LOCUS       NM_009680               4020 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus adaptor-related protein complex 3, beta 1 subunit
            (Ap3b1), mRNA.
ACCESSION   NM_009680
VERSION     NM_009680.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Jain,S., Yee,A.G., Maas,J., Gierok,S., Xu,H., Stansil,J.,
            Eriksen,J., Nelson,A.B., Silm,K., Ford,C.P. and Edwards,R.H.
  TITLE     Adaptor protein-3 produces synaptic vesicles that release phasic
            dopamine
  JOURNAL   Proc Natl Acad Sci U S A 120 (42), e2309843120 (2023)
   PUBMED   37812725
REFERENCE   2  (bases 1 to 4020)
  AUTHORS   Xu,H., Oses-Prieto,J.A., Khvotchev,M., Jain,S., Liang,J.,
            Burlingame,A. and Edwards,R.H.
  TITLE     Adaptor protein AP-3 produces synaptic vesicles that release at
            high frequency by recruiting phospholipid flippase ATP8A1
  JOURNAL   Nat Neurosci 26 (10), 1685-1700 (2023)
   PUBMED   37723322
  REMARK    GeneRIF: Adaptor protein AP-3 produces synaptic vesicles that
            release at high frequency by recruiting phospholipid flippase
            ATP8A1.
REFERENCE   3  (bases 1 to 4020)
  AUTHORS   Rimann,I., Gonzalez-Quintial,R., Baccala,R., Kiosses,W.B.,
            Teijaro,J.R., Parker,C.G., Li,X., Beutler,B., Kono,D.H. and
            Theofilopoulos,A.N.
  TITLE     The solute carrier SLC15A4 is required for optimal trafficking of
            nucleic acid-sensing TLRs and ligands to endolysosomes
  JOURNAL   Proc Natl Acad Sci U S A 119 (14), e2200544119 (2022)
   PUBMED   35349343
REFERENCE   4  (bases 1 to 4020)
  AUTHORS   Poli,V., Di Gioia,M., Sola-Visner,M., Granucci,F., Frelinger,A.L.
            3rd, Michelson,A.D. and Zanoni,I.
  TITLE     Inhibition of transcription factor NFAT activity in activated
            platelets enhances their aggregation and exacerbates gram-negative
            bacterial septicemia
  JOURNAL   Immunity 55 (2), 224-236 (2022)
   PUBMED   34995475
REFERENCE   5  (bases 1 to 4020)
  AUTHORS   Kook,S., Wang,P., Meng,S., Jetter,C.S., Sucre,J.M.S.,
            Benjamin,J.T., Gokey,J.J., Hanby,H.A., Jaume,A., Goetzl,L.,
            Marks,M.S. and Guttentag,S.H.
  TITLE     AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies
            suppresses activation of YAP in alveolar epithelial type 2 cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (20) (2021)
   PUBMED   33990468
REFERENCE   6  (bases 1 to 4020)
  AUTHORS   Timmerman,V., Nelis,E., Van Hul,W., Nieuwenhuijsen,B.W., Chen,K.L.,
            Wang,S., Ben Othman,K., Cullen,B., Leach,R.J., Hanemann,C.O. et al.
  TITLE     The peripheral myelin protein gene PMP-22 is contained within the
            Charcot-Marie-Tooth disease type 1A duplication
  JOURNAL   Nat Genet 1 (3), 171-175 (1992)
   PUBMED   1303230
  REMARK    Erratum:[Nat Genet 1992 Sep;2(1):84]
REFERENCE   7  (bases 1 to 4020)
  AUTHORS   Swank,R.T., Sweet,H.O., Davisson,M.T., Reddington,M. and Novak,E.K.
  TITLE     Sandy: a new mouse model for platelet storage pool deficiency
  JOURNAL   Genet Res 58 (1), 51-62 (1991)
   PUBMED   1936982
REFERENCE   8  (bases 1 to 4020)
  AUTHORS   Holcombe,R.F., Stephenson,D.A., Zweidler,A., Stewart,R.M.,
            Chapman,V.M. and Seidman,J.G.
  TITLE     Linkage of loci associated with two pigment mutations on mouse
            chromosome 13
  JOURNAL   Genet Res 58 (1), 41-50 (1991)
   PUBMED   1682216
REFERENCE   9  (bases 1 to 4020)
  AUTHORS   McGarry,M.P., Novak,E.K. and Swank,R.T.
  TITLE     Progenitor cell defect correctable by bone marrow transplantation
            in five independent mouse models of platelet storage pool
            deficiency
  JOURNAL   Exp Hematol 14 (4), 261-265 (1986)
   PUBMED   3516713
REFERENCE   10 (bases 1 to 4020)
  AUTHORS   Novak,E.K. and Swank,R.T.
  TITLE     Lysosomal dysfunctions associated with mutations at mouse pigment
            genes
  JOURNAL   Genetics 92 (1), 189-204 (1979)
   PUBMED   115747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK171595.1, AK143559.1, AK163996.1, CK129787.1 and BQ032961.1.
            
            On Dec 19, 2007 this sequence version replaced NM_009680.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF103809.2, SRR9219380.26049.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK171595.1         2-6
            6-2574              AK143559.1         2-2570
            2575-3375           AK163996.1         633-1433
            3376-3464           CK129787.1         112-200
            3465-3884           AK163996.1         1523-1942
            3885-4020           BQ032961.1         18-153              c
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 49.22 cM"
     gene            1..4020
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /note="adaptor-related protein complex 3, beta 1 subunit"
                     /db_xref="GeneID:11774"
                     /db_xref="MGI:MGI:1333879"
     exon            1..272
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..348
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..423
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..519
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..680
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..747
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..930
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1089
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1187
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1242
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1314
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1377
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1510
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1620
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1797
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1984
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2115
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2278
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2426
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2574
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2647
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2754
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2986
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3071
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3169
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3308
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..4020
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3998..4003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /note="hexamer: AATAAA"
     polyA_site      4020
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /note="major polyA site"
ORIGIN      
        1 ggagcagtga cgagcccgga agcgccggcg cgcgccccct ccgccccaga actagtttgg
       61 ttcggtgtcc tccgaacgcc agccatccgt agaggacccc gcacgctctc tcccgcaccc
      121 gcctgctggc cagcaccgcc cgcgatgtct agcaacagtt tcgcctacaa cgagcagtcg
      181 ggaggagggg aggcggcgga gctcgggcag gaggccacct cgaccatctc tccctcgggc
      241 gccttcggcc tcttcagcag cgattggaag aagaatgaag acctgaagca gatgctggag
      301 agcaacaaag attctgccaa gctagatgct atgaagcgaa ttgttgggat gattgcgaag
      361 gggaaaaatg cctcggaact cttccctgct gttgtgaaga atgtggccag taaaaacatc
      421 gagatcaaga agttggtgta cgtttacctt gtccgatatg ctgaagaaca gcaggacctg
      481 gctcttctgt ccataagcac tttccagcga gctttgaagg acccgaatca actaatccgt
      541 gcaagtgcct tgagagtttt gtcaagtatt agagtgccaa ttatcgtgcc tgtcatgatg
      601 ctggctatta aggaggcttc agctgacctg tcgccatatg ttaggaagaa tgcagcccat
      661 gctattcaga agctgtacag tcttgacccc gagcagaagg agatgttaat tgaagtcatt
      721 gagaagcttc tgaaagacaa gagcacgctg gtggctggca gtgtggtgat ggcctttgaa
      781 gaagtgtgcc cggatagaat cgatctgatt cacaggaatt accgaaagct ttgtaacctg
      841 ctggttgatg ttgaagagtg ggggcaggtg gtcataatcc atatgctaac aagatacgct
      901 cggacccagt ttgtcagtcc ttggagagag gatggtggtc tggaagacaa tgagaagaac
      961 ttctatgaat ctgaggagga ggaggaggag aaggagaaga gcagcaggaa gaagtcgtat
     1021 gccatggacc cagaccacag actcttaatt agaaacacca agccgttgct tcagagcagg
     1081 aatgcagcgg tggttatggc tgtcgctcag ctatattggc acatctcacc caagtcggag
     1141 gctggtgtca tttctaaatc actggtgcgc ttattgcgca gcaataggga ggtgcagtat
     1201 attgtattgc aaaatattgc aactatgtca attgagagaa agggtatgtt tgaaccttac
     1261 ctgaagagtt tctatgtcag atccactgat ccaactatga tcaaaacact gaagcttgaa
     1321 attttgacaa acttggcaaa tgaagccaac atatcaactc ttcttcgaga atttcagacc
     1381 tacgtgagaa gccaggacaa acagtttgca gcagccacta ttcagaccat aggcagatgt
     1441 gcaaccagca ttagcgaggt caccgacaca tgcctcaacg gcctggtctg cctgctgtcc
     1501 aacagggatg aaatagttgt tgctgagagt gtggttgtta taaagaaatt gttgcaaatg
     1561 cagcctgcac agcatggtga aattatcaga catatggcca agctcttgga cagtatcact
     1621 gttcctgtgg ctagagcaag catcctttgg ctaattggag aaaactgtga acgagttcct
     1681 aaaattgctc ctgatgtttt gaggaaaatg gctaaaagtt tcactagtga agatgatctc
     1741 gtgaaactgc agattttaaa tcttgcagca aaattgtatt taactaattc caaacagaca
     1801 aaattgctta cccagtacat attaaatctc ggcaagtatg atcaaaacta cgacatcaga
     1861 gaccgcacac gatttattag gcagcttatt gttccgaacg agaagagtgg agccttaagt
     1921 aaatatgcca aaaaaatctt cctagcaccg aagcctgcgc cactgctcga gtctcccttt
     1981 aaagataggg atcgcttcca gcttggcacc ttatctcata ctctcaacat taaagcgtcc
     2041 gggtacctgg aattatctaa ttggccagag gtggcgcctg acccatcggt tcgcaatgta
     2101 gaagtaatag agtcagcaaa agaatggacc ccacttggga aaacaaagaa agaaaaaccc
     2161 atgaagaaat tttactctga atctgaggag gaggaggacg aggacgagga tgaggacgag
     2221 gaggaggaag aaaaggaaga tgaggatgag aacccctctg atagcagcag tgacagtgag
     2281 agcgggtccg gaagtgagag tggagacaca ggcaccgagg acagcagtga ggactcgtcc
     2341 agtggacaag acagcgagac cggaagccag gcagaagcgg aacgccagaa ggtggccaag
     2401 aggaactcca aaaccaagag gaaaagtgat tcagaaaata gggagaagaa aaatgaaaac
     2461 tcaaaagctt ctgaatcgtc cagtgaggag tccagttcca tggaagacag ttcttccgag
     2521 tcagagtcag agtcaggctc tgacagtgag cctgcgccca gaaacgtggc tccggcaaaa
     2581 gaaagaaaac cccagcaaga aagacatcct ccctccaaag atgttttcct tctagatctg
     2641 gacgacttta acccagtatc caccccagtt gcccttccta caccagccct ttctccaagc
     2701 ttgatagctg atcttgaagg tctaaacttg tcaacttctt catcagtcat caacgtcagt
     2761 acgcctgtct tcgtgccaac aaaaacacat gagctgcttc accgaatgca tgggaaagga
     2821 ctggccgccc actactgctt cccaagacag ccctgcatct tcagtgacaa gatggtctct
     2881 gtacagatca ccctgactaa tacttctgat cgaaaaatag aaaacatcca catagggggg
     2941 aaagggcttc ctgtgggcat gcagatgcat gcctttcatc caatagactc tctggagcct
     3001 aaggggtccg tgactgtctc agtgggtatt gacttttgtg attctacaca gacggccagt
     3061 ttccaattgt gcaccaagga tgactgcttc aacgtcaccc tccagccacc tgttggggag
     3121 ctgctttcac ctgtggccat gtcagagaag gactttaaga aggagcaagg aacgctcact
     3181 ggaatgaacg agacttcggc tacactcatc gctgctccac agaacttcac tccctccatg
     3241 atcctccaga aggttgtaaa tgtggccaac ctcggtgctg tgccttccag ccaagataac
     3301 gtacacaggt ttgcagctag aactgtgcac agtgggtcgc tgatgctagt cacagtggaa
     3361 ctgaaggaag gctccacagc ccagcttatc atcaacaccg agaaaaccgt gattggttct
     3421 gttctgctgc gggagctgaa gcctgtcctg tcccaggggt aacctgctta catctggact
     3481 tcagaatctg gcacacaaca aaagtgcctg gcacccactg ctgctgcctt tcatttataa
     3541 taatagccct tccatctggc agcaggaaga gcgcactctc gacattcttg tctctgcttt
     3601 agaatgctgc tgtgtctgtc atgtgtgcac tcctcgcccc tcctcgcttt gctaaccaaa
     3661 gaacatatat tttactgtcc atttcctcag ctccccagtc cgagtagcat tttctctgcc
     3721 ctccgacttc ttttgacctc atcttccttc tgggttttga gaacagtggg tgtgaatcag
     3781 tgcttggcaa tcgtccttct tacagcagta agcaaaaatt agcaaggaac gtgtccgcat
     3841 ggcctctcag cttggtatgt gaaaaggaaa tagcatactt tttcaaaaat aaataaataa
     3901 aaatggcatc tctgaaaatc ccattctttg attttcctgg tattgtaatt ggttattgac
     3961 aattgtcatc atgaaattac ccctgaataa tcaggtaaat aaaggagtat atgaatagca
//
