.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3419)
  AUTHORS   Ding,W., Li,X., Zhang,J., Ji,M., Zhang,M., Zhong,X., Cao,Y.,
            Liu,X., Li,C., Xiao,C., Wang,J., Li,T., Yu,Q., Mo,F., Zhang,B.,
            Qi,J., Yang,J.C., Qi,J., Tian,L., Xu,X., Peng,Q., Zhou,W.Z.,
            Liu,Z., Fu,A., Zhang,X., Zhang,J.J., Sun,Y., Hu,B., An,N.A.,
            Zhang,L. and Li,C.Y.
  TITLE     Adaptive functions of structural variants in human brain
            development
  JOURNAL   Sci Adv 10 (14), eadl4600 (2024)
   PUBMED   38579006
REFERENCE   2  (bases 1 to 3419)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3419)
  AUTHORS   Siguero-Alvarez,M., Salguero-Jimenez,A., Grego-Bessa,J., de la
            Barrera,J., MacGrogan,D., Prados,B., Sanchez-Saez,F.,
            Pineiro-Sabaris,R., Felipe-Medina,N., Torroja,C., Gomez,M.J.,
            Sabater-Molina,M., Escriba,R., Richaud-Patin,I.,
            Iglesias-Garcia,O., Sbroggio,M., Callejas,S., O'Regan,D.P.,
            McGurk,K.A., Dopazo,A., Giovinazzo,G., Ibanez,B., Monserrat,L.,
            Perez-Pomares,J.M., Sanchez-Cabo,F., Pendas,A.M., Raya,A.,
            Gimeno-Blanes,J.R. and de la Pompa,J.L.
  TITLE     A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With
            Bicuspid Aortic Valve
  JOURNAL   Circulation 147 (1), 47-65 (2023)
   PUBMED   36325906
  REMARK    Erratum:[Circulation. 2023 Jan 17;147(3):e63. doi:
            10.1161/CIR.0000000000001129.. PMID: 36649398]
REFERENCE   4  (bases 1 to 3419)
  AUTHORS   Biswas,S., Shahriar,S., Giangreco,N.P., Arvanitis,P., Winkler,M.,
            Tatonetti,N.P., Brunken,W.J., Cutforth,T. and Agalliu,D.
  TITLE     Mural Wnt/beta-catenin signaling regulates Lama2 expression to
            promote neurovascular unit maturation
  JOURNAL   Development 149 (17) (2022)
   PUBMED   36098369
REFERENCE   5  (bases 1 to 3419)
  AUTHORS   Drake,K.A., Chaney,C., Patel,M., Das,A., Bittencourt,J., Cohn,M.
            and Carroll,T.J.
  TITLE     Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal
            Myofibroblasts in the Developing Mouse Kidney
  JOURNAL   J Am Soc Nephrol 33 (9), 1694-1707 (2022)
   PUBMED   35918150
  REMARK    Erratum:[J Am Soc Nephrol. 2023 Mar 1;34(3):515-516. doi:
            10.1681/ASN.0000000000000056.. PMID: 36857501]
REFERENCE   6  (bases 1 to 3419)
  AUTHORS   Saarimaki-Vire,J., Peltopuro,P., Lahti,L., Naserke,T., Blak,A.A.,
            Vogt Weisenhorn,D.M., Yu,K., Ornitz,D.M., Wurst,W. and Partanen,J.
  TITLE     Fibroblast growth factor receptors cooperate to regulate neural
            progenitor properties in the developing midbrain and hindbrain
  JOURNAL   J Neurosci 27 (32), 8581-8592 (2007)
   PUBMED   17687036
REFERENCE   7  (bases 1 to 3419)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
REFERENCE   8  (bases 1 to 3419)
  AUTHORS   Jukkola,T., Lahti,L., Naserke,T., Wurst,W. and Partanen,J.
  TITLE     FGF regulated gene-expression and neuronal differentiation in the
            developing midbrain-hindbrain region
  JOURNAL   Dev Biol 297 (1), 141-157 (2006)
   PUBMED   16782087
REFERENCE   9  (bases 1 to 3419)
  AUTHORS   Lillevali,K., Haugas,M., Matilainen,T., Pussinen,C., Karis,A. and
            Salminen,M.
  TITLE     Gata3 is required for early morphogenesis and Fgf10 expression
            during otic development
  JOURNAL   Mech Dev 123 (6), 415-429 (2006)
   PUBMED   16806848
REFERENCE   10 (bases 1 to 3419)
  AUTHORS   Jukkola,T., Sinjushina,N. and Partanen,J.
  TITLE     Drapc1 expression during mouse embryonic development
  JOURNAL   Gene Expr Patterns 4 (6), 755-762 (2004)
   PUBMED   15465500
  REMARK    GeneRIF: mouse Drapc1 is a novel in vivo target gene of
            Wnt/beta-catenin signaling pathway
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130204.4.
            
            On Jul 21, 2018 this sequence version replaced NM_133237.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156319.1, AK172004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               AC130204.4         112539-112933
            396-579             AC130204.4         124087-124270
            580-1111            AC130204.4         127118-127649
            1112-1433           AC130204.4         140087-140408
            1434-3419           AC130204.4         142042-144027
FEATURES             Location/Qualifiers
     source          1..3419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 35.95 cM"
     gene            1..3419
                     /gene="Apcdd1"
                     /gene_synonym="Drapc1; EIG180"
                     /note="adenomatosis polyposis coli down-regulated 1"
                     /db_xref="GeneID:494504"
                     /db_xref="MGI:MGI:3513977"
     exon            1..395
                     /gene="Apcdd1"
                     /gene_synonym="Drapc1; EIG180"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1882
                     /gene="Apcdd1"
                     /gene_synonym="Drapc1; EIG180"
                     /note="protein APCDD1; ethanol induced gene product
                     EIG180; adenomatosis polyposis coli down-regulated 1
                     protein homolog"
                     /codon_start=1
                     /product="protein APCDD1 precursor"
                     /protein_id="NP_573500.2"
                     /db_xref="CCDS:CCDS37843.1"
                     /db_xref="GeneID:494504"
                     /db_xref="MGI:MGI:3513977"
                     /translation="MSRVRRLLLGYLFPALLLHGLGEGSALLHPDSRSHPRSLEKSAW
                     RAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVSTGCEVRSGPEFMTRSYRFYNNNT
                     FKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHGVQVICHTEAVA
                     EQLSRLVNRTCPGFLAPGGPWVQDVAYDLWQEESNHECTKAVNFAMHELQLIRVEKQY
                     PHHSLDHLVEELFLGDIHTDATQRVFYRPSSYQPPLQNAKNHNHACIACRIIFRSDEH
                     HPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPVC
                     KHPTFTIYARGRYSRGVLSSKVMGGTEFVFKVNHMKVTPMDAATASLLNVFSGNECGA
                     EGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQDTRGRYLLFNGQRPSDGSSPD
                     RPEKRATSYQMPLVQCASSSPRAEELLEDSQGHLYGRAAGRTAGSLLLPAFVSLWTLP
                     HWRILR"
     exon            396..579
                     /gene="Apcdd1"
                     /gene_synonym="Drapc1; EIG180"
                     /inference="alignment:Splign:2.1.0"
     exon            580..1111
                     /gene="Apcdd1"
                     /gene_synonym="Drapc1; EIG180"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1433
                     /gene="Apcdd1"
                     /gene_synonym="Drapc1; EIG180"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..3419
                     /gene="Apcdd1"
                     /gene_synonym="Drapc1; EIG180"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3390..3395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apcdd1"
                     /gene_synonym="Drapc1; EIG180"
                     /note="hexamer: AACAAA"
     polyA_site      3409
                     /gene="Apcdd1"
                     /gene_synonym="Drapc1; EIG180"
                     /note="major polyA site"
ORIGIN      
        1 agcggccact gtacctctga gctgtgcacg ccgcggccgg ggcgggcctc gggactgggg
       61 ctgggagcca aggggccggg gcgggacgcg gagaggctgg gctgcggttc ggagtcccgc
      121 gcggacaggg gccggacggc ggcgagggag cgcgcgcccc gcagtcccgc gctgcgccgg
      181 ccggggatgg ggcgcgctgc tgcctgaggc ccggcctggc gggcgcccgc cgggggctgc
      241 ggctgaggag ccgagggcgc cctgtaccgg agtggcccgc gcgcgcgctc ggagggggac
      301 agagacggac tacagcgagg cccggaggag ccccgagatg tcccgtgtgc gccgccttct
      361 gcttggatac ctgttcccag ccctcctgtt gcatgggctg ggagagggct ctgccctcct
      421 tcatccagac agcagatcgc accctcggtc cttagagaaa agcgcctgga gggctttcaa
      481 ggagtcacag tgtcatcaca tgctgaagca tctccacaac ggtgcgcgga tcacagtgca
      541 gatgcccccg accatcgagg gccactgggt gtccacaggc tgtgaagtaa ggtcgggtcc
      601 ggagttcatg acaaggtctt acaggttcta caacaataat accttcaagg cctaccagtt
      661 ttactatggc agcaaccgct gtacaaaccc cacctacacc ctcatcatcc gaggcaagat
      721 ccggcttcgc caggcgtcct ggatcatccg tgggggcacc gaagctgact accagcttca
      781 cggcgtccaa gtcatctgcc acacagaggc agtcgctgaa cagctcagcc gactggtgaa
      841 ccgaacttgc ccaggcttcc tggctcctgg tggtccctgg gtacaggacg tagcctatga
      901 cctgtggcag gaggagagta accacgagtg caccaaggct gtgaactttg ccatgcacga
      961 gctgcagctc atccgtgtgg agaagcagta tccccaccac agcctggacc acctggtgga
     1021 ggagctcttc ctgggcgaca tccacacgga cgctacccag agggtgttct accggccgtc
     1081 cagttaccag ccgcccctgc agaatgccaa gaaccacaac catgcgtgca tagcctgccg
     1141 catcattttc cggtcagatg aacaccaccc tcccatactg ccccccaagg ctgacctgac
     1201 cattggcctc cacggggaat gggtgagcca gcgctgcgag gtacgccccg aggtcctctt
     1261 cctcacccgc cacttcatct tccacgacaa caacaacacc tgggaagggc attactacca
     1321 ctactcagac cctgtctgca agcaccccac attcaccatc tacgctcgag gccgctacag
     1381 ccgcggtgtg ctctcatcta aggtcatggg tggcacggag tttgtgttca aagtgaatca
     1441 catgaaggtt actcccatgg acgcagccac agcctccctc ctcaatgtct tcagtgggaa
     1501 tgagtgtggg gctgagggct cctggcaggt gggtatccaa caggatgtga cacataccaa
     1561 tggctgcgtg gctctgggca tcaaactacc tcacacagaa tatgagatct tcaaaatgga
     1621 gcaagacacc cgaggccgct acctgctgtt caatggccag aggcccagcg atggctccag
     1681 cccagacaga ccagagaaga gagccacatc ctaccagatg cccttggtcc agtgtgcctc
     1741 ttcctcacca agagctgaag agttgttgga agacagtcaa ggtcatctgt atggcagggc
     1801 agcagggagg acagctgggt ccctgttgct tcctgccttt gtcagccttt ggactctccc
     1861 acattggcgc atcctcagat agaagacatt tcctgaacca agactcttta ccgtgtatga
     1921 ctttccttca cacagagaaa ggacattgat tcttttgatg cacttgaatg ccttgagacc
     1981 tgccgttgcc tctcctctcc ccacctcttc cagcctctgc gccatgagca gtgtgtttga
     2041 agtttcagct ttgaatgtct tcccgcccga tccgtggcct gagaacttca tagaggtgtg
     2101 attgcacttt atgtctgcag agagctgggg cgagtgtgtt taggggtggc agctgccttc
     2161 ttctctctgt cccctgactc ctgactgtgt ttctgagctg agcttaaaag atacaaatga
     2221 caagctgcag ctctctctgc cattgcttct ctttatctct ccaaatccct tccacactcg
     2281 aggttttcga cactggaacc cagtgcagcg ttggcttggg accgccatga agaccccatg
     2341 tttgcgacag gagagcctgg gttggtgttg agtacataag agacgaggca aggttcagct
     2401 aagtctttgt cccagcctta atgctaacca acactttcag aaatgttgag tagagaggtg
     2461 tccctaaagc ttcaatggaa cttaaactct gttgacaagc gagtgccggt tttcacttgt
     2521 tgagaagaga tgtgtgccat atacttggtt tggtggctac agagtacagc ctgctgctta
     2581 accctcagag gagactgatc cagttgggaa attcagagca gctcctgctc caggcagcca
     2641 gaagcagcag tggggggtgg gggtggggat tccttgtgtt aagtgccaca caactgacaa
     2701 ggagatctgt ggagtttttc tccaagtgaa ccaatcccct gtgtcctggc tcacactgtg
     2761 gttagggtgg gcacatccac tctgccatct ttaacacaca gaaaccaaac atcagtgctc
     2821 cagtagctta ctaatggaaa gaggttgggg tgagactcac ccacagatga gccactctgc
     2881 taggagccag ctgtccctgt gctccttggt ggggtctagg aggagtcacc ctgttactag
     2941 aattaccagc ttgattcggc ttcctctctg catttccctg gttctgcccc acctgcgagg
     3001 tccagagcca tctcattcag ggttcgccgc ttcacagtca tccgaaggga ggaggggatg
     3061 gccgccaccc attcctttgt attattgcaa ctggtgctat aaacaccaag tgctattgct
     3121 cacagagacc catgaaggta ggtggaggag agacaaaaaa cctagctgga actgaaagca
     3181 gacatggaga ccaggaccca ggagaagagt cagtcgtgta tttaagagtt cactttgtga
     3241 agcagtagct ttcagtgcgg tgttaaatta taacgaaggc atggagtacc agagtgcttt
     3301 atatttagat tatattttaa gtcatggtgc atacttgagg gggtttatta aaaatgaaag
     3361 tactaactta atgtctacta agtttaataa acaaagaatt tggaagtaac cccacgaaa
//
