LOCUS       NM_009684               6514 bp    mRNA    linear   ROD 03-FEB-2024
DEFINITION  Mus musculus apoptotic peptidase activating factor 1 (Apaf1),
            transcript variant 2, mRNA.
ACCESSION   NM_009684
VERSION     NM_009684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6514)
  AUTHORS   Shakeri,R., Kheirollahi,A. and Davoodi,J.
  TITLE     Contribution of Apaf-1 to the pathogenesis of cancer and
            neurodegenerative diseases
  JOURNAL   Biochimie 190, 91-110 (2021)
   PUBMED   34298080
  REMARK    GeneRIF: Contribution of Apaf-1 to the pathogenesis of cancer and
            neurodegenerative diseases.
            Review article
REFERENCE   2  (bases 1 to 6514)
  AUTHORS   Urbanek,M.E. and Zuo,J.
  TITLE     Genetic predisposition to tinnitus in the UK Biobank population
  JOURNAL   Sci Rep 11 (1), 18150 (2021)
   PUBMED   34518561
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6514)
  AUTHORS   Zhang,Y., Huang,K., Zhang,Y., Han,T., Li,L., Ruan,C., Sun,Y.H.,
            Shi,W., Han,W., Wu,S.Q., Song,J., Liu,J. and Han,J.
  TITLE     A unique death pathway keeps RIPK1 D325A mutant mice in check at
            embryonic day 10.5
  JOURNAL   PLoS Biol 19 (8), e3001304 (2021)
   PUBMED   34437534
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6514)
  AUTHORS   Xu,W., Che,Y., Zhang,Q., Huang,H., Ding,C., Wang,Y., Wang,G.,
            Cao,L. and Hao,H.
  TITLE     Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition
  JOURNAL   Cell Metab 33 (2), 424-436 (2021)
   PUBMED   33308446
REFERENCE   5  (bases 1 to 6514)
  AUTHORS   Karki,R., Sharma,B.R., Tuladhar,S., Williams,E.P., Zalduondo,L.,
            Samir,P., Zheng,M., Sundaram,B., Banoth,B., Malireddi,R.K.S.,
            Schreiner,P., Neale,G., Vogel,P., Webby,R., Jonsson,C.B. and
            Kanneganti,T.D.
  TITLE     Synergism of TNF-alpha and IFN-gamma Triggers Inflammatory Cell
            Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and
            Cytokine Shock Syndromes
  JOURNAL   Cell 184 (1), 149-168 (2021)
   PUBMED   33278357
REFERENCE   6  (bases 1 to 6514)
  AUTHORS   Yoshida,H., Kong,Y.Y., Yoshida,R., Elia,A.J., Hakem,A., Hakem,R.,
            Penninger,J.M. and Mak,T.W.
  TITLE     Apaf1 is required for mitochondrial pathways of apoptosis and brain
            development
  JOURNAL   Cell 94 (6), 739-750 (1998)
   PUBMED   9753321
REFERENCE   7  (bases 1 to 6514)
  AUTHORS   Cecconi,F., Alvarez-Bolado,G., Meyer,B.I., Roth,K.A. and Gruss,P.
  TITLE     Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian
            development
  JOURNAL   Cell 94 (6), 727-737 (1998)
   PUBMED   9753320
REFERENCE   8  (bases 1 to 6514)
  AUTHORS   Kuida,K., Haydar,T.F., Kuan,C.Y., Gu,Y., Taya,C., Karasuyama,H.,
            Su,M.S., Rakic,P. and Flavell,R.A.
  TITLE     Reduced apoptosis and cytochrome c-mediated caspase activation in
            mice lacking caspase 9
  JOURNAL   Cell 94 (3), 325-337 (1998)
   PUBMED   9708735
REFERENCE   9  (bases 1 to 6514)
  AUTHORS   Chowdhury,K., Bonaldo,P., Torres,M., Stoykova,A. and Gruss,P.
  TITLE     Evidence for the stochastic integration of gene trap vectors into
            the mouse germline
  JOURNAL   Nucleic Acids Res 25 (8), 1531-1536 (1997)
   PUBMED   9092658
REFERENCE   10 (bases 1 to 6514)
  AUTHORS   Harris,B.S., Franz,T., Ullrich,S., Cook,S., Bronson,R.T. and
            Davisson,M.T.
  TITLE     Forebrain overgrowth (fog): a new mutation in the mouse affecting
            neural tube development
  JOURNAL   Teratology 55 (4), 231-240 (1997)
   PUBMED   9216040
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ160169.1, AK220340.1, DT924066.1 and BC083191.1.
            
            [WARNING] On Mar 11, 2024 this sequence was replaced by
            NM_009684.3.
            
            On Jul 14, 2006 this sequence version replaced NM_009684.1.
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (1). Variants 1 and 2 encode the same isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083191.1, BC131683.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CJ160169.1         10-13
            5-561               AK220340.1         1-557
            562-4304            AK220340.1         601-4343
            4305-4593           DT924066.1         131-419
            4594-6507           AK220340.1         4633-6546
            6508-6514           BC083191.1         6426-6432
FEATURES             Location/Qualifiers
     source          1..6514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 45.47 cM"
     gene            1..6514
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /note="apoptotic peptidase activating factor 1"
                     /db_xref="GeneID:11783"
                     /db_xref="MGI:MGI:1306796"
     exon            1..561
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            562..763
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     CDS             626..4375
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /note="isoform 1 is encoded by transcript variant 2;
                     apoptotic protease-activating factor 1; forebrain
                     overgrowth"
                     /codon_start=1
                     /product="apoptotic protease-activating factor 1 isoform
                     1"
                     /protein_id="NP_033814.2"
                     /db_xref="CCDS:CCDS36030.1"
                     /db_xref="GeneID:11783"
                     /db_xref="MGI:MGI:1306796"
                     /translation="MDAKARNCLLQHREALEKDIKTSYIMDHMISNGVLSVIEEEKVK
                     SQATQYQRAAALIKMILNKDNCAYISFYNALLHEGYKDLAALLQSGLPLVSSSSGKDT
                     DGGITSFVRTVLCEGGVPQRPVIFVTRKKLVHAIQQKLWKLNGEPGWVTIYGMAGCGK
                     SVLAAEAVRDHSLLEGCFSGGVHWVSIGKQDKSGLLMKLQNLCMRLDQEESFSQRLPL
                     NIEEAKDRLRVLMLRKHPRSLLILDDVWDPWVLKAFDNQCQILLTTRDKSVTDSVMGP
                     KHVVPVESGLGREKGLEILSLFVNMKKEDLPAEAHSIIKECKGSPLVVSLIGALLRDF
                     PNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKD
                     VKVPTKVLCVLWDLETEEVEDILQEFVNKSLLFCNRNGKSFCYYLHDLQVDFLTEKNR
                     SQLQDLHRKMVTQFQRYYQPHTLSPDQEDCMYWYNFLAYHMASANMHKELCALMFSLD
                     WIKAKTELVGPAHLIHEFVAYRHILDEKDCAVCENFQEFLSLNGHLLGRQPFPNIVQL
                     GLCEPETSEVYRQAKLQAKQEGDTGRLYLEWINKKTIKNLSRLVVRPHTDAVYHACFS
                     QDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVK
                     IWDSATGKLVHTYDEHSEQVNCCHFTNKSNHLLLATGSNDFFLKLWDLNQKECRNTMF
                     GHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANERKSINVKRFFLSSEDPPEDVE
                     VIVKCCSWSADGDKIIVAAKNKVLLFDIHTSGLLAEIHTGHHSTIQYCDFSPYDHLAV
                     IALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETKKV
                     CKNSAIVLKQEIDVVFQENETMVLAVDNIRGLQLIAGKTGQIDYLPEAQVSCCCLSPH
                     LEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVW
                     NWQTGDYVFLQAHQETVKDFRLLQDSRLLSWSFDGTVKVWNVITGRIERDFTCHQGTV
                     LSCAISSDATKFSSTSADKTAKIWSFDLLSPLHELKGHNGCVRCSAFSLDGILLATGD
                     DNGEIRIWNVSDGQLLHSCAPISVEEGTATHGGWVTDVCFSPDSKTLVSAGGYLKWWN
                     VATGDSSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGILYILQVLE"
     exon            764..953
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1151
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1335
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1448
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1580
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1819
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1987
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2119
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2233
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2418
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2545
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2671
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2803
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2929
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3091
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3220
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3346
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3466
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3583
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3709
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3829
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3955
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4081
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4228
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..6514
                     /gene="Apaf1"
                     /gene_synonym="6230400I06Rik; Apaf-1; Apaf1l; fog;
                     mKIAA0413"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggactg ggcgggccca gcggtgtttg agtgctccgc ggtcctgagg cagagaccag
       61 gaggcagcta gaggagcaga cgtctcactc cgctcgcgga agggtgtgag aggggtgtgt
      121 gggggtcggc agcgaggggt gtgtgccatc agccaccggc gacgatctga gacagtcgca
      181 gcggctttcc gagcggcgtc cgcttcccgc ccgggcagct cccgccagag gggtgaagcg
      241 gcgactggag tggccgtgct tttgtgccct gggtcccggt accctcccct ggtgcggccc
      301 gaggcaagcc caccgaggtg accacccctc gacgccgctt ggagatcccg ggcatccacc
      361 ctgcgccccg agcagctgat acccagggag gtgtcaggac ctgcccgggg cgcggggtcg
      421 ccggaagcca ggcgggagcc ccggctgctt tctggcaatc tagtctcata agtgaccctc
      481 cctgggctgc tttctttcga ttatcatcag tgaccctccc ccggctgctc ttcccagcac
      541 aactccggtg caaaggcttg ggcatcctgg tgctttgcct ctagcccatg ctccacagcg
      601 aggagagaga aaaccctgag gcacaatgga tgcaaaggcc cgcaattgtt tgcttcaaca
      661 tagagaagct ttggaaaagg acatcaaaac atcctacatc atggatcaca tgatcagtaa
      721 tggcgtcttg tcagtgatag aggaggagaa ggtcaaaagt caggccactc aatatcaacg
      781 agcagccgct ttaattaaaa tgatacttaa taaagacaac tgtgcctaca tttcattcta
      841 caacgctctg ctacacgagg gctataagga ccttgctgcg cttctgcaga gtggccttcc
      901 tcttgtgtcg tcttccagtg gcaaggacac agatggtgga ataacttcat ttgtaaggac
      961 agtgctgtgt gaaggtggag taccccagag gccggttatt ttcgttacta gaaagaagct
     1021 ggttcatgcg attcagcaga agctctggaa actgaatgga gaaccagggt gggtcaccat
     1081 ctatgggatg gcaggctgcg gcaagtctgt gttagctgcg gaagccgttc gagatcactc
     1141 cctcttagaa ggttgctttt cagggggtgt acactgggtt tccattggaa aacaagacaa
     1201 atctgggctt ctcatgaaac tgcagaatct gtgcatgcgc ttggaccaag aagagagttt
     1261 ctctcagagg cttccactta atattgagga ggccaaagac cgcctccgtg ttctgatgct
     1321 gcgcaaacac ccaaggtctc tgttgatctt ggatgatgtt tgggatcctt gggtgttaaa
     1381 agcttttgac aatcagtgtc agattcttct tacaaccaga gataagagtg ttacagattc
     1441 agtaatgggt cctaagcatg ttgtccctgt ggagagtggt ctagggagag agaaaggact
     1501 tgagatcttg tcactttttg ttaacatgaa gaaagaagat ctgccagcgg aggctcacag
     1561 tattataaag gaatgcaaag gttctcctct tgtagtgtct ttaattggtg cgcttttacg
     1621 tgattttccc aatcgctggg catactacct cagacagctt cagaataagc agtttaagag
     1681 aataaggaag tcttcatctt atgattatga ggctctagat gaagccatgt cgataagtgt
     1741 tgaaatgctc agagaagaca tcaaagacta ttacacagac ctttccatcc ttcagaagga
     1801 cgtcaaggta cctacaaagg tgttgtgcgt tctctgggac ttggaaacgg aagaagttga
     1861 agacatcctg caggagttcg ttaataagtc tctcttattc tgtaatcgga atggaaagtc
     1921 attttgttat tatttacatg atcttcaagt agattttctt acagagaaga atcgcagtca
     1981 gcttcaggat ctgcacagga agatggtcac tcagtttcag aggtattacc agccccacac
     2041 gctgtctcca gaccaggagg actgcatgta ttggtacaac ttcctagcct atcacatggc
     2101 tagtgccaat atgcacaaag aactttgtgc tttaatgttt tccctggact ggattaaagc
     2161 aaaaacagaa cttgtcggcc ctgcccatct gattcacgag ttcgtggcat ataggcatat
     2221 attggatgaa aaggattgtg cagtctgtga gaattttcaa gagtttttat ctttaaatgg
     2281 acacctcctt ggacgacagc catttcctaa tattgtacag ctgggcctct gtgaaccaga
     2341 aacttccgaa gtttatcgac aagcaaagct gcaggccaag caggaggggg atactgggcg
     2401 cctttacctg gaatggataa acaaaaaaac tatcaagaat ctgtcccgct tagtcgtccg
     2461 cccccacaca gatgctgttt accacgcgtg tttttctcag gatggtcaga gaatagcttc
     2521 ttgtggggct gataaaacct tacaggtgtt caaagccgag acaggagaga aacttcttga
     2581 catcaaagct cacgaagatg aggtgctttg ctgcgcgttc tcctcagacg acagttacat
     2641 agcgacctgc tcagcggata agaaggttaa gatttgggat tctgcgactg ggaagcttgt
     2701 gcacacctac gacgagcact cggagcaagt caattgctgc catttcacca acaagagtaa
     2761 ccaccttctc ttggccactg ggtcaaatga tttcttcctc aagctctggg atttgaatca
     2821 aaaagaatgt cgaaatacca tgtttggtca cacgaactca gtcaaccact gcaggttctc
     2881 accagacgat gagctcttgg ctagctgctc agctgacggg actttaaggc tttgggatgt
     2941 gagatcagca aacgagagga aaagcattaa tgtgaagcgc ttcttcctga gttcagaaga
     3001 ccctccagag gatgtggagg tgatcgtgaa gtgttgttcc tggtctgcag atggtgacaa
     3061 aataatagtg gcagcaaaaa acaaagtcct cctttttgat attcatacta gtggcctatt
     3121 ggcagagatc cacacaggcc atcacagcac catccagtac tgtgacttct ccccctatga
     3181 ccatttggct gtgattgccc tgtctcagta ctgtgtggag ttgtggaaca tagactcccg
     3241 cctaaaggtg gccgactgca gaggacattt gagttgggtt cacggtgtga tgttttctcc
     3301 cgatggctcc tcatttttga cagcttctga tgaccaaaca ataagggtct gggagacaaa
     3361 aaaggtatgc aagaactctg ccatcgtgct aaagcaggaa atagacgtcg tgtttcaaga
     3421 gaacgaaacg atggtccttg cagttgacaa cataagaggc ctgcaactca ttgctggaaa
     3481 aacaggccag attgattacc tgcctgaagc ccaagtgagt tgctgctgcc tcagtccaca
     3541 ccttgagtac gtggcattcg gagatgaaga tggagccatt aagattatag aacttccaaa
     3601 caacagagtc ttcagttctg gggttgggca caagaaagct gtgcggcaca tccagttcac
     3661 agctgatggg aagacactga tttcaagttc tgaagattct gtgattcagg tatggaattg
     3721 gcagacaggg gactatgtat ttttgcaagc ccaccaggaa acggtaaagg acttcaggct
     3781 cctccaagat tcaagattgc tttcttggtc atttgatgga acggtgaagg tgtggaatgt
     3841 cattaccgga agaatagaaa gagactttac ttgtcatcag ggcacagtgc tttcctgtgc
     3901 tatctcttct gatgcgacca agttttcatc tacctctgct gataagactg ccaagatctg
     3961 gagttttgac ctcctttccc ctcttcatga gctgaagggc cataatggct gtgtccgctg
     4021 ctctgccttc tcgctggatg gcatcctgtt ggcaactgga gatgacaatg gagaaatccg
     4081 gatatggaat gtctcagatg gccagcttct tcattcgtgt gctccgatct cggtagagga
     4141 aggaactgct acccacggcg gctgggtaac tgatgtgtgc ttctctcccg acagtaaaac
     4201 gcttgtctct gctggaggat atctcaagtg gtggaatgtt gccactgggg actcctcaca
     4261 gaccttctac acaaatggaa caaacctcaa gaaaatccac gtgtcccctg acttcagaac
     4321 ctatgtgact gtcgataatc tcggtatttt atatatttta caggttttag agtgaaatgg
     4381 ctaagcgtta atgtagttca gctccttaag tttgaattgg aaaaaaaatc taaaccctct
     4441 atatcaactt tttataaagc tgtgaattgt actgcagtat tgcaaacatt acaaaagtgt
     4501 ttacagctgg gccagtgctc tgtatagttg ggtgaatcat agtatatctc cacaaaggaa
     4561 catactttta ctctattttt ttaaatatag tcatcattgt tattaacagt ttgtccttaa
     4621 catgcaaatg aaatgtaaat atgtaccttg ttatgctatt ggtaaattct ttgatgcatt
     4681 caaattggtt ggcaaaatta gtgagaatca tttgaaggcc ttctataggt tgatgctgtc
     4741 attatgtagg ctatgtccca aggtaatggt ggtcagtttt ctgaaccaca cttactccca
     4801 gggggtatgg ttttccaaat aaatcatgct tatttgcact ctttaaattt gctttaagat
     4861 attgtgtcat ggtgcaagca cagtctgcaa catttctctt gttaactcag tgagtattgg
     4921 ttttcaacag ttcttcctat gagctagtca tgtgttagag agatttctct ctgtagctct
     4981 gtgtttagct ggactctggc tgtcagtgtc tgtgaattgg gcaccaacca ccttgcactc
     5041 ttttagttgt ttcgtttata aagacagggt ttatgtagtc ctggctctct tggcactcag
     5101 catgtacacc aggttagcct tgaactcaga gctcagcctg cctctctgcc tcctgagttc
     5161 tggaattgaa ggcgtgtgcc aatagcacct ctctctctca gttatactcg actgagcttg
     5221 acctcttcta acttcttctc catgcttagg tgttagtcag ccagtgacgt gtgaagcggt
     5281 aacacatact tcccctttta cctgtacatc acccatgctg ttctctccac gactttcaag
     5341 agtcgcagaa acccttcccc aaaaccccct gggaaatgag acatttgccc atgtcttcct
     5401 gggaaatgtg acctcattgt attatgcagt gattgtgatc ctcctgcatc agactcctaa
     5461 gtagctagga gaggtgtctt ttgatgcaga aaaagctttg caacatcagt atctagtttt
     5521 gttttcaatc ttcttttagg atctataatt gaagcttaag tttaatcact gttccctgaa
     5581 atattattaa ggacaataga gataaattag tagtagatgt agttttcata taaaataaaa
     5641 aatgaaatat cttcattttg caataggagt taatgggtct cagcattaac agttgacagc
     5701 cagtgaagct gtttccattg ttgatgcata ttaccagctc tggtgtgggc agagggaacg
     5761 aggcactcct gtgttttaga tttacttctt tatggtgctg aagattgaag ccagggcctt
     5821 gcgcacacta gacaggcact ccaccgctgg gctacacgac cagcccttcc ttaggtggat
     5881 tttagattag atatcctcac agggcatttt taggagctgt aaatagagtg aacaaaatct
     5941 tgtatagggt taaggaaggt tttgtttgtc aggttgagga accactttac atacttactg
     6001 tgatttaagc caatgtgatg ggtgaaacat ctcaattgta taaaacaaat atttgaagaa
     6061 gtatgtcttg cttagaactt gctgagaatg aaccaaactt tgattttcag ataacattag
     6121 cggctcatct gttctgtagc tggctagtga agtgaacagc aaccgtcagt ttttaaaaag
     6181 tcttggtctt ttgtcttcaa gtggagagaa agacacagta actcgaagat ggctgtggct
     6241 cacacgcagc agctctggag gctgaccttg aaggcctggc ctgtgctctg gcggcctgca
     6301 tgaccacttg tggccctttc cttgctgaac tttttatgtg agaaattaca ttggactttg
     6361 tatatatgaa ggtggtttta tatcatgttt tatgtacttt gaagactttt ttgtatttat
     6421 aatttccatg acttattatt atttttgcct tgaaatactg tttaaacatg aattttaaaa
     6481 caaaaataaa attactgaaa tttttggaaa aaca
//
