LOCUS       NM_029505               3405 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus adaptor-related protein complex 3, mu 2 subunit
            (Ap3m2), transcript variant 2, mRNA.
ACCESSION   NM_029505
VERSION     NM_029505.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3405)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3405)
  AUTHORS   Bubier,J.A., Jay,J.J., Baker,C.L., Bergeson,S.E., Ohno,H.,
            Metten,P., Crabbe,J.C. and Chesler,E.J.
  TITLE     Identification of a QTL in Mus musculus for alcohol preference,
            withdrawal, and Ap3m2 expression using integrative functional
            genomics and precision genetics
  JOURNAL   Genetics 197 (4), 1377-1393 (2014)
   PUBMED   24923803
  REMARK    GeneRIF: We have demonstrated genetic and alcohol-induced
            regulation of Ap3m2 expression. Although sequence analysis revealed
            no polymorphisms in the Ap3m2-coding region that could account for
            all phenotypic differences, there are several upstream SNPs that
            could.
REFERENCE   4  (bases 1 to 3405)
  AUTHORS   Bultema,J.J. and Di Pietro,S.M.
  TITLE     Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous
            lysosome biogenesis machinery to synthesize specialized
            lysosome-related organelles
  JOURNAL   Small GTPases 4 (1), 16-21 (2013)
   PUBMED   23247405
  REMARK    Review article
REFERENCE   5  (bases 1 to 3405)
  AUTHORS   Larimore,J., Tornieri,K., Ryder,P.V., Gokhale,A., Zlatic,S.A.,
            Craige,B., Lee,J.D., Talbot,K., Pare,J.F., Smith,Y. and Faundez,V.
  TITLE     The schizophrenia susceptibility factor dysbindin and its
            associated complex sort cargoes from cell bodies to the synapse
  JOURNAL   Mol Biol Cell 22 (24), 4854-4867 (2011)
   PUBMED   21998198
REFERENCE   6  (bases 1 to 3405)
  AUTHORS   Nakatsu,F., Okada,M., Mori,F., Kumazawa,N., Iwasa,H., Zhu,G.,
            Kasagi,Y., Kamiya,H., Harada,A., Nishimura,K., Takeuchi,A.,
            Miyazaki,T., Watanabe,M., Yuasa,S., Manabe,T., Wakabayashi,K.,
            Kaneko,S., Saito,T. and Ohno,H.
  TITLE     Defective function of GABA-containing synaptic vesicles in mice
            lacking the AP-3B clathrin adaptor
  JOURNAL   J Cell Biol 167 (2), 293-302 (2004)
   PUBMED   15492041
REFERENCE   7  (bases 1 to 3405)
  AUTHORS   Blumstein,J., Faundez,V., Nakatsu,F., Saito,T., Ohno,H. and
            Kelly,R.B.
  TITLE     The neuronal form of adaptor protein-3 is required for synaptic
            vesicle formation from endosomes
  JOURNAL   J Neurosci 21 (20), 8034-8042 (2001)
   PUBMED   11588176
REFERENCE   8  (bases 1 to 3405)
  AUTHORS   Gwynn,B., Ciciotte,S.L., Hunter,S.J., Washburn,L.L., Smith,R.S.,
            Andersen,S.G., Swank,R.T., Dell'Angelica,E.C., Bonifacino,J.S.,
            Eicher,E.M. and Peters,L.L.
  TITLE     Defects in the cappuccino (cno) gene on mouse chromosome 5 and
            human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent
            mechanism
  JOURNAL   Blood 96 (13), 4227-4235 (2000)
   PUBMED   11110696
REFERENCE   9  (bases 1 to 3405)
  AUTHORS   Dell'Angelica,E.C., Klumperman,J., Stoorvogel,W. and
            Bonifacino,J.S.
  TITLE     Association of the AP-3 adaptor complex with clathrin
  JOURNAL   Science 280 (5362), 431-434 (1998)
   PUBMED   9545220
REFERENCE   10 (bases 1 to 3405)
  AUTHORS   Simpson,F., Peden,A.A., Christopoulou,L. and Robinson,M.S.
  TITLE     Characterization of the adaptor-related protein complex, AP-3
  JOURNAL   J Cell Biol 137 (4), 835-845 (1997)
   PUBMED   9151686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB610934.1 and AK081220.1.
            
            On Mar 25, 2008 this sequence version replaced NM_029505.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081220.1, SRR1660817.279967.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BB610934.1         1-32
            33-3405             AK081220.1         2-3374
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.42 cM"
     gene            1..3405
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /note="adaptor-related protein complex 3, mu 2 subunit"
                     /db_xref="GeneID:64933"
                     /db_xref="MGI:MGI:1929214"
     exon            1..79
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /inference="alignment:Splign:2.1.0"
     exon            80..422
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1406
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /note="m3B; P47B; mu3B-adaptin; HA1 47 kDa subunit homolog
                     2; golgi adaptor AP-1 47 kDa protein homolog 2; clathrin
                     coat assembly protein AP47 homolog 2; adapter-related
                     protein complex 3 mu-2 subunit; clathrin coat-associated
                     protein AP47 homolog 2; clathrin assembly protein assembly
                     protein complex 1 medium chain homolog 2; adapter-related
                     protein complex 3 subunit mu-2; clathrin assembly protein
                     assembly protein complex 3 mu-2 medium chain;
                     adaptor-related protein complex 3 subunit mu-2"
                     /codon_start=1
                     /product="AP-3 complex subunit mu-2"
                     /protein_id="NP_083781.2"
                     /db_xref="CCDS:CCDS22184.1"
                     /db_xref="GeneID:64933"
                     /db_xref="MGI:MGI:1929214"
                     /translation="MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAEN
                     VPPVIPTPHHYLLSVYRHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVI
                     KDNVVVVYEVLEEMLDNGFPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTG
                     QLSVVPWRRTGVKYTNNEAYFDVVEEIDAIIDKSGSTVTAEIQGVIDACVKLTGMPDL
                     TLSFMNPRLLDDVSFHPCVRFKRWESERILSFIPPDGNFRLLAYHVSAQNLVAIPVYV
                     KHSISFRDSSSLGRFEITVGPKQTMGKTIEGVIVTSQMPKGVLNMSLTPSQGTHTFDP
                     VTKMLSWDVGKINPQKLPSLKGTMGLQVGASKPDENPTINLQFKIQQLAISGLKVNRL
                     DMYGEKYKPFKGIKYMTKAGKFQVRT"
     exon            423..594
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /inference="alignment:Splign:2.1.0"
     exon            595..732
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /inference="alignment:Splign:2.1.0"
     exon            733..818
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /inference="alignment:Splign:2.1.0"
     exon            819..952
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1160
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1305
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..3405
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3383..3388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /note="hexamer: AATAAA"
     polyA_site      3405
                     /gene="Ap3m2"
                     /gene_synonym="5830445E16Rik; AP-3B"
                     /note="major polyA site"
ORIGIN      
        1 ggagccttcg tgcaaggagc actgcgcagc gcgactgcgc tgcggagccg gaacggagcc
       61 tgagacctgg tcgaagctgg gttgaaaact agctgaatcc agaggctcgc agactgaacc
      121 agcgttcctc tcccaccagc ctctccacca tgattcacag ccttttcttg attaactctt
      181 ccggagatat tttcctggag aaacactgga aaagtgtggt cagccgctct gtgtgtgatt
      241 acttcttcga ggcccaagag agagctaccg aggcagaaaa tgtgcctccg gtcatcccca
      301 cccctcacca ctacctcctg agtgtttacc ggcacaagat cttctttgtg gctgtaatcc
      361 agacagaggt cccgcctctg tttgtcattg aattccttca ccgagtagtg gatacatttc
      421 aggactattt tggggtctgt tccgagccag tgatcaaaga caatgtggtg gtggtgtacg
      481 aggtgttgga agagatgctg gacaacgggt tccccttggc tacggagtca aacatcctca
      541 aagaactgat aaagcctccc actattctcc ggacagtggt caacaccatc acaggaagca
      601 ccaatgtggg ggaccagctt ccaactgggc agctgtcggt ggtgccttgg cgacggacag
      661 gggtgaaata taccaacaac gaggcctatt tcgatgtggt ggaagagata gacgccatca
      721 ttgacaagtc aggttccaca gtcaccgctg agatccaagg ggtgatcgat gcctgtgtta
      781 agctgaccgg gatgccggat ctcactctgt ccttcatgaa ccccaggttg ctggacgatg
      841 ttagcttcca cccctgtgtc cgtttcaagc gctgggaatc tgagcgcatc ctctccttca
      901 tccctcctga cggcaacttc cgcctgctcg cctaccacgt cagtgcacag aacctcgttg
      961 ccattccagt ctatgtcaaa catagcatca gcttccggga cagcagttca cttggacgct
     1021 ttgaaatcac ggtgggaccc aagcagacca tggggaagac catagagggt gtgattgtca
     1081 ccagccagat gcccaaagga gtcctgaata tgagcctcac tccatctcag gggacacaca
     1141 cgtttgaccc cgtgacaaag atgctgtctt gggatgtagg aaaaataaac ccacagaagc
     1201 tgccaagttt gaaggggacg atgggtctcc aggtcggagc ttctaaacca gatgagaacc
     1261 ctacgattaa cctgcagttt aagatccagc agctggccat ttctggactc aaagtgaacc
     1321 gtctggatat gtacggggag aagtacaagc cctttaaagg catcaaatac atgaccaaag
     1381 ccggcaagtt ccaagtccga acctgaaggg aacgtcttgc cgaaggagca gttcacggac
     1441 actttttcat ttcttacttg tctaaaagta aaatgtcagc ctgtttctta ggtccgttcc
     1501 ctccgggctc catctactcc cttttgtcct ccgtcttcag ccacataagt gatggaggga
     1561 gagaaagttc attcggggaa aaaaacgagg ccaaccccag cgcagcactg actgagttct
     1621 ggaggcgtgg cctggagagc agcggcctgt gacactgcat ttcatcactt ttaacacagt
     1681 tgccgtgggg aaagaccggc ctgtgatgtt tggtttcagt cacctaaacc caatggaaga
     1741 tgtctctatt gatttctttt tttttaagat agaaagatat gagaggggaa aaaagaagat
     1801 cggaagaaaa atgggtgtta gtccaagaaa gagcagttga gatttgactc atgggtctgg
     1861 gttgtacctc ggtgatcaag ccctgacctg gagtcctggt tcatcctggt accacccaca
     1921 atgaagacag atctgctcga tggggggcag gactgagagg ctggtgtgaa gagataccat
     1981 agtgaagggt tgtcgagaaa agcgattgga atctccccgg tgggtgaggc taggacaagc
     2041 cgagtgcagt agtttctttc agacccctct cacgtgtaga aaggctttgt atgtccagga
     2101 ctttgaaagt tcaagtccac gcttgacgtg aaaccgcact gggattagct ttctttggag
     2161 actaaggtgc cacagcctgg ctcttaagat tgtcactggc tgcttgcgct ggcccgtcgt
     2221 cttgttggga aggttacctg ctagagcggc gtacagactt ttgctggcta tctgactcct
     2281 cagtgggatc gctcccaaaa cagcagtgct cggtgcaggc aggttttatg agtgatagtg
     2341 gtggagttga tgtgggggac tcgccaccca gtggatcatg tccatgctcc ctgacctcca
     2401 ctgatgtttg tgaagccgga ctggccctgg gccttgcttt tcctgtctga aggtcccatc
     2461 agaatcccca agtgagtgtg agcccactga ggacattcag tgtacgaagc tgctttccat
     2521 tgtctgtacc tatcggctac agctcccaga cagacagaca gacagctccc aaatagctcc
     2581 cagtccgcac ttaaaacaaa aacaaaacaa aacaaaaagt gtcttgaacc tctgaataaa
     2641 attaatacca taggagggca ggctgtgttg accacgagta gtccacagtt taaaccatag
     2701 ccgctgaagg agcacagagt attcttaatt cgtttcaatg tgtccactag tcattttact
     2761 gaatacataa aaggcgggtg tgttgttttt aatttacagc ttagggcgca acttgcctct
     2821 gtgttgtgct tggagggaga aggagaccgg cttccttcag tctgcatggc tctcctctga
     2881 agtcctattt ctaagtactt ggacttcact tacttatttt ctatcttttg gctagtgttc
     2941 tcttgctgcg gtcaggactt gtttttgctg ccgagtagag tttctctgtg gtttcctcgt
     3001 ggggttgaac tgtgctatgt gcaatcagat gtttcctacc aggatctgca tgagtgtccc
     3061 acaccctgct gtggagggta cacactttgc aggtcacttt cacaggctct gggggtgggg
     3121 attccaagtt ttcttgggtc acagggaatt atgtatattg gaccctgagc gcgtttaagt
     3181 tagtgagtgc agctcattta tcccctcgag cacagcatag cttgtttttt tctaggaggc
     3241 cgtgttggga gtataggatc agcagaccta ggcatcatgg gtactgccaa gcctcgccaa
     3301 ccccacccag tgattgtcag caaaggttgt gcagggaaac ttaatagctg ctcgctctgt
     3361 gtgtggtcca tgttaaagtc ttaataaagc tttaccagtc ctggg
//
