LOCUS       NM_001411935            3448 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus amyloid beta precursor protein binding family A member
            2 (Apba2), transcript variant 8, mRNA.
ACCESSION   NM_001411935 XM_030242008
VERSION     NM_001411935.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3448)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3448)
  AUTHORS   Lin,A.Y., Henry,S., Reissner,C., Neupert,C., Kenny,C., Missler,M.,
            Beffert,U. and Ho,A.
  TITLE     A rare autism-associated MINT2/APBA2 mutation disrupts neurexin
            trafficking and synaptic function
  JOURNAL   Sci Rep 9 (1), 6024 (2019)
   PUBMED   30988517
  REMARK    GeneRIF: A rare autism-associated MINT2/APBA2 mutation disrupts
            neurexin trafficking and synaptic function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3448)
  AUTHORS   Motodate,R., Saito,H., Sobu,Y., Hata,S., Saito,Y., Nakaya,T. and
            Suzuki,T.
  TITLE     X11 and X11-like proteins regulate the level of extrasynaptic
            glutamate receptors
  JOURNAL   J Neurochem 148 (4), 480-498 (2019)
   PUBMED   30411795
  REMARK    GeneRIF: X11 and X11L regulate the glutamate receptor
            micro-localization to the extrasynaptic region
REFERENCE   4  (bases 1 to 3448)
  AUTHORS   Motodate,R., Saito,Y., Hata,S. and Suzuki,T.
  TITLE     Expression and localization of X11 family proteins in neurons
  JOURNAL   Brain Res 1646, 227-234 (2016)
   PUBMED   27268412
  REMARK    GeneRIF: Results indicate that both X11 and X11L exert largely in
            brain neurons, but X11 may also function in peripheral tissues.
REFERENCE   5  (bases 1 to 3448)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 3448)
  AUTHORS   Lee,D.S., Tomita,S., Kirino,Y. and Suzuki,T.
  TITLE     Regulation of X11L-dependent amyloid precursor protein metabolism
            by XB51, a novel X11L-binding protein
  JOURNAL   J Biol Chem 275 (30), 23134-23138 (2000)
   PUBMED   10833507
REFERENCE   7  (bases 1 to 3448)
  AUTHORS   Tomita,S., Ozaki,T., Taru,H., Oguchi,S., Takeda,S., Yagi,Y.,
            Sakiyama,S., Kirino,Y. and Suzuki,T.
  TITLE     Interaction of a neuron-specific protein containing PDZ domains
            with Alzheimer's amyloid precursor protein
  JOURNAL   J Biol Chem 274 (4), 2243-2254 (1999)
   PUBMED   9890987
REFERENCE   8  (bases 1 to 3448)
  AUTHORS   Blanco,G., Irving,N.G., Brown,S.D., Miller,C.C. and McLoughlin,D.M.
  TITLE     Mapping of the human and murine X11-like genes (APBA2 and apba2),
            the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2):
            genes encoding phosphotyrosine-binding domain proteins that
            interact with the Alzheimer's disease amyloid precursor protein
  JOURNAL   Mamm Genome 9 (6), 473-475 (1998)
   PUBMED   9585438
REFERENCE   9  (bases 1 to 3448)
  AUTHORS   Duclos,F. and Koenig,M.
  TITLE     Comparison of primary structure of a neuron-specific protein, X11,
            between human and mouse
  JOURNAL   Mamm Genome 6 (1), 57-58 (1995)
   PUBMED   7719031
REFERENCE   10 (bases 1 to 3448)
  AUTHORS   Duclos,F., Boschert,U., Sirugo,G., Mandel,J.L., Hen,R. and
            Koenig,M.
  TITLE     Gene in the region of the Friedreich ataxia locus encodes a
            putative transmembrane protein expressed in the nervous system
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 109-113 (1993)
   PUBMED   7678331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129199.3, AC140297.3 and AC127306.3.
            
            On Sep 13, 2022 this sequence version replaced XM_030242008.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR10662772.4088140.1,
                                    SRR10662774.2360256.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164131, SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AC129199.3         151844-152091
            249-373             AC140297.3         99908-100032
            374-427             AC127306.3         44718-44771
            428-1421            AC127306.3         104711-105704
            1422-1502           AC127306.3         124118-124198
            1503-1539           AC127306.3         125198-125234
            1540-1685           AC127306.3         143200-143345
            1686-1721           AC127306.3         144342-144377
            1722-1808           AC127306.3         146568-146654
            1809-1994           AC127306.3         149386-149571
            1995-2174           AC127306.3         152947-153126
            2175-2387           AC127306.3         154103-154315
            2388-2507           AC127306.3         155385-155504
            2508-2648           AC127306.3         159790-159930
            2649-3448           AC127306.3         162758-163557
FEATURES             Location/Qualifiers
     source          1..3448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 34.65 cM"
     gene            1..3448
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /note="amyloid beta precursor protein binding family A
                     member 2"
                     /db_xref="GeneID:11784"
                     /db_xref="MGI:MGI:1261791"
     exon            1..248
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            249..373
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            374..427
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            428..1421
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..2720
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /note="isoform a is encoded by transcript variant 8;
                     mint-2; adapter protein X11beta; neuron-specific X11L
                     protein; neuronal Munc18-1-interacting protein 2; Mint 2;
                     amyloid beta (A4) precursor protein-binding, family A,
                     member 2"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform a"
                     /protein_id="NP_001398864.1"
                     /db_xref="GeneID:11784"
                     /db_xref="MGI:MGI:1261791"
                     /translation="MAHRKRQSTASSMLDHRARPGPIPHDQEPESEDTELPLESYVPT
                     GLELGTLRPESPTPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGVTYYIR
                     YCPEDDSYLEGMDCNGEEYIAHGAHPVDTDECQEAVEDWTDSVGPHTHSHGAENSQEY
                     PDGHLPIPEDDPTVLEVHDQEEDGHYCSSKESYQDYYPPETNGNTGGASPYRMRRGDG
                     DLEEQEEDIDQIVAEIKMSLSMTSITSASEASPEHMPELDPGDSTEACPPSDTGHGPG
                     RQEARPKSLNLPPEVKHPGDLQRGLKTKTRTPEERPKWPQEQVCNGLEQPRKQQRSDL
                     NGPTDNNNIPETKKVASFPSFVAVPGPCEAEDLIDGIIFAANYLGSTQLLSERNPSKN
                     IRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETM
                     MDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESE
                     DAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSEN
                     CKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSING
                     TSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIIC
                     SLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRL
                     LTGQETPLYI"
     exon            1422..1502
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1539
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1685
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1721
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1808
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1994
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2174
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2387
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2507
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2648
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..3448
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3428..3433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /note="hexamer: AATAAA"
     polyA_site      3448
                     /gene="Apba2"
                     /gene_synonym="mXllL; X11-like; X11L; XllL"
                     /note="major polyA site"
ORIGIN      
        1 agactgttaa ggctccccaa ctggccggtc ccagctcact cccaggaacc tgtgtgctcc
       61 tcaaggggcc accgcgactc gcggagccta tctcagcccg tatcccaagg acccaggtcc
      121 caggtgggct cgtccgctgt ccccgccgct gtccccgcgc cgcacccgga ggcgccgcgc
      181 tgggcgccga agcatctttg tctgcgcttt gcgcggccgc gcggtcttga atcccttgat
      241 tccctaagtt ctctggatat tgaggcactg ttgaagctca gccaggggac cccaccccta
      301 cccccaagcc gtcggtggta gactttcctg cagacaggga cagggagagc catcctgtgt
      361 gtggagactg ccggaagact ggatcaccag ggaagttctc aggacattat cacggcactc
      421 atttctgtgg ctgcttccag gtaacaatgg ctgtgtgagc gtctgccatg gcccaccgca
      481 agcgtcagag cactgcaagc agcatgctgg accacagggc caggccaggt cctatccccc
      541 atgaccagga gcctgagagt gaggacacag aactgcctct ggagagctat gtacccacag
      601 gcctggagct gggcactctg aggccagaga gccccacgcc cgaggaacag gagtgccaca
      661 accatagtcc tgatggggac tccagctctg actatgtgaa caacacatct gaggaggagg
      721 actatgacga gggcctccct gaggaggagg agggtgtcac ctactacatc cgctactgtc
      781 ctgaggatga cagctacctg gagggcatgg actgtaatgg ggaggaatac atagcacacg
      841 gtgcacatcc cgtggacacc gatgagtgtc aggaggcggt ggaggactgg acggactcag
      901 tgggccctca tactcatagc cacggggctg aaaacagcca ggagtaccca gatggccacc
      961 tgcctatccc agaggatgac cctactgtcc tggaggtcca tgaccaggaa gaagatggcc
     1021 actactgttc cagcaaggag agctaccagg actattaccc cccagagacc aatgggaaca
     1081 caggtggcgc ctccccctat cgcatgaggc gtggggatgg ggacctagag gagcaggagg
     1141 aagacatcga ccagatagtg gctgagatca agatgagcct gagcatgacc agtattacca
     1201 gtgccagcga ggccagccct gagcacatgc cggagctgga tcccggggat tccactgagg
     1261 cctgtccacc cagtgacact ggccatggac ccggtaggca agaagcaagg cccaagtcgc
     1321 tgaaccttcc ccctgaggtt aagcaccctg gagacctcca gagaggactc aagaccaaga
     1381 ccaggacccc agaggagagg ccaaagtggc cccaagagca ggtttgcaat ggcttagagc
     1441 agccaaggaa gcagcagcgc tctgatctca atgggcccac tgacaataac aacatcccag
     1501 agacaaagaa ggtggcatca tttccaagct ttgtggctgt tccagggccc tgtgaggcag
     1561 aagacctcat cgatggaatc atctttgcag ccaactacct gggctccacc cagctgctct
     1621 ctgagcgcaa cccctccaaa aacatccgaa tgatgcaggc tcaagaagcc gtcagcaggg
     1681 tcaagaggat gcagaaggct gctaagatca agaaaaaagc gaattctgag ggtgatgctc
     1741 agacactgac agaagtagac ctcttcattt cgacccagag gatcaaggtc ttaaacgctg
     1801 acacgcagga aaccatgatg gaccatgcct tgcgcaccat ctcctacatt gcagacattg
     1861 ggaacatcgt ggttctgatg gccaggcgcc gcatgcccag gtcagcctct caggactgca
     1921 ttgagaccac gcctggggcc caggagggaa agaagcagta caagatgatc tgtcacgtgt
     1981 tcgagtcaga ggatgcccag ctgatcgccc agtccattgg gcaggccttc agcgtggctt
     2041 accaggagtt cctgagggcc aatggcatca accccgaaga cctgagccag aaggaatata
     2101 gcgacatcat aaatacccaa gagatgtata atgacgacct catccacttc tcaaactcag
     2161 agaactgcaa ggagctgcag ctagagaagc acaagggtga gattttgggt gtggtggtcg
     2221 tggaatcggg ctggggctcc atcctgccca ctgtgatcct ggcgaacatg atgaacggcg
     2281 gcccagcggc tcgctcaggg aagctgagca ttggggacca gatcatgtcc atcaacggca
     2341 ccagcctggt ggggctgccc ctggctacgt gccagggcat catcaagggc ctgaagaacc
     2401 aaacccaggt aaagctcaac attgtcagct gccccccggt caccaccgtc ctcatcaagc
     2461 gtccagacct caagtaccag ctgggtttca gcgtgcagaa tggaatcatc tgcagcctca
     2521 tgagaggggg tattgcagag cgaggtggtg tccgagtcgg ccaccgtatc atcgagatca
     2581 acggacagag tgtggtagcc acagcccatg agaagatagt ccaggctctg tctaactcgg
     2641 tgggagagat tcacatgaag accatgcctg cagccatgtt taggctcctc acgggccagg
     2701 agaccccgct gtacatctag gtacacccaa cctcaccgtg gagccgggat accaggcaga
     2761 cccacctggg tccggacgag ccagaagcca ggacaaagcc ctgaccccct gacccccttg
     2821 cagccacccc aaccaggacc tctggctccc tcaaaggaag ggtgtgtcct tgtcacctag
     2881 tttttttgtt tggttgtttt tgttttgttt tgttttgttt tagttttgtt ttcagttttg
     2941 ctacaacaaa aaaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag
     3001 aaagaaagaa agaaagaaaa gggggaaaaa taggtatgtc cttactgaag gagagttgca
     3061 gggcaatcct ttgtgaaact taccagtctt ctgccacatt ctcatcacgg ctgatgaagg
     3121 gtgctcacag gtagttctgt gtggtgtgct gtctctactc cctgaggcta tggaatgtga
     3181 atgtggtgcc cacccctccc gtctccgtgg ctgtgaaagg agtcccccct gtgatgcagc
     3241 tgcagccttt tctgcccttg gctgtgaccc ctggggtcca ggggtgtcct agagggccca
     3301 tctgctggcc ttgcctcctc tgcacaggca caggggcaac ctggcttcca ggctgagact
     3361 tgtgccaagt gtgggaacgt gtgattgatt gtaagtattt acgcagcaag gggatgctcc
     3421 cgagttaaat aaaaaatcat ggtcacga
//
