LOCUS       NM_172725               3817 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus adaptor-related protein complex 5, zeta 1 subunit
            (Ap5z1), mRNA.
ACCESSION   NM_172725
VERSION     NM_172725.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3817)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3817)
  AUTHORS   Pierga,A., Matusiak,R., Cauhape,M., Branchu,J., Danglot,L.,
            Boutry,M. and Darios,F.
  TITLE     Spatacsin regulates directionality of lysosome trafficking by
            promoting the degradation of its partner AP5Z1
  JOURNAL   PLoS Biol 21 (10), e3002337 (2023)
   PUBMED   37871017
  REMARK    GeneRIF: Spatacsin regulates directionality of lysosome trafficking
            by promoting the degradation of its partner AP5Z1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3817)
  AUTHORS   Khundadze,M., Ribaudo,F., Hussain,A., Rosentreter,J., Nietzsche,S.,
            Thelen,M., Winter,D., Hoffmann,B., Afzal,M.A., Hermann,T., de
            Heus,C., Piskor,E.M., Kosan,C., Franzka,P., von Kleist,L.,
            Stauber,T., Klumperman,J., Damme,M., Proikas-Cezanne,T. and
            Hubner,C.A.
  TITLE     A mouse model for SPG48 reveals a block of autophagic flux upon
            disruption of adaptor protein complex five
  JOURNAL   Neurobiol Dis 127, 419-431 (2019)
   PUBMED   30930081
REFERENCE   4  (bases 1 to 3817)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 3817)
  AUTHORS   Hirst,J., Barlow,L.D., Francisco,G.C., Sahlender,D.A., Seaman,M.N.,
            Dacks,J.B. and Robinson,M.S.
  TITLE     The fifth adaptor protein complex
  JOURNAL   PLoS Biol 9 (10), e1001170 (2011)
   PUBMED   22022230
  REMARK    Erratum:[PLoS Biol. 2012 Mar;10(3). doi:
            10.1371/annotation/89dff893-c156-44bb-a731-bfcc91843583]
REFERENCE   6  (bases 1 to 3817)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY125380.1, AK152402.1 and CAAA01097582.1.
            
            On Nov 18, 2005 this sequence version replaced NM_172725.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152402.1, AK146431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               BY125380.1         2-324
            324-2904            AK152402.1         202-2782
            2905-3817           CAAA01097582.1     18931-19843
FEATURES             Location/Qualifiers
     source          1..3817
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 81.53 cM"
     gene            1..3817
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /note="adaptor-related protein complex 5, zeta 1 subunit"
                     /db_xref="GeneID:231855"
                     /db_xref="MGI:MGI:1924908"
     exon            1..205
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            206..340
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            341..527
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            528..672
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            673..782
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            783..951
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1092
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1130
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1293
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1475
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1618
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1759
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1871
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1969
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2102
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2317
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..3817
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2881..2886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2907
                     /gene="Ap5z1"
                     /gene_synonym="C330006K01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gattctccca cgtgatccag ccaggacgcg ggagggtggt ggcgggggta agaggtgggg
       61 cgaaagaggg cagacacagt ccggtcacat gacacgtcat gtgacacgat cccggaagtc
      121 cgcggcaacg tttcgggcac tggtgggctt ggagccgtgt cggcatgttc tcggcgggcg
      181 cggaaagtct gctgcaccag gccagggaaa tccaggatga ggagctacgg cgtttctgct
      241 cccgggtcac taagctgctg caggaagccc caggaccagc caccgtggat gccctgcaga
      301 gactcttcct catcgtctca gccaccaagt acccccgtag gctggagaag atgtgtgtgg
      361 acctgttaca gaccactctc tgcttgcctg ccagccctga gcagctccag gtcctctgtg
      421 ctgctatctt gagagagatg tcacctttta acgacctggc cctgtcctgt gatcacaccc
      481 caaacacccg gcagcttagc cttgtggcct ctgtgctctt ggcccaggga gacagaaaag
      541 gagagatcag atgtgtgagc cagcgcatct tcaagatcct cgagaaccgg cagcctgagg
      601 ggcccagtgt ccggcccctc ctccccatcc tgtccaaggt cattggcctt gccccgggca
      661 tcctcatgga agaccagacc aacctgctca gcaaaaggct ggtggactgg cttcgctacg
      721 ccagcatcca gcaggggctt ccgtactcag ggggcttctt ctccacaccc aggacccggc
      781 agcccggtcc catcactgag gtggatggag cagtagcttc tgacttcttc acggtactct
      841 ccacgggcca gcacttcaca gaggaccagt gggtgaacat gcaggccttc tccatgctga
      901 ggaaatggct gctgcacagt ggtcccgagg acccctgcag tcctgatgca gatgacaagt
      961 cagagctcga gggctccacc ctgtctgtgc tgtctgcggc ctccactgcc agccgactgc
     1021 tgccccctcg ggagcggctg agggaggtgg cctttgagta ctgccagcgc ctgttggagc
     1081 agagtaaccg gagagcgctg aggaaggggg actcggacct acagaaagct tgcctggtgg
     1141 aagctgtgtc ggtgttggat gtgctgtgcc ggcaggaccc ctccttcctc tatcgcaccc
     1201 tctcctgcct gaaggccctg cacaggaggc tgggcgagga ccctggcagc gagcgggcac
     1261 tggtgcctct tgcccagttc ttcctgaacc atggggaagc ggccgccatg gacgcagaag
     1321 ccgtctacgg gcagctgctc cgaggtctcc cttctgaacg cttccacagc ccgaccctgg
     1381 cctttgaggt catacacttc tgcacacaca acctggctct cttcgactcc cactttctca
     1441 gccttctcag gctgagcttc ccaagtctgt tcaagttcct ggcttggaac agccctcctc
     1501 tcacagcgga gtttgtggtc ctcctcccag ctctcgtgga tgctggcacc gccgtggaga
     1561 tgctgcatgc gctgcttgac ctgccctgtc tgactgccgc cctggacctt cagctcaggt
     1621 ccacacagac tccgtcggaa aggctgcttt gggatatctc cctcagggtc cccagctgcc
     1681 tggaggcctt ccaggaccca cagttccaag gactcttccg gcacctgctc cgtaccaagg
     1741 ccagcggttc cacagagagg ctgacgccac ttcaccaggt gctgaagccc atggccagct
     1801 gtgcccgggt aacccagtgt gcggaggcgg tgcccgtcct gcttcaggcc ttcttctcag
     1861 ctgtgaccca gactgccgat ggggccctaa tcaaccagct ggcactgctg ctcctggaga
     1921 gaagtgactc cctctacccg gtccctcagt atgaggcccg tgtgcacggg gtgctgagct
     1981 cccagctcct ggtgctgtgt aagctgaagc catcgctggt ggtggagctt tcacgagagc
     2041 tcctggagtt cgtggggagc gtgagcagca tccacagccg agccagcgtg ttcacttgtg
     2101 tggtgtgggc cattggtgag tacctgtcgg tgacttggga caagaggtgc acagcggaac
     2161 agatcaacaa gttctttgaa gccctggaag ccctgctgtt tgaagtcacc cagtcccgcc
     2221 ccttagccga cttgccctgc tgtcctccag aggtggtcac tgcactcatg accacactga
     2281 ccaaactagc ctcccggagc caagacctga tcccaagggt gtcactgttc ctgtcaaaaa
     2341 tgcgaaccct ggcccagaac ccagccacca gctctgtgca cagtgaagag ggtgcggaat
     2401 ccatccggac ccgggcctca gagctgctaa ccttactaaa gatgcccagt gtggcccagt
     2461 ttgtgttcac acctcctgca ggcgtgtgcc agccccgcta ccaccgggac accaacgtgg
     2521 ccctgcctct ggctctgcgc acggtcagcc ggctggtgga gaaggaggct ggcctcctgc
     2581 caggttgaag ggacagtcac cacctgaaca gtagctacag cgtgagagcc tgggcagtca
     2641 gcagtattgg agctgagctg caggcgtggg tgactcgtga ggcatggtgg acatgactgt
     2701 caggatggga tcaccagccc ctggggatga gtcatctcac cttgtctctg tggctggcca
     2761 gtcagccttg agcagccggt aggtgactga gtgttacttc ctaggccgag cagaaatggc
     2821 ctggtctgct tgctgctgtt actcatttct ggatttgggg gcagggagca gtgcaggaaa
     2881 aataaactaa agaattattt atgctgagca gtggtggcac atgcctttca tctcagcact
     2941 caggaggtag aggcaggtgg atttctgagt tcaaggccag cctggtctac agagtgagtt
     3001 ccaggacagc caggactaca cagagaaacc ctgtctcaaa aaaccaaaag agaattcttt
     3061 aatattacat gtatgtgctt gcacacacca cagtgcacac gagatcagga gacagctttt
     3121 gctactcggt tctctcctca gccatgtggg tcttggctgg ttgcctggct cagtgacaag
     3181 cgcctttacc tactgagcca ttgtgcctgc caccaagtaa atcttccagt gctgtgtaca
     3241 gcccaggccc ctctctctgc cttccttgga cttggagagc cagggagcct gggctgctgc
     3301 cttcccaccc tgccctctgt tgagggaaat acctgggtcc cctgattggc tcctgtgtcc
     3361 ttgatgtgac agaaatgaca tgctctggag ctgaaactca caaagccctg agtttaatcc
     3421 tgagtgtaac cccaggcatg gggtgcacac tgcaatccca gcactcagca ggtggagtga
     3481 agttcgagaa aggtcagaag ttcaaggtca gccttggcta ggtaacaact tgaaatgcag
     3541 cctgggctac aaaagaaatt gggcctagaa gatgactcag cacataaaag gccttgctag
     3601 atgcccctga tgacccaggg ttgacccctg gatctcatgt gtaaggctgc gtaccatggt
     3661 gtgtatgtag ctgtgaagac agcagttcaa agctcaaagg cttgctacag cagtggaaga
     3721 acgagctgga aagcaagaac caactctcag aacgcacgcc atgccttggt cacataagac
     3781 attttaaaag ctaaataaaa ctcaaggtgt attcatg
//
