LOCUS       NM_009682               5823 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus adaptor-related protein complex 3, sigma 2 subunit
            (Ap3s2), mRNA.
ACCESSION   NM_009682
VERSION     NM_009682.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5823)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5823)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 5823)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 5823)
  AUTHORS   Bultema,J.J. and Di Pietro,S.M.
  TITLE     Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous
            lysosome biogenesis machinery to synthesize specialized
            lysosome-related organelles
  JOURNAL   Small GTPases 4 (1), 16-21 (2013)
   PUBMED   23247405
  REMARK    Review article
REFERENCE   5  (bases 1 to 5823)
  AUTHORS   Larimore,J., Tornieri,K., Ryder,P.V., Gokhale,A., Zlatic,S.A.,
            Craige,B., Lee,J.D., Talbot,K., Pare,J.F., Smith,Y. and Faundez,V.
  TITLE     The schizophrenia susceptibility factor dysbindin and its
            associated complex sort cargoes from cell bodies to the synapse
  JOURNAL   Mol Biol Cell 22 (24), 4854-4867 (2011)
   PUBMED   21998198
REFERENCE   6  (bases 1 to 5823)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
REFERENCE   7  (bases 1 to 5823)
  AUTHORS   Gwynn,B., Ciciotte,S.L., Hunter,S.J., Washburn,L.L., Smith,R.S.,
            Andersen,S.G., Swank,R.T., Dell'Angelica,E.C., Bonifacino,J.S.,
            Eicher,E.M. and Peters,L.L.
  TITLE     Defects in the cappuccino (cno) gene on mouse chromosome 5 and
            human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent
            mechanism
  JOURNAL   Blood 96 (13), 4227-4235 (2000)
   PUBMED   11110696
REFERENCE   8  (bases 1 to 5823)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   9  (bases 1 to 5823)
  AUTHORS   Dell'Angelica,E.C., Klumperman,J., Stoorvogel,W. and
            Bonifacino,J.S.
  TITLE     Association of the AP-3 adaptor complex with clathrin
  JOURNAL   Science 280 (5362), 431-434 (1998)
   PUBMED   9545220
REFERENCE   10 (bases 1 to 5823)
  AUTHORS   Simpson,F., Peden,A.A., Christopoulou,L. and Robinson,M.S.
  TITLE     Characterization of the adaptor-related protein complex, AP-3
  JOURNAL   J Cell Biol 137 (4), 835-845 (1997)
   PUBMED   9151686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127127.1, AK150085.1, AC109221.32 and BC060236.1.
            
            On Nov 20, 2007 this sequence version replaced NM_009682.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060236.1, SRR1660817.299615.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY127127.1         2-10
            10-1207             AK150085.1         3-1200
            1208-4802           AC109221.32        150072-153666       c
            4803-5823           BC060236.1         4761-5781
FEATURES             Location/Qualifiers
     source          1..5823
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.23 cM"
     gene            1..5823
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /note="adaptor-related protein complex 3, sigma 2 subunit"
                     /db_xref="GeneID:11778"
                     /db_xref="MGI:MGI:1337060"
     exon            1..132
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..645
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /note="sigma3B-adaptin; sigma-3B-adaptin; sigma-adaptin
                     3b; AP-3 complex sigma-3B subunit; adapter-related protein
                     complex 3 sigma-2 subunit; AP-3 complex subunit sigma-3B;
                     adaptor-related protein complex AP-3, sigma 2 subunit;
                     sigma 3B; adapter-related protein complex 3 subunit
                     sigma-2; adaptor-related protein complex 3 subunit
                     sigma-2"
                     /codon_start=1
                     /product="AP-3 complex subunit sigma-2"
                     /protein_id="NP_033812.3"
                     /db_xref="CCDS:CCDS21389.1"
                     /db_xref="GeneID:11778"
                     /db_xref="MGI:MGI:1337060"
                     /translation="MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDD
                     NICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFE
                     NVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPAR
                     AVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV"
     exon            133..224
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /inference="alignment:Splign:2.1.0"
     exon            225..336
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /inference="alignment:Splign:2.1.0"
     exon            337..408
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /inference="alignment:Splign:2.1.0"
     exon            409..516
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /inference="alignment:Splign:2.1.0"
     exon            517..5804
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1347..1352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /note="hexamer: AATACA"
     polyA_site      1372
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /note="major polyA site"
     regulatory      4808..4813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
                     /note="hexamer: ATTAAA"
     polyA_site      4828
                     /gene="Ap3s2"
                     /gene_synonym="[s]3B"
ORIGIN      
        1 gttgtgccgg aagaaggtgc gttcttggag caggtggtac cgagagaagc gggaccggca
       61 aagatgattc aggcgattct ggttttcaac aaccatggaa aaccgcggct ggtccgcttc
      121 taccagcgtt ttccagaaga aattcaacag cagattgttc gagagacttt ccatctggtc
      181 ctcaagcgag atgacaacat ctgtaacttc ttagaaggtg gaagtttgat tggtggctct
      241 gactacaaac tgatttaccg gcactatgcc accctctact ttgtgttttg tgtggattca
      301 tcagagagtg aacttgggat cttggacctc atccaggttt ttgtggagac actggataag
      361 tgttttgaga atgtatgtga gttggacttg atcttccata tggataaggt gcactacatc
      421 ctgcaggagg tggtgatggg tggaatggtg ttggagacaa acatgaatga aattgtggct
      481 caaatcgaag ctcaaaaccg actggagaag tcggagggcg gcctctctgc agctccagca
      541 agggccgtgt ccgctgtgaa gaacatcaac ctccctgaga tccccaggaa catcaacatc
      601 ggtgacctca acatcaaagt ccccaacctg tcccagtttg tgtgaaggtg ggggactggg
      661 ctgaactgga gttcgcagga tgagcaaagc agtcaagtcc agaagcagaa ccccgttgag
      721 cctttagagt cgcaccttgg ggccctgcac ctttcccaga gtgggaatgg agttgggtgc
      781 acacttcctg gccatcctgc tgctcctgac tcacggctgt gatagacatc agggcactaa
      841 gccactgctc cttcgcctcc cccacacagc tgccctcagg gccagggact gtgaacgcgc
      901 cacctgcttc ccagggcccc accactggga ctgaacacat ctgacttcct ctctagcacc
      961 aagggcttct gagatcctgt atcacttact gggggaaaga ccagggggaa agactagcct
     1021 ttgagctgtc aggcatggta agtggcaggt gagggcaggg tgtacaccac ctctgctagg
     1081 gcctctatac cctctgaatg gtcaagcatt gtggtccgca gttgctgcag agcagtttcc
     1141 tagtatatac ctagtcttgt tgtcagaggc atctgtgcgc tggatggttt aagtcacact
     1201 ctgtgtgcgt gccactacca cccccccccc ccacacacac acacacagag ttggtgcgac
     1261 ccccagaacc ctctcgcaga ggagaccaat gtctgtagac tgtggcgact ggatccctcc
     1321 taggttatga cttttcccaa gtttaaaata cactgttctc ttggaagcag aaggttcagt
     1381 gctgtgctgt gaatgaagaa gtccccacat acacacactt gctcagaatc cactaaccag
     1441 tctcagattc tagagctggg agcctgggct gggtgctata tgggctgagc ctgcagcatg
     1501 ctagctgtag tgctgtgtgc ttcccagctt gagtcctgca gtgaacacac tgggctccct
     1561 tggttgacat tctacagctc tggaaccctg caaagttgca tgtgctggtg tggaggctga
     1621 tgcaccgcca tggggaaccg ccccacgcag gcccctctcc ctccctcccg ataggatagt
     1681 gtatttccat ggcttgtgat gctgatgtcc taggagaccg tgtgtcttac ccagtgtgtc
     1741 tcagtcccca gcagggcttc ctgcactctg ccggtgctga tgcagcatcc tgtcctcacc
     1801 tttcagtcct ctgtcagagc tgcagtgatg gtgggcactt ggctagagga cagacctgag
     1861 atcaatccta ctgcattctc tggaagcatc tcattgctat tttatgttat tttattgcca
     1921 tttgtgtaca ttcatctcct tttacagtgg ctggaatcaa gcatttgctc tagggggaca
     1981 tgaagagtcc tttaatagtc cttactagag acattttttt aagctttatt ttatttctgg
     2041 ggtgtgtctg tctgtctgtc tgtctgatgg tatgctctga ggccagagga gagtatacat
     2101 gccctctgag gctagagaag ggtatggaat tccttggacc tcaaattaac aggaggttga
     2161 gaagccccct aaaattgtgg tgctgggaag cagactcagg tcctctgcaa gagcagcagt
     2221 gctctgaact ggagccacct ctctggcccc acccatggac attttactgc ctggttaagc
     2281 agacttttgt cacccagggc taaggttgga aacgtgcctg cctggctcca aagctctttt
     2341 tttttctcct tactattcaa gatagtctct cccagtttta caaccctctc ttttatagat
     2401 gacagacagg gaaactgaga cttcagggga ttgagcaatc tcacaaacta ataaagacag
     2461 gcttagttct ctaaggtagg cagaggagag tggaggatcc tgtgtccctt cagttaattg
     2521 cctgagatgg agccgcccag agtgctgtca ggctgagggt caaaagggcc acagtgctgc
     2581 tctaaagtat gcttgctgtt ggcctaaggc accattgagt tggaagcact tggcttccca
     2641 ggtagtttag atttcaggtg tttgcttgct agaaactact tggttcccca aaactgtgtc
     2701 ctggtactgt agactgcaaa agcaagcatc acacaacggc ttgcaccatg tcccctgaca
     2761 gtctgctggt tcaggcttgg aaaactcaat tcctctagtc aagccagagg gattaattca
     2821 ttgctaatga cttgcatcta ctttgtctgc tattaagaaa gccattgtct gagattctca
     2881 ttctctctct ctctctctct ctctctctct ctctcccccc tccctccttc cttccctcct
     2941 ttccttcctc tttccctctc ccccctttgt gctttgagac aagatctcac tttgtaacct
     3001 aaattctcaa tcctcctgca tcacctccaa aatgctgaga ttacaagtgc cctgtgcact
     3061 ttgctgtgac atagaggaag tccttggtcc ttctggagag gggtgttcct tttgctcttg
     3121 agacatcagt gacgcaacca gaggccaggg ttgtgtttgc cttggggtcc tggacctggg
     3181 tggttacaca ggggcttccc tgggtgttct cactgactct agttaacagc tggaaccccc
     3241 cactccctgt cttctgtgta actactcttg ggtctaaact aagagagagg ctgtctttgc
     3301 tccactgtct ttgaccatcc ctgacagtgc tctgtagtga caattctgga actttgattt
     3361 ttttttttta aaagaaagaa ataagaatac atttttggtt tactcccagg cgtggggttt
     3421 tgggtctact tcacagcagc tgaccatgac ttaccttatg ctctagcaga tggtttctgc
     3481 gattgtgtga cgtttggaac tttttagagg gtatatactg ctagggccca gataggtggg
     3541 atcagtggtt gttggttgtt gggggttggg ggggtggttg gttatagttt ttagtagttt
     3601 gtgttcaaag aagaaacaga aagaaatttg attctgagat ctctatttct ctctctccca
     3661 cctctatcct ctctcttcta tctaatgata gggggtgaaa atgaggggct aaagggtagg
     3721 gaaaagaagg acccacaaaa gtagcaaaga ccagctataa gcgaaaagaa acaagaagga
     3781 attagattca gagatctcta tctttctccc ctctctctgt tctctcctat ctagtgatag
     3841 aggtaaaact tggggggggg gggtcgtgta aagggtggga aaagaactca caatatagca
     3901 aggcccagct acagtgctta cgtggttgga acatgggcac tgactggcag cctggcacca
     3961 tggaggccag actctgactg cagtgtggaa gatttaaagg acagtcccca cccctgactt
     4021 gccagtgtca tgcctactgc atacagtgct ggacaaatta cctttcccaa gcctgaccat
     4081 ggcaccatac atgctacact gagggtagcg agtctcctag ccctgatgtt tcgtcctctg
     4141 ccagatgcag agccagccct ctctccctcc ctccctcacc actgcagagc cagtttagca
     4201 attctttctg tgacctcagc ttcagaaaag aaattaggag caatgcctct gcctaggtcc
     4261 cagacacgat ccctggcctg gcctggcctg taaaggcttt cctcagcatg gccacatcag
     4321 ccatgggtac ctggaaatga agctccagag caggtccctg ccctccttca cagtgaccaa
     4381 gaggagtact gagccccacc tgctctgcac acatcctgga tgcccactct tccaagtgtg
     4441 ctgaccaccc agagtgagcc agctctttgt gggggctgcc aggctaggcc caaacctcaa
     4501 ggtcacagta agccttgacc ttttgggaag ctgtggggtg ttcttcacct gcatgttctg
     4561 gcagatgggg ctgttgaaat acctcaatgc aagtgattaa ccctttccag agctctttct
     4621 tatttcaact cttcctttcc aaataagaac ttaatttatg tagttcgggt tttgaggggt
     4681 ttgttttgtt tagttattct gttttgtttt gattttcaag acaagatatc tctgtagccc
     4741 tggctgtcct agaacttgct ccatagacca ggctggcctt gaactcatag atctgcctgc
     4801 ctctgggatt aaaggcatgc aacaccaaca tctggctata ggtcagtatt tttacatgga
     4861 ggtggagaag taccctcaga gaccagacga aggccttgga tctcttggag ctggagttga
     4921 atgggggtac tctgaactgc tgagccgtct ctccagcccc atgcacttta catgttaaga
     4981 aaacaaaaaa ccagtttagc agaggatagc ctattcccag ccactgagca ctgccctcct
     5041 ggcagcaagt gtttgcagtt tgaagaagaa acaagcgtcc tttatcttca ctttcaaaac
     5101 taaggtcata gcttcagttg ccctcagctc agtacagtct tactgtcctc cagaaatgca
     5161 gagtccaccc tacacataca cctgtgagca ctcacaccaa gaagtccatc cttacagtcc
     5221 cacggtacct ctgcgttcta ggactgtagg actgtgacat gggagtaggg aggcccatgg
     5281 gtgcaggtgg aggacagcaa ggattgtacc gagaaaagga tgagatgatg ggcatgttcg
     5341 cttgcttggg gataaacgcc tgctggtgag tgagtggaca ggagagcgtg ggtccagctc
     5401 tgtcacgtat ggagttggag taagtgacat ggccaaggga tgagagtaaa ggacagcctg
     5461 ggcaagggct gaggagtgtg cacattggag caacctgacg tccggggaga gcagaacagg
     5521 aaacacactg gtcagacagg aagggacccc agagccacag ctctaatcct gcctggaagc
     5581 tgtatatgag ggtatgagca gagctggaga gacactgctc gctcacctca tggacgggtc
     5641 atctgctcct cctcctgtcc cacatcccca gcttcaccat gaatccttta acaagccctg
     5701 aacttaacct aagccattca cggcgtctct tttctaggac ctgttcctgc tctacagctt
     5761 ggcctcctaa actatcagaa actataataa aacttctaaa aaccaaaaaa aaaaaaaaaa
     5821 aaa
//
