LOCUS       NM_001301211            6882 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus adaptor protein complex AP-1, gamma 1 subunit (Ap1g1),
            transcript variant 2, mRNA.
ACCESSION   NM_001301211 XM_006530584
VERSION     NM_001301211.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6882)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6882)
  AUTHORS   Perea-Gomez,A., Cases,O., Lelievre,V., Pulina,M.V., Collignon,J.,
            Hadjantonakis,A.K. and Kozyraki,R.
  TITLE     Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs
            visceral endoderm endocytosis and endodermal patterning in the
            mouse
  JOURNAL   Sci Rep 9 (1), 10168 (2019)
   PUBMED   31308417
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6882)
  AUTHORS   Johnson,K.R., Gagnon,L.H. and Chang,B.
  TITLE     A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes
            inner ear, retina, thyroid, and testes abnormalities in mice
  JOURNAL   Mamm Genome 27 (5-6), 200-212 (2016)
   PUBMED   27090238
  REMARK    GeneRIF: Ap1g1 (fgt) mutant mice provide a new animal model to
            study the in vivo roles of gamma-1 adaptin and the AP-1 complex
            throughout development and to investigate factors that underlie its
            associated phenotypic abnormalities
REFERENCE   4  (bases 1 to 6882)
  AUTHORS   Folsch,H.
  TITLE     Role of the epithelial cell-specific clathrin adaptor complex AP-1B
            in cell polarity
  JOURNAL   Cell Logist 5 (2), e1074331 (2015)
   PUBMED   27057418
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6882)
  AUTHORS   Jia,X., Weber,E., Tokarev,A., Lewinski,M., Rizk,M., Suarez,M.,
            Guatelli,J. and Xiong,Y.
  TITLE     Structural basis of HIV-1 Vpu-mediated BST2 antagonism via
            hijacking of the clathrin adaptor protein complex 1
  JOURNAL   Elife 3, e02362 (2014)
   PUBMED   24843023
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6882)
  AUTHORS   Zizioli,D., Meyer,C., Guhde,G., Saftig,P., von Figura,K. and
            Schu,P.
  TITLE     Early embryonic death of mice deficient in gamma-adaptin
  JOURNAL   J Biol Chem 274 (9), 5385-5390 (1999)
   PUBMED   10026148
REFERENCE   7  (bases 1 to 6882)
  AUTHORS   Takatsu,H., Sakurai,M., Shin,H.W., Murakami,K. and Nakayama,K.
  TITLE     Identification and characterization of novel clathrin
            adaptor-related proteins
  JOURNAL   J Biol Chem 273 (38), 24693-24700 (1998)
   PUBMED   9733768
REFERENCE   8  (bases 1 to 6882)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   9  (bases 1 to 6882)
  AUTHORS   Peyrard,M., Parveneh,S., Lagercrantz,S., Ekman,M., Fransson,I.,
            Sahlen,S. and Dumanski,J.P.
  TITLE     Cloning, expression pattern, and chromosomal assignment to 16q23 of
            the human gamma-adaptin gene (ADTG)
  JOURNAL   Genomics 50 (2), 275-280 (1998)
   PUBMED   9653655
REFERENCE   10 (bases 1 to 6882)
  AUTHORS   Robinson,M.S.
  TITLE     Cloning and expression of gamma-adaptin, a component of
            clathrin-coated vesicles associated with the Golgi apparatus
  JOURNAL   J Cell Biol 111 (6 Pt 1), 2319-2326 (1990)
   PUBMED   2126014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY738987.1, X54424.1, AC122807.3 and BU755831.1.
            
            On Jul 25, 2014 this sequence version replaced XM_006530584.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X54424.1, SRR10223970.10806.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                BY738987.1         2-79
            79-2982             X54424.1           1-2904
            2983-6861           AC122807.3         102177-106055       c
            6862-6882           BU755831.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..6882
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.26 cM"
     gene            1..6882
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /note="adaptor protein complex AP-1, gamma 1 subunit"
                     /db_xref="GeneID:11765"
                     /db_xref="MGI:MGI:101919"
     exon            1..380
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            381..584
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..2852
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /note="isoform 2 is encoded by transcript variant 2; AP-1
                     complex subunit gamma-1; gamma1-adaptin; adaptor protein
                     complex AP-1 subunit gamma-1; golgi adaptor HA1/AP1
                     adaptin subunit gamma-1; adapter-related protein complex 1
                     subunit gamma-1; clathrin assembly protein complex 1
                     gamma-1 large chain; gamma-adaptin; adaptor-related
                     protein complex 1 subunit gamma-1"
                     /codon_start=1
                     /product="AP-1 complex subunit gamma-1 isoform 2"
                     /protein_id="NP_001288140.1"
                     /db_xref="CCDS:CCDS80929.1"
                     /db_xref="GeneID:11765"
                     /db_xref="MGI:MGI:101919"
                     /translation="MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNT
                     YRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLL
                     MTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALC
                     AVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQ
                     LVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVAT
                     NTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALTSLLK
                     TVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSC
                     EPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVE
                     MHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDI
                     LESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEY
                     NALFKKYDHMRSALLERMPVMEKVTTNGPSEIVQTNGETEPAPLETKPPPSGPQPTSQ
                     ANDLLDLLGGNDITPVIPTAPTSKPASAGGELLDLLGDITLTGAPAAAPTPASVPQIS
                     QPPFLLDGLSSQPLFNDIAPGIPSITAYSKNGLKIEFTFERSNTNPSVTVITIQASNS
                     TELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKVLNPQKQQLRMRIKL
                     TYNHKGSAMQDLAEVNNFPPQSWQ"
     exon            585..709
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            710..851
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            852..948
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1025
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1121
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1202
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1301
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1357
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1471
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1612
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1667
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1790
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1880
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2008
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2113
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2255
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2382
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2490
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2651
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2750
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..6867
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3991..3996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /note="hexamer: AATAAA"
     polyA_site      4015
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
     regulatory      6839..6844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /note="hexamer: AATAAA"
     polyA_site      6867
                     /gene="Ap1g1"
                     /gene_synonym="Adtg; D8Ertd374e"
                     /note="major polyA site"
ORIGIN      
        1 agcggtgact cggcagcggc gtcgagcgtc atcagtgaca gccccgaccc ttgctacgct
       61 ttgagtcgct ctgcccggcg cagtcgcctc ctcctcggca aatagtcctc ggcgggggcc
      121 gagtcctcgg gtcatccggg gtgggagacg gcacgggctg cagtcggagg gacgcggggc
      181 ggccggcgag agggagccgg ggagcggcgt ctcccgggga agcgcgaggc gtgaggtaga
      241 ggcgccctcc tcgcccggga tccctccgcc tgcagtcgcg gtgctgaggc cgagggagcc
      301 gccattttgg atgttcggtt cctgctgcca ctgccgccgc cgcccccgaa gctgctggtt
      361 tccttcgagg tttcgggccg aggatgccag cccccatcag attgcgggag ctgatccgga
      421 ccatccggac agcccgaacc caagctgagg aacgagaaat gatccagaaa gaatgtgctg
      481 caatccggtc ctcatttaga gaagaagaca atacataccg gtgtcggaat gtggcaaagt
      541 tactatatat gcacatgctg ggctaccctg ctcactttgg acagttggag tgcctcaagc
      601 taatcgcctc acaaaaattc acagacaaac gcattggcta tttaggagca atgctattat
      661 tagatgaaag acaagatgtg catcttctca tgaccaactg tatcaagaat gatcttaatc
      721 atagcacgca gtttgtgcag gggctagcac tttgtaccct cggctgcatg ggctcctcgg
      781 agatgtgcag agatcttgcg ggagaggtag aaaagcttct gaaaacctcc aactcttact
      841 taagaaaaaa ggcagcactg tgtgctgttc acgtcatcag gaaggttcct gaacttatgg
      901 agatgttttt accagcaaca aaaaatttat tgaatgagaa gaaccatggt gtccttcaca
      961 cgtctgtagt cctcctcaca gagatgtgtg aacggagccc agacatgctc gcacatttca
     1021 gaaagcttgt gccccaatta gttcgtattc taaagaacct catcatgtcc ggatattccc
     1081 cagaacatga tgtctctggt atcagtgacc cctttttgca ggtacgaatt ttgcggttat
     1141 taagaatttt aggacggaat gacgatgatt caagtgaagc tatgaatgat atattagcac
     1201 aggttgccac taatacagag actagtaaaa atgtaggaaa tgctattctg tatgagacgg
     1261 ttttgactat catggatatt aaatcagaga gtggattgcg agttctagcc ataaatattc
     1321 ttggtcgatt cttattgaac aatgacaaaa atattagata tgttgctctg acatctctgt
     1381 tgaagactgt gcagacagat cataacgctg tacagaggca tagaagcaca attgtggact
     1441 gtctgaaaga tctggatgtc tccataaaaa gacgtgcaat ggaactgagt tttgccctgg
     1501 tgaatgggaa taatatccga ggcatgatga aagaattact ttattttctg gattcctgtg
     1561 agccagaatt taaagctgat tgtgcatctg gaatcttcct tgctgcagaa aagtacgcac
     1621 cttccaaacg gtggcatata gatacaatta tgcgtgtctt gacaacggca ggaagttatg
     1681 ttcgcgatga tgcagttcct aacttgattc agttaataac caacagtgtg gagatgcacg
     1741 cttacaccgt ccagcgcctg tacaaggcga ttctcggtga ctattctcaa caacccttgg
     1801 tacaagtggc tgcgtggtgt ataggtgaat atggcgatct tcttgtgtct ggccagtgtg
     1861 aagaggaaga gcctattcag gtgacagaag atgaagtgct ggatatttta gaaagtgtcc
     1921 tgatctctaa tatgtccacc tctgtgacaa gaggctatgc tctcactgcc attatgaagc
     1981 tgtctacccg attcacctgt actgtaaacc gaattaagaa agtggtttcc atctatggga
     2041 gcagcatcga cgtagagctc cagcagaggg cagtagagta caacgcactt tttaagaagt
     2101 atgaccacat gaggtctgcc ctacttgaaa gaatgcctgt catggaaaaa gtgaccacaa
     2161 atggcccttc ggagatcgtg cagacaaatg gagagacaga accagcgccc ctagagacta
     2221 aaccaccacc ctcagggcca caacccacaa gccaggccaa tgatctattg gatttgttgg
     2281 gaggaaatga cataacacct gttatcccaa ctgcacctac aagcaaacca gcatcagctg
     2341 gtggagaact tctcgacttg ctaggagaca tcaccctgac aggtgctcca gctgctgctc
     2401 ctacccctgc ctcagtgcca cagatatccc agcccccctt cttgttggat gggctttcct
     2461 cacagcctct cttcaatgac atcgctccag gcatcccctc catcacagcg tacagtaaga
     2521 acggcttgaa gatagagttc acctttgaac ggtcaaacac caaccccagc gtaacagtga
     2581 taacgataca ggcctctaac agcacagagc tagacatgac ggactttgtt ttccaggctg
     2641 cagtaccaaa gacattccag ctgcagcttc tgtctcctag cagcagcgtt gtcccagcct
     2701 ttaatacagg gaccatcaca caagtcatta aagttctgaa tccacagaag caacagctgc
     2761 gaatgcggat caagctcaca tataatcaca agggctcggc aatgcaagat ctagcagaag
     2821 tgaacaattt cccccctcag tcctggcaat gaggatgcag caccattctc attcttatcc
     2881 cactcaatca aaggaattct gggaaggagg ttgtgattgc tggcaagtcc ccccaactgt
     2941 accatgggca cgaggagctg agagaactgt tgaggagggt tttcctcaag ttactgctga
     3001 ccttgaagca tcagtaaaga ctaatgtcct ctcctccgct gttgaggctg gctgcttctc
     3061 gaggctactt tgcactcttc ctcctctcct cccttttctg cacttcaccc ctcccacatt
     3121 tgcagccaga atcaacattc tctgggccac tgaggcaatc agcagctggc ctggaggaga
     3181 ggactgggat tcacggcaag aaaacaaaca ctctgtctct acagtcaaga gtggccccta
     3241 ctttctactg ttgcatctct gtggactggg caaggtgggg tgtttattcc tcactagctg
     3301 gtttccatcg taagtctgga atggaattgt aacagtggac acgagggagc tctgcccttt
     3361 tctgctggtt ctcctgatgt ttgaaagagg tgttaggctc ctggagcctt atctgtgcat
     3421 tgctgtatac acacagacac acatgtatgt atgtttgtta tataaaaaag ctggttagac
     3481 cttgagaggt tgtttgtaaa cactggacag atgcagttca gagagcttgg gttgagattt
     3541 ggcatgaagg atatggtgct ctatttgtaa tagaaacttt caaggctctt ccagctccct
     3601 ttctcttcgt tctttagctg tagtcacgag ttctcgctcc atgattttca agatcaattc
     3661 ccattaaatt gcaaagtgga tactttctaa aagacacatg aatagttatt aatgatccta
     3721 ttcccccaca atgattctcc caagcctgtc acttgcctgt ttgagctgtg gtaaatgggt
     3781 caaaagagga gttcagtctt aaggagcaga ctctgtcaca aaacaccgtg gcccatagga
     3841 agagcagacc cagactcact ctggagtcag cttatccgtt gctccaatcc tcccttttag
     3901 tttcctgagc ctggcttgga ccttggcatt ccgtttgaat tccttcttct aactggaaca
     3961 tttgtgttgt atctgtaaca ctggcactga aataaagacc acacggttaa agaaatcgtt
     4021 cccacattgt actttatggt gttgaaatga agctttgtag cttccttgcc ccctatgtga
     4081 gagcaagtct tacggtcacc atagggtagg aatgtccttt cctgagtatg agaaattggt
     4141 ctcttaagaa accaatctca tgaacattcg aattaaaggt ttgagctttt taaacagtaa
     4201 gagtgccgag tgttttttag aaaagacccc aatattacca aatctttatg ttgaattgtt
     4261 ggaatgaggt gaaggtgatt gtctgtggta cacgttgaat gtactatgta tgttcaggta
     4321 ttcaggcatc atgtccagtt tactgcagga gaaagtaaaa gtgggccccc ttgcttgtaa
     4381 agcgtttgca gttgttactg tattatgcag taagacgaca ctttggcttc agttttaact
     4441 cttgatacaa atctcccttt ctccctgctc catttcacca cgcctttact taaattcttc
     4501 agtgtcttgt caaacctagc tctgtatcag atgctagact attcctaaca ttgacaaact
     4561 ggagttgaac taaaggctcc aaaagggaaa gtttctggtc ttaatagtcc tgtaagagca
     4621 agatttactg aaatttactt gactgggtaa atggacatct gagttacaaa caggatattt
     4681 ctcctgtgtt cagcaaaaca ggtgtggaca agtgcagact ttagacagcc gctctgcctg
     4741 atcagtggga gccgttagga tttcctgcag acggatttca ttggatgcat agttaatgct
     4801 gtgaaacgtg ataggattaa tgctgtattg gtggatttct tgaatagaat tttgtcttaa
     4861 cattcctttt ttgtgtggag gctttatttt ctccatttgt agctaaccag ctcaggtttt
     4921 ttggttgctt tttgttgttg ttgttgttga actgagttga atctgaagaa atctgctcaa
     4981 gaccaagtgc tagccgatgg agctggaaag atctcctctg tggacaaagc ctcagcccgg
     5041 gtgatgagtt tggaggtagc atttacaatc atccatggct ttatcgagaa ggaaaaaaaa
     5101 aatcatggcc ttaacacaaa gggtgctgtg tagatatgga gttcatttgg gagacgacct
     5161 gaacaccata ctgacggact agcagccaga tgcctgccta ggatgctgac ggttgtgaag
     5221 actgtcccct gtgattggat ctttgaaagc ttcagcgtgc cttcttagtt tctaggagca
     5281 ttagttctct tctcactcgg ccttgcagct taaaggagga atctcttcgt ttctgtgact
     5341 acgcgcgcac atttcagtca ttcctttccc acacgtgacc cttcaagagg aaacagattt
     5401 ggatgtatat gacaacctcg gagcctttgt gaagagagtg atttctgtga cttttgaata
     5461 aagccaaggt gataagcagt gagccccact tattgacagt tttatacgca cttgtacctc
     5521 attagcatcg ccttcctcga ggagtagttt ttatgtcatc cttctttccc atcccagagt
     5581 caccctaagg gagagttcct ctaagtaatc tcagacaact gtacacgctt ctcccacaat
     5641 gctttggtgc tgttaccttg agatggttta gggagtcatg gaggttttct gctgtgtatg
     5701 ttatcatctg ttaaacttcg aggtgttttg gttttttttt tggttgttgt tttttggttt
     5761 tttcatttaa agcaacattc ctcagtgtaa cagtacaggt attccttgct tggttcctgg
     5821 tgtggctctt aacctttgtt tgtttccctc acatatgaaa acagactttt aaaactgtcc
     5881 agcactaata gtttgaaatt ttccatctcc catatgacac cttgcttttc atttctgcgc
     5941 ccttttagag aatgttggaa gttagggaat accgcttttg tggttcaact ttattttctt
     6001 ctacattgga atatatttcg gccgtgaaaa cttggggaag gaggagtttg aatgtgtatt
     6061 tttcttttcc tactgaatgt attttaacta cagagcccta aactgagaga gaacaacaac
     6121 aacaacaaaa aatgcatatt cacaaacttt gtggttggga gggcatttgt cagtctgggt
     6181 gtgggggaag ggagaactgc acaggaagtt ctgaagttta aaatacttct gaccagcttt
     6241 ggctcgggag ggtggggctg tttgtggaac tgaaagtgaa aacccttttc aagcaatagc
     6301 agagagtggg tcccatggac aaggttccag tcccagaacc tggaactctt aaacagaaga
     6361 aaaagctgaa gcggcttgaa gcagcttgag cagttgcttc ttgctcctgg cttcaagaca
     6421 gagcattgga gactttctcc ccttaaagac ctgcatttgc gctttgtgtg ttttgttttt
     6481 attttatttg ggggacctca tgggaaaggg cttctgcact ccttcctttg tgaaccccac
     6541 tgtgttcttg tatcatcgtc cttctccttt tactatgttg taagttacgg ttttcattag
     6601 gccccatcac atcttcttta ctgtaaaatt attaaaaggc tgtttccaag tggggcagct
     6661 aatgaagttc taattattgc agacatattt ttgagatgta aaacacttta aagtgaaatg
     6721 ataagtctct tggaggcgag tgaggaataa catggatgta aacatttaca tgggatgcat
     6781 tcggattctg ctgtgtgtat tgtcttttgg ttgaaacaaa ttatgaacag tgactaataa
     6841 taaaaagtca atactcaatg atttaaaaaa aaaaaaaaaa aa
//
