LOCUS       NM_007455               2688 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus adaptor protein complex AP-1, gamma 2 subunit (Ap1g2),
            transcript variant 1, mRNA.
ACCESSION   NM_007455 NM_001110795 XM_989916
VERSION     NM_007455.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2688)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   2  (bases 1 to 2688)
  AUTHORS   Zizioli,D., Geumann,C., Kratzke,M., Mishra,R., Borsani,G.,
            Finazzi,D., Candiello,E. and Schu,P.
  TITLE     gamma2 and gamma1AP-1 complexes: Different essential functions and
            regulatory mechanisms in clathrin-dependent protein sorting
  JOURNAL   Eur J Cell Biol 96 (4), 356-368 (2017)
   PUBMED   28372831
REFERENCE   3  (bases 1 to 2688)
  AUTHORS   Liu,K., Lei,R., Li,Q., Wang,X.X., Wu,Q., An,P., Zhang,J., Zhu,M.,
            Xu,Z., Hong,Y., Wang,F., Shen,Y., Li,H. and Li,H.
  TITLE     Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency
            and Synaptic Plasticity
  JOURNAL   Sci Rep 6, 21019 (2016)
   PUBMED   26880306
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2688)
  AUTHORS   Muthusamy,N., Faundez,V. and Bergson,C.
  TITLE     Calcyon, a mammalian specific NEEP21 family member, interacts with
            adaptor protein complex 3 (AP-3) and regulates targeting of AP-3
            cargoes
  JOURNAL   J Neurochem 123 (1), 60-72 (2012)
   PUBMED   22650988
REFERENCE   5  (bases 1 to 2688)
  AUTHORS   Lewin,D.A., Sheff,D., Ooi,C.E., Whitney,J.A., Yamamoto,E.,
            Chicione,L.M., Webster,P., Bonifacino,J.S. and Mellman,I.
  TITLE     Cloning, expression, and localization of a novel gamma-adaptin-like
            molecule
  JOURNAL   FEBS Lett 435 (2-3), 263-268 (1998)
   PUBMED   9762922
REFERENCE   6  (bases 1 to 2688)
  AUTHORS   Takatsu,H., Sakurai,M., Shin,H.W., Murakami,K. and Nakayama,K.
  TITLE     Identification and characterization of novel clathrin
            adaptor-related proteins
  JOURNAL   J Biol Chem 273 (38), 24693-24700 (1998)
   PUBMED   9733768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC157212.2 and AK151844.1.
            
            On Jan 13, 2015 this sequence version replaced NM_007455.4.
            
            Summary: This gene encodes the gamma-2 subunit of the adaptor
            protein complex 1 (AP-1). AP-1 complex is a heterotetramer
            comprised of two heavy and one each of medium and small subunits.
            The encoded protein is a heavy subunit of AP-1 complex that
            regulates polarized sorting of cargo at the trans-Golgi network and
            endosomes. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108374.1, AK147177.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC157212.2         155018-155058       c
            42-1900             AK151844.1         3-1861
            1901-1901           AC157212.2         149162-149162       c
            1902-2544           AK151844.1         1863-2505
            2545-2688           AC157212.2         147300-147443       c
FEATURES             Location/Qualifiers
     source          1..2688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.07 cM"
     gene            1..2688
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /note="adaptor protein complex AP-1, gamma 2 subunit"
                     /db_xref="GeneID:11766"
                     /db_xref="MGI:MGI:1328307"
     exon            1..86
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            87..291
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2463
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /note="isoform 1 is encoded by transcript variant 1; AP-1
                     complex subunit gamma-like 2; gamma 2-adaptin"
                     /codon_start=1
                     /product="AP-1 complex subunit gamma-like 2 isoform 1"
                     /protein_id="NP_031481.2"
                     /db_xref="CCDS:CCDS36929.1"
                     /db_xref="GeneID:11766"
                     /db_xref="MGI:MGI:1328307"
                     /translation="MVVHSLRLQDLIEEIRGAKTQAQEREVIQKECAQIRASFRDGDP
                     LQRHRQLAKLLYVHMLGYPAHFGQMECLKLIASPRFTDKRVGYLGAMLLLDERHDSHL
                     LITNSIKNDLSQGNQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAIL
                     TAVHMIRKDPELSGIFLPPCTKLLRERHHGIQLGTVTLITELCERNPAALRHFRKVVP
                     QLVQILRTLVTTGYSTEHSISGVSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVA
                     TNTDTSRNAGNAVLLETVLTIMAIHSAAGLRVLAVNILGRFLLNNDKNIRYVALTSLL
                     QLVQSDHSAVQRHRSTVVECLQETDASLSRRALELSLALVNSSNVRAMMQELQAFLES
                     CPPDLRADCASGILLAAERFAPSKRWHIDTILHVLTTAGAHVRDDAVANLTQLIGEAE
                     ELHTYSVRRLYSALAEDISQQPLVQVAAWCIGEYGDLLLEGNCEETEPFQVEEEDVLA
                     LLEKVLQSHMSLPATRGYAITALMKLSTRLRGDNNRIRQVVSIYGSCVDLELQQRAVE
                     YNTLFQKYDHMRAAILEKMPLVERGDPHVKEGGKEKQTEAQPLEVTAPAPTEPQATKL
                     LDLLDLLGDTSEPLSSGHAQHLPPQTPSPGEALIHLLDLPCTPPPPAPIPSVRVFERE
                     GLQLDLSFMRPLETPALLLVTATTTNSSKEDVTHFVCQAAVPKSFQLQLQAPSGNTIP
                     AQGGLPITQVFRILNPNQAPLRLKLRLTYNHSGQPVQEIFEVDNLPVETWQ"
     exon            292..416
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            417..558
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            559..655
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            656..732
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            733..828
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            829..909
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1008
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1064
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1178
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1319
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1374
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1497
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1587
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1715
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1820
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1947
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2098
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2262
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2361
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2688
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /note="hexamer: AATAAA"
     polyA_site      2673
                     /gene="Ap1g2"
                     /gene_synonym="Adtg2; G2ad"
                     /note="major polyA site"
ORIGIN      
        1 cccgaaccga gcaccaaccc cagctctgtc ccataccagg aagtgctggg tggggggtag
       61 aggagcaaag ttgacaccga agccaggatg gtggtgcatt cgttgagact tcaggaccta
      121 atcgaagaga ttcgcggggc caagacgcag gcccaggaac gggaggtgat ccagaaggag
      181 tgcgcccaaa ttcgggcctc cttccgcgat ggggatcccc tgcagaggca tcgccagctg
      241 gccaaactgc tctacgtcca catgttgggc taccccgccc actttggaca gatggagtgc
      301 ctgaaactga tcgcctcccc cagattcaca gacaagaggg tgggctacct tggggccatg
      361 cttctattgg atgagaggca cgattcccat ctgctcatca ccaacagcat caagaatgac
      421 ctgagccaag ggaaccagcc agttcaaggc ctggccctgt gtactctgag taccatgggc
      481 tctgctgaga tgtgccggga cctagcccct gaggtggaaa agctgcttct gcagcccagt
      541 ccctatgtgc ggaagaaggc tattttgact gcagtgcaca tgatccggaa ggaccctgag
      601 ctctccggca tcttcctccc accttgtacc aaactgcttc gtgagcgtca tcatggcatc
      661 cagctgggca cagtcacgct gatcacggag ctctgtgaaa gaaaccctgc agccctcagg
      721 cactttcgca aggtagtgcc gcagctggta cagatcctcc ggactctggt gactacagga
      781 tactccacgg agcacagcat ctctggagtc agcgacccct tcttgcaggt ccagatactc
      841 cgcctacttc ggatcctggg acggaaccat gaagaaagta gcgagaccat gaacgacttg
      901 ctggcccagg tcgccaccaa cacagacacc agccgaaatg caggcaacgc tgtcctgttg
      961 gaaacagtgc ttaccatcat ggccatccac tctgctgctg gcctccgggt tctagctgtt
     1021 aacattcttg gtcgtttctt gctcaacaat gacaagaata ttaggtatgt ggctctgaca
     1081 tcattgctgc agctggtgca gtctgaccac agtgctgtac aacgtcaccg gtccactgtg
     1141 gtggagtgtc tacaggaaac ggacgcctcc cttagcaggc gggccctgga gctgagcctg
     1201 gctctggtga acagctccaa tgtacgagcc atgatgcagg agctgcaggc ctttctggag
     1261 tcctgccccc ctgatcttcg ggctgattgt gcctcaggca ttctgttggc tgcggagagg
     1321 tttgctccca gcaagcgatg gcacatagac accatcctgc acgtgctgac cacggcagga
     1381 gcccatgtga gggatgacgc agtggccaac ctgacccagc tgattggaga ggccgaggag
     1441 ctgcatacct actctgtgcg ccgtctctac agtgccttag cagaggatat ctcccagcaa
     1501 ccactggttc aggtggcagc ctggtgcatt ggcgagtatg gggacctcct gctggaaggt
     1561 aactgtgagg agacggagcc ttttcaggtg gaagaagagg acgtgctagc actgctggaa
     1621 aaggtgctgc agtcccatat gtccctgcca gccactcggg gctacgccat cacagccctc
     1681 atgaagctga gcacccgact ccggggagac aacaatcgta ttcgccaggt ggtgtccatc
     1741 tacgggagct gtgtggactt agagctgcaa cagcgggctg tggagtataa cacactcttc
     1801 cagaagtacg accacatgag agccgccatc ctagaaaaga tgcctcttgt agagcgtggt
     1861 gacccccacg ttaaagaggg agggaaggag aagcaaacgg aagcccagcc cttggaagtg
     1921 acagcccctg cccccacaga accccaggcc accaaactct tagatctact ggatctcctg
     1981 ggtgacactt cagagcctct ctcttctggg catgcccagc atcttcctcc tcagactcct
     2041 tccccagggg aagccttaat tcatctcctt gaccttccct gtacaccgcc acccccagct
     2101 cccatcccca gtgtcagagt gtttgagcgt gagggcctac agctggatct ttctttcatg
     2161 cggcccttgg agacccctgc tttgctctta gtcactgcca ccaccaccaa ctcctcaaag
     2221 gaggatgtta cccacttcgt ttgccaggca gctgtgccca agagtttcca gctgcagtta
     2281 caggccccca gtgggaacac aattccagct cagggtggtc ttcccatcac ccaggtcttc
     2341 agaatcctca atcctaacca ggcacctttg cgacttaagc tgcgcctcac ctacaaccac
     2401 tctggccagc cagtacagga gatctttgag gtggataact tgcctgtgga gacgtggcag
     2461 taaccgactg tggtcagtgt ctggcctggg tgtctccagg ctcctggtgt tcaaggaacg
     2521 gaaataaaga cccacgtaaa tggcgaagta aactttattt aaaggcaaac tgagcgtaca
     2581 aattagaagt gctctgtaaa cgggtgatga ccacagtctt aagagcccag ggcagtcacc
     2641 cggtgttcct ttaataaagt ctcagggaac gaaggtgtta gctgtgaa
//
