LOCUS       NM_001253887            1878 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus amyloid beta precursor protein binding family B member
            1 (Apbb1), transcript variant 3, mRNA.
ACCESSION   NM_001253887
VERSION     NM_001253887.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Strecker,P., Ludewig,S., Rust,M., Mundinger,T.A., Gorlich,A.,
            Krachan,E.G., Mehrfeld,C., Herz,J., Korte,M., Guenette,S.Y. and
            Kins,S.
  TITLE     FE65 and FE65L1 share common synaptic functions and genetically
            interact with the APP family in neuromuscular junction formation
  JOURNAL   Sci Rep 6, 25652 (2016)
   PUBMED   27734846
  REMARK    GeneRIF: These data demonstrate a role for FE65 proteins at central
            and peripheral synapses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Lee,H.J., Yoon,J.H., Ahn,J.S., Jo,E.H., Kim,M.Y., Lee,Y.C.,
            Kim,J.W., Ann,E.J. and Park,H.S.
  TITLE     Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1
            protein stability through the E3 ligase Neuralized-like 1
  JOURNAL   Biochim Biophys Acta 1853 (11 Pt A), 2918-2928 (2015)
   PUBMED   26276215
  REMARK    GeneRIF: Jagged1 is a novel binding partner of Fe65, and Fe65 may
            act as a novel effector of Jagged1 signaling.
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Durst,R., Sauls,K., Peal,D.S., deVlaming,A., Toomer,K., Leyne,M.,
            Salani,M., Talkowski,M.E., Brand,H., Perrocheau,M., Simpson,C.,
            Jett,C., Stone,M.R., Charles,F., Chiang,C., Lynch,S.N.,
            Bouatia-Naji,N., Delling,F.N., Freed,L.A., Tribouilloy,C., Le
            Tourneau,T., LeMarec,H., Fernandez-Friera,L., Solis,J.,
            Trujillano,D., Ossowski,S., Estivill,X., Dina,C., Bruneval,P.,
            Chester,A., Schott,J.J., Irvine,K.D., Mao,Y., Wessels,A.,
            Motiwala,T., Puceat,M., Tsukasaki,Y., Menick,D.R., Kasiganesan,H.,
            Nie,X., Broome,A.M., Williams,K., Johnson,A., Markwald,R.R.,
            Jeunemaitre,X., Hagege,A., Levine,R.A., Milan,D.J., Norris,R.A. and
            Slaugenhaupt,S.A.
  TITLE     Mutations in DCHS1 cause mitral valve prolapse
  JOURNAL   Nature 525 (7567), 109-113 (2015)
   PUBMED   26258302
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Ryu,S., Teles,F., Minopoli,G., Russo,T., Rosenfeld,M.G. and Suh,Y.
  TITLE     An epigenomic role of Fe65 in the cellular response to DNA damage
  JOURNAL   Mutat Res 776, 40-47 (2015)
   PUBMED   26255939
  REMARK    GeneRIF: results provide strong evidence that Fe65 plays a role in
            DNA damage response and cell viability by epigenomic regulation of
            specific transcriptional programs activated upon genotoxic stress.
REFERENCE   5  (bases 1 to 1878)
  AUTHORS   Suh,J., Moncaster,J.A., Wang,L., Hafeez,I., Herz,J., Tanzi,R.E.,
            Goldstein,L.E. and Guenette,S.Y.
  TITLE     FE65 and FE65L1 amyloid precursor protein-binding protein compound
            null mice display adult-onset cataract and muscle weakness
  JOURNAL   FASEB J 29 (6), 2628-2639 (2015)
   PUBMED   25757569
  REMARK    GeneRIF: Findings show that amyloid precursor protein-binding
            proteins FE65 and FE65L1 are essential for the maintenance of lens
            transparency.
REFERENCE   6  (bases 1 to 1878)
  AUTHORS   Pappolla,M.A., Chyan,Y.J., Omar,R.A., Hsiao,K., Perry,G.,
            Smith,M.A. and Bozner,P.
  TITLE     Evidence of oxidative stress and in vivo neurotoxicity of
            beta-amyloid in a transgenic mouse model of Alzheimer's disease: a
            chronic oxidative paradigm for testing antioxidant therapies in
            vivo
  JOURNAL   Am J Pathol 152 (4), 871-877 (1998)
   PUBMED   9546346
REFERENCE   7  (bases 1 to 1878)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   8  (bases 1 to 1878)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 1878)
  AUTHORS   Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G.,
            Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A.,
            Disteche,C.M. and Martin,G.M.
  TITLE     cDNA cloning and chromosome mapping of the human Fe65 gene:
            interaction of the conserved cytoplasmic domains of the human
            beta-amyloid precursor protein and its homologues with the mouse
            Fe65 protein
  JOURNAL   Hum Mol Genet 5 (10), 1589-1598 (1996)
   PUBMED   8894693
REFERENCE   10 (bases 1 to 1878)
  AUTHORS   Simeone,A., Duilio,A., Fiore,F., Acampora,D., De Felice,C.,
            Faraonio,R., Paolocci,F., Cimino,F. and Russo,T.
  TITLE     Expression of the neuron-specific FE65 gene marks the development
            of embryo ganglionic derivatives
  JOURNAL   Dev Neurosci 16 (1-2), 53-60 (1994)
   PUBMED   7867517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125227.6.
            
            On Sep 13, 2022 this sequence version replaced NM_001253887.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and has
            multiple coding region differences compared to variant 1. These
            differences cause translation initiation at a downstream AUG and
            result in an isoform (3) with a shorter N-terminus compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075730.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC125227.6         80538-80591         c
            55-67               AC125227.6         79917-79929         c
            68-243              AC125227.6         78876-79051         c
            244-300             AC125227.6         78726-78782         c
            301-386             AC125227.6         78552-78637         c
            387-450             AC125227.6         78381-78444         c
            451-600             AC125227.6         77846-77995         c
            601-728             AC125227.6         77349-77476         c
            729-734             AC125227.6         77244-77249         c
            735-849             AC125227.6         76831-76945         c
            850-934             AC125227.6         76599-76683         c
            935-1018            AC125227.6         76270-76353         c
            1019-1134           AC125227.6         70741-70856         c
            1135-1311           AC125227.6         70430-70606         c
            1312-1878           AC125227.6         69782-70348         c
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.9 cM"
     gene            1..1878
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="amyloid beta precursor protein binding family B
                     member 1"
                     /db_xref="GeneID:11785"
                     /db_xref="MGI:MGI:107765"
     exon            1..54
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            55..67
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            68..243
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1479
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="isoform 3 is encoded by transcript variant 3;
                     amyloid beta (A4) precursor protein-binding, family B,
                     member 1"
                     /codon_start=1
                     /product="amyloid beta precursor protein binding family B
                     member 1 isoform 3"
                     /protein_id="NP_001240816.1"
                     /db_xref="CCDS:CCDS80773.1"
                     /db_xref="GeneID:11785"
                     /db_xref="MGI:MGI:107765"
                     /translation="MRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWT
                     GFAHQEGFEEGEFWKDEPSEEAPMELGLKDPEEATLSFPAQSLSPEPVPQEEEKLSQR
                     NANPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMAGGWGEG
                     KDLLLQLEDETLKLVEPQNQTLLHAQPIVSIRVWGVGRDSGRERDFAYVARDKLTQML
                     KCHVFRCEAPAKNIATSLHEICSKIMSERRNARCLVNGLSLDHSKLVDVPFQVEFPAP
                     KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTIL
                     HQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQ
                     AACMLRYQKCLDARSQTSTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGSQT
                     P"
     exon            244..300
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            301..386
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            387..450
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            451..600
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            601..728
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            729..734
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            735..849
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            850..934
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1018
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1134
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1311
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1878
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1858..1863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="hexamer: AATAAA"
     polyA_site      1878
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="major polyA site"
ORIGIN      
        1 atcccggtgc tgcggttgcc gaggagacac tgcagcctag ctgggccctg gcaggacaac
       61 agtccagatt ccttctggaa ccccaacgct ttcgagacgg attccgatct accggctgga
      121 tggatgaggg tacaggacac ctcagggacc tactactggc acatcccaac agggaccacc
      181 cagtgggaac ccccaggccg ggcctccccc tcacagggga gcagccccca agaagagtcc
      241 cagctcacct ggactggctt tgctcaccaa gaaggctttg aggaaggaga gttttggaag
      301 gatgaaccca gtgaggaggc cccaatggag ttgggactga aggaccccga ggaggcgaca
      361 ttgtccttcc cagctcagag cctcagccca gaaccagttc cccaggagga agagaagctg
      421 tcccaacgga atgccaaccc agggatcaag tgtttcgctg tgcgctccct aggctgggta
      481 gagatgaccg aggaggagct ggccccagga cgcagcagtg tggcagtcaa caattgtatc
      541 cgccagctct cctaccacaa aaacaatcta catgatccga tggctggggg ctggggagag
      601 ggaaaggatc tgctgctcca gctggaggac gagactctaa agttggtgga gccacagaac
      661 cagacgctgc tgcatgcaca gcccatcgtc agcattcgtg tgtggggcgt tgggcgggac
      721 agtggaagag agagggactt tgcctacgta gctcgagata agctgaccca gatgctcaag
      781 tgccacgtgt ttcgctgtga ggcacctgcc aagaacatcg ccaccagcct gcatgagatc
      841 tgctccaaga tcatgtctga acggcgcaat gctcgctgct tggtcaatgg actctcccta
      901 gaccactcta aactcgtgga tgtccctttc caagtggaat tcccagcacc aaagaatgag
      961 ctggtgcaga agttccaagt ctattacctg ggaaatgtgc cagttgctaa acctgttggg
     1021 gtagacgtga ttaatggggc cctggagtca gtcctgtctt ccagtagccg tgagcagtgg
     1081 actccaagtc acgtcagcgt ggcccctgcc accctcacca tcttgcacca gcagacagaa
     1141 gcggtgctgg gggagtgccg ggtgcggttt ctctccttcc tggctgtggg cagagatgtg
     1201 cacacattcg cgttcatcat ggctgccggc ccagcctcct tctgctgtca catgttttgg
     1261 tgtgagccca atgctgccag tctctcagag gctgtgcagg ctgcatgcat gctccgctac
     1321 cagaagtgtc tggatgctcg ctcccagacc tccacctcct gcctcccagc accccctgcg
     1381 gagtcagttg caagacgtgt agggtggaca gtccgcaggg gtgttcagtc gctgtggggt
     1441 tccctcaagc ccaaacgtct gggatcccag accccatgaa gaactcccat ccttcctctg
     1501 cctgcttgtt tggggcccca gggaactcaa gggtttgggg caggtagggg ctgtggatgt
     1561 tcttcctaca ccccacgtcc cctgggctgc ccttcctcag tagctggggt tccctaccta
     1621 ggggctggga gagagaaatt gaattccttc acagaagtca ttacactgga ctgatgacat
     1681 gaggggccag aagcaaagcc agccttgggc tctccatccc cagtgtttga ggtagagcaa
     1741 gaggaactgg tccaagccag gccccatcct caaaggccca gcaggggcag gagaggactg
     1801 gtctcatgga tcccctctcc cctgttctgc gggcacctcc gctgtactga tatcactaat
     1861 aaagtctgtc tgcgctgc
//
