LOCUS       NM_001243043            4281 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1),
            transcript variant 1, mRNA.
ACCESSION   NM_001243043
VERSION     NM_001243043.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4281)
  AUTHORS   Ninkina,N., Millership,S.J., Peters,O.M., Connor-Robson,N.,
            Chaprov,K., Kopylov,A.T., Montoya,A., Kramer,H., Withers,D.J. and
            Buchman,V.L.
  TITLE     beta-synuclein potentiates synaptic vesicle dopamine uptake and
            rescues dopaminergic neurons from MPTP-induced death in the absence
            of other synucleins
  JOURNAL   J Biol Chem 297 (6), 101375 (2021)
   PUBMED   34736896
REFERENCE   2  (bases 1 to 4281)
  AUTHORS   Zhang,X., Wang,Z., Xu,Q., Chen,Y., Liu,W., Zhong,T., Li,H.,
            Quan,C., Zhang,L. and Cui,C.P.
  TITLE     Splicing factor Srsf5 deletion disrupts alternative splicing and
            causes noncompaction of ventricular myocardium
  JOURNAL   iScience 24 (10), 103097 (2021)
   PUBMED   34622152
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4281)
  AUTHORS   San Agustin,J.T., Klena,N., Granath,K., Panigrahy,A., Stewart,E.,
            Devine,W., Strittmatter,L., Jonassen,J.A., Liu,X., Lo,C.W. and
            Pazour,G.J.
  TITLE     Genetic link between renal birth defects and congenital heart
            disease
  JOURNAL   Nat Commun 7, 11103 (2016)
   PUBMED   27002738
  REMARK    Erratum:[Nat Commun. 2016 Jun 08;7:11910. doi:
            10.1038/ncomms11910.. PMID: 27273704]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4281)
  AUTHORS   Folsch,H.
  TITLE     Role of the epithelial cell-specific clathrin adaptor complex AP-1B
            in cell polarity
  JOURNAL   Cell Logist 5 (2), e1074331 (2015)
   PUBMED   27057418
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4281)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   6  (bases 1 to 4281)
  AUTHORS   Nakagawa,T., Setou,M., Seog,D., Ogasawara,K., Dohmae,N., Takio,K.
            and Hirokawa,N.
  TITLE     A novel motor, KIF13A, transports mannose-6-phosphate receptor to
            plasma membrane through direct interaction with AP-1 complex
  JOURNAL   Cell 103 (4), 569-581 (2000)
   PUBMED   11106728
REFERENCE   7  (bases 1 to 4281)
  AUTHORS   Takatsu,H., Sakurai,M., Shin,H.W., Murakami,K. and Nakayama,K.
  TITLE     Identification and characterization of novel clathrin
            adaptor-related proteins
  JOURNAL   J Biol Chem 273 (38), 24693-24700 (1998)
   PUBMED   9733768
REFERENCE   8  (bases 1 to 4281)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   9  (bases 1 to 4281)
  AUTHORS   Seroussi,E., Pan,H.Q., Kedra,D., Roe,B.A. and Dumanski,J.P.
  TITLE     Characterization of the human NIPSNAP1 gene from 22q12: a member of
            a novel gene family
  JOURNAL   Gene 212 (1), 13-20 (1998)
   PUBMED   9661659
REFERENCE   10 (bases 1 to 4281)
  AUTHORS   Guilbaud,C., Peyrard,M., Fransson,I., Clifton,S.W., Roe,B.A.,
            Carter,N.P. and Dumanski,J.P.
  TITLE     Characterization of the mouse beta-prime adaptin gene; cDNA
            sequence, genomic structure, and chromosomal localization
  JOURNAL   Mamm Genome 8 (9), 651-656 (1997)
   PUBMED   9271666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645522.12.
            
            On Mar 2, 2023 this sequence version replaced NM_001243043.1.
            
            Transcript Variant: This variant (1) represents the longest variant
            and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-454               AL645522.12        61756-62209
            455-517             AL645522.12        123794-123856
            518-623             AL645522.12        127146-127251
            624-759             AL645522.12        129870-130005
            760-1005            AL645522.12        130870-131115
            1006-1196           AL645522.12        132280-132470
            1197-1418           AL645522.12        133545-133766
            1419-1539           AL645522.12        137361-137481
            1540-1635           AL645522.12        138636-138731
            1636-1751           AL645522.12        139858-139973
            1752-1917           AL645522.12        140509-140674
            1918-2016           AL645522.12        145226-145324
            2017-2276           AL645522.12        145894-146153
            2277-2478           AL645522.12        146682-146883
            2479-2499           AL645522.12        147506-147526
            2500-2655           AL645522.12        147951-148106
            2656-2801           AL645522.12        151896-152041
            2802-2931           AL645522.12        153389-153518
            2932-3016           AL645522.12        153783-153867
            3017-3103           AL645522.12        154358-154444
            3104-3258           AL645522.12        154531-154685
            3259-3267           AL645522.12        155185-155193
            3268-4281           AL645522.12        155982-156995
FEATURES             Location/Qualifiers
     source          1..4281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.15 cM"
     gene            1..4281
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="adaptor protein complex AP-1, beta 1 subunit"
                     /db_xref="GeneID:11764"
                     /db_xref="MGI:MGI:1096368"
     exon            1..454
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            455..517
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..3342
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-adaptin 1; golgi adaptor HA1/AP1 adaptin beta
                     subunit; adaptor protein complex AP-1 subunit beta-1;
                     clathrin assembly protein complex 1 beta large chain;
                     adaptor-related protein complex AP-1, beta 1 subunit;
                     beta-prime adaptin"
                     /codon_start=1
                     /product="AP-1 complex subunit beta-1 isoform 1"
                     /protein_id="NP_001229972.1"
                     /db_xref="GeneID:11764"
                     /db_xref="MGI:MGI:1096368"
                     /translation="MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVG
                     KDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLI
                     RALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQG
                     FLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWG
                     QIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDY
                     YATLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYV
                     KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV
                     STLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIW
                     IVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLS
                     LATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICY
                     IGTLASVYHKPPNAFVEGGRGVVHKSLPPRTASSESTESPETAPAGAPAGDQPDVIPA
                     QGDLLGDLLNLDLGPPVSGPPLAASSVQMGAVDLLGGGLDSLMGDESEGIGDSNFGAP
                     SASVAAAPAPARLGAPISSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISG
                     TFTRQAGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHVPLSPNQTVEIS
                     LPLNTVGSVLKMEPLNNLQVAVKNNIDVFYFSTLYPLHVLFVEDGKMDRQMFLATWKD
                     IANENEAQFQIRDCPLNTEAASNKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLA
                     ELRIQPGNPSFTDLELSLKCRAPEVSQHVYQAYETILKN"
     exon            518..623
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            624..759
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1005
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1196
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1418
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1539
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1635
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1751
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1917
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2016
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2276
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2478
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2499
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2655
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2801
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2931
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3016
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3103
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3258
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3267
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..4281
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4105..4110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="hexamer: AATAAA"
     polyA_site      4129
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="major polyA site"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="hexamer: AATAAA"
     polyA_site      4281
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
ORIGIN      
        1 acctcgcgct cgtacagctc gcccatggcg gcgcggccgg cttgctgctg ccgcagcgcc
       61 gccgcctcgc cctccaggct gcggttgtgc gcctcgagct gcctcacctt gtcgatgtag
      121 cccgcgaagc ggtcgttcag agcctgcagc tgctccttct cgctgcgcgc cgccaccgcc
      181 gccaccacgc agccctctgg gccgttgctt agggtgtcta gcgagtcggt gctcgaggcg
      241 gcgccgcgga agcggctggg tgaggcggac acggagctca cggacgtccg cgcccacgag
      301 tggaagccgc tggaggagcc ggccgcggag cgcgtgccgc ccgggcctgc cttgcggctc
      361 agcgagtagt gcaggctgcc gcctccgtgc agcggcgcga acggggcgcc cagcagcgca
      421 tcggcgctgc cgaagctcat catggccgga gcagagtctg gccacagata aaggaccaaa
      481 atgactgact caaaatactt caccacaacc aagaaagggg agatctttga gctgaaggca
      541 gagcttaaca gtgacaagaa ggagaagaag aaggaggcag tgaagaaagt gattgcatca
      601 atgactgtgg gcaaagatgt cagtgctctc ttccctgatg tggtgaactg catgcagaca
      661 gacaacctgg agctaaagaa gctggtgtac ctgtacttga tgaactatgc caagagtcag
      721 cctgacatgg ccattatggc tgtcaacacc tttgtgaagg actgtgagga ccccaatcct
      781 ctcatccggg ccctggctgt gaggactatg ggctgcatcc gagttgacaa gattacagag
      841 tacttgtgtg aaccactccg gaagtgcctg aaggatgaag acccatatgt gcgcaagaca
      901 gcggctgtgt gtgtggccaa gctccatgac atcaatgccc agctggtaga agaccagggc
      961 ttcctggaca cgcttaaaga cctcatctca gactctaacc ccatggtggt agcgaatgca
     1021 gtggctgccc tgtcagagat cgctgagtct caccccagta gcaacctgct tgacttgaac
     1081 ccacagtcta tcaacaagct gctgacagcc cttaatgagt gcactgaatg gggccagatc
     1141 ttcattctgg actgtctggc caactacatg cccaaggatg accgtgaggc ccagagcatc
     1201 tgtgagcggg tcactcctag actctcccat gccaactctg ctgtggtgct gtctgcggtg
     1261 aaggtgctga tgaagttcat ggagatgctg tccaaggacc tggactacta tgccacactg
     1321 ctcaagaagc tggcccctcc cctggtcaca ctgctgtccg cagagccaga gctgcagtat
     1381 gtggccctgc gcaacatcaa tctcattgta cagaaaaggc cagagatctt gaagcatgaa
     1441 atgaaggttt tctttgtgaa gtacaatgac cccatctacg tgaagctgga gaaactggac
     1501 attatgatcc gcctggcctc ccaggccaac attgcccagg tattggcaga actcaaagag
     1561 tatgctacag aagtagacgt ggatttcgta cggaaggcag tgcgtgccat tggccgctgt
     1621 gccatcaagg tggagcaatc tgcagagcgc tgtgtgagca cattgcttga tctcatccag
     1681 accaaggtca actatgtggt tcaggaagcc attgtggtca ttaaggacat cttccgcaag
     1741 taccccaaca agtatgagag tgtgatagct acactgtgtg agaatctgga ctctctggat
     1801 gagcctgagg cccgagccgc tatgatctgg atagtgggcg agtatgccga gcggattgac
     1861 aatgcagacg agctgctcga gagcttcctg gaaggtttcc atgatgagag cactcaggtc
     1921 cagctacagc tactgacagc cattgtgaaa ctcttcctga agaagccaac agagactcag
     1981 gagctggtgc agcaggtcct cagtttggcc actcaggact cagacaatcc agaccttcgg
     2041 gaccgtggct acatctactg gcgcttgctc tccacggacc ctgtagctgc taaagaggtg
     2101 gtactggctg agaagcccct catctcagag gagacagacc ttattgagcc tacacttctg
     2161 gatgaactca tctgctacat tggcacgctg gcctctgtct accacaagcc tcccaacgcc
     2221 tttgtggagg gtggccgggg agtggtacat aagagcctgc caccccgcac tgcctcgagt
     2281 gagagcacag agagccctga gacagctcct gctggagcac ctgctggtga tcagcctgat
     2341 gtcattcctg cccagggtga cctgttaggt gacctcctca acctggacct tgggccccca
     2401 gtgagtggcc cacccttagc tgcctcctcc gtgcaaatgg gagctgtgga tcttcttggt
     2461 ggtggcctcg acagcctgat gggggatgag tctgaaggga ttggagatag caactttggg
     2521 gcaccttcag catcagtggc cgcagcacca gcaccagcca gacttggagc acccatcagc
     2581 agtggcttaa gtgacctctt tgacctgacc agtggtgtgg gcaccctttc aggatcctat
     2641 gtagctccca aagcagtctg gctccctgcc atgaaggcca agggactgga gatctctggc
     2701 accttcaccc ggcaggctgg ctccatctct atggacctgc agctgactaa caaggccctg
     2761 caggtcatga cagattttgc tatccagttc aatcgtaaca gctttggctt ggcccctgct
     2821 gcacctctcc aggtgcacgt accactcagc cccaaccaga ccgtggagat ctccctgcct
     2881 cttaacacag tgggctcagt cttgaagatg gagcctctaa acaatcttca ggtggctgtg
     2941 aagaacaaca ttgacgtctt ctacttcagc actttgtacc cactgcatgt cctcttcgtg
     3001 gaggatggga agatggaccg gcagatgttc ctggccacat ggaaggacat tgccaacgag
     3061 aacgaagccc agttccagat cagagactgc ccgcttaaca cagaggctgc gagcaacaag
     3121 ctacagagca gtaacatttt cactgtcgcc aagaggaacg tggagggcca ggatatgctc
     3181 taccaatctc tgaagttgac caatggcatc tgggtgctgg cggagctgcg gatccagcca
     3241 ggcaacccca gcttcacgga cttggagctg tccctgaagt gtcgagcacc ggaggtgtcc
     3301 cagcatgtat accaggccta cgagactatc ctcaagaact gaagccctgt cgcatccacc
     3361 ccagccttct gccagcccag tcatggaacc ctgcaggtgg cagtacctcc tcctttcttt
     3421 gaggaaaggc caggtgggct cctgaaccac ccaggaggct cccctgatcc taactgaggg
     3481 tctggagcag ggccatgtct cctcccagag tgaaatctca gtgcatctcc agtggctgct
     3541 tttttctatt gctgttgatg tgggatcaaa ggaaatggag ccagcacagc atcagaagct
     3601 ggacagaggg ccacagggtg ctcttccttc tcttctcctg ggtgtgaaca tggaccccac
     3661 ccccaccccc agggtcctag cccataatcc ctgcccagtc tcctcagtga gcctgtcctg
     3721 ggtggagtcc tctgggtgcc aatattactg cttgggactc caagggctgg aagtggtgat
     3781 gggcagatgt gagcccagag gagcagcctg ggccagcacc atctgcccca tgtaacccca
     3841 gtcggtgctc tgtggccacc tgcaggtccc agagcccagc tgggattatg ttctctgtgc
     3901 cccggaagat ggtcactgcc tacaaaacat tcctggtgtc ccctctgtga gtccagggct
     3961 cttagaacag aaatagggta agaggtggag caaggggcag tggacatgct tctggtgtga
     4021 ggtcctgtgg gttctccagc agccgctggc tcccctggct cccagtctgt gtgtgtgaca
     4081 gctatcctgt cactgctgtt tgataataaa gagattctgc tttcggcaat catgcacatt
     4141 tcttccctct acaaactgct tctggtaact ggggatgtct gatcctgcag taattatatc
     4201 taatacatat aatgaaatat atattgtata tttacccttt tttcaaataa gaaagtgaat
     4261 aaaaacgatg acatcaagta a
//
