LOCUS       NM_146085               2083 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus amyloid beta precursor protein binding family B member
            3 (Apbb3), transcript variant 1, mRNA.
ACCESSION   NM_146085
VERSION     NM_146085.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2083)
  AUTHORS   Guenette,S., Chang,Y., Hiesberger,T., Richardson,J.A., Eckman,C.B.,
            Eckman,E.A., Hammer,R.E. and Herz,J.
  TITLE     Essential roles for the FE65 amyloid precursor protein-interacting
            proteins in brain development
  JOURNAL   EMBO J 25 (2), 420-431 (2006)
   PUBMED   16407979
REFERENCE   2  (bases 1 to 2083)
  AUTHORS   Pappolla,M.A., Chyan,Y.J., Omar,R.A., Hsiao,K., Perry,G.,
            Smith,M.A. and Bozner,P.
  TITLE     Evidence of oxidative stress and in vivo neurotoxicity of
            beta-amyloid in a transgenic mouse model of Alzheimer's disease: a
            chronic oxidative paradigm for testing antioxidant therapies in
            vivo
  JOURNAL   Am J Pathol 152 (4), 871-877 (1998)
   PUBMED   9546346
REFERENCE   3  (bases 1 to 2083)
  AUTHORS   Cao,H., Mattison,J., Zhao,Y., Joki,N., Grasso,M. and Chang,N.S.
  TITLE     Regulation of tumor necrosis factor-and Fas-mediated apoptotic cell
            death by a novel cDNA TR2L
  JOURNAL   Biochem Biophys Res Commun 227 (1), 266-272 (1996)
   PUBMED   8858135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024809.1 and AI844683.1.
            
            On Nov 4, 2017 this sequence version replaced NM_146085.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024809.1, AK141878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2062              BC024809.1         1-2062
            2063-2083           AI844683.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..2083
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /note="amyloid beta precursor protein binding family B
                     member 3"
                     /db_xref="GeneID:225372"
                     /db_xref="MGI:MGI:108404"
     exon            1..370
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1782
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Fe65-like 2; amyloid beta (A4) precursor
                     protein-binding, family B, member 3"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     B member 3 isoform 1"
                     /protein_id="NP_666197.1"
                     /db_xref="CCDS:CCDS29157.1"
                     /db_xref="GeneID:225372"
                     /db_xref="MGI:MGI:108404"
                     /translation="MLGKDYMLAIILVNCDDDLWGDQNLEGETGLPPGWRKIRDAAGT
                     YYWHVPSGSTQWQRPTWELPGAEDPGRGTEGIWELRPPKGRSFSSLDSSLNRSNSLTW
                     YSEDSYVRSLEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRNRSQPH
                     DGTWGEGQNMLMILKKDAMSLLNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVAG
                     DKDSCMLKCHVFHCDVPAKAIASALQGLCAQILSERVGVSGEAACCSPDPISPEDLPR
                     QVELLDAVSQAAQKYEALYMGILPVTKAMGMDVLNEAIGTLTARGDRKTWVPAMLSVS
                     DSLMTAHAIQAEAGAEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGCQSFQCAAFWC
                     EPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPP
                     PLLKGGAGGAGAAPRKRGVFSFLDAFRLKPSLLHMS"
     exon            371..534
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            535..611
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            612..672
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            673..819
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            820..947
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            948..953
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1068
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1153
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1237
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1353
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1545
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..2067
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2044..2049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /note="hexamer: AATAAA"
     polyA_site      2067
                     /gene="Apbb3"
                     /gene_synonym="Fe65l2; Rirl2; TR2S"
                     /note="major polyA site"
ORIGIN      
        1 ctcattcgcc ccctggtgca ccgtgtgcag gatctcctcg cccggcttcc gccgtccgag
       61 gaactcatag ttactaacct gtgcggagtt cgtagtgtca gtacgcttcg taggacagca
      121 cgtaccgaaa cacgcgagga ctcgggaaag cagacgcgcc agcagctctg ccctccccca
      181 aggccgtccc tatcccgccc agcgtttgtt tgcgcggtgc cagttggccg ggccggcggt
      241 ctccggcgca gagaggctgg gcttgtggcc cctgcagctc cggaggtcgc gttgggctga
      301 gagcacaggc cagcagaggc tatgctgggc aaggattata tgctggccat cattctggtc
      361 aactgcgatg atgacttgtg gggggaccaa aatctggagg gggaaacagg cctaccccct
      421 ggctggagaa agatccgtga tgctgcagga acttattatt ggcatgtacc cagcggtagc
      481 actcagtggc agcgcccaac ctgggagcta ccaggtgcag aggacccagg aaggggaaca
      541 gaggggattt gggaactgcg accccccaag ggaagatctt tctccagcct ggacagttca
      601 ttgaaccgga gtaactctct aacatggtat agtgaagatt cctatgtccg gagcctggag
      661 ccaggagcta agtgctttgc agtccgctct ctgggctggg tagaggtccc cgaggaggac
      721 ctggcgccag ggaagagcag tattgctgtc aataactgta tccagcagct ggcccagacc
      781 cgaaaccgga gccagcctca tgatggtacc tggggtgagg gccagaacat gctgatgatc
      841 ctgaaaaagg atgccatgag cctgctgaat cccctggacc acagcctgat ccattgccag
      901 cctctggttc acatccgtgt gtggggtgtg ggcagctcca agggccgtga cagggacttc
      961 gcttttgttg cgggtgacaa agacagctgt atgctcaaat gtcatgtgtt tcactgtgat
     1021 gttcccgcaa aagccatagc aagtgctcta caggggctct gtgcacagat cttgtcagag
     1081 agggtaggag tcagtggaga ggctgcttgc tgttccccag atcctatttc ccctgaagac
     1141 ttacctagac aagtggagtt gctggatgca gtgagccagg ctgctcagaa gtatgaggca
     1201 ctgtacatgg ggatcctacc agtcactaaa gccatgggta tggatgtgct gaatgaggcc
     1261 attggtaccc tcactgcccg gggggaccgg aaaacctggg tccctgctat gctcagtgtg
     1321 tctgactctc tgatgactgc acatgctatc caggcagagg ctggtgcaga ggaagagcca
     1381 ctgtggcagt gccctgttcg ccttgtaacc tttattggtg ttggccgtga tccgcatacc
     1441 tttggcctca tcgctgatct tggttgtcag agcttccagt gtgcagcttt ttggtgcgag
     1501 cctcatgctg ggggactctc tgaagctgtg caagccgcct gcatggttca gtaccagaag
     1561 tgtctagtgg cctcagcagc tcggggtaag gcctggggtg ctcaggcccg tgctcgcctg
     1621 cggctcaagc ggaccagctc catggactcc ccaggcggcc cccttcctcc ccctctactc
     1681 aaaggagggg ctgggggtgc tggagcagct cctcgaaagc ggggtgtctt ctcatttctt
     1741 gatgccttca ggctaaaacc ttctcttctc catatgtcct aacttgatct tagatggctg
     1801 ggtaaagagg ctctctactc ttctggaccc tagggttctg tagcctctta ccttcctgcc
     1861 catccctgat ccttgcctac tctgtattta ttaccaagtt tgttgtttat atggatgact
     1921 gagaggccct gcactgtaac ttaggcctgt ggcacccctt tccttgggtc ctcttgttcc
     1981 ttgcccctgt ccagccctgg acaattggct ctacctcagc aactttatag cagaatcagt
     2041 gcaaataaaa atccctcagt gacctcaaaa aaaaaaaaaa aaa
//
