LOCUS       NM_001291031            1617 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus adaptor-related protein 5 complex, sigma 1 subunit
            (Ap5s1), transcript variant 2, mRNA.
ACCESSION   NM_001291031 XM_006500142
VERSION     NM_001291031.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1617)
  AUTHORS   Hirst,J., Barlow,L.D., Francisco,G.C., Sahlender,D.A., Seaman,M.N.,
            Dacks,J.B. and Robinson,M.S.
  TITLE     The fifth adaptor protein complex
  JOURNAL   PLoS Biol 9 (10), e1001170 (2011)
   PUBMED   22022230
  REMARK    Erratum:[PLoS Biol. 2012 Mar;10(3). doi:
            10.1371/annotation/89dff893-c156-44bb-a731-bfcc91843583]
REFERENCE   2  (bases 1 to 1617)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY264259.1, AK002807.1, DV061712.1 and AW060727.1.
            
            On Mar 22, 2014 this sequence version replaced XM_006500142.1.
            
            Transcript Variant: This variant (2) includes an additional segment
            that results in a frameshift in the 3' coding region, compared to
            variant 1. The encoded isoform (b) has a distinct C-terminus and is
            shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002807.1, CN684176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BY264259.1         2-77
            77-800              AK002807.1         2-725
            801-921             DV061712.1         623-743
            922-1595            AK002807.1         842-1515
            1596-1617           AW060727.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..1617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.29 cM"
     gene            1..1617
                     /gene="Ap5s1"
                     /gene_synonym="0610038L13Rik; 2310035K24Rik; sigma5"
                     /note="adaptor-related protein 5 complex, sigma 1 subunit"
                     /db_xref="GeneID:69596"
                     /db_xref="MGI:MGI:1916846"
     exon            1..322
                     /gene="Ap5s1"
                     /gene_synonym="0610038L13Rik; 2310035K24Rik; sigma5"
                     /inference="alignment:Splign:2.1.0"
     exon            323..533
                     /gene="Ap5s1"
                     /gene_synonym="0610038L13Rik; 2310035K24Rik; sigma5"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..960
                     /gene="Ap5s1"
                     /gene_synonym="0610038L13Rik; 2310035K24Rik; sigma5"
                     /note="isoform b is encoded by transcript variant 2;
                     protein C20orf29 homolog; adapter-related protein complex
                     5 sigma subunit; AP-5 complex subunit sigma-1;
                     adaptor-related protein complex 5 sigma subunit"
                     /codon_start=1
                     /product="AP-5 complex subunit sigma-1 isoform b"
                     /protein_id="NP_001277960.1"
                     /db_xref="CCDS:CCDS71148.1"
                     /db_xref="GeneID:69596"
                     /db_xref="MGI:MGI:1916846"
                     /translation="MVHAFLIHTLRAPNLEDTGLCRVLYSCVFGAEKSPDDPRSHGAE
                     RDRLFRKEQILAVARQVESLCRLQQQAAGCSSTDLQPQFSAEPVSLHEAPHGAFHLAA
                     GDPFQEPRTVLWLGILSLGFALVLDTHENLLLAERTLRLLARLLLDHLRLLTPGTNFL
                     LRADRIEGILTRFLPHGQLLFLNDQFVQDLEKEFSAAWPR"
     exon            534..1601
                     /gene="Ap5s1"
                     /gene_synonym="0610038L13Rik; 2310035K24Rik; sigma5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap5s1"
                     /gene_synonym="0610038L13Rik; 2310035K24Rik; sigma5"
                     /note="hexamer: ATTAAA"
     polyA_site      1601
                     /gene="Ap5s1"
                     /gene_synonym="0610038L13Rik; 2310035K24Rik; sigma5"
                     /note="major polyA site"
ORIGIN      
        1 aactggggca gatagtggga ggaggacgtg gtgccctggg gtaatgacgc gctcagctgg
       61 cggcagaagg gtgaccagag gtcaaagtct gcaaatctag gttcccttcc tgaagcgggc
      121 ttgctaaatt tcctgttggg taactttgaa ttcttggtct gtttagcttt agctgtggct
      181 aaacactgtt tctcctcagc cttgagaccg ggggctgcca ctctcgcttt gcccagagcg
      241 gccaggctct ctctctgtgt atctgtggct gacttgaatt cctgattctc ttgcctccgc
      301 ctcccgaggg ttgggatttc aggtctctgg ctttcctgga gcacccaccc tggagctatg
      361 gtccacgctt tcctcatcca cactctgagg gccccgaatt tggaagatac aggcctttgc
      421 cgagtgctct attcctgtgt ctttggtgct gagaaatcac ccgatgatcc acggtcacat
      481 ggtgcagaaa gggacaggct cttccgcaag gaacagattt tggcagtggc cagacaggtg
      541 gagtcactgt gtaggctgca gcagcaagcg gctggatgtt cctccacaga ccttcagcct
      601 cagttctcag ctgaacctgt gtccctgcat gaggcccctc atggagcctt ccacctggca
      661 gccggggacc ctttccagga gcctcggaca gtgctatggc tgggtatact ctccttaggt
      721 ttcgccctgg tgttggacac ccatgagaac ctgctgctgg ctgagcgcac gctccggctc
      781 ttggctcgcc tcctccttga ccacctccgg ctgctgacac caggtaccaa cttcttgttg
      841 cgggctgacc gtattgaggg aatcctcacc cgcttcctgc cacatgggca gctgcttttc
      901 ctcaatgacc agtttgtcca ggatctggag aaggaattca gtgctgcttg gccccgctga
      961 cccctcacca gacaaagagc gagggtaaag gttgcatact gctaggggaa gtgtggcatc
     1021 tgcctcttgc ccagcctgct ccctgctctg atgtgtggcc acgctcagga catacggatt
     1081 gggcaagccc gaaggaaggg acctgggtag aaggctgtct gtgcctgtcc tcaggccact
     1141 ggaattgtaa agtattcatt gtagagcatc ctgaagctgg aaccgccccg tgatcgcgta
     1201 ggctctacag tgtccaccac gcgagtcttt gactcctctt cattcaaccc taccagctgt
     1261 cagcactgga gcagcatact gccgagctca ccctagtcga tagccccagc acaaaaggag
     1321 cctctgagac ccacttcacg gctggagaac tgggctggta ccctagcaag ccccggtccc
     1381 tgcctttgct catcagcaag gattttgtcg gcaaggcctg ttctgcttct agctccccca
     1441 cagtgcagag cagggggatt ctgcggttcc ttatgtgcca tgcccccgtg tctgccaaga
     1501 gagctgagaa cacaacagct tttcttgtct gctggctggc aggggccagg cgtctggccc
     1561 aggtgatgcc ttattttgaa ttaaaaacaa tggcggtctg aaaaaaaaaa aaaaaaa
//
