LOCUS       NM_001411945            3140 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus amyloid beta precursor protein binding family A member
            2 (Apba2), transcript variant 18, mRNA.
ACCESSION   NM_001411945 XM_036152593
VERSION     NM_001411945.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Lin,A.Y., Henry,S., Reissner,C., Neupert,C., Kenny,C., Missler,M.,
            Beffert,U. and Ho,A.
  TITLE     A rare autism-associated MINT2/APBA2 mutation disrupts neurexin
            trafficking and synaptic function
  JOURNAL   Sci Rep 9 (1), 6024 (2019)
   PUBMED   30988517
  REMARK    GeneRIF: A rare autism-associated MINT2/APBA2 mutation disrupts
            neurexin trafficking and synaptic function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Motodate,R., Saito,H., Sobu,Y., Hata,S., Saito,Y., Nakaya,T. and
            Suzuki,T.
  TITLE     X11 and X11-like proteins regulate the level of extrasynaptic
            glutamate receptors
  JOURNAL   J Neurochem 148 (4), 480-498 (2019)
   PUBMED   30411795
  REMARK    GeneRIF: X11 and X11L regulate the glutamate receptor
            micro-localization to the extrasynaptic region
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Motodate,R., Saito,Y., Hata,S. and Suzuki,T.
  TITLE     Expression and localization of X11 family proteins in neurons
  JOURNAL   Brain Res 1646, 227-234 (2016)
   PUBMED   27268412
  REMARK    GeneRIF: Results indicate that both X11 and X11L exert largely in
            brain neurons, but X11 may also function in peripheral tissues.
REFERENCE   5  (bases 1 to 3140)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 3140)
  AUTHORS   Lee,D.S., Tomita,S., Kirino,Y. and Suzuki,T.
  TITLE     Regulation of X11L-dependent amyloid precursor protein metabolism
            by XB51, a novel X11L-binding protein
  JOURNAL   J Biol Chem 275 (30), 23134-23138 (2000)
   PUBMED   10833507
REFERENCE   7  (bases 1 to 3140)
  AUTHORS   Tomita,S., Ozaki,T., Taru,H., Oguchi,S., Takeda,S., Yagi,Y.,
            Sakiyama,S., Kirino,Y. and Suzuki,T.
  TITLE     Interaction of a neuron-specific protein containing PDZ domains
            with Alzheimer's amyloid precursor protein
  JOURNAL   J Biol Chem 274 (4), 2243-2254 (1999)
   PUBMED   9890987
REFERENCE   8  (bases 1 to 3140)
  AUTHORS   Blanco,G., Irving,N.G., Brown,S.D., Miller,C.C. and McLoughlin,D.M.
  TITLE     Mapping of the human and murine X11-like genes (APBA2 and apba2),
            the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2):
            genes encoding phosphotyrosine-binding domain proteins that
            interact with the Alzheimer's disease amyloid precursor protein
  JOURNAL   Mamm Genome 9 (6), 473-475 (1998)
   PUBMED   9585438
REFERENCE   9  (bases 1 to 3140)
  AUTHORS   Duclos,F. and Koenig,M.
  TITLE     Comparison of primary structure of a neuron-specific protein, X11,
            between human and mouse
  JOURNAL   Mamm Genome 6 (1), 57-58 (1995)
   PUBMED   7719031
REFERENCE   10 (bases 1 to 3140)
  AUTHORS   Duclos,F., Boschert,U., Sirugo,G., Mandel,J.L., Hen,R. and
            Koenig,M.
  TITLE     Gene in the region of the Friedreich ataxia locus encodes a
            putative transmembrane protein expressed in the nervous system
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 109-113 (1993)
   PUBMED   7678331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129199.3, AC140297.3 and AC127306.3.
            
            On Sep 13, 2022 this sequence version replaced XM_036152593.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.619361.1,
                                           SRR7345562.474655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC129199.3         152285-152401
            118-242             AC140297.3         99908-100032
            243-296             AC127306.3         44718-44771
            297-1290            AC127306.3         104711-105704
            1291-1371           AC127306.3         124118-124198
            1372-1408           AC127306.3         125198-125234
            1409-1554           AC127306.3         143200-143345
            1555-1641           AC127306.3         146568-146654
            1642-1827           AC127306.3         149386-149571
            1828-2007           AC127306.3         152947-153126
            2008-2220           AC127306.3         154103-154315
            2221-2340           AC127306.3         155385-155504
            2341-3140           AC127306.3         162758-163557
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 34.65 cM"
     gene            1..3140
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /note="amyloid beta precursor protein binding family A
                     member 2"
                     /db_xref="GeneID:11784"
                     /db_xref="MGI:MGI:1261791"
     exon            1..117
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            118..242
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            243..296
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            297..1290
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..2412
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /note="isoform d is encoded by transcript variant 18;
                     mint-2; adapter protein X11beta; neuron-specific X11L
                     protein; neuronal Munc18-1-interacting protein 2; Mint 2;
                     amyloid beta (A4) precursor protein-binding, family A,
                     member 2"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform d"
                     /protein_id="NP_001398874.1"
                     /db_xref="GeneID:11784"
                     /db_xref="MGI:MGI:1261791"
                     /translation="MAHRKRQSTASSMLDHRARPGPIPHDQEPESEDTELPLESYVPT
                     GLELGTLRPESPTPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGVTYYIR
                     YCPEDDSYLEGMDCNGEEYIAHGAHPVDTDECQEAVEDWTDSVGPHTHSHGAENSQEY
                     PDGHLPIPEDDPTVLEVHDQEEDGHYCSSKESYQDYYPPETNGNTGGASPYRMRRGDG
                     DLEEQEEDIDQIVAEIKMSLSMTSITSASEASPEHMPELDPGDSTEACPPSDTGHGPG
                     RQEARPKSLNLPPEVKHPGDLQRGLKTKTRTPEERPKWPQEQVCNGLEQPRKQQRSDL
                     NGPTDNNNIPETKKVASFPSFVAVPGPCEAEDLIDGIIFAANYLGSTQLLSERNPSKN
                     IRMMQAQEAVSRVKNSEGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIA
                     DIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQA
                     FSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGE
                     ILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQ
                     GIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIIHMKTMPAAMFRLL
                     TGQETPLYI"
     exon            1291..1371
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1408
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1554
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1641
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1827
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2007
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2220
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2340
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..3140
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3120..3125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /note="hexamer: AATAAA"
     polyA_site      3140
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /note="major polyA site"
ORIGIN      
        1 agcagtctcg gtgtgcggct cggcgcgggc tcacaaagag ctgctgcggc gccccgctct
       61 cggcctcgcc gacccagtcg ggggcggcgg cgcatcgcgc aacccgcgcg ggcgcagttc
      121 tctggatatt gaggcactgt tgaagctcag ccaggggacc ccacccctac ccccaagccg
      181 tcggtggtag actttcctgc agacagggac agggagagcc atcctgtgtg tggagactgc
      241 cggaagactg gatcaccagg gaagttctca ggacattatc acggcactca tttctgtggc
      301 tgcttccagg taacaatggc tgtgtgagcg tctgccatgg cccaccgcaa gcgtcagagc
      361 actgcaagca gcatgctgga ccacagggcc aggccaggtc ctatccccca tgaccaggag
      421 cctgagagtg aggacacaga actgcctctg gagagctatg tacccacagg cctggagctg
      481 ggcactctga ggccagagag ccccacgccc gaggaacagg agtgccacaa ccatagtcct
      541 gatggggact ccagctctga ctatgtgaac aacacatctg aggaggagga ctatgacgag
      601 ggcctccctg aggaggagga gggtgtcacc tactacatcc gctactgtcc tgaggatgac
      661 agctacctgg agggcatgga ctgtaatggg gaggaataca tagcacacgg tgcacatccc
      721 gtggacaccg atgagtgtca ggaggcggtg gaggactgga cggactcagt gggccctcat
      781 actcatagcc acggggctga aaacagccag gagtacccag atggccacct gcctatccca
      841 gaggatgacc ctactgtcct ggaggtccat gaccaggaag aagatggcca ctactgttcc
      901 agcaaggaga gctaccagga ctattacccc ccagagacca atgggaacac aggtggcgcc
      961 tccccctatc gcatgaggcg tggggatggg gacctagagg agcaggagga agacatcgac
     1021 cagatagtgg ctgagatcaa gatgagcctg agcatgacca gtattaccag tgccagcgag
     1081 gccagccctg agcacatgcc ggagctggat cccggggatt ccactgaggc ctgtccaccc
     1141 agtgacactg gccatggacc cggtaggcaa gaagcaaggc ccaagtcgct gaaccttccc
     1201 cctgaggtta agcaccctgg agacctccag agaggactca agaccaagac caggacccca
     1261 gaggagaggc caaagtggcc ccaagagcag gtttgcaatg gcttagagca gccaaggaag
     1321 cagcagcgct ctgatctcaa tgggcccact gacaataaca acatcccaga gacaaagaag
     1381 gtggcatcat ttccaagctt tgtggctgtt ccagggccct gtgaggcaga agacctcatc
     1441 gatggaatca tctttgcagc caactacctg ggctccaccc agctgctctc tgagcgcaac
     1501 ccctccaaaa acatccgaat gatgcaggct caagaagccg tcagcagggt caagaattct
     1561 gagggtgatg ctcagacact gacagaagta gacctcttca tttcgaccca gaggatcaag
     1621 gtcttaaacg ctgacacgca ggaaaccatg atggaccatg ccttgcgcac catctcctac
     1681 attgcagaca ttgggaacat cgtggttctg atggccaggc gccgcatgcc caggtcagcc
     1741 tctcaggact gcattgagac cacgcctggg gcccaggagg gaaagaagca gtacaagatg
     1801 atctgtcacg tgttcgagtc agaggatgcc cagctgatcg cccagtccat tgggcaggcc
     1861 ttcagcgtgg cttaccagga gttcctgagg gccaatggca tcaaccccga agacctgagc
     1921 cagaaggaat atagcgacat cataaatacc caagagatgt ataatgacga cctcatccac
     1981 ttctcaaact cagagaactg caaggagctg cagctagaga agcacaaggg tgagattttg
     2041 ggtgtggtgg tcgtggaatc gggctggggc tccatcctgc ccactgtgat cctggcgaac
     2101 atgatgaacg gcggcccagc ggctcgctca gggaagctga gcattgggga ccagatcatg
     2161 tccatcaacg gcaccagcct ggtggggctg cccctggcta cgtgccaggg catcatcaag
     2221 ggcctgaaga accaaaccca ggtaaagctc aacattgtca gctgcccccc ggtcaccacc
     2281 gtcctcatca agcgtccaga cctcaagtac cagctgggtt tcagcgtgca gaatggaatc
     2341 attcacatga agaccatgcc tgcagccatg tttaggctcc tcacgggcca ggagaccccg
     2401 ctgtacatct aggtacaccc aacctcaccg tggagccggg ataccaggca gacccacctg
     2461 ggtccggacg agccagaagc caggacaaag ccctgacccc ctgaccccct tgcagccacc
     2521 ccaaccagga cctctggctc cctcaaagga agggtgtgtc cttgtcacct agtttttttg
     2581 tttggttgtt tttgttttgt tttgttttgt tttagttttg ttttcagttt tgctacaaca
     2641 aaaaaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag
     2701 aaagaaagaa aagggggaaa aataggtatg tccttactga aggagagttg cagggcaatc
     2761 ctttgtgaaa cttaccagtc ttctgccaca ttctcatcac ggctgatgaa gggtgctcac
     2821 aggtagttct gtgtggtgtg ctgtctctac tccctgaggc tatggaatgt gaatgtggtg
     2881 cccacccctc ccgtctccgt ggctgtgaaa ggagtccccc ctgtgatgca gctgcagcct
     2941 tttctgccct tggctgtgac ccctggggtc caggggtgtc ctagagggcc catctgctgg
     3001 ccttgcctcc tctgcacagg cacaggggca acctggcttc caggctgaga cttgtgccaa
     3061 gtgtgggaac gtgtgattga ttgtaagtat ttacgcagca aggggatgct cccgagttaa
     3121 ataaaaaatc atggtcacga
//
