LOCUS       NM_021392               1734 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus adaptor-related protein complex AP-4, mu 1 (Ap4m1),
            mRNA.
ACCESSION   NM_021392
VERSION     NM_021392.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Chen,X., Dong,T., Hu,Y., De Pace,R., Mattera,R., Eberhardt,K.,
            Ziegler,M., Pirovolakis,T., Sahin,M., Bonifacino,J.S.,
            Ebrahimi-Fakhari,D. and Gray,S.J.
  TITLE     Intrathecal AAV9/AP4M1 gene therapy for hereditary spastic
            paraplegia 50 shows safety and efficacy in preclinical studies
  JOURNAL   J Clin Invest 133 (10), e164575 (2023)
   PUBMED   36951961
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1734)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1734)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   6  (bases 1 to 1734)
  AUTHORS   Verkerk,A.J., Schot,R., Dumee,B., Schellekens,K., Swagemakers,S.,
            Bertoli-Avella,A.M., Lequin,M.H., Dudink,J., Govaert,P., van
            Zwol,A.L., Hirst,J., Wessels,M.W., Catsman-Berrevoets,C.,
            Verheijen,F.W., de Graaff,E., de Coo,I.F., Kros,J.M., Willemsen,R.,
            Willems,P.J., van der Spek,P.J. and Mancini,G.M.
  TITLE     Mutation in the AP4M1 gene provides a model for neuroaxonal injury
            in cerebral palsy
  JOURNAL   Am J Hum Genet 85 (1), 40-52 (2009)
   PUBMED   19559397
REFERENCE   7  (bases 1 to 1734)
  AUTHORS   Matsuda,S., Miura,E., Matsuda,K., Kakegawa,W., Kohda,K.,
            Watanabe,M. and Yuzaki,M.
  TITLE     Accumulation of AMPA receptors in autophagosomes in neuronal axons
            lacking adaptor protein AP-4
  JOURNAL   Neuron 57 (5), 730-745 (2008)
   PUBMED   18341993
REFERENCE   8  (bases 1 to 1734)
  AUTHORS   Hirst,J., Bright,N.A., Rous,B. and Robinson,M.S.
  TITLE     Characterization of a fourth adaptor-related protein complex
  JOURNAL   Mol Biol Cell 10 (8), 2787-2802 (1999)
   PUBMED   10436028
REFERENCE   9  (bases 1 to 1734)
  AUTHORS   Dell'Angelica,E.C., Mullins,C. and Bonifacino,J.S.
  TITLE     AP-4, a novel protein complex related to clathrin adaptors
  JOURNAL   J Biol Chem 274 (11), 7278-7285 (1999)
   PUBMED   10066790
REFERENCE   10 (bases 1 to 1734)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ159660.1, AF242858.1 and BE627979.1.
            
            On Dec 20, 2007 this sequence version replaced NM_021392.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011174.1, AK031638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               CJ159660.1         21-183
            164-1713            AF242858.1         32-1581
            1714-1734           BE627979.1         2-22                c
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.98 cM"
     gene            1..1734
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /note="adaptor-related protein complex AP-4, mu 1"
                     /db_xref="GeneID:11781"
                     /db_xref="MGI:MGI:1337063"
     exon            1..228
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1520
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /note="adaptor-related protein complex AP-4 mu4 subunit;
                     mu-ARP2; mu4-adaptin; mu subunit of AP-4;
                     mu-adaptin-related protein 2; AP-4 adapter complex mu
                     subunit; adapter-related protein complex 4 mu-1 subunit;
                     adapter-related protein complex 4 subunit mu-1; AP-4
                     adaptor complex mu subunit; adaptor-related protein
                     complex 4 subunit mu-1"
                     /codon_start=1
                     /product="AP-4 complex subunit mu-1"
                     /protein_id="NP_067367.3"
                     /db_xref="CCDS:CCDS19794.1"
                     /db_xref="GeneID:11781"
                     /db_xref="MGI:MGI:1337063"
                     /translation="MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGGE
                     SPVVMYHGDRHFIHIRHSGLYLVATTLENVSPFSLLELLSRLATLLGDYCGSLNEGTI
                     SRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQ
                     QNKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKS
                     FLPSGSEICIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQ
                     GELTVMRYQLSDDLPSPLPFRLFPSVQWDQGSGRLQVYLKLRCDLPPKSQALNIHLHL
                     PLPRGVISLSQELSSPDQKAELGEGALHWDLPRVQGGSQLSGLFQMDVPGLQGLPNHG
                     PSPLGLGPASLSFELPRHTCSGLQVRFLRLSFSACGNANPHKWVRHLSHSNAYVIRI"
     exon            229..317
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            318..424
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            425..521
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            522..632
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..713
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            714..776
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            777..843
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            844..897
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1004
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1099
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1144
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1195
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1307
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1718
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1699..1704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /note="hexamer: AAGAAA"
     polyA_site      1718
                     /gene="Ap4m1"
                     /gene_synonym="4930443L05Rik; Ap4m4"
                     /note="major polyA site"
ORIGIN      
        1 ctggcgggtt ggacaccctg tttcccgcgg ttcgaaatta atgctcgcga gtgtgtgtgt
       61 gggaggagtg tttcttaaag cgccagcctc cgtgcggcct tttgttccgc gtccacaagg
      121 cggggtgggt tcaactttca ccgtgttctc gtctatcctc cagaaccgcc atgatttccc
      181 agttcttcat tctgtcttcc aagggggatc cgctcatcta taaagacttc cgcggggaca
      241 gtggtggtcg tgatgtggca gagctcttct accggaagct gacgggactg cctggaggcg
      301 agtccccggt tgtcatgtat cacggtgatc gtcattttat tcacatcaga cacagtgggc
      361 tctatttggt ggccacaacc ttagaaaacg tctctccttt cagccttctg gagctgcttt
      421 cccggctagc cactctcttg ggtgactact gtggctcact caatgaggga accatctcac
      481 gcaatgtggc gcttgtctac gaactcctgg atgaagtgct ggattatggc tatgtgcaga
      541 ctacatccac agaaatgctg aggaacttca tccaaactga agctgtggtc agcaagccct
      601 tcagcctctt tgacctcagc agtgttggat tgttcggggc agagacacag cagaataaag
      661 tggccccaag cagcgcagcc agccgccctg tcctgtccag tcgttctgac cagagccaaa
      721 agaatgaggt gtttttggat gtggtggaga gactgtctgt actgattgca tctaatggct
      781 cgttgttgaa ggtggacgtc caaggagaga tacggctcaa gagcttcctt cccagcggtt
      841 ctgagatatg cattggcttg acagaagaat tttgtgttgg aaagtcagaa ctgagaggtt
      901 atgggccagg gattcgagtt gatgaggtgt cattccatag ttctgtcaat ctagatgagt
      961 ttgagtctca tcggatcctc cgcctgcagc cacctcaggg cgagctgact gtgatgagat
     1021 accagctctc tgatgacctc ccctcaccac tccccttccg gctctttccc tctgtgcagt
     1081 gggaccaagg ctcaggccgg ctccaggttt acctgaagtt acggtgtgac ctgcccccaa
     1141 agagccaagc tctcaacatt catctgcacc ttcccctgcc ccgaggggtc atcagcctgt
     1201 ctcaggaact gagcagtcca gatcagaagg cagagctggg agaaggagcc cttcactggg
     1261 atctgccccg ggtacaagga ggctctcaac tctccggcct tttccagatg gatgtccctg
     1321 gcttgcaggg acttcccaac catggacctt ctcccttggg gctgggtcct gccagcctct
     1381 cctttgaact ccctcggcac acatgctccg gtctccaggt tcgattcctc agactgtcct
     1441 ttagtgcctg tggtaatgcc aatcctcaca agtgggttcg acatctaagc cacagcaacg
     1501 cctacgtaat tcggatttga agctccccaa gcaaggatat ggacagcaat gtgagcaggc
     1561 agttgaacag gaagaggaca ttttctttgt ggctttggac ctggacagga aggtcccacg
     1621 gaccttatgt gatgcgggag gctcacaaac ttacaaatcc aacttttatt ctgaggaact
     1681 tactgtacaa tatctaaaaa gaaagtcact ggggaaaaaa aaaaaaaaaa aaaa
//
