LOCUS       NM_001253885            2630 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus amyloid beta precursor protein binding family B member
            1 (Apbb1), transcript variant 1, mRNA.
ACCESSION   NM_001253885
VERSION     NM_001253885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2630)
  AUTHORS   Strecker,P., Ludewig,S., Rust,M., Mundinger,T.A., Gorlich,A.,
            Krachan,E.G., Mehrfeld,C., Herz,J., Korte,M., Guenette,S.Y. and
            Kins,S.
  TITLE     FE65 and FE65L1 share common synaptic functions and genetically
            interact with the APP family in neuromuscular junction formation
  JOURNAL   Sci Rep 6, 25652 (2016)
   PUBMED   27734846
  REMARK    GeneRIF: These data demonstrate a role for FE65 proteins at central
            and peripheral synapses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2630)
  AUTHORS   Lee,H.J., Yoon,J.H., Ahn,J.S., Jo,E.H., Kim,M.Y., Lee,Y.C.,
            Kim,J.W., Ann,E.J. and Park,H.S.
  TITLE     Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1
            protein stability through the E3 ligase Neuralized-like 1
  JOURNAL   Biochim Biophys Acta 1853 (11 Pt A), 2918-2928 (2015)
   PUBMED   26276215
  REMARK    GeneRIF: Jagged1 is a novel binding partner of Fe65, and Fe65 may
            act as a novel effector of Jagged1 signaling.
REFERENCE   3  (bases 1 to 2630)
  AUTHORS   Durst,R., Sauls,K., Peal,D.S., deVlaming,A., Toomer,K., Leyne,M.,
            Salani,M., Talkowski,M.E., Brand,H., Perrocheau,M., Simpson,C.,
            Jett,C., Stone,M.R., Charles,F., Chiang,C., Lynch,S.N.,
            Bouatia-Naji,N., Delling,F.N., Freed,L.A., Tribouilloy,C., Le
            Tourneau,T., LeMarec,H., Fernandez-Friera,L., Solis,J.,
            Trujillano,D., Ossowski,S., Estivill,X., Dina,C., Bruneval,P.,
            Chester,A., Schott,J.J., Irvine,K.D., Mao,Y., Wessels,A.,
            Motiwala,T., Puceat,M., Tsukasaki,Y., Menick,D.R., Kasiganesan,H.,
            Nie,X., Broome,A.M., Williams,K., Johnson,A., Markwald,R.R.,
            Jeunemaitre,X., Hagege,A., Levine,R.A., Milan,D.J., Norris,R.A. and
            Slaugenhaupt,S.A.
  TITLE     Mutations in DCHS1 cause mitral valve prolapse
  JOURNAL   Nature 525 (7567), 109-113 (2015)
   PUBMED   26258302
REFERENCE   4  (bases 1 to 2630)
  AUTHORS   Ryu,S., Teles,F., Minopoli,G., Russo,T., Rosenfeld,M.G. and Suh,Y.
  TITLE     An epigenomic role of Fe65 in the cellular response to DNA damage
  JOURNAL   Mutat Res 776, 40-47 (2015)
   PUBMED   26255939
  REMARK    GeneRIF: results provide strong evidence that Fe65 plays a role in
            DNA damage response and cell viability by epigenomic regulation of
            specific transcriptional programs activated upon genotoxic stress.
REFERENCE   5  (bases 1 to 2630)
  AUTHORS   Suh,J., Moncaster,J.A., Wang,L., Hafeez,I., Herz,J., Tanzi,R.E.,
            Goldstein,L.E. and Guenette,S.Y.
  TITLE     FE65 and FE65L1 amyloid precursor protein-binding protein compound
            null mice display adult-onset cataract and muscle weakness
  JOURNAL   FASEB J 29 (6), 2628-2639 (2015)
   PUBMED   25757569
  REMARK    GeneRIF: Findings show that amyloid precursor protein-binding
            proteins FE65 and FE65L1 are essential for the maintenance of lens
            transparency.
REFERENCE   6  (bases 1 to 2630)
  AUTHORS   Pappolla,M.A., Chyan,Y.J., Omar,R.A., Hsiao,K., Perry,G.,
            Smith,M.A. and Bozner,P.
  TITLE     Evidence of oxidative stress and in vivo neurotoxicity of
            beta-amyloid in a transgenic mouse model of Alzheimer's disease: a
            chronic oxidative paradigm for testing antioxidant therapies in
            vivo
  JOURNAL   Am J Pathol 152 (4), 871-877 (1998)
   PUBMED   9546346
REFERENCE   7  (bases 1 to 2630)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   8  (bases 1 to 2630)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 2630)
  AUTHORS   Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G.,
            Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A.,
            Disteche,C.M. and Martin,G.M.
  TITLE     cDNA cloning and chromosome mapping of the human Fe65 gene:
            interaction of the conserved cytoplasmic domains of the human
            beta-amyloid precursor protein and its homologues with the mouse
            Fe65 protein
  JOURNAL   Hum Mol Genet 5 (10), 1589-1598 (1996)
   PUBMED   8894693
REFERENCE   10 (bases 1 to 2630)
  AUTHORS   Simeone,A., Duilio,A., Fiore,F., Acampora,D., De Felice,C.,
            Faraonio,R., Paolocci,F., Cimino,F. and Russo,T.
  TITLE     Expression of the neuron-specific FE65 gene marks the development
            of embryo ganglionic derivatives
  JOURNAL   Dev Neurosci 16 (1-2), 53-60 (1994)
   PUBMED   7867517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125227.6.
            
            On Sep 13, 2022 this sequence version replaced NM_001253885.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164140.1, AK083830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC125227.6         92433-92516         c
            85-819              AC125227.6         84980-85714         c
            820-995             AC125227.6         78876-79051         c
            996-1052            AC125227.6         78726-78782         c
            1053-1138           AC125227.6         78552-78637         c
            1139-1202           AC125227.6         78381-78444         c
            1203-1352           AC125227.6         77846-77995         c
            1353-1480           AC125227.6         77349-77476         c
            1481-1486           AC125227.6         77244-77249         c
            1487-1601           AC125227.6         76831-76945         c
            1602-1686           AC125227.6         76599-76683         c
            1687-1770           AC125227.6         76270-76353         c
            1771-1886           AC125227.6         70741-70856         c
            1887-2063           AC125227.6         70430-70606         c
            2064-2630           AC125227.6         69782-70348         c
FEATURES             Location/Qualifiers
     source          1..2630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.9 cM"
     gene            1..2630
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="amyloid beta precursor protein binding family B
                     member 1"
                     /db_xref="GeneID:11785"
                     /db_xref="MGI:MGI:107765"
     exon            1..84
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            85..819
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2231
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amyloid beta (A4) precursor protein-binding, family B,
                     member 1"
                     /codon_start=1
                     /product="amyloid beta precursor protein binding family B
                     member 1 isoform 1"
                     /protein_id="NP_001240814.1"
                     /db_xref="CCDS:CCDS80776.1"
                     /db_xref="GeneID:11785"
                     /db_xref="MGI:MGI:107765"
                     /translation="MSVPSSLSQSAINANSHGGPALSFPLPLHAAHNQLLNAKLQATA
                     VVPKDLRSAMGEGSVPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQE
                     AETAPLGPKGLMHLYSELELSAHNAANRGLHGSALIINTQEQGPDEGEEKAAGEAEED
                     DEDEEEEEEEEDLSSPPGLPEPLENVEVPSGPQALTDGPREHSKSASLLFGMRNSAAS
                     DEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTG
                     TTQWEPPGRASPSQGSSPQEESQLTWTGFAHQEGFEEGEFWKDEPSEEAPMELGLKDP
                     EEATLSFPAQSLSPEPVPQEEEKLSQRNANPGIKCFAVRSLGWVEMTEEELAPGRSSV
                     AVNNCIRQLSYHKNNLHDPMAGGWGEGKDLLLQLEDETLKLVEPQNQTLLHAQPIVSI
                     RVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMSERRN
                     ARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGAL
                     ESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFI
                     MAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQTSTSCLPAPPAESVA
                     RRVGWTVRRGVQSLWGSLKPKRLGSQTP"
     exon            820..995
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1052
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1138
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1202
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1352
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1480
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1486
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1601
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1686
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1770
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1886
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2063
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2630
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2610..2615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="hexamer: AATAAA"
     polyA_site      2630
                     /gene="Apbb1"
                     /gene_synonym="Fe65; Rir"
                     /note="major polyA site"
ORIGIN      
        1 gttgtgatgg agaagctgcg gtgttgcggg agccttgcag cttgagctac cttcgccacc
       61 tgggcctggg gcctcgccgc gcaggatcta ccaaggccat gtctgttcca tcatccctga
      121 gccagtcggc cattaacgct aacagccacg gaggccctgc actcagcttc cccttacccc
      181 tgcacgctgc ccataaccag ctgctcaacg ccaagctgca agccacagct gtggtaccca
      241 aggaccttcg aagtgctatg ggagagggta gtgtgcctga accaggccct gccaatgcca
      301 agtggttaaa ggaaggccag aaccagcttc ggagggctgc cacagcccac cgagaccaga
      361 accgaaatgt gaccttgacc ttggcggagg aggccagcca ggaggctgag acggcacctt
      421 tgggtcccaa aggcttaatg catctatact ctgagctgga gctctcggcc cacaatgcag
      481 ccaaccgagg gcttcatgga tccgccttga tcatcaacac ccaggaacag ggaccagatg
      541 aaggagagga gaaggcagca ggagaggctg aggaggatga tgaagacgaa gaggaggagg
      601 aggaggagga ggacttgtct tctcctccag ggctacctga gcctctggag aatgtggaag
      661 tcccctctgg gccccaggcc ctcacagacg gcccccggga acacagcaag agtgctagcc
      721 tcctatttgg catgcgaaac agtgcagcca gtgatgagga ctcaagctgg gccaccttat
      781 cacagggcag cccctcctat ggctccccgg aggacacaga ttccttctgg aaccccaacg
      841 ctttcgagac ggattccgat ctaccggctg gatggatgag ggtacaggac acctcaggga
      901 cctactactg gcacatccca acagggacca cccagtggga acccccaggc cgggcctccc
      961 cctcacaggg gagcagcccc caagaagagt cccagctcac ctggactggc tttgctcacc
     1021 aagaaggctt tgaggaagga gagttttgga aggatgaacc cagtgaggag gccccaatgg
     1081 agttgggact gaaggacccc gaggaggcga cattgtcctt cccagctcag agcctcagcc
     1141 cagaaccagt tccccaggag gaagagaagc tgtcccaacg gaatgccaac ccagggatca
     1201 agtgtttcgc tgtgcgctcc ctaggctggg tagagatgac cgaggaggag ctggccccag
     1261 gacgcagcag tgtggcagtc aacaattgta tccgccagct ctcctaccac aaaaacaatc
     1321 tacatgatcc gatggctggg ggctggggag agggaaagga tctgctgctc cagctggagg
     1381 acgagactct aaagttggtg gagccacaga accagacgct gctgcatgca cagcccatcg
     1441 tcagcattcg tgtgtggggc gttgggcggg acagtggaag agagagggac tttgcctacg
     1501 tagctcgaga taagctgacc cagatgctca agtgccacgt gtttcgctgt gaggcacctg
     1561 ccaagaacat cgccaccagc ctgcatgaga tctgctccaa gatcatgtct gaacggcgca
     1621 atgctcgctg cttggtcaat ggactctccc tagaccactc taaactcgtg gatgtccctt
     1681 tccaagtgga attcccagca ccaaagaatg agctggtgca gaagttccaa gtctattacc
     1741 tgggaaatgt gccagttgct aaacctgttg gggtagacgt gattaatggg gccctggagt
     1801 cagtcctgtc ttccagtagc cgtgagcagt ggactccaag tcacgtcagc gtggcccctg
     1861 ccaccctcac catcttgcac cagcagacag aagcggtgct gggggagtgc cgggtgcggt
     1921 ttctctcctt cctggctgtg ggcagagatg tgcacacatt cgcgttcatc atggctgccg
     1981 gcccagcctc cttctgctgt cacatgtttt ggtgtgagcc caatgctgcc agtctctcag
     2041 aggctgtgca ggctgcatgc atgctccgct accagaagtg tctggatgct cgctcccaga
     2101 cctccacctc ctgcctccca gcaccccctg cggagtcagt tgcaagacgt gtagggtgga
     2161 cagtccgcag gggtgttcag tcgctgtggg gttccctcaa gcccaaacgt ctgggatccc
     2221 agaccccatg aagaactccc atccttcctc tgcctgcttg tttggggccc cagggaactc
     2281 aagggtttgg ggcaggtagg ggctgtggat gttcttccta caccccacgt cccctgggct
     2341 gcccttcctc agtagctggg gttccctacc taggggctgg gagagagaaa ttgaattcct
     2401 tcacagaagt cattacactg gactgatgac atgaggggcc agaagcaaag ccagccttgg
     2461 gctctccatc cccagtgttt gaggtagagc aagaggaact ggtccaagcc aggccccatc
     2521 ctcaaaggcc cagcaggggc aggagaggac tggtctcatg gatcccctct cccctgttct
     2581 gcgggcacct ccgctgtact gatatcacta ataaagtctg tctgcgctgc
//
