LOCUS       NM_018829               4424 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus adaptor-related protein complex 3, mu 1 subunit
            (Ap3m1), mRNA.
ACCESSION   NM_018829
VERSION     NM_018829.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4424)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
  REMARK    GeneRIF: These data suggest that excess mu3A acts independently of
            the AP-3A complex to reroute AMPAR to recycling endosomes.
REFERENCE   2  (bases 1 to 4424)
  AUTHORS   Mardones,G.A., Burgos,P.V., Lin,Y., Kloer,D.P., Magadan,J.G.,
            Hurley,J.H. and Bonifacino,J.S.
  TITLE     Structural basis for the recognition of tyrosine-based sorting
            signals by the mu3A subunit of the AP-3 adaptor complex
  JOURNAL   J Biol Chem 288 (13), 9563-9571 (2013)
   PUBMED   23404500
  REMARK    GeneRIF: Structural basis for the recognition of tyrosine-based
            sorting signals by the mu3A subunit of the AP-3 adaptor complex
REFERENCE   3  (bases 1 to 4424)
  AUTHORS   Bultema,J.J. and Di Pietro,S.M.
  TITLE     Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous
            lysosome biogenesis machinery to synthesize specialized
            lysosome-related organelles
  JOURNAL   Small GTPases 4 (1), 16-21 (2013)
   PUBMED   23247405
  REMARK    Review article
REFERENCE   4  (bases 1 to 4424)
  AUTHORS   Larimore,J., Tornieri,K., Ryder,P.V., Gokhale,A., Zlatic,S.A.,
            Craige,B., Lee,J.D., Talbot,K., Pare,J.F., Smith,Y. and Faundez,V.
  TITLE     The schizophrenia susceptibility factor dysbindin and its
            associated complex sort cargoes from cell bodies to the synapse
  JOURNAL   Mol Biol Cell 22 (24), 4854-4867 (2011)
   PUBMED   21998198
REFERENCE   5  (bases 1 to 4424)
  AUTHORS   Nie,Z., Boehm,M., Boja,E.S., Vass,W.C., Bonifacino,J.S., Fales,H.M.
            and Randazzo,P.A.
  TITLE     Specific regulation of the adaptor protein complex AP-3 by the Arf
            GAP AGAP1
  JOURNAL   Dev Cell 5 (3), 513-521 (2003)
   PUBMED   12967569
REFERENCE   6  (bases 1 to 4424)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 4424)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4424)
  AUTHORS   Gwynn,B., Ciciotte,S.L., Hunter,S.J., Washburn,L.L., Smith,R.S.,
            Andersen,S.G., Swank,R.T., Dell'Angelica,E.C., Bonifacino,J.S.,
            Eicher,E.M. and Peters,L.L.
  TITLE     Defects in the cappuccino (cno) gene on mouse chromosome 5 and
            human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent
            mechanism
  JOURNAL   Blood 96 (13), 4227-4235 (2000)
   PUBMED   11110696
REFERENCE   9  (bases 1 to 4424)
  AUTHORS   Dell'Angelica,E.C., Klumperman,J., Stoorvogel,W. and
            Bonifacino,J.S.
  TITLE     Association of the AP-3 adaptor complex with clathrin
  JOURNAL   Science 280 (5362), 431-434 (1998)
   PUBMED   9545220
REFERENCE   10 (bases 1 to 4424)
  AUTHORS   Simpson,F., Peden,A.A., Christopoulou,L. and Robinson,M.S.
  TITLE     Characterization of the adaptor-related protein complex, AP-3
  JOURNAL   J Cell Biol 137 (4), 835-845 (1997)
   PUBMED   9151686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY774570.1, CD551381.1, BC090983.1 and AC163681.3.
            
            On Jul 18, 2009 this sequence version replaced NM_018829.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004740.1, BC090983.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BY774570.1         2-55
            55-301              CD551381.1         51-297
            302-2410            BC090983.1         50-2158
            2411-4424           AC163681.3         55932-57945
FEATURES             Location/Qualifiers
     source          1..4424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.58 cM"
     gene            1..4424
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /note="adaptor-related protein complex 3, mu 1 subunit"
                     /db_xref="GeneID:55946"
                     /db_xref="MGI:MGI:1929212"
     exon            1..303
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            304..579
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..1563
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /note="clathrin adaptor protein mu3A; mu3A-adaptin;
                     mu-adaptin 3A; AP-3 adapter complex mu3A subunit;
                     adapter-related protein complex 3 mu-1 subunit;
                     adaptor-related protein complex AP-3, mu 1 subunit;
                     adapter-related protein complex 3 subunit mu-1; AP-3
                     adaptor complex mu3A subunit; adaptor-related protein
                     complex 3 subunit mu-1"
                     /codon_start=1
                     /product="AP-3 complex subunit mu-1"
                     /protein_id="NP_061299.3"
                     /db_xref="CCDS:CCDS26861.1"
                     /db_xref="GeneID:55946"
                     /db_xref="MGI:MGI:1929212"
                     /translation="MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVEN
                     VPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAI
                     KDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTG
                     QLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDL
                     SLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYV
                     KHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDP
                     VTKVLAWDVGKITPQKLPSLKGLVNLQSGAPKPEENPNLNIQFKIQQLAISGLKVNRL
                     DMYGEKYKPFKGVKYVTKAGKFQVRT"
     exon            580..751
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            752..889
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            890..975
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1109
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1317
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1462
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..4424
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3342..3347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /note="hexamer: AATATA"
     polyA_site      3359
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /note="major polyA site"
     regulatory      4397..4402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4418
                     /gene="Ap3m1"
                     /gene_synonym="1200013D09Rik"
ORIGIN      
        1 aaacggagtt aggctgcggg tgagcgcctg cgctcaggga gtgccaacct ccccgttcct
       61 tcagcccctg agtaatgtgg aagagtcaga tcttcaacct ctgtagacac cgagcctctc
      121 actgaacgcc gttccgctcg ttgtgtctat ctagtccagc cgacctcctt ggtgcctctg
      181 cggctgctag tcaggcaatc tgctgggcac tccgagcgcg gggtcctcgc ggcattctct
      241 gctgcttcag ctgcggtgca gagaggaccc ggcaccgaat cactgagtcg cccaggtgtc
      301 gggaaaatga tccacagtct atttctcata aactgctctg gcgacatttt tctagaaaaa
      361 cactggaaga gcgttgtaag ccagtcagtg tgtgactatt tctttgaagc tcaggagaaa
      421 gctgctgatg ttgaaaatgt cccacctgtc atttcaacac ctcaccacta cctcattagt
      481 atctaccggg ataagctctt ctttgtgtct gtgatacaga ccgaagtgcc acctctcttt
      541 gtaattgaat ttctgcatcg agttgctgac acttttcagg actactttgg tgagtgttca
      601 gaggctgcaa ttaaggataa tgtggtcata gtatatgagc tcttggaaga aatgttagac
      661 aatggattcc cactggctac tgaatctaac attttgaaag aactgattaa accaccaaca
      721 attctacgtt ctgtcgtcaa ttctattaca ggcagtagta atgttgggga tacactcccc
      781 actgggcagc tatccaacat cccatggcgt cgagcaggag tgaagtacac aaacaatgaa
      841 gcctattttg atgtagttga agagatagat gcaattatag ataaatcagg atctacagtc
      901 tttgcagaaa ttcaaggggt cattgatgct tgcattaagc tgtctggaat gcctgatctc
      961 tccctctctt tcatgaaccc aaggctacta gatgacgtca gcttccaccc atgcatccga
     1021 ttcaaacgct gggagtctga aagagttttg tcattcattc ctccagatgg aaatttccga
     1081 ctcatatcgt atcgtgtcag ctcacaaaat ctagtggcaa taccagtgta tgtgaaacac
     1141 agtatcagct ttaaggaaaa cagctcttgt ggccggtttg atataacaat tggaccgaaa
     1201 cagaatatgg gaaaaacaat tgaaggaatc acagtgactg ttcacatgcc caaagttgtg
     1261 ctgaatatga acctgacacc aacgcaaggc agctatacat ttgatcccgt gaccaaggta
     1321 ctagcatggg atgtgggcaa aattactcca caaaagctcc caagtcttaa aggactagta
     1381 aatttacagt caggagcacc caagccagaa gagaacccaa acctcaacat acagttcaag
     1441 atccagcagc ttgctatttc aggcttaaaa gtgaaccgct tggacatgta tggtgagaag
     1501 tataagccat ttaaaggagt caaatatgtc acaaaggctg ggaagttcca agtgaggaca
     1561 tgagaagagg ccaaacttgc tcaagatcag tttgtttttt caagtgtcat tgcaatttat
     1621 tactattagg taccaagtgg gtgggaataa tatacagcat ttgtgtcaag ctaccctgct
     1681 aacaaagttg cttagtaatt gatgtagggt tcttacggag ctttaagcta aggaaagttt
     1741 tctaaagact tagcttattt tgtatctttt cacttaggaa aaggtttaga tgatttcttc
     1801 catgggggct accagctgaa tgctgcacat tctaacagtc aaagcagaag gctacagtga
     1861 tatcctctct cctaaagcaa gccaactggt ctcatctacc agcaggaact gtctcagtct
     1921 gtgatgtgtc aggtgcagcc aagtgtcaca ccttctgatc ttagccatct cagtgtctgt
     1981 cccaagagag gagattgccc caccccaaga agtttacaga aaactgcctc ttcaagtgtt
     2041 tgccttactc agcttttcac ttgtgccatt aagcaagcac tgtagcaaaa gccacttcca
     2101 catggccctg gcagggagca ctacagctcc gtgctccatt ctcactgtac ttggtattat
     2161 attttttata aataagattt ttatgtaaag ctcagatttt gatttacaag gaccttgctg
     2221 cagtaaatat tccatcaatc ttgtgccact agttcagctg ttaagatagc acagtcaaat
     2281 catttgcatc aaaagggcaa atactttatt aagacaacga aagggaacac tacttctgtt
     2341 gttagcgagt tactgcaggc acagctgttt gtgcttttaa acaaattaaa gtagtaaaag
     2401 agaaaatcaa gcaaaacctt tgccattctc atgttttatt aaagctttat ttaatgccac
     2461 taacctaatt agcttgaaac cctagtttag ctaaagaagg aaatcatgag tttcactatg
     2521 ttgctctttt caatctttgt gtgtttaaat agttgaattt gcttgtgtgc ccttcatttg
     2581 ggggagcgcc tttccatact acatatatct ccaggccatt gtgatgacac cttctccaaa
     2641 ctcctatcaa attcgagtga agcacttaag tgtctttgcc gtactgcgta cgtggaagaa
     2701 ccattcacgg aaggacagag tcctcagtaa ccatttatac taattggtct ttactcctga
     2761 aaagccagtc tgtgactcag gccattctgc atctttcact tggaaatcct tgttcaatga
     2821 caaaagaaaa tggaggaaga caaaagtgct tgcccttcct agctgccttg tcatcctttg
     2881 tccctcctta ccatgctagg tcatgtccta ggctcactcc acgttggcgt gccaacgatg
     2941 cagcagcagt gccgccgtgg cccccatcta atagggaggc caactgttgc aaaacttcaa
     3001 gtagactttt cttgagtaac gaatctcaga ttgacaatta tattttaagt aaaaacataa
     3061 aatattccct ttgactaaga tctagttcta gttttagtat cttgttcttt tacctcaaaa
     3121 gcaagcacat aagttttagt tcttcaccat cctttatctc acgaccatac ctagaccgca
     3181 cagcttcctt cctgtgcatc ttcttgtcta agtttcttgt ctccagggat ttctgctaaa
     3241 gtagctaagc agactgaatt cttttactgt taaattgttg tatttattaa tttgacagac
     3301 cctaataagc cctttctcta gttctggcta tcatgtcaat aaatatatga gcaaccaaat
     3361 gatttttaaa gtttgattgt tgatggaata ttctcatatt caggctgtat taatgcaggc
     3421 tgcactggat cagtttcttc tgtatcataa aatgttacag ttgcttgaag aacattgaag
     3481 aggcctcttc ctgaatagag catatttaca accattcatc ttctggtaac agaccacgtg
     3541 ataaaaatga tcaaagctat cttccttacc acttcaatat agacccagga aaacccagta
     3601 tcaaaagatt ttttaaacag agttctgggt aagccaccat attctccttt tttctgttgt
     3661 tcttaagaaa tcataatcta agagtaaata aaacagatac ttattgtctg ggtgaggtag
     3721 ccccaccccc accccccagt ggaattcggc tggtagcctc atttcctaaa ggtgctacag
     3781 aagaacactg gaaagatgct ggtaatgttg tccttaaaag caactgctta aaaatacaac
     3841 taactgcaga gtctgcggca cacagttccg gtgaacaagg tgaacagcaa atagaggctg
     3901 cagggatttc caagtctatt cagcagccgt gaacacaggc tgccatccat tctgtaagtc
     3961 aatgcaatgg aaagtttacc ctgtggtatt atttaacctt ttctttttct tcttcagttc
     4021 tagaaaatta ggcaaaaaag catgtttgtt tgttttttta ttttagtcag tgtttcctca
     4081 aacaagagga ggactatgtc ctcaaagcta gttctgcctc acacccatag ctatgtactg
     4141 gggttgggaa caaacaaaag tgtccctcac atttcacaac ttcagctttt taagggacac
     4201 tggtggtctc tactaaaatt agggtgtctc tagccaggag gtgacctaca tttggctgct
     4261 ttgcccactg gtaacttgtg atttcttctc cttctaatgt ataagaatac attagctaga
     4321 attgttgcca agattgttct tgatcacgca gaccctctta cgtaactaca ctattatata
     4381 actcctttat ggattgaata aagctgttgg tttccagacc ttga
//
