LOCUS       NM_007456               2085 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus adaptor-related protein complex AP-1, mu subunit 1
            (Ap1m1), mRNA.
ACCESSION   NM_007456
VERSION     NM_007456.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2085)
  AUTHORS   Fornasiero,E.F., Mandad,S., Wildhagen,H., Alevra,M., Rammner,B.,
            Keihani,S., Opazo,F., Urban,I., Ischebeck,T., Sakib,M.S.,
            Fard,M.K., Kirli,K., Centeno,T.P., Vidal,R.O., Rahman,R.U.,
            Benito,E., Fischer,A., Dennerlein,S., Rehling,P., Feussner,I.,
            Bonn,S., Simons,M., Urlaub,H. and Rizzoli,S.O.
  TITLE     Precisely measured protein lifetimes in the mouse brain reveal
            differences across tissues and subcellular fractions
  JOURNAL   Nat Commun 9 (1), 4230 (2018)
   PUBMED   30315172
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2085)
  AUTHORS   Dib,K., Tikhonova,I.G., Ivetic,A. and Schu,P.
  TITLE     The cytoplasmic tail of L-selectin interacts with the
            adaptor-protein complex AP-1 subunit mu1A via a novel basic binding
            motif
  JOURNAL   J Biol Chem 292 (16), 6703-6714 (2017)
   PUBMED   28235798
  REMARK    GeneRIF: L-selectin is transported constitutively by the AP-1
            complex, leading to the formation of a trans-Golgi network reserve
            pool; phosphorylation of the L-selectin tail blocks AP-1-dependent
            retrograde transport of L-selectin
REFERENCE   3  (bases 1 to 2085)
  AUTHORS   Bonnemaison,M.L., Back,N., Duffy,M.E., Ralle,M., Mains,R.E. and
            Eipper,B.A.
  TITLE     Adaptor Protein-1 Complex Affects the Endocytic Trafficking and
            Function of Peptidylglycine alpha-Amidating Monooxygenase, a
            Luminal Cuproenzyme
  JOURNAL   J Biol Chem 290 (35), 21264-21279 (2015)
   PUBMED   26170456
REFERENCE   4  (bases 1 to 2085)
  AUTHORS   Hirata,Y., Funato,Y. and Miki,H.
  TITLE     Basolateral sorting of the Mg(2) transporter CNNM4 requires
            interaction with AP-1A and AP-1B
  JOURNAL   Biochem Biophys Res Commun 455 (3-4), 184-189 (2014)
   PUBMED   25449265
REFERENCE   5  (bases 1 to 2085)
  AUTHORS   Bonnemaison,M., Back,N., Lin,Y., Bonifacino,J.S., Mains,R. and
            Eipper,B.
  TITLE     AP-1A controls secretory granule biogenesis and trafficking of
            membrane secretory granule proteins
  JOURNAL   Traffic 15 (10), 1099-1121 (2014)
   PUBMED   25040637
REFERENCE   6  (bases 1 to 2085)
  AUTHORS   Bonifacino,J.S.
  TITLE     Adaptor proteins involved in polarized sorting
  JOURNAL   J Cell Biol 204 (1), 7-17 (2014)
   PUBMED   24395635
  REMARK    Review article
REFERENCE   7  (bases 1 to 2085)
  AUTHORS   Ohno,H., Tomemori,T., Nakatsu,F., Okazaki,Y., Aguilar,R.C.,
            Foelsch,H., Mellman,I., Saito,T., Shirasawa,T. and Bonifacino,J.S.
  TITLE     Mu1B, a novel adaptor medium chain expressed in polarized
            epithelial cells
  JOURNAL   FEBS Lett 449 (2-3), 215-220 (1999)
   PUBMED   10338135
REFERENCE   8  (bases 1 to 2085)
  AUTHORS   Nakatsu,F., Kadohira,T., Gilbert,D.J., Jenkins,N.A., Kakuta,H.,
            Copeland,N.G., Saito,T. and Ohno,H.
  TITLE     Genomic structure and chromosome mapping of the genes encoding
            clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B
            (Ap1m2)
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 53-58 (1999)
   PUBMED   10640811
REFERENCE   9  (bases 1 to 2085)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   10 (bases 1 to 2085)
  AUTHORS   Nakayama,Y., Goebl,M., O'Brine Greco,B., Lemmon,S., Pingchang
            Chow,E. and Kirchhausen,T.
  TITLE     The medium chains of the mammalian clathrin-associated proteins
            have a homolog in yeast
  JOURNAL   Eur J Biochem 202 (2), 569-574 (1991)
   PUBMED   1761056
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ075420.1, AK148173.1,
            CX240144.1 and AC158898.7.
            
            On Jul 13, 2016 this sequence version replaced NM_007456.4.
            
            Summary: This gene encodes the mu-1 subunit of the scaffolding
            adapter protein complex AP-1 and is a member of the mu adaptin
            family. The AP-1 complex, which consists of 4 subunits (mu-adaptin,
            beta-prime adaptin, gamma-adaptin, and the small chain adaptin), is
            one of the predominant coat proteins of membrane vesicles involved
            in eukaryotic post-Golgi trafficking. The AP-1 complex is located
            at the Golgi vesicle and links clathrin to receptors in coated
            vesicles. These vesicles are involved in endocytosis and Golgi
            processing. AP-1 complex subunit mu-1 and other mu-adaptins select
            cargo proteins bearing sequence-specific sorting motifs. [provided
            by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148173.1, M62419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               CJ075420.1         1-100
            101-1299            AK148173.1         2-1200
            1300-1738           CX240144.1         234-672
            1739-2085           AC158898.7         2581-2927           c
FEATURES             Location/Qualifiers
     source          1..2085
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.92 cM"
     gene            1..2085
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /note="adaptor-related protein complex AP-1, mu subunit 1"
                     /db_xref="GeneID:11767"
                     /db_xref="MGI:MGI:102776"
     exon            1..226
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1456
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /note="mu-adaptin 1; mu1A-adaptin; AP-mu chain family
                     member mu1A; clathrin coat assembly protein AP47; clathrin
                     coat-associated protein AP47; adaptor protein complex AP-1
                     mu-1 subunit; golgi adaptor HA1/AP1 adaptin mu-1 subunit;
                     adaptor-related protein complex 1 mu-1 subunit; clathrin
                     assembly protein complex 1 medium chain 1; adapter-related
                     protein complex 1 subunit mu-1; clathrin assembly protein
                     complex 1 mu-1 medium chain 1"
                     /codon_start=1
                     /product="AP-1 complex subunit mu-1"
                     /protein_id="NP_031482.1"
                     /db_xref="CCDS:CCDS22411.1"
                     /db_xref="GeneID:11767"
                     /db_xref="MGI:MGI:102776"
                     /translation="MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEG
                     MLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEES
                     IRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWR
                     SEGIKYRKNEVFLDVIEAVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKV
                     LFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPL
                     IWIESVIEKHSHSRIEYMVKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKW
                     VPENSEIVWSVKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQV
                     RYLKIIEKSGYQALPWVRYITQNGDYQLRTQ"
     exon            227..383
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            384..451
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            452..582
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            583..730
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            731..857
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1000
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1072
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1231
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1357
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1433
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..2085
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2060..2065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /note="hexamer: ATTAAA"
     polyA_site      2084
                     /gene="Ap1m1"
                     /gene_synonym="Adtm1A; AP47; Cltnm; mu1A"
                     /note="major polyA site"
ORIGIN      
        1 ttgcactcag ttacgcgcct gcgcacttgc ggctcccttc agaccggaca taacggtcca
       61 cgcgctgctt catggaccgg aagtggaggg gaagtgtctc ggggcgcgcc gggccttgct
      121 gaacgcccgc agttcctgcc gttgccgccg ccctcggcta ctgccgagac cttccaaagc
      181 cgccatgtcc gccagcgccg tctacgtact ggatctgaag ggcaaggtgc tcatctgcag
      241 gaactaccgt ggggatgtgg acatgtcaga ggtggagcac ttcatgccca ttctgatgga
      301 gaaggaggag gagggcatgc tgtcacctat cttggcccat ggtggcgttc gtttcatgtg
      361 gattaagcac aacaacctgt acctggtcgc cacttcaaaa aagaatgctt gtgtgtcact
      421 ggtgttctcc ttcctctaca aggtggtaca ggtcttctcc gagtacttta aggagttgga
      481 ggaggagagc atccgagaca actttgtcat catctacgag ctgctagatg agctcatgga
      541 ctttggctac ccgcagacca ctgacagcaa gatcttgcag gagtacatca ctcaggaagg
      601 ccacaagctg gaaacggggg cccctaggcc cccagccaca gtcaccaatg ctgtgtcctg
      661 gcgttcagaa ggcatcaagt atcggaagaa tgaagtattc ctggatgtca ttgaggctgt
      721 taacctcttg gtcagtgcca atggcaacgt gctgcgcagt gagattgtgg gttccatcaa
      781 gatgcgggtc ttcctctcag gcatgcctga gttacgcctg ggtctcaatg acaaggtcct
      841 cttcgacaac acaggccgag ggaagagcaa gtcagtggag ctggaggatg tgaaattcca
      901 ccagtgtgtg cggctgtcac gttttgagaa cgaccgcact atctccttca tcccacccga
      961 cggagagttt gaactcatgt cctaccgcct caacacccat gtgaagcctt tgatctggat
     1021 tgagtccgtg attgagaagc attcccacag ccgcattgag tacatggtca aggccaagag
     1081 ccagttcaag aggcggtcaa cagccaacaa tgtagagatc catataccag tccccaacga
     1141 tgctgattca cccaagttca agactacagt ggggagtgtc aagtgggtcc ctgaaaacag
     1201 tgagatcgtg tggtccgtca agtcctttcc gggtggcaag gagtacctga tgcgggccca
     1261 ctttggcctt cccagtgtgg aagctgaaga caaggaggga aagcccccca tcagcgtcaa
     1321 gtttgagatc ccctatttca ctacctctgg catccaggtg cgctacctga aaatcattga
     1381 gaagagtggg taccaggccc tgccctgggt acgatatatc acacagaacg gagattatca
     1441 gctccggacc cagtgagagg cctctgccac cagcccagcc cacctagcct cagggcacac
     1501 ctgccacact caccaaaact gaagctagag ggtggccctg gacatgcagc caccctctcc
     1561 tcaagcctga gtggactcac acagaacccc ttccctggtc ccattctgat ccagggtggg
     1621 aaggaagggc ctgccagcct cccccaggga caagccagct ggagctgtgc tcctggtgcc
     1681 tcatgactgg ccacccacca ccctgtagac gccatccctg cccacctccg aagcctccct
     1741 tctgttgcca ttttgctgag catgttggtc attgtcattg tcatctgtgg ctgtcctgtc
     1801 acctttcttc aagtgtcctg tgcagctgcc atgctgcact taatgagggc agctgtcccc
     1861 tatccatgct ggtctgtatg ccggatagtt gctctgcctg ggccggctgt gcctcccttg
     1921 ccagcccttg accacatcag tgttttctca gaagggcaca tggcctcagc ctttgcccta
     1981 aaattcctgg gcaggcacag gctaccctca ctgtacaagg cctcgttgtc ctggacccat
     2041 gtgtgtgtgt gacagttata ttaaaatcca tttgttacat ctgct
//
