LOCUS       NM_001372241            9364 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus APC regulator of WNT signaling pathway 2 (Apc2),
            transcript variant 6, mRNA.
ACCESSION   NM_001372241 XM_006513644
VERSION     NM_001372241.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9364)
  AUTHORS   Yuan,W., Ma,S., Brown,J.R., Kim,K., Murek,V., Trastulla,L.,
            Meissner,A., Lodato,S., Shetty,A.S., Levin,J.Z., Buenrostro,J.D.,
            Ziller,M.J. and Arlotta,P.
  TITLE     Temporally divergent regulatory mechanisms govern neuronal
            diversification and maturation in the mouse and marmoset neocortex
  JOURNAL   Nat Neurosci 25 (8), 1049-1058 (2022)
   PUBMED   35915179
REFERENCE   2  (bases 1 to 9364)
  AUTHORS   Mohamed,N.E., Hay,T., Reed,K.R., Smalley,M.J. and Clarke,A.R.
  TITLE     APC2 is critical for ovarian WNT signalling control, fertility and
            tumour suppression
  JOURNAL   BMC Cancer 19 (1), 677 (2019)
   PUBMED   31291912
  REMARK    GeneRIF: This work adds APC2 to the growing list of WNT-signalling
            members that regulate ovarian homeostasis, fertility and suppress
            granulosa cell tumour formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9364)
  AUTHORS   Young,M.A., Daly,C.S., Taylor,E., James,R., Clarke,A.R. and
            Reed,K.R.
  TITLE     Subtle Deregulation of the Wnt-Signaling Pathway Through Loss of
            Apc2 Reduces the Fitness of Intestinal Stem Cells
  JOURNAL   Stem Cells 36 (1), 114-122 (2018)
   PUBMED   29027285
  REMARK    GeneRIF: Authors show that systemic loss of Apc2 results in an
            increase in the number of cells displaying nuclear beta-catenin at
            the base of the intestinal crypt. This subsequently impacts the
            expression levels of several ISC markers and the fitness of ISCs as
            assessed by organoid formation efficiency.
REFERENCE   4  (bases 1 to 9364)
  AUTHORS   Daly,C.S., Shaw,P., Ordonez,L.D., Williams,G.T., Quist,J.,
            Grigoriadis,A., Van Es,J.H., Clevers,H., Clarke,A.R. and Reed,K.R.
  TITLE     Functional redundancy between Apc and Apc2 regulates tissue
            homeostasis and prevents tumorigenesis in murine mammary epithelium
  JOURNAL   Oncogene 36 (13), 1793-1803 (2017)
   PUBMED   27694902
  REMARK    Erratum:[Oncogene. 2024 Mar;43(12):918. doi:
            10.1038/s41388-024-02941-5.. PMID: 38263250]
REFERENCE   5  (bases 1 to 9364)
  AUTHORS   Pataskar,A., Jung,J., Smialowski,P., Noack,F., Calegari,F.,
            Straub,T. and Tiwari,V.K.
  TITLE     NeuroD1 reprograms chromatin and transcription factor landscapes to
            induce the neuronal program
  JOURNAL   EMBO J 35 (1), 24-45 (2016)
   PUBMED   26516211
REFERENCE   6  (bases 1 to 9364)
  AUTHORS   Morgan,D., Eley,L., Sayer,J., Strachan,T., Yates,L.M.,
            Craighead,A.S. and Goodship,J.A.
  TITLE     Expression analyses and interaction with the anaphase promoting
            complex protein Apc2 suggest a role for inversin in primary cilia
            and involvement in the cell cycle
  JOURNAL   Hum Mol Genet 11 (26), 3345-3350 (2002)
   PUBMED   12471060
REFERENCE   7  (bases 1 to 9364)
  AUTHORS   Yamanaka,H., Hashimoto,N., Koyama,K., Nakagawa,H., Nakamura,Y. and
            Noguchi,K.
  TITLE     Expression of Apc2 during mouse development
  JOURNAL   Brain Res Gene Expr Patterns 1 (2), 107-114 (2002)
   PUBMED   15018807
  REMARK    GeneRIF: Apc2 is expressed in post-mitotic cells and may contribute
            to the development of neuronal cells
REFERENCE   8  (bases 1 to 9364)
  AUTHORS   van Es,J.H., Kirkpatrick,C., van de Wetering,M., Molenaar,M.,
            Miles,A., Kuipers,J., Destree,O., Peifer,M. and Clevers,H.
  TITLE     Identification of APC2, a homologue of the adenomatous polyposis
            coli tumour suppressor
  JOURNAL   Curr Biol 9 (2), 105-108 (1999)
   PUBMED   10021369
REFERENCE   9  (bases 1 to 9364)
  AUTHORS   Bell,S.M., Lam,W.K., Carr,I.M., Cartwright,E.J., Pinchin,K.,
            Wedgwood,S., Markham,A.F. and Coletta,P.L.
  TITLE     Assignment of the murine adenomatous polyposis coli 2 (Apc2) gene
            to mouse chromosome band 10B5-C2 by in situ hybridisation
  JOURNAL   Cytogenet Cell Genet 86 (1), 81-82 (1999)
   PUBMED   10516441
REFERENCE   10 (bases 1 to 9364)
  AUTHORS   Hart,M.J., de los Santos,R., Albert,I.N., Rubinfeld,B. and
            Polakis,P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140229.3 and AC152062.6.
            
            On Aug 26, 2019 this sequence version replaced XM_006513644.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.686824.1,
                                           SRR7652917.21282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AC140229.3         151195-151468
            275-433             AC140229.3         151973-152131
            434-524             AC140229.3         152290-152380
            525-705             AC140229.3         152467-152647
            706-814             AC140229.3         154849-154957
            815-928             AC140229.3         155060-155173
            929-1006            AC140229.3         155338-155415
            1007-1105           AC140229.3         155682-155780
            1106-1420           AC140229.3         156287-156601
            1421-1493           AC152062.6         130598-130670       c
            1494-1589           AC152062.6         129895-129990       c
            1590-1729           AC152062.6         129543-129682       c
            1730-1807           AC152062.6         129110-129187       c
            1808-1924           AC152062.6         128789-128905       c
            1925-2139           AC152062.6         127944-128158       c
            2140-9364           AC152062.6         118862-126086       c
FEATURES             Location/Qualifiers
     source          1..9364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..9364
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /note="APC regulator of WNT signaling pathway 2"
                     /db_xref="GeneID:23805"
                     /db_xref="MGI:MGI:1346052"
     exon            1..274
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..7132
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /note="isoform 6 is encoded by transcript variant 6;
                     adenomatous polyposis coli protein 2; adenomatosis
                     polyposis coli 2"
                     /codon_start=1
                     /product="adenomatous polyposis coli protein 2 isoform 6"
                     /protein_id="NP_001359170.1"
                     /db_xref="GeneID:23805"
                     /db_xref="MGI:MGI:1346052"
                     /translation="MNRATGDPCVSGGMWGHRGSRPRTQTPGRIVALQELKMTSSMAS
                     YEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVLV
                     SSGQTEVLEQLKALQTDISSLYNLKFHAPALGPEPAARTPEGSPVHGSGPSKDSFGEL
                     SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTFSMQMDL
                     IRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQA
                     LLAVKPVAVEEEQEAEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAM
                     SSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRAGIPGAPGAKDARMRANAALHNIVF
                     SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAT
                     CAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNL
                     TFGDVANKATLCARRGCMEAIVAQLGSESEELHQVVSSILRNLSWRADINSKKVLREV
                     GSMTALMECVLRASKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYRC
                     QGNSLAVIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACG
                     TLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQAA
                     AMAVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQSLPEAETTSKKPLPPLRH
                     LDGLVQDYASDSGCFDDDDAPSLAAAATTAEPASPAVMSMFLGGPFLQGQALARTPPA
                     RQGGLEAEKEAGGEAAVAAKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDPG
                     QEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKAAHTSLSNDSLNSGSTSDGYCT
                     REHMTPCPLAALAEHRDDPVRGQTRPSRLDLDLPSRAELPARDTAATDARVRTIKLSP
                     TYQHVPLLDGAAGAGVRPLVGPGTSPGARKQAWIPADSLSKVPEKLVASPLPIASKVL
                     QKLVAQDGPMSLSRCSSLSSLSSTGHAVPSQAENLDSDSSLEGLEEAGPGEAELGRAW
                     RASGSTSLPVSIPAPQRGRSRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFE
                     SRSIASSIPSDPCSGLGSGTVSPSELPDSPGQTMPPSRSKTPPAPPGQPETSQFSLQW
                     ESYVKRFLDIADCRERCQPPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQQD
                     VELRLRPPACPERAVGGGGHRRRDEAASRLDGPAPAGSRARSATDKELEALRECLGAA
                     MPARLRKVASALVPGRRSLPVPVYMLVPAPARGDDSGTDSAEGTPVNFSSAASLSDET
                     LQGPSRDKPAGPGDRQKPTGRAAPARQTRSHRPKAAGAGKSTEHTRGPCRNRAGLELP
                     LSRPQSARSNRDSSCQTRTRGDGALQSLCLTTPTEEAVYCFYDSDEEPPATAPPPRRA
                     SAIPRALKREKPAGRKETPSRAAQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPE
                     APEQPANHARGPEQGSKQDSSPSPRAEEELLQRCISLAMPRRRTQVPGSRRRKPRALR
                     SDIRPTEITQKCQEEVAGSDPASDLDSVEWQAIQEGANSIVTWLHQAAAKASLEASSE
                     SDSLLSLVSGVSAGSTLQPSKLRKGRKPAAEAGGAWRPEKRGTTSTKINGSPRLPNGP
                     EKAKGTQKMMAGESTMLRGRTVIYSAGPASRTQSKGISGPCTTPKKTGTSGTTQPETV
                     TKAPSPEQQRSRSLHRPGKISELAALRHPPRSATPPARLAKTPSSSSSQTSPASQPLP
                     RRSPLATPTGGPLPGPGGSLVPKSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLA
                     RPSPEPGSRGRAGAEGTPGARGSRLGLVRMASARSSGSESSDRSGFRRQLTFIKESPG
                     LLRRRRSELSSADSTASTSQAASPRRGRPALPAVFLCSSRCDELRVSPRQPLAAQRSP
                     QAKPGLAPRAPRRTSSESPSRLPVRASPGRPETVKRYASLPHISVSRRSDSAVSVPTT
                     QANATRRGSDGEARPLPRVAPPGTTWRRIKDEDVPHILRSTLPATALPLRVSSPEDSP
                     AGTPQRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPASGPVAPQGSDVDGPVLT
                     KPPASAPFPHEGLSAVIAGFPTSRHGSPSRAARVPPFNYVPSPMAAATMASDSAVEKA
                     PVSSPASLLE"
     exon            275..433
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            434..524
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            525..705
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            706..814
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            815..928
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1006
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1105
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1493
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1589
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1729
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1807
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1924
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2139
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..9364
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9342..9347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /note="hexamer: AATAAA"
     polyA_site      9364
                     /gene="Apc2"
                     /gene_synonym="APCL"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtggag gtctcaggat agccttggag ggagagccaa gctgggggag aaggtgctgg
       61 ccaactggac agagggagga ggccggacag agagagaaag aaaagacaga cagaagcaca
      121 aagaatgggg ctgtgacgga gctgagggag gcatggtatc caggctggag gttgctgagc
      181 catgaacaga gccactgggg acccttgcgt gagtggaggg atgtggggcc acagggggtc
      241 ccggcccagg acacaaacac ctgggaggat tgtggcactg caggagttga aaatgaccag
      301 ctccatggcc tcatatgagc agctggtgcg ccaggtggag gccctgaagg ccgagaacac
      361 tcacttaagg caggagctga gggataactc tagccatctc tccaagcttg agacagagac
      421 ttctggaatg aaggaggtcc tgaaacacct ccagggcaag ctggagcagg aggcgagagt
      481 gctcgtgtct tccgggcaga cagaagtgtt agagcaactg aaagctcttc agactgacat
      541 cagtagcctg tacaacctca agtttcatgc tccagccctg ggcccggagc ctgccgcccg
      601 gactccagag ggaagcccag tgcacggctc tggaccatcc aaggacagct ttggagagct
      661 gagccgggcc accatccgcc tgctggaaga actggaccag gagagatgct tcctgctgag
      721 cgagatagag aaagaggaga aggagaagct atggtattac tctcagctcc agggcctgtc
      781 caagcgcttg gatgagctgc cgcacgtgga cacgttttcg atgcagatgg atctgattcg
      841 gcagcagctg gagttcgagg cccagcacat ccgctcgctg atggaggagc gcttcggtac
      901 ctccgacgag atggtgcagc gggcgcagat ccgggcttcg cgcttggagc agattgacaa
      961 ggagctgttg gaagcccagg accgggtgca gcagacagag cctcaggctc tgctggcggt
     1021 gaagcctgtg gcagtagagg aggagcagga ggcagaagtc cccacacatc ctgaggatgg
     1081 cacccctcag cctggcaaca gcaaggtgga ggtggtgttc tggcttctat ctatgttggc
     1141 aacgcgcgac caggaagata ctgcgcgcac actgctggcc atgtccagct ctccagagag
     1201 ctgtgtagcc atgcgccgct cgggctgtct gccactgctg ctccagatcc ttcatggcac
     1261 tgaggctggg tctgtggggc gcgcagggat ccccggagcg cctggtgcca aagatgcacg
     1321 catgcgcgcc aatgcggccc tgcacaacat cgttttctcc cagccggatc agggcctggc
     1381 acgcaaggag atgcgtgtgc tgcatgtgct ggagcagatc cgagcctact gcgagacctg
     1441 ctgggactgg cttcaggcgc gggacagcgg gacagaaagt ggtacaggag acactcctgt
     1501 cccaatcgag ccgcagatct gccaggctac ctgtgcagtg atgaagctgt catttgacga
     1561 agaataccgt cgggctatga atgagctagg ggggctgcag gctgtggcag aactactgca
     1621 ggtggactat gaaatgcaca agatgacccg ggacccactc aaccttgccc tgcgccgcta
     1681 cgctggcatg accctcacca acctcacctt tggagacgtt gccaacaagg ccacactgtg
     1741 tgcccgccga ggctgcatgg aagccattgt ggcccagctt ggctctgaga gcgaggagct
     1801 gcatcaggtt gtttccagta ttctgcgtaa tctgtcatgg agggcagaca tcaacagcaa
     1861 gaaggtgctg agggaggttg gcagcatgac cgccttgatg gaatgtgtgc tgcgggcctc
     1921 caaggagtcg accctaaaga gtgtgctcag tgctctgtgg aacctgtcag cacacagcac
     1981 agagaacaag gcagccatct gccaggtaga tggtgcactg ggtttcctgg tgagcaccct
     2041 cacataccgt tgccaaggga actccctggc agtcatcgag agtggcggtg ggatcctgcg
     2101 caacgtgtca agcctcattg ccacacggga ggactacagg caggtgctcc gtgaccacaa
     2161 ctgcctgcag acactgctgc agcacctcac atcacacagt ttgaccatcg tgagcaatgc
     2221 ctgtggcacc ctctggaacc tgtctgcccg cagcccccgc gatcaggaac tgttgtggga
     2281 cctgggggcc gtgggcatgc tacgcaacct cgtccactcc aaacacaaga tgatcgccat
     2341 gggtagtgct gctgctctgc ggaacctgct agcccaccga cccgccaagt atcaggccgc
     2401 agccatggct gtctccccag gcacctgcgt gcccagtctt tacgtccgca agcagagggc
     2461 tctggaagct gagttggaca ctcggcacct ggtgcatgca ctcggtcact tagagaagca
     2521 gagtctgcct gaggcagaga ccacttcaaa gaagcccctg ccacccctcc gccacctgga
     2581 cgggctggtg caggactatg cctctgattc tggctgcttt gacgatgatg atgcaccatc
     2641 cctggctgct gctgccacca cagctgagcc cgccagccca gcagtgatgt ctatgttcct
     2701 tggcggtccc ttccttcagg gccaggcact ggcccgcacc ccacctgccc gccagggtgg
     2761 cctagaagcc gagaaggagg ctggtgggga ggcagctgtg gctgccaagg ccaaggccaa
     2821 gctggcgttg gctgtggctc ggatcgacag attggtggag gacatctctg ccctgcacac
     2881 ctcatcagac gacagcttca gtctcagctc gggggaccct gggcaggagg cgccaaggga
     2941 gggccgtgct cagtcctgct ctccatgccg gggcactgag ggtgggaggc gtgaggctgg
     3001 cagccgggcg caccctcttt tgaggctcaa ggcagcccac actagcctct ctaatgatag
     3061 cttgaacagc ggtagcacca gcgatggcta ctgtacccgg gaacacatga cgccttgccc
     3121 gctggctgca ctggccgagc accgtgatga ccctgtgcgc ggacagactc ggcccagccg
     3181 actggacctg gaccttccca gccgggctga gcttcctgcc cgggacacag cagccaccga
     3241 tgcccgagtg cgcacaatca agttatcccc aacctatcag catgttccac tgctggatgg
     3301 ggccgctggg gcaggtgttc gacccctggt tgggccggga acctccccgg gggctcggaa
     3361 acaggcatgg atacctgcag acagcctgag caaagtccct gagaaactgg tggcctctcc
     3421 actgcccata gctagcaagg tgctgcagaa gctggtcgca caggatgggc cgatgtccct
     3481 ctccaggtgc agctctctgt cctctctatc ttccacgggc catgctgtcc ccagccaggc
     3541 agagaacctt gacagcgatt catccctgga ggggcttgag gaggctggtc ctggtgaggc
     3601 cgagctgggc agggcgtggc gagcatccgg gtccacctct cttccggtgt ccatcccagc
     3661 cccgcagcgg gggcgcagta gaggtcttgg ggtggaggat gcaacaccat ccagctcatc
     3721 tgagaactgc gtccaggaga cgcctttggt cctgagccgt tgtagttccg tgagctccct
     3781 gggcagcttc gagagccgct ccattgccag ctccatcccc agtgacccgt gcagcgggct
     3841 gggcagtggc acagtgagtc ccagcgagct gccagacagc cccgggcaga cgatgccacc
     3901 gagccgcagc aagacgccac cggcacctcc tgggcagcct gagaccagcc agttcagcct
     3961 gcagtgggaa agctatgtga agcgcttcct agacatcgca gactgtcgag aaagatgcca
     4021 gccgccctcg gagctggacg cgggcagcgt tcgcttcaca gtggagaagc cagatgagaa
     4081 tttctcctgc gcctccagcc tcagtgcact ggcccttcat gagctgtatg tccagcagga
     4141 tgtggagctg cgtctgaggc cacctgcctg cccagagcgt gcggtgggtg gtgggggcca
     4201 ccgtcggagg gacgaggctg ccagccgcct ggatggtcca gcaccagctg gttctagggc
     4261 tcggtcagca actgataaag aactggaggc tttgcgtgaa tgcctggggg cagccatgcc
     4321 cgcccggctc cgcaaggtgg cctcggcctt ggtgcctggc cgccgctcat tgccagtccc
     4381 tgtgtacatg ttagtgcccg ccccggctcg gggtgatgac tcgggcacgg actccgcaga
     4441 gggcacaccc gttaactttt ccagtgcagc ctcgctcagt gacgagacct tacagggacc
     4501 ctccagggac aagccagccg ggcctgggga caggcagaaa cctacaggcc gagctgcccc
     4561 tgccaggcag acccgatctc accggcccaa agcagcaggc gctggtaaga gcacagaaca
     4621 cacccggggg ccctgtagga accgggcagg attggagcta ccactcagca ggccccagag
     4681 tgctcggtcc aacagggata gctcatgcca gacccggacc cgcggagatg gtgccctgca
     4741 gtcgctatgc ctcacaacac ccacagagga agctgtgtac tgcttctatg actctgatga
     4801 ggaaccacca gccactgcac caccacctcg gcgggcatcc gccatcccac gggctctaaa
     4861 gcgcgagaaa ccggcaggca gaaaggagac tccatccagg gcagcccagc ctgccacact
     4921 ccctgtgaga gcccaaccca gactgatcgt ggatgagacc ccgccctgct attccctgac
     4981 ttcctcagct agttccctca gtgagcctga ggcccctgaa cagccggcca accatgctcg
     5041 aggcccggag cagggtagta aacaggacag ctctcctagc ccaagggcag aagaggaact
     5101 tctgcagaga tgtatcagct tggccatgcc caggcgccgg acccaggtgc ctggctcacg
     5161 gcgtcgcaag cccagagcct tgaggtcaga cataaggccc actgagataa cccagaaatg
     5221 ccaggaggag gtggctggct ccgatccagc ctctgaccta gacagtgtgg agtggcaggc
     5281 tatccaagag ggcgcaaact ccattgtcac atggctgcat caggcagcgg ccaaagccag
     5341 cctggaagca tcttctgagt ctgactccct cttgtctttg gtgtccgggg tgtcagcagg
     5401 ctccaccctc cagccctcca agctcaggaa agggcgaaag cctgcagcag aggctggagg
     5461 tgcctggcgt cctgagaaac ggggcacaac ttccactaag atcaatggga gtccccggct
     5521 acctaacggt cctgagaagg caaagggtac ccagaaaatg atggcagggg agtcaaccat
     5581 gctccgggga cggacagtga tctactcagc cggcccagcc tcccgcactc agtccaaagg
     5641 tatttctgga ccttgtacca cacctaagaa gacagggaca tctggtacca ctcagccaga
     5701 aactgtcacc aaagccccca gccctgagca acaacgttca cggagcctcc accgaccggg
     5761 caagatctct gagctggcag ctttgcgcca cccgcccagg agtgccactc ctccagcccg
     5821 cctcgccaag accccgtcct caagctcttc acagacctct ccagcatccc agcccctgcc
     5881 taggcggtcc cctctggcca ctcccacagg aggacctctg cctggccctg gggggtccct
     5941 ggtgcccaag tcaccagcac gggcccttct ggctaagcaa cacaagaccc agaagtcacc
     6001 tgtgcggatc ccattcatgc aaaggccagc caggcgagtg ccacctccac tggccaggcc
     6061 atccccagaa cctggctcta ggggccgagc tggggctgag ggtactcctg gggcacgtgg
     6121 cagccgcctg ggcctggtgc gtatggcttc agctcgctcc agtggcagcg agtcctcgga
     6181 tcgctcaggc ttccgaagac agctgacttt catcaaggaa tccccaggtc tccttcggcg
     6241 tcgcagatca gagctgtcct ctgcggactc cacggcctcc acctcccagg ctgcttcgcc
     6301 ccgccgtgga cggcctgcac tccctgctgt ctttctctgc tcctctcgtt gcgatgagct
     6361 gcgggtatcc ccacggcagc ccctggcagc acagaggtcc ccacaggcca agccaggtct
     6421 cgccccacgt gcgcccagac gcaccagctc tgagagcccc tcacgcctgc ctgtgcgggc
     6481 gagccctgga cggcctgaga cagtcaagcg gtacgcatcc ctgccacata ttagtgtgtc
     6541 ccgcaggtcc gatagcgctg tctctgtgcc caccacccag gccaatgcca ctcgccgggg
     6601 aagtgatggc gaggccaggc cgctgcccag ggtagctcct ccgggtacga cctggcgtcg
     6661 aatcaaagat gaagatgtcc cccacatcct gcgcagcaca ctgcctgcca ctgccctgcc
     6721 tctcagggtc tcgtcacccg aagacagccc cgctggaact ccacagcgca agaccagtga
     6781 cgcagtggtg caaacagagg acgtggccac ttctaagacc aactctagca cgtcacctag
     6841 cctggagagc agggatccgc cacaggcccc tgccagcggc cctgtggctc cccagggcag
     6901 cgatgtggat ggaccagtac tcaccaagcc tcctgcctca gcgcccttcc cccatgaggg
     6961 tctgagtgct gtcatagcag gctttcccac cagcaggcat ggctccccca gcagggctgc
     7021 acgggttccc cccttcaact atgtgcccag ccctatggca gcggccacaa tggccagtga
     7081 ctccgcagtg gagaaagccc cggtctcctc tccagccagt ctcctggagt agtaggtata
     7141 ggcctgaatc tggaactttc tctcctcacc ctgtggccca ggctggctgc gcgtgggcct
     7201 gctctctaaa tgctctgagt aggcgcatct atgtcctcag agccgctgtc cagctcgtac
     7261 ctctgcacct tagggccagt ccgtgcttct atgccgtggg ctcgagggaa tcggctatag
     7321 actggccgca gggcacacac agccccattt tctgaagttg gcctgggaag gggtagacag
     7381 ccgatctctg agagccacta gctgtgggcc catgcaggac ctgccctgag ctgcacccag
     7441 cgggagggtg ggtggacctg gcttctaggg agatgactga gcttgcctgc ctgaggtggg
     7501 cacaggctgg ggggtagggc agtgagcctc tgcttggcag ctggggctgc ctcagccctg
     7561 cactgtggaa gcctgtaatt agcgctgggg taattggtta ataatgactc tgccaggggt
     7621 gtttgccttc tccgaggcgg gctgaagagt gcttggcgag ggactgtaga taagctgctc
     7681 ccagcattcg tcatggccgc tgagagattg ccaagggcaa acagccctct tgacataaaa
     7741 cctgtggatc agccgacact atgtcccttt actgacagga gggactctaa ttccaaggac
     7801 aagctggcta ggctctgcgg gggcccagga gtcagccagc atccctgaag tgaggcgggc
     7861 ccgtctgtgc gagcctggtc cttcccaggc ctgcctgttt tatgatgcag gtgttaggac
     7921 cagatcagat ctcgtgcctc agtcacagcc tggaatcaca atggaggctt ggtgacagtg
     7981 tggggcgcct ggagctgcta cagggcaggg atccaggtgg agagtgggat ccagacctaa
     8041 ggtagccaag ccttcaagga cctgggccgt gggtctgcgt gtgtcaatca cagggacccg
     8101 ggacagagtg aggactcagc tcggtctttc cacagagagc caacaacatc tctactgtgg
     8161 aatgccaggc tgctcctggt aaggggccct atagccacgg ccatctgcat gagctgcccc
     8221 cagagaaggg accgtccctt gagctggcct caagtccctc ttctgagatg agggaagtgg
     8281 ctttgagaat ggggtggggc gggaggcctc gggagggacg atgacactgc tgtcctcttc
     8341 cccatgggtc ccttttatgg cgggaagccg agagccaagc atgctgcctc acaggggcag
     8401 gctgatgact aggggccacc acgtgtgggc tacccctatc atgatacccg tccagtgctt
     8461 tgaaagccca cagtctaagc aatgcctgat gtttccttgt ctggggggct ctggccctaa
     8521 ctgttggggt cagtgtcata gcagaaactc cagacaccaa ctgctcaatg ccaggacctt
     8581 gcctgccagc cagggctgct ggcctacagg tgactggtag ggaggggaaa gggaaggccc
     8641 ttttcagaac agagccaagt ggctctagga gaccctctca aacctcagag gcatcccagg
     8701 atgaccctga actggggttg tagactgagc ctgtgcacca cacactgtgg gagcccaggt
     8761 agccagcatg ctgctctgtg cctcagtttc cccatgtggg ccgtggggag gactcagagt
     8821 agagcagcag agatgtctgg gctgtggtac cagcatgcaa gggccatctt tctcccagcc
     8881 acctcctccc atcctgccag ccttgggggc ccagcagcca catttgcctt cttcacccca
     8941 gacagtgggg gacacaggac acagtgtgac atccagccca gggtaggcaa gagctgacga
     9001 gcccttagat tcagagcagg aggggtctgc tagccgccag gctgccgatg gctgctagcg
     9061 ctctgagctg gacaccagtg gtctaccgga gactaaccac tgggtgcttg accagggcat
     9121 catgcctacc agttacctca ctgtgtgtgt gtgtgtgtct gtcgctgtcc ctggccaatg
     9181 tcaccccttg ctcatacctg gtcagtgtgt cctctgctgc cataccgtct cccgccctgt
     9241 tctactacag tgttacactt ctgtacatac tgacccccga ccccccacgc agacccccga
     9301 gtggacaccc tgcctggctt ctgattcttg ttcatatctt taataaagcg agccactcca
     9361 tcga
//
