LOCUS       NM_021492               3816 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus adaptor-related protein complex 3, beta 2 subunit
            (Ap3b2), mRNA.
ACCESSION   NM_021492 XM_358374
VERSION     NM_021492.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3816)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3816)
  AUTHORS   Jain,S., Yee,A.G., Maas,J., Gierok,S., Xu,H., Stansil,J.,
            Eriksen,J., Nelson,A.B., Silm,K., Ford,C.P. and Edwards,R.H.
  TITLE     Adaptor protein-3 produces synaptic vesicles that release phasic
            dopamine
  JOURNAL   Proc Natl Acad Sci U S A 120 (42), e2309843120 (2023)
   PUBMED   37812725
REFERENCE   3  (bases 1 to 3816)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3816)
  AUTHORS   Zhu,M., Jia,L., Li,F. and Jia,J.
  TITLE     Identification of KIAA0513 and Other Hub Genes Associated With
            Alzheimer Disease Using Weighted Gene Coexpression Network Analysis
  JOURNAL   Front Genet 11, 981 (2020)
   PUBMED   33005179
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3816)
  AUTHORS   Zhang,Z., Li,Q., Diao,M., Liu,N., Cheng,W., Xiao,P., Zou,J., Su,L.,
            Yu,K., Wu,J., Li,L. and Jiang,Q.
  TITLE     Sporadic Hirschsprung Disease: Mutational Spectrum and Novel
            Candidate Genes Revealed by Next-generation Sequencing
  JOURNAL   Sci Rep 7 (1), 14796 (2017)
   PUBMED   29093530
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3816)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   7  (bases 1 to 3816)
  AUTHORS   Dell'Angelica,E.C., Klumperman,J., Stoorvogel,W. and
            Bonifacino,J.S.
  TITLE     Association of the AP-3 adaptor complex with clathrin
  JOURNAL   Science 280 (5362), 431-434 (1998)
   PUBMED   9545220
REFERENCE   8  (bases 1 to 3816)
  AUTHORS   Fletcher,C.F., Okano,H.J., Gilbert,D.J., Yang,Y., Yang,C.,
            Copeland,N.G., Jenkins,N.A. and Darnell,R.B.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (bases 1 to 3816)
  AUTHORS   Simpson,F., Peden,A.A., Christopoulou,L. and Robinson,M.S.
  TITLE     Characterization of the adaptor-related protein complex, AP-3
  JOURNAL   J Cell Biol 137 (4), 835-845 (1997)
   PUBMED   9151686
REFERENCE   10 (bases 1 to 3816)
  AUTHORS   Newman,L.S., McKeever,M.O., Okano,H.J. and Darnell,R.B.
  TITLE     Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific
            vesicle coat protein
  JOURNAL   Cell 82 (5), 773-783 (1995)
   PUBMED   7671305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ064603.1 and AY528675.1.
            
            On Aug 1, 2006 this sequence version replaced NM_021492.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY528675.1, SRR1660817.219919.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               CJ064603.1         2-220
            220-3816            AY528675.1         1-3597
FEATURES             Location/Qualifiers
     source          1..3816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.71 cM"
     gene            1..3816
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /note="adaptor-related protein complex 3, beta 2 subunit"
                     /db_xref="GeneID:11775"
                     /db_xref="MGI:MGI:1100869"
     exon            1..418
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..3554
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /note="adaptor-related protein complex 3 subunit beta-2;
                     beta3B-adaptin; AP-3 complex beta-2 subunit; adaptor
                     protein complex AP-3 beta-2 subunit; adapter-related
                     protein complex 3 subunit beta-2; clathrin assembly
                     protein complex 3 beta-2 large chain; beta-3B-adaptin;
                     adaptor protein complex AP-3 subunit beta-2;
                     adaptor-related protein complex AP-3, beta 2 subunit"
                     /codon_start=1
                     /product="AP-3 complex subunit beta-2"
                     /protein_id="NP_067467.2"
                     /db_xref="CCDS:CCDS21403.1"
                     /db_xref="GeneID:11775"
                     /db_xref="MGI:MGI:1100869"
                     /translation="MSAAPAYSEDKGGSAGPGEPEYGHDPASGGIFSSDYKRHDDLKE
                     MLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAE
                     EQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPY
                     VRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIH
                     KNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENPEKAFYGSEEDE
                     AKGPGSEEAATAALPARKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPK
                     AEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKI
                     LKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNG
                     LVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLI
                     GEYCEHVPKIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSL
                     AKYDQNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKPAPILESSFKDRDHFQL
                     GSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSE
                     GESGPTESADSEPESESESESKSSSGSGSGESSSESDNEEEDEEKGGGSESEQSEEED
                     EKKKKTKKKKASEGHREGSSSEEGSDSSSSSESEVTSESEEEQVEPASWRKKTPPGSK
                     SAPVAKEISLLDLEDFTPPSVQPVSPPMVVSTSLAADLEGLTLTDSSLVPSLLSPVSS
                     IGRQELLHRVAGEGLSVDYAFSRQPFSGDPHMVSLHIYFSNNSETPIKGLHVGTPKLP
                     AGISIQEFPEIESLAPGESTTTVMGINFCDSTQAANFQLCTQTRQFYVSIQPPVGELM
                     APVFMSENEFKKEQGKLTGMNEITEKLTLPDTCRSDHMVVQKVTATANLGRVPCGTSD
                     EYRFAGRTLTSGSLVLLTLDARAAGAAQLTVNSEKMVIGTMLVKDVIQALTQ"
     exon            419..494
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            495..569
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            570..665
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            666..826
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            827..893
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1076
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1360
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1415
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1487
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1550
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1683
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1793
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1970
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2157
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2276
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2385
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2503
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2684
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2745
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2852
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3081
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3166
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3264
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3403
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3806
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3785..3790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /note="hexamer: AATAAA"
     polyA_site      3804
                     /gene="Ap3b2"
                     /gene_synonym="beta-NAP; beta3B; Naptb; [b]-NAP"
                     /note="major polyA site"
ORIGIN      
        1 gactatacag tcatcagccc tgcagccttg ctcactgtga gagaccttta gatgcttgca
       61 gttgccagag agttctgaga gattgggaca gggcaggcgc tgttcctccg tcccctgtca
      121 gctcacccca accctgcact ccgcgggtgg tgccggtccc tttaagaacc ttagcgctca
      181 gccctgattg ctgaatctgc gcgctgcctc cgccgcgcag attgcagctc cgcagagcta
      241 ggcgtgcatc ccattcctcg accaaagccc aacccggccg ctcagccacc cctcagcgca
      301 gatccatgtc ggccgctccg gcctacagcg aagacaaggg cggctcagcc ggtcccgggg
      361 agccagaata tggccacgac ccggcgagcg gcggtatctt ctcctcggac tacaagcggc
      421 atgatgacct gaaagagatg ttggacacca acaaggactc cctcaagctg gaggccatga
      481 agaggattgt ggcaatgatc gcccggggaa agaatgcctc ggacctgttc cctgcagtgg
      541 tgaagaatgt ggcctgtaag aacatagagg tgaagaagct tgtctacgtg tatctggtcc
      601 gatatgccga ggagcagcaa gacctcgctc tactgtccat ctctactttc caacgtggcc
      661 taaaggatcc caaccagctg atccgtgcca gtgcgctccg ggttctctct agcatccgtg
      721 tgcccatcat agtgcccatc atgatgctag ccatcaagga agctgcctcg gacatgtcac
      781 cctacgttcg gaaaacagct gctcatgcca tccccaaact ctacagtttg gactccgatc
      841 agaaggacca gctgatagaa gtcattgaga agcttttggc agataagacc acgctggtgg
      901 caggcagtgt agtgatggcc tttgaagagg tatgtccaga acgtattgac ctgattcaca
      961 aaaactaccg gaagctctgc aacctgctca ttgatgtgga ggagtggggc caggtggtga
     1021 ttatcagcat gctcacgcgt tatgcgcgaa cgcaattcct gagccctacg cagaatgagt
     1081 ccttgctgga ggagaatccc gagaaggcct tctatggctc cgaggaggac gaggccaaag
     1141 gccctggatc agaggaggca gccactgcgg cgctgcccgc tcggaagccc tatgtaatgg
     1201 acccagatca ccggctgctg ctgcggaaca ccaagcccct gctgcagagc cgcagcgccg
     1261 cggtggtcat ggcggtggcg cagctttact tccacctagc gcctaaggca gaggtgggcg
     1321 tcatcgccaa ggcgctggta cgcctgctgc gcagccacag tgaggtgcag tacgtagtgc
     1381 tccagaacgt ggccaccatg tccatcaagc gcaggggtat gtttgaaccc tacctgaaga
     1441 gcttctacat taggtccacg gatcctaccc agatcaagat cctgaagctg gaagtgctga
     1501 ccaacctggc caatgagact aacatcccca ctgttctccg ggaattccag acctacattc
     1561 gcagcatgga caaagacttt gtggcagcca cgatccaggc cattggacga tgtgcaacga
     1621 acataggccg agtccgtgac acctgtctca atggcttggt gcagcttctg tccaaccgtg
     1681 acgagcttgt ggttgcagag tcagtggtgg tcattaagaa gctgctgcaa atgcagccag
     1741 cgcagcacgg tgagatcatc aaacacttgg caaagctcac agacaacatc caggtgccca
     1801 tggcacgagc cagcatcctc tggctcattg gagagtactg tgagcatgtc cccaagatcg
     1861 cacctgatgt cctgagaaaa atggccaagt ccttcacagc agaggaggac atcgtgaagc
     1921 tgcaggtcat caacctggca gccaagctgt acctgactaa ctcaaagcag accaagctct
     1981 tgacccagta tgtgctgagt ctggccaagt acgaccagaa ctatgatatc cgggatcgag
     2041 cccgcttcac ccggcagctc attgttccct ctgagcaggg tggtgccctc agtcgccatg
     2101 ccaagaaact cttcctggcc cctaagccag cccctatctt ggagtcatcc ttcaaagatc
     2161 gtgaccattt ccagctgggc tcactgtcac acctgctcaa tgcaaaggct acaggctacc
     2221 aggagctccc ggactggcca gaggaagccc cagatccatc tgtgcgcaat gtggaggtac
     2281 ctgaatggac caaatgttca aatcgggaga agaggaagga gaaggaaaag cctttctatt
     2341 ctgactccga gggggagtct ggccccactg agtctgcaga cagcgagcct gaatctgaga
     2401 gtgagtcaga gagtaagagc agcagtggga gtggctccgg ggagtctagc agtgagtcgg
     2461 acaatgaaga agaggatgag gagaaaggcg gaggcagcga gagtgaacag agtgaggagg
     2521 aagatgagaa gaagaagaag acaaagaaga agaaggcatc agagggacac agagaaggct
     2581 catcatcaga agagggcagt gactccagca gcagctcaga gtctgaggtg acgtcagagt
     2641 cggaggagga acaggtggaa cctgcctcct ggaggaagaa aacgcctcca ggcagcaaga
     2701 gtgcccctgt agccaaggag atttccctgc tggacctaga ggatttcacc cctcctagtg
     2761 tccagcctgt gtctcctccc atggttgtgt ctaccagtct ggctgctgac ctggaagggc
     2821 tgacactcac agactcctct ctggtgcctt cgctgctgag tccagtgtcc agcattggga
     2881 ggcaggagct gctgcaccgg gtagctggag aggggctgtc tgtggactat gccttcagcc
     2941 gccagccttt ctctggggat ccccacatgg tgtctctgca tatctacttc tccaacaact
     3001 cggagactcc catcaagggg ctgcatgtgg gcactcccaa gctgcctgct ggcatcagca
     3061 ttcaagaatt ccctgaaatc gagtccctgg cacctggaga atccaccact actgtgatgg
     3121 gcattaactt ctgcgactca acccaggcag ccaacttcca gctgtgcacc caaacccgac
     3181 agttctatgt ctccattcag ccacctgtcg gggagctgat ggcccctgta tttatgagtg
     3241 agaatgagtt caagaaggaa cagggaaagc tgacaggcat gaatgagatc acagagaagc
     3301 ttacattgcc agacacctgt cgaagtgatc acatggtggt gcagaaagtg actgccaccg
     3361 ccaacctagg tcgtgtccca tgtgggacat ctgatgagta caggtttgca gggaggacat
     3421 taactagtgg gagtctggtc ctgctgactc tggatgcccg ggcagctgga gccgcccagc
     3481 tgaccgtcaa cagtgagaag atggtgattg gcaccatgct ggtgaaggat gtgattcagg
     3541 ctctgaccca gtgacttctc agcactgtta cccactgatc ttcacctagc cttccatgtg
     3601 acatctgctc acagatctct ccccctcgcc tctcttttcc tctcatcacc cacctagtgc
     3661 tggcgctgtc tcccttctac ctgtttccta tgggttcctt agtgacttcc taggggaaga
     3721 cagaagctgc tccttcagca acccttttcc tcagctttct gtatgcattt atgtagcaaa
     3781 tctcaataaa atgctttctc cctagaaaaa aaaaaa
//
