LOCUS       NM_018758               2124 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus amyloid beta precursor protein binding family A member
            3 (Apba3), mRNA.
ACCESSION   NM_018758
VERSION     NM_018758.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2124)
  AUTHORS   Uematsu,T., Tsuchiya,K., Kobayashi,N., Seiki,M., Inoue,J.I.,
            Kaneko,S. and Sakamoto,T.
  TITLE     Mint3 depletion-mediated glycolytic and oxidative alterations
            promote pyroptosis and prevent the spread of Listeria monocytogenes
            infection in macrophages
  JOURNAL   Cell Death Dis 12 (4), 404 (2021)
   PUBMED   33854054
  REMARK    GeneRIF: Mint3 depletion-mediated glycolytic and oxidative
            alterations promote pyroptosis and prevent the spread of Listeria
            monocytogenes infection in macrophages.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2124)
  AUTHORS   Lin,A.Y., Henry,S., Reissner,C., Neupert,C., Kenny,C., Missler,M.,
            Beffert,U. and Ho,A.
  TITLE     A rare autism-associated MINT2/APBA2 mutation disrupts neurexin
            trafficking and synaptic function
  JOURNAL   Sci Rep 9 (1), 6024 (2019)
   PUBMED   30988517
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2124)
  AUTHORS   Hara,T., Murakami,Y., Seiki,M. and Sakamoto,T.
  TITLE     Mint3 in bone marrow-derived cells promotes lung metastasis in
            breast cancer model mice
  JOURNAL   Biochem Biophys Res Commun 490 (3), 688-692 (2017)
   PUBMED   28634075
  REMARK    GeneRIF: Mint3 depletion attenuated metastasis to the lungs in
            breast cancer model mice.
REFERENCE   4  (bases 1 to 2124)
  AUTHORS   Hara,T., Nakaoka,H.J., Hayashi,T., Mimura,K., Hoshino,D., Inoue,M.,
            Nagamura,F., Murakami,Y., Seiki,M. and Sakamoto,T.
  TITLE     Control of metastatic niche formation by targeting APBA3/Mint3 in
            inflammatory monocytes
  JOURNAL   Proc Natl Acad Sci U S A 114 (22), E4416-E4424 (2017)
   PUBMED   28507122
  REMARK    GeneRIF: APBA3-deficient mice show reduced metastasis, with no
            apparent effect on primary tumor growth. APBA3 deficiency in
            inflammatory monocytes hampers glycolysis-dependent chemotaxis of
            cells toward metastatic sites.
REFERENCE   5  (bases 1 to 2124)
  AUTHORS   Huai,W., Song,H., Yu,Z., Wang,W., Han,L., Sakamoto,T., Seiki,M.,
            Zhang,L., Zhang,Q. and Zhao,W.
  TITLE     Mint3 potentiates TLR3/4- and RIG-I-induced IFN-beta expression and
            antiviral immune responses
  JOURNAL   Proc Natl Acad Sci U S A 113 (42), 11925-11930 (2016)
   PUBMED   27698125
  REMARK    GeneRIF: we have identified Mint3 as a physiological positive
            regulator of TLR3/4 and RIG-I-induced IFN-beta production and have
            outlined a feedback mechanism for the control of antiviral immune
            responses.
REFERENCE   6  (bases 1 to 2124)
  AUTHORS   Gulyas-Kovacs,A., de Wit,H., Milosevic,I., Kochubey,O., Toonen,R.,
            Klingauf,J., Verhage,M. and Sorensen,J.B.
  TITLE     Munc18-1: sequential interactions with the fusion machinery
            stimulate vesicle docking and priming
  JOURNAL   J Neurosci 27 (32), 8676-8686 (2007)
   PUBMED   17687045
  REMARK    GeneRIF: Binding of Munc18-1 to closed, target-SNARE syntaxin 1
            stimulates vesicle docking and regulates the consecutive priming
            step during exocytosis of secretory or synaptic vesicles.
REFERENCE   7  (bases 1 to 2124)
  AUTHORS   Ho,A., Morishita,W., Atasoy,D., Liu,X., Tabuchi,K., Hammer,R.E.,
            Malenka,R.C. and Sudhof,T.C.
  TITLE     Genetic analysis of Mint/X11 proteins: essential presynaptic
            functions of a neuronal adaptor protein family
  JOURNAL   J Neurosci 26 (50), 13089-13101 (2006)
   PUBMED   17167098
  REMARK    GeneRIF: Mints are important regulators of presynaptic
            neurotransmitter release that are essential for mouse survival.
REFERENCE   8  (bases 1 to 2124)
  AUTHORS   Wang,P., Wang,X. and Pei,D.
  TITLE     Mint-3 regulates the retrieval of the internalized membrane-type
            matrix metalloproteinase, MT5-MMP, to the plasma membrane by
            binding to its carboxyl end motif EWV
  JOURNAL   J Biol Chem 279 (19), 20461-20470 (2004)
   PUBMED   14990567
  REMARK    GeneRIF: Mint-3 regulates the retrieval of the internalized
            membrane-type matrix metalloproteinase, MT5-MMP, to the plasma
            membrane by binding to its carboxyl end motif EWV
REFERENCE   9  (bases 1 to 2124)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2124)
  AUTHORS   Borg,J.P., Straight,S.W., Kaech,S.M., de Taddeo-Borg,M.,
            Kroon,D.E., Karnak,D., Turner,R.S., Kim,S.K. and Margolis,B.
  TITLE     Identification of an evolutionarily conserved heterotrimeric
            protein complex involved in protein targeting
  JOURNAL   J Biol Chem 273 (48), 31633-31636 (1998)
   PUBMED   9822620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045965.1, AK169462.1 and BQ031518.1.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_018758.3.
            
            On Apr 9, 2009 this sequence version replaced NM_018758.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045965.1, AK169462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-975               AK045965.1         2-976
            976-2093            AK169462.1         960-2077
            2094-2124           BQ031518.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2124
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /note="amyloid beta precursor protein binding family A
                     member 3"
                     /db_xref="GeneID:57267"
                     /db_xref="MGI:MGI:1888527"
     exon            1..148
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            149..831
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1980
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /note="Mint 3; adapter protein X11gamma; neuron-specific
                     X11L2 protein; neuronal munc18-1-interacting protein 3;
                     amyloid beta (A4) precursor protein-binding, family A,
                     member 3"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 3"
                     /protein_id="NP_061228.1"
                     /db_xref="CCDS:CCDS24050.1"
                     /db_xref="GeneID:57267"
                     /db_xref="MGI:MGI:1888527"
                     /translation="MEFLPGPQHPPGPPTMDLEEPKGPEVPSENHPSNTQSALGPGGP
                     VTLSEMELDTSSVQELVQQLEALPSDLGGPFPDGAPCPLHIATGQGLATQENPDAGGL
                     LSAEAGGDDLLGLLRDEASSPAQSVPQDPAQTAPRLLQPPEDPDGDPGWMEGASAEPA
                     DSRSSSSSPEPWLETAPLVTQQEPPVGTQSRETLASCPAVTEVPGPCGPEELMDGVIF
                     GAKYLGSTQLLSERSPAPSTRMGQAQEAMDRVKAPEGETQPMVEVDIFISTKRVKVLA
                     ADSQDALMDHALQTISYIADIGPVLVLMARRRLARRTTPQDRQRRLYKMLCHVFHSED
                     AQLIAQAIGQAFSIAYSQFLQENRIDPSQVGTQPSTAASHPHNGDLDHFCNSQNCREV
                     CIQKRPGEGLGVALVESGWGSLLPTAVIANLLHGGPAERCGALSIGDRVTAINGTSLV
                     GLSLAACQAAVREVRRLSSVTLSIIHCPPVTTAVIRRPHVREQLGFCVEDGIICSLLR
                     GGAAERGGVRVGHRIIEVNGQSVVAMPHARIIQLLTETREIHIKTMPAATYRLLTGQE
                     QPVYL"
     exon            832..871
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1017
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1104
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1266
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1437
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1650
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1770
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1908
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2107
                     /gene="Apba3"
                     /gene_synonym="lin-10; Mint-3; mint3; X11gamma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggccgtttg agagtgtgta tgcgcaatag tcctggatgg tgcagtgacc gatgatccgg
       61 ttccaaagct gggatcccag agagctgctg actcttctgg aaggacgggc ggaccgtccg
      121 gacaatcctg cccgggccgg agacacaggc cccatgggga tggaatctgt cacctgtagg
      181 accatggctt gcctacgaga tccacactca gagccctcat cttccagctt ggtgacaatg
      241 ccggcctgaa cctgggtctc agacatggag ttcctgccag gaccccagca tcccccaggg
      301 cccccaacca tggacttgga ggagcccaaa ggccccgagg tgccctctga gaaccacccc
      361 tctaacaccc agtcggcctt agggcctgga ggccctgtca ccctgagtga gatggagctg
      421 gacacatcca gtgtgcagga gctggttcag cagctagaag ctctacccag cgacctgggt
      481 ggcccattcc cagatggagc cccctgtccc ctgcacattg ctaccggcca aggacttgcc
      541 acccaggaga acccagatgc tggtgggctc ttgtcggccg aggcaggcgg ggacgacctt
      601 ctgggtctgc tgagggatga ggcctcttcg cctgcccaat ctgtccccca agatcctgca
      661 cagactgcac cccgccttct gcagccgcca gaggaccctg atggggaccc gggatggatg
      721 gaaggggcat cagcagagcc agcagacagc aggagctcca gcagttcccc ggagccctgg
      781 ctggagacag cacccctggt gacacagcag gaaccacctg tgggtaccca gagccgggag
      841 accctggcct cgtgccctgc cgtcaccgag gtcccaggtc cctgtgggcc ggaggagctc
      901 atggatggtg tcatcttcgg ggcgaaatac ctgggctcca cccagctgct gtcagagcgc
      961 agcccggcgc ccagcacacg catggggcag gcgcaggagg ccatggaccg cgtcaaggcc
     1021 cctgaaggcg agacccagcc catggtggaa gtggacatct ttatctccac caagcgtgtc
     1081 aaagtgttgg ctgctgactc ccaggatgcc ctgatggacc atgccctgca gaccatctcc
     1141 tacatcgcag acattgggcc tgtactggtc ttgatggccc ggaggcggct ggccaggagg
     1201 acaactcccc aggaccgcca gcggcgactc tacaagatgc tgtgccatgt cttccactca
     1261 gaggatgccc agctcatagc acaagccatc ggccaggcct tcagcatcgc ctacagccag
     1321 ttcctacagg agaacaggat cgaccccagc caggtgggca cgcagccctc aaccgctgcc
     1381 agccacccgc acaacggcga cctggaccac ttctgcaaca gccagaactg tagggaggtt
     1441 tgcatccaga agcggccagg tgaaggcctg ggcgtcgcgc tagttgaatc aggctggggc
     1501 tcgctactgc ccactgcggt cattgccaac ctgctccatg ggggccctgc cgagcgctgc
     1561 ggggccctga gcatagggga ccgcgtcact gccatcaatg gaaccagcct ggtggggctg
     1621 tcgctggctg cctgccaggc tgcggtgcgc gaggtgcggc gactttcatc cgtgacgctg
     1681 agtattatcc actgcccacc ggtcaccacg gccgtcatcc gccggcccca cgtgcgcgag
     1741 cagctgggct tctgtgtgga ggatggaatc atttgtagcc tgctgcgtgg gggcgctgct
     1801 gagcgtggtg gagtccgcgt tggacaccgc atcattgagg tcaacgggca gagcgtggtg
     1861 gctatgcccc atgcgcgcat catccagctg ctcacagaga caagagaaat ccacatcaag
     1921 accatgccag ctgccaccta ccgactgctc acgggacagg aacaaccagt atacctatga
     1981 ctgccccacc catgtgtgcc ttcatccctg ccaccgtcac tccttcactg gcagggacca
     2041 aagagtcctc agtcttgtat tattttctaa tataaaaaat tttttttaaa gatttattaa
     2101 gtggtcaaaa aaaaaaaaaa aaaa
//
