LOCUS       NM_019456               2540 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus amyloid beta precursor protein binding family B member
            1 interacting protein (Apbb1ip), mRNA.
ACCESSION   NM_019456
VERSION     NM_019456.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2540)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2540)
  AUTHORS   Sun,H., Lee,H.S., Kim,S.H., Fernandes de Lima,M., Gingras,A.R.,
            Du,Q., McLaughlin,W., Ablack,J., Lopez-Ramirez,M.A., Lagarrigue,F.,
            Fan,Z., Chang,J.T., VanDyke,D., Spangler,J.B. and Ginsberg,M.H.
  TITLE     IL-2 can signal via chemokine receptors to promote regulatory T
            cells' suppressive function
  JOURNAL   Cell Rep 42 (8), 112996 (2023)
   PUBMED   37598341
REFERENCE   3  (bases 1 to 2540)
  AUTHORS   Lagarrigue,F., Tan,B., Du,Q., Fan,Z., Lopez-Ramirez,M.A.,
            Gingras,A.R., Wang,H., Qi,W. and Sun,H.
  TITLE     Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes
            Integrin Activation in CD4+ T Cells
  JOURNAL   J Immunol 208 (6), 1378-1388 (2022)
   PUBMED   35197328
REFERENCE   4  (bases 1 to 2540)
  AUTHORS   Sun,H., Lagarrigue,F., Wang,H., Fan,Z., Lopez-Ramirez,M.A.,
            Chang,J.T. and Ginsberg,M.H.
  TITLE     Distinct integrin activation pathways for effector and regulatory T
            cell trafficking and function
  JOURNAL   J Exp Med 218 (2) (2021)
   PUBMED   33104169
REFERENCE   5  (bases 1 to 2540)
  AUTHORS   Lagarrigue,F., Gingras,A.R., Paul,D.S., Valadez,A.J., Cuevas,M.N.,
            Sun,H., Lopez-Ramirez,M.A., Goult,B.T., Shattil,S.J., Bergmeier,W.
            and Ginsberg,M.H.
  TITLE     Rap1 binding to the talin 1 F0 domain makes a minimal contribution
            to murine platelet GPIIb-IIIa activation
  JOURNAL   Blood Adv 2 (18), 2358-2368 (2018)
   PUBMED   30242097
REFERENCE   6  (bases 1 to 2540)
  AUTHORS   Worth,D.C., Hodivala-Dilke,K., Robinson,S.D., King,S.J.,
            Morton,P.E., Gertler,F.B., Humphries,M.J. and Parsons,M.
  TITLE     Alpha v beta3 integrin spatially regulates VASP and RIAM to control
            adhesion dynamics and migration
  JOURNAL   J Cell Biol 189 (2), 369-383 (2010)
   PUBMED   20404115
  REMARK    GeneRIF: Data demonstrate a novel mechanism by which alphavbeta3
            integrin acts to locally suppress beta1 integrin activation and
            regulate VASP and RIAM to control cell adhesion and migration.
REFERENCE   7  (bases 1 to 2540)
  AUTHORS   Menasche,G., Kliche,S., Chen,E.J., Stradal,T.E., Schraven,B. and
            Koretzky,G.
  TITLE     RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating
            T-cell-receptor-mediated integrin activation
  JOURNAL   Mol Cell Biol 27 (11), 4070-4081 (2007)
   PUBMED   17403904
REFERENCE   8  (bases 1 to 2540)
  AUTHORS   Jenzora,A., Behrendt,B., Small,J.V., Wehland,J. and Stradal,T.E.
  TITLE     PREL1 provides a link from Ras signalling to the actin cytoskeleton
            via Ena/VASP proteins
  JOURNAL   FEBS Lett 579 (2), 455-463 (2005)
   PUBMED   15642358
REFERENCE   9  (bases 1 to 2540)
  AUTHORS   Inagaki,T., Suzuki,S., Miyamoto,T., Takeda,T., Yamashita,K.,
            Komatsu,A., Yamauchi,K. and Hashizume,K.
  TITLE     The retinoic acid-responsive proline-rich protein is identified in
            promyeloleukemic HL-60 cells
  JOURNAL   J Biol Chem 278 (51), 51685-51692 (2003)
   PUBMED   14530287
REFERENCE   10 (bases 1 to 2540)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB638237.1, AK041552.1, AK021331.1, AK089987.1 and CT030013.7.
            
            On Oct 25, 2007 this sequence version replaced NM_019456.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023110.1, SRR7345562.2733614.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               BB638237.1         3-197
            196-1041            AK041552.1         199-1044
            1042-1233           AK021331.1         921-1112
            1234-1573           AK089987.1         108-447
            1574-1686           CT030013.7         50683-50795
            1687-2540           CT030013.7         54034-54887
FEATURES             Location/Qualifiers
     source          1..2540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 15.15 cM"
     gene            1..2540
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /note="amyloid beta precursor protein binding family B
                     member 1 interacting protein"
                     /db_xref="GeneID:54519"
                     /db_xref="MGI:MGI:1861354"
     exon            1..195
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2208
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /note="proline-rich protein 48; PREL-1; proline-rich EVH1
                     ligand 1; APBB1-interacting protein 1; amyloid beta (A4)
                     precursor protein-binding, family B, member 1 interacting
                     protein"
                     /codon_start=1
                     /product="amyloid beta A4 precursor protein-binding family
                     B member 1-interacting protein"
                     /protein_id="NP_062329.2"
                     /db_xref="CCDS:CCDS38056.1"
                     /db_xref="GeneID:54519"
                     /db_xref="MGI:MGI:1861354"
                     /translation="MGESNEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPREEFN
                     YTVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESSQNQDRFALLRAS
                     DGQGTASGGYGASAAAIDVSHHEEALPPPPVEPMLDLLPPPPPPPPPELLSKEEEEAK
                     AKADKIKLALEKLKEAKVKKLVVKVHMDDSSTKSLMVDERQLARDVLDNLFEKTHCDC
                     NVDWCLYEIYPELQIERVFEDHENVVEVLSDWTRDTENKVLFLEKEERYAVFKNPQNF
                     YLDNKGKKENKETNEKMNAKNKEYLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRY
                     FLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGIQCKMKYKAPTDHCFVLKHPQI
                     QKESQYIKYLCCDDARTLSQWVMGIRIAKYGKTLYDNYQRAVARAGLASRWTNLGTVG
                     TPMPAQPSTVSSGLKTGTSQPNGQMPQAIPSAGPPLQEAQTQIETTKDEKQGLGNHSP
                     GATRENHRPKSSLPPPPPPVRRSSDTCGSPALPSKVKGPGTCTFPHPPENFLPPPPPP
                     PPEEDNSGLLPPPPPPPYLEEPPDFVPPPPPPAAVEDSALPPPPPPPPCLSQEITKSS
                     PLPPKKPLVPPKRQENQGLPGAPGNSEQDFMSDLMKALQKKRGNIP"
     exon            196..267
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            268..355
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            356..657
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            658..735
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            736..895
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1017
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1104
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1248
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1359
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1458
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1573
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1686
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..2540
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2517..2522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /note="hexamer: ATTAAA"
     polyA_site      2540
                     /gene="Apbb1ip"
                     /gene_synonym="9930118P07Rik; Prp48"
                     /note="major polyA site"
ORIGIN      
        1 aaagcacttc ctcctccctg agcccacgtc ctcgcctcga ggccggtcca gcccagaggc
       61 gccaaccact catctctgct cattccggtg cacttaggct caacccggcc catctctggc
      121 tcagccccgc gcatctctgc acagcctcct cgcatctctg caagcccccc tcgcaccctc
      181 ctcccagcag tcaagatggg tgaatcaaat gaagacatag accagatgtt cagcacttta
      241 ctgggggaga tggatctctt gacccagagt ttaggagtgg acactcttcc tcctccagac
      301 cccaacccac cccgagaaga gtttaactac actgtggggt ttaaggattt aaatgagtcc
      361 ttaaatgcac tggaagacca agatttagat gccctcatgg cagatctggt agcagatata
      421 agtgaagccg aacagagaac catccaggct cagaaagagt cctctcagaa tcaagatcgt
      481 tttgcacttc tgagggcttc ggatggccag ggtacagcct caggaggtta tggagcaagt
      541 gctgctgcta ttgatgttag tcaccatgag gaagctttac cacctccacc cgtagaaccc
      601 atgctagacc ttctgcctcc tcctcctcct cctcctcctc ctgaacttct ctctaaagaa
      661 gaagaagaag ccaaagcaaa ggctgataaa attaagttag cactggaaaa gctgaaggaa
      721 gccaaggtta agaagcttgt agttaaggtg cacatggatg acagcagtac caagtcactg
      781 atggtggatg agcggcagtt ggctcgggat gttctggaca acctttttga aaaaacccat
      841 tgtgactgca atgtggactg gtgcctttat gaaatatatc ccgaactgca aattgagaga
      901 gtttttgaag accatgaaaa tgttgttgaa gtcttatcag actggacaag agacacagag
      961 aacaaagtac tgtttttgga gaaagaggaa agatatgctg tgtttaaaaa ccctcagaat
     1021 ttctacttgg ataataaggg gaaaaaagaa aacaaggaaa ccaatgagaa aatgaacgct
     1081 aaaaacaaag aatacttact tgaggaaagc ttctgcggca catccatcat tgtaccagaa
     1141 cttgaaggag ctctttattt gaaagaagat ggaaagaaat cctggaaacg gcgctacttt
     1201 cttctgagag cttctggaat ttattatgtt cccaaaggaa agacaaagac atcccgcgat
     1261 ctggcatgtt ttatacagtt tgaaaatgta aacatttact atgggattca gtgtaaaatg
     1321 aaatacaaag cacccactga ccactgcttt gttttaaagc atcctcaaat tcagaaggaa
     1381 tctcaatata tcaagtatct ctgctgtgat gacgcaagaa ctctcagtca atgggtaatg
     1441 ggaataagga tcgccaagta tgggaagact ctctatgata actatcagcg ggctgtggca
     1501 agagctggac ttgcctctcg gtggacaaac ctggggactg ttggtacacc gatgccagct
     1561 cagccttcta cagtttcctc aggacttaaa acaggcacca gccagcccaa tggtcagatg
     1621 ccccaggcca tcccttctgc aggtcctcct ctgcaagagg cccagacaca aattgaaacg
     1681 actaaggatg aaaagcaagg cttgggtaac cattccccag gagcaaccag ggagaaccac
     1741 cgtcctaagt ccagcctgcc accgccaccc cctccagtaa gacggtcttc agacacctgt
     1801 ggcagccccg ccttgccatc caaggtcaag ggccctggca cctgcacctt cccccacccg
     1861 ccggagaact tcctgccacc tccaccgccc ccaccgcctg aggaggacaa cagcgggcta
     1921 ctcccgccac ccccgccccc gccctacctg gaggagccac cagacttcgt gccaccaccc
     1981 ccaccgcctg cagctgttga agactctgca ttgccacccc cgccaccacc cccgccctgt
     2041 ctctcccagg agataactaa gtcatctccg ttgcccccca aaaagcccct agtccccccc
     2101 aagaggcaag agaaccaagg actccccggt gcaccaggga acagtgagca agattttatg
     2161 tcagacctca tgaaagcatt gcaaaagaaa agaggcaata taccctaggg acatgttagt
     2221 atttgggatg ctctctatta aaattcatgt tttggtactc tattgtcata tatcttgttc
     2281 attttagtaa aatgttttcc gactagaaat aatgtaaaat ctcttcactg ttgtgcatac
     2341 tatgttcata gccattaagg tagccatatt cagggtttct aactacatat atccaagcac
     2401 acccacatgt acatcctgtg tgctttcaca tgatacattt ttgtcttgca gtccaggttc
     2461 actgaaatga tattctgggt atgttttcgt gtgttcagaa ggctcaaatt ttaaaaatta
     2521 aagtttgtct gaaaacagta
//
