LOCUS       NM_001110300            1726 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus adaptor protein complex AP-1, mu 2 subunit (Ap1m2),
            transcript variant 1, mRNA.
ACCESSION   NM_001110300
VERSION     NM_001110300.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1726)
  AUTHORS   Matsumoto,R., Ogata,K., Takahashi,D., Kinashi,Y., Yamada,T.,
            Morita,R., Tanaka,K., Hattori,K., Endo,M., Fujimura,Y., Sasaki,N.,
            Ohno,H., Ishihama,Y., Kimura,S. and Hase,K.
  TITLE     AP-1B regulates interactions of epithelial cells and
            intraepithelial lymphocytes in the intestine
  JOURNAL   Cell Mol Life Sci 81 (1), 425 (2024)
   PUBMED   39369131
  REMARK    GeneRIF: AP-1B regulates interactions of epithelial cells and
            intraepithelial lymphocytes in the intestine.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1726)
  AUTHORS   Kinashi,Y., Tanaka,K., Kimura,S., Hirota,M., Komiyama,S.,
            Shindo,T., Hashiguchi,A., Takahashi,D., Shibata,S., Karaki,S.I.,
            Ohno,H. and Hase,K.
  TITLE     Intestinal epithelium dysfunctions cause IgA deposition in the
            kidney glomeruli of intestine-specific Ap1m2-deficient mice
  JOURNAL   EBioMedicine 106, 105256 (2024)
   PUBMED   39059316
  REMARK    GeneRIF: Intestinal epithelium dysfunctions cause IgA deposition in
            the kidney glomeruli of intestine-specific Ap1m2-deficient mice.
REFERENCE   3  (bases 1 to 1726)
  AUTHORS   Jangid,A., Fukuda,S., Seki,M., Horiuchi,T., Suzuki,Y., Taylor,T.D.,
            Ohno,H. and Prakash,T.
  TITLE     Association of colitis with gut-microbiota dysbiosis in clathrin
            adapter AP-1B knockout mice
  JOURNAL   PLoS One 15 (3), e0228358 (2020)
   PUBMED   32208434
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1726)
  AUTHORS   Folsch,H.
  TITLE     Role of the epithelial cell-specific clathrin adaptor complex AP-1B
            in cell polarity
  JOURNAL   Cell Logist 5 (2), e1074331 (2015)
   PUBMED   27057418
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1726)
  AUTHORS   Uwada,J., Yoshiki,H., Masuoka,T., Nishio,M. and Muramatsu,I.
  TITLE     Intracellular localization of the M1 muscarinic acetylcholine
            receptor through clathrin-dependent constitutive internalization is
            mediated by a C-terminal tryptophan-based motif
  JOURNAL   J Cell Sci 127 (Pt 14), 3131-3140 (2014)
   PUBMED   24829147
REFERENCE   6  (bases 1 to 1726)
  AUTHORS   Schreiner,R., Frindt,G., Diaz,F., Carvajal-Gonzalez,J.M., Perez
            Bay,A.E., Palmer,L.G., Marshansky,V., Brown,D., Philp,N.J. and
            Rodriguez-Boulan,E.
  TITLE     The absence of a clathrin adapter confers unique polarity essential
            to proximal tubule function
  JOURNAL   Kidney Int 78 (4), 382-388 (2010)
   PUBMED   20531453
REFERENCE   7  (bases 1 to 1726)
  AUTHORS   Friocourt,G., Chafey,P., Billuart,P., Koulakoff,A., Vinet,M.C.,
            Schaar,B.T., McConnell,S.K., Francis,F. and Chelly,J.
  TITLE     Doublecortin interacts with mu subunits of clathrin adaptor
            complexes in the developing nervous system
  JOURNAL   Mol Cell Neurosci 18 (3), 307-319 (2001)
   PUBMED   11591131
REFERENCE   8  (bases 1 to 1726)
  AUTHORS   Ohno,H., Tomemori,T., Nakatsu,F., Okazaki,Y., Aguilar,R.C.,
            Foelsch,H., Mellman,I., Saito,T., Shirasawa,T. and Bonifacino,J.S.
  TITLE     Mu1B, a novel adaptor medium chain expressed in polarized
            epithelial cells
  JOURNAL   FEBS Lett 449 (2-3), 215-220 (1999)
   PUBMED   10338135
REFERENCE   9  (bases 1 to 1726)
  AUTHORS   Nakatsu,F., Kadohira,T., Gilbert,D.J., Jenkins,N.A., Kakuta,H.,
            Copeland,N.G., Saito,T. and Ohno,H.
  TITLE     Genomic structure and chromosome mapping of the genes encoding
            clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B
            (Ap1m2)
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 53-58 (1999)
   PUBMED   10640811
REFERENCE   10 (bases 1 to 1726)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122525.4.
            
            On Aug 8, 2022 this sequence version replaced NM_001110300.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010478.1, SRR5189685.149035.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC122525.4         99399-99513
            116-272             AC122525.4         101928-102084
            273-340             AC122525.4         102286-102353
            341-619             AC122525.4         105949-106227
            620-746             AC122525.4         106312-106438
            747-895             AC122525.4         108949-109097
            896-967             AC122525.4         109193-109264
            968-1126            AC122525.4         112283-112441
            1127-1252           AC122525.4         113395-113520
            1253-1328           AC122525.4         115212-115287
            1329-1726           AC122525.4         115866-116263
FEATURES             Location/Qualifiers
     source          1..1726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.76 cM"
     gene            1..1726
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /note="adaptor protein complex AP-1, mu 2 subunit"
                     /db_xref="GeneID:11768"
                     /db_xref="MGI:MGI:1336974"
     exon            1..115
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1351
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /note="isoform 1 is encoded by transcript variant 1; AP-1
                     complex subunit mu-2; mu-adaptin 2; mu1B-adaptin; AP-mu
                     chain family member mu1B; golgi adaptor HA1/AP1 adaptin
                     mu-2 subunit; adaptor-related protein complex 1 mu-2
                     subunit; clathrin assembly protein complex 1 medium chain
                     2; adaptor-related protein complex AP-1, mu 2 subunit;
                     adaptor protein complex AP-1 subunit mu-2; adaptor-related
                     protein complex 1 subunit mu-2; clathrin assembly protein
                     complex 1 mu-2 medium chain 2"
                     /codon_start=1
                     /product="AP-1 complex subunit mu-2 isoform 1"
                     /protein_id="NP_001103770.1"
                     /db_xref="CCDS:CCDS52734.1"
                     /db_xref="GeneID:11768"
                     /db_xref="MGI:MGI:1336974"
                     /translation="MSASAVFILDVKGKPLISRNYKGDVPMTEIDHFMPLLMQREEEG
                     VLAPLLSHGRVHFLWIKHSNLYLVATTLKNANASLVYSFLYKTVEVFCEYFKELEEES
                     IRDNFVIVYELLDELMDFGFPQTTDSKILQEYITQQGNKLETGKSRVPPTVTNAVSWR
                     SEGIKYKKNEVFIDVIESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRV
                     LFELTGLSGSKNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVK
                     PLIWIESVIEKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSA
                     KYVPEKNVVIWSIKSFPGGKEYLMRAHFGLPSVETEEVEGRPPIGVKFEIPYFTVSGI
                     QVRYMKIIEKSGYQALPWVRYITQSGDYQLRTS"
     exon            116..272
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     exon            273..340
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     exon            341..619
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     exon            620..746
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     exon            747..895
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     exon            896..967
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1126
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1252
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1328
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1726
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /note="hexamer: ATTAAA"
     polyA_site      1725
                     /gene="Ap1m2"
                     /gene_synonym="D9Ertd818e; mu1B; [m]1B"
                     /note="major polyA site"
ORIGIN      
        1 gcaggaagaa ggaagccgca gcgctgccgc ctctgcagct cgctctcgcc tcctagcttc
       61 acggactgcc accatgtcgg cctcggcagt cttcattctg gacgtcaagg gcaagcctct
      121 gattagccga aactacaaag gtgatgtgcc catgacagag attgaccact tcatgccgct
      181 gcttatgcag cgtgaggagg agggcgtgct ggccccgctg ctgagccacg gccgagtgca
      241 cttcctgtgg atcaaacaca gcaacctcta cttggtggcc accacgctga agaacgctaa
      301 tgcctctctg gtgtactcct ttctgtacaa gactgtggag gtcttctgcg agtactttaa
      361 ggagctggag gaggagagca tccgggacaa cttcgtcatc gtgtacgagc tgctggatga
      421 gctcatggac ttcggctttc cgcagaccac agacagcaag atcctgcagg agtacatcac
      481 acaacagggc aacaagctgg agactggcaa atctcgtgta ccacctacag tcaccaatgc
      541 ggtgtcgtgg cgctctgagg gcattaagta caaaaagaat gaggtcttca ttgatgtcat
      601 tgagtctgtc aaccttctgg tcaatgctaa tgggagtgtc ttgctcagcg agattgtggg
      661 caccatcaag ctgaaggtgt ttctgtctgg gatgccagag ctgcggctgg gcctcaatga
      721 ccgagtgctc tttgagctta ctggcctttc aggcagcaag aacaagtctg tggaactgga
      781 agatgtgaaa ttccaccaat gtgtgaggct ttcacgcttt gacaacgacc gaaccatctc
      841 cttcataccc ccagatgggg actttgaact catgtcctac cggcttagca cccaggtcaa
      901 acccctgatc tggatcgagt cagtcattga gaaattctcg cacagccgag tggagatcat
      961 ggtgaaggcc aagggtcagt ttaagaagca gtcggtggcc aatggcgtgg aaatctctgt
     1021 gcccgttcct agtgatgcag actctccgcg cttcaagacc agtgtgggca gtgccaagta
     1081 tgtgcctgag aagaatgttg tcatctggag catcaagtca ttccctgggg gaaaggagta
     1141 cttgatgcgt gcccactttg gcctccccag cgtggaaact gaggaggtag agggccgacc
     1201 acccatcggg gtcaagtttg agattccata ctttaccgtt tctggcatcc aggtccgtta
     1261 catgaagatc atcgagaaaa gtgggtacca ggccctgccc tgggtccgtt acatcacgca
     1321 gagtggtgat tatcaacttc gtaccagcta gaagggagaa gaagtggggc ttccatctcc
     1381 ccagatacca gctgcagact tttaagagct gtgtgtgtgt gtttgtgagt gtgcacacgc
     1441 gagtgtgtgc agggttaggg cactgactta acacatcctt gctgcccaca cctaaccccc
     1501 tttacctctc tcagccatct ggggtggttt ctttgtgtcc caccctaatt ttatatgaag
     1561 aaatataaga gggcctgaac tctgctgccc ggcccgcccc ccatgagtgc cttcttgcag
     1621 taaactgcct tgggcagatc tagggcccac cttttatagc tgctgagccg aggccactgg
     1681 tcctccatct gggttttagg gtgtcattaa aatgaatcta acagct
//
