LOCUS       NM_001310600            1958 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus amyloid beta precursor protein binding family B member
            1 (Apbb1), transcript variant 5, mRNA.
ACCESSION   NM_001310600 XM_006507237
VERSION     NM_001310600.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Strecker,P., Ludewig,S., Rust,M., Mundinger,T.A., Gorlich,A.,
            Krachan,E.G., Mehrfeld,C., Herz,J., Korte,M., Guenette,S.Y. and
            Kins,S.
  TITLE     FE65 and FE65L1 share common synaptic functions and genetically
            interact with the APP family in neuromuscular junction formation
  JOURNAL   Sci Rep 6, 25652 (2016)
   PUBMED   27734846
  REMARK    GeneRIF: These data demonstrate a role for FE65 proteins at central
            and peripheral synapses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Lee,H.J., Yoon,J.H., Ahn,J.S., Jo,E.H., Kim,M.Y., Lee,Y.C.,
            Kim,J.W., Ann,E.J. and Park,H.S.
  TITLE     Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1
            protein stability through the E3 ligase Neuralized-like 1
  JOURNAL   Biochim Biophys Acta 1853 (11 Pt A), 2918-2928 (2015)
   PUBMED   26276215
  REMARK    GeneRIF: Jagged1 is a novel binding partner of Fe65, and Fe65 may
            act as a novel effector of Jagged1 signaling.
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Durst,R., Sauls,K., Peal,D.S., deVlaming,A., Toomer,K., Leyne,M.,
            Salani,M., Talkowski,M.E., Brand,H., Perrocheau,M., Simpson,C.,
            Jett,C., Stone,M.R., Charles,F., Chiang,C., Lynch,S.N.,
            Bouatia-Naji,N., Delling,F.N., Freed,L.A., Tribouilloy,C., Le
            Tourneau,T., LeMarec,H., Fernandez-Friera,L., Solis,J.,
            Trujillano,D., Ossowski,S., Estivill,X., Dina,C., Bruneval,P.,
            Chester,A., Schott,J.J., Irvine,K.D., Mao,Y., Wessels,A.,
            Motiwala,T., Puceat,M., Tsukasaki,Y., Menick,D.R., Kasiganesan,H.,
            Nie,X., Broome,A.M., Williams,K., Johnson,A., Markwald,R.R.,
            Jeunemaitre,X., Hagege,A., Levine,R.A., Milan,D.J., Norris,R.A. and
            Slaugenhaupt,S.A.
  TITLE     Mutations in DCHS1 cause mitral valve prolapse
  JOURNAL   Nature 525 (7567), 109-113 (2015)
   PUBMED   26258302
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Ryu,S., Teles,F., Minopoli,G., Russo,T., Rosenfeld,M.G. and Suh,Y.
  TITLE     An epigenomic role of Fe65 in the cellular response to DNA damage
  JOURNAL   Mutat Res 776, 40-47 (2015)
   PUBMED   26255939
  REMARK    GeneRIF: results provide strong evidence that Fe65 plays a role in
            DNA damage response and cell viability by epigenomic regulation of
            specific transcriptional programs activated upon genotoxic stress.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Suh,J., Moncaster,J.A., Wang,L., Hafeez,I., Herz,J., Tanzi,R.E.,
            Goldstein,L.E. and Guenette,S.Y.
  TITLE     FE65 and FE65L1 amyloid precursor protein-binding protein compound
            null mice display adult-onset cataract and muscle weakness
  JOURNAL   FASEB J 29 (6), 2628-2639 (2015)
   PUBMED   25757569
  REMARK    GeneRIF: Findings show that amyloid precursor protein-binding
            proteins FE65 and FE65L1 are essential for the maintenance of lens
            transparency.
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Pappolla,M.A., Chyan,Y.J., Omar,R.A., Hsiao,K., Perry,G.,
            Smith,M.A. and Bozner,P.
  TITLE     Evidence of oxidative stress and in vivo neurotoxicity of
            beta-amyloid in a transgenic mouse model of Alzheimer's disease: a
            chronic oxidative paradigm for testing antioxidant therapies in
            vivo
  JOURNAL   Am J Pathol 152 (4), 871-877 (1998)
   PUBMED   9546346
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G.,
            Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A.,
            Disteche,C.M. and Martin,G.M.
  TITLE     cDNA cloning and chromosome mapping of the human Fe65 gene:
            interaction of the conserved cytoplasmic domains of the human
            beta-amyloid precursor protein and its homologues with the mouse
            Fe65 protein
  JOURNAL   Hum Mol Genet 5 (10), 1589-1598 (1996)
   PUBMED   8894693
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Simeone,A., Duilio,A., Fiore,F., Acampora,D., De Felice,C.,
            Faraonio,R., Paolocci,F., Cimino,F. and Russo,T.
  TITLE     Expression of the neuron-specific FE65 gene marks the development
            of embryo ganglionic derivatives
  JOURNAL   Dev Neurosci 16 (1-2), 53-60 (1994)
   PUBMED   7867517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125227.6.
            
            On Sep 13, 2022 this sequence version replaced NM_001310600.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at an
            alternate start codon, compared to variant 1. It encodes isoform 4,
            which is shorter and has a distinct N-terminus, compared to isoform
            1.
            
            CCDS Note: This coding region lacks full-length transcript support.
            Therefore this CCDS representation has an inferred exon combination
            based on partial transcripts, RNA-seq alignments and orthologous
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784651.656623.1,
                                           SRR17784643.1665496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC125227.6         79917-80069         c
            154-329             AC125227.6         78876-79051         c
            330-386             AC125227.6         78726-78782         c
            387-472             AC125227.6         78552-78637         c
            473-536             AC125227.6         78381-78444         c
            537-686             AC125227.6         77846-77995         c
            687-814             AC125227.6         77349-77476         c
            815-929             AC125227.6         76831-76945         c
            930-1014            AC125227.6         76599-76683         c
            1015-1098           AC125227.6         76270-76353         c
            1099-1214           AC125227.6         70741-70856         c
            1215-1391           AC125227.6         70430-70606         c
            1392-1958           AC125227.6         69782-70348         c
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.9 cM"
     gene            1..1958
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="amyloid beta precursor protein binding family B
                     member 1"
                     /db_xref="GeneID:11785"
                     /db_xref="MGI:MGI:107765"
     exon            1..153
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1559
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="isoform 4 is encoded by transcript variant 5;
                     amyloid beta (A4) precursor protein-binding, family B,
                     member 1"
                     /codon_start=1
                     /product="amyloid beta precursor protein binding family B
                     member 1 isoform 4"
                     /protein_id="NP_001297529.1"
                     /db_xref="CCDS:CCDS80774.1"
                     /db_xref="GeneID:11785"
                     /db_xref="MGI:MGI:107765"
                     /translation="MFSQDFFLAIILQDNSPDSFWNPNAFETDSDLPAGWMRVQDTSG
                     TYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHQEGFEEGEFWKDEPSEEA
                     PMELGLKDPEEATLSFPAQSLSPEPVPQEEEKLSQRNANPGIKCFAVRSLGWVEMTEE
                     ELAPGRSSVAVNNCIRQLSYHKNNLHDPMAGGWGEGKDLLLQLEDETLKLVEPQNQTL
                     LHAQPIVSIRVWGVGRDSGRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSK
                     IMSERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGV
                     DVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRD
                     VHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQTSTSCLPA
                     PPAESVARRVGWTVRRGVQSLWGSLKPKRLGSQTP"
     exon            154..329
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            330..386
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            387..472
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            473..536
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            537..686
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            687..814
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            815..929
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1014
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1098
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1214
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1391
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1958
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1938..1943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="hexamer: AATAAA"
     polyA_site      1958
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="major polyA site"
ORIGIN      
        1 cttttctctg cagcccagca gcaggctgtg agcccagctg gctaggctag aggggatgtg
       61 aggagggagg gtggaggcag gaggggcagg gagtaagcgc catgttctcc caggacttct
      121 tcctggctat catcctgcag gacaacagtc cagattcctt ctggaacccc aacgctttcg
      181 agacggattc cgatctaccg gctggatgga tgagggtaca ggacacctca gggacctact
      241 actggcacat cccaacaggg accacccagt gggaaccccc aggccgggcc tccccctcac
      301 aggggagcag cccccaagaa gagtcccagc tcacctggac tggctttgct caccaagaag
      361 gctttgagga aggagagttt tggaaggatg aacccagtga ggaggcccca atggagttgg
      421 gactgaagga ccccgaggag gcgacattgt ccttcccagc tcagagcctc agcccagaac
      481 cagttcccca ggaggaagag aagctgtccc aacggaatgc caacccaggg atcaagtgtt
      541 tcgctgtgcg ctccctaggc tgggtagaga tgaccgagga ggagctggcc ccaggacgca
      601 gcagtgtggc agtcaacaat tgtatccgcc agctctccta ccacaaaaac aatctacatg
      661 atccgatggc tgggggctgg ggagagggaa aggatctgct gctccagctg gaggacgaga
      721 ctctaaagtt ggtggagcca cagaaccaga cgctgctgca tgcacagccc atcgtcagca
      781 ttcgtgtgtg gggcgttggg cgggacagtg gaagggactt tgcctacgta gctcgagata
      841 agctgaccca gatgctcaag tgccacgtgt ttcgctgtga ggcacctgcc aagaacatcg
      901 ccaccagcct gcatgagatc tgctccaaga tcatgtctga acggcgcaat gctcgctgct
      961 tggtcaatgg actctcccta gaccactcta aactcgtgga tgtccctttc caagtggaat
     1021 tcccagcacc aaagaatgag ctggtgcaga agttccaagt ctattacctg ggaaatgtgc
     1081 cagttgctaa acctgttggg gtagacgtga ttaatggggc cctggagtca gtcctgtctt
     1141 ccagtagccg tgagcagtgg actccaagtc acgtcagcgt ggcccctgcc accctcacca
     1201 tcttgcacca gcagacagaa gcggtgctgg gggagtgccg ggtgcggttt ctctccttcc
     1261 tggctgtggg cagagatgtg cacacattcg cgttcatcat ggctgccggc ccagcctcct
     1321 tctgctgtca catgttttgg tgtgagccca atgctgccag tctctcagag gctgtgcagg
     1381 ctgcatgcat gctccgctac cagaagtgtc tggatgctcg ctcccagacc tccacctcct
     1441 gcctcccagc accccctgcg gagtcagttg caagacgtgt agggtggaca gtccgcaggg
     1501 gtgttcagtc gctgtggggt tccctcaagc ccaaacgtct gggatcccag accccatgaa
     1561 gaactcccat ccttcctctg cctgcttgtt tggggcccca gggaactcaa gggtttgggg
     1621 caggtagggg ctgtggatgt tcttcctaca ccccacgtcc cctgggctgc ccttcctcag
     1681 tagctggggt tccctaccta ggggctggga gagagaaatt gaattccttc acagaagtca
     1741 ttacactgga ctgatgacat gaggggccag aagcaaagcc agccttgggc tctccatccc
     1801 cagtgtttga ggtagagcaa gaggaactgg tccaagccag gccccatcct caaaggccca
     1861 gcaggggcag gagaggactg gtctcatgga tcccctctcc cctgttctgc gggcacctcc
     1921 gctgtactga tatcactaat aaagtctgtc tgcgctgc
//
