LOCUS       NM_023617               4360 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus aldehyde oxidase 3 (Aox3), mRNA.
ACCESSION   NM_023617
VERSION     NM_023617.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4360)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4360)
  AUTHORS   Cerqueira,N.M., Coelho,C., Bras,N.F., Fernandes,P.A., Garattini,E.,
            Terao,M., Romao,M.J. and Ramos,M.J.
  TITLE     Insights into the structural determinants of substrate specificity
            and activity in mouse aldehyde oxidases
  JOURNAL   J Biol Inorg Chem 20 (2), 209-217 (2015)
   PUBMED   25287365
  REMARK    GeneRIF: Although mAOX2 and mAOX3 are very similar to each other,
            we propose the following pairs of overlapping substrate
            specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
REFERENCE   3  (bases 1 to 4360)
  AUTHORS   Mahro,M., Bras,N.F., Cerqueira,N.M., Teutloff,C., Coelho,C.,
            Romao,M.J. and Leimkuhler,S.
  TITLE     Identification of crucial amino acids in mouse aldehyde oxidase 3
            that determine substrate specificity
  JOURNAL   PLoS One 8 (12), e82285 (2013)
   PUBMED   24358164
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4360)
  AUTHORS   Kurosaki,M., Bolis,M., Fratelli,M., Barzago,M.M., Pattini,L.,
            Perretta,G., Terao,M. and Garattini,E.
  TITLE     Structure and evolution of vertebrate aldehyde oxidases: from gene
            duplication to gene suppression
  JOURNAL   Cell Mol Life Sci 70 (10), 1807-1830 (2013)
   PUBMED   23263164
REFERENCE   5  (bases 1 to 4360)
  AUTHORS   Coelho,C., Mahro,M., Trincao,J., Carvalho,A.T., Ramos,M.J.,
            Terao,M., Garattini,E., Leimkuhler,S. and Romao,M.J.
  TITLE     The first mammalian aldehyde oxidase crystal structure: insights
            into substrate specificity
  JOURNAL   J Biol Chem 287 (48), 40690-40702 (2012)
   PUBMED   23019336
  REMARK    GeneRIF: AOX3 forms a homodimer and each monomer comprises three
            major domains involved in binding to the cofactors.
REFERENCE   6  (bases 1 to 4360)
  AUTHORS   Reynolds,S.D., Zemke,A.C., Giangreco,A., Brockway,B.L.,
            Teisanu,R.M., Drake,J.A., Mariani,T., Di,P.Y., Taketo,M.M. and
            Stripp,B.R.
  TITLE     Conditional stabilization of beta-catenin expands the pool of lung
            stem cells
  JOURNAL   Stem Cells 26 (5), 1337-1346 (2008)
   PUBMED   18356571
REFERENCE   7  (bases 1 to 4360)
  AUTHORS   Kurosaki,M., Terao,M., Barzago,M.M., Bastone,A., Bernardinello,D.,
            Salmona,M. and Garattini,E.
  TITLE     The aldehyde oxidase gene cluster in mice and rats. Aldehyde
            oxidase homologue 3, a novel member of the molybdo-flavoenzyme
            family with selective expression in the olfactory mucosa
  JOURNAL   J Biol Chem 279 (48), 50482-50498 (2004)
   PUBMED   15383531
REFERENCE   8  (bases 1 to 4360)
  AUTHORS   Vila,R., Kurosaki,M., Barzago,M.M., Kolek,M., Bastone,A.,
            Colombo,L., Salmona,M., Terao,M. and Garattini,E.
  TITLE     Regulation and biochemistry of mouse molybdo-flavoenzymes. The
            DBA/2 mouse is selectively deficient in the expression of aldehyde
            oxidase homologues 1 and 2 and represents a unique source for the
            purification and characterization of aldehyde oxidase
  JOURNAL   J Biol Chem 279 (10), 8668-8683 (2004)
   PUBMED   14665639
REFERENCE   9  (bases 1 to 4360)
  AUTHORS   Terao,M., Kurosaki,M., Marini,M., Vanoni,M.A., Saltini,G.,
            Bonetto,V., Bastone,A., Federico,C., Saccone,S., Fanelli,R.,
            Salmona,M. and Garattini,E.
  TITLE     Purification of the aldehyde oxidase homolog 1 (AOH1) protein and
            cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes.
            Identification of a novel molybdo-flavoprotein gene cluster on
            mouse chromosome 1
  JOURNAL   J Biol Chem 276 (49), 46347-46363 (2001)
   PUBMED   11562361
REFERENCE   10 (bases 1 to 4360)
  AUTHORS   Terao,M., Kurosaki,M., Saltini,G., Demontis,S., Marini,M.,
            Salmona,M. and Garattini,E.
  TITLE     Cloning of the cDNAs coding for two novel molybdo-flavoproteins
            showing high similarity with aldehyde oxidase and xanthine
            oxidoreductase
  JOURNAL   J Biol Chem 275 (39), 30690-30700 (2000)
   PUBMED   10893244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025116.14, AK054065.1, BX633666.1, BB616838.1, AK004700.1 and
            AV275739.1.
            
            On Sep 8, 2006 this sequence version replaced NM_023617.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF172276.2, AK149434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC025116.14        163549-163590       c
            43-630              AK054065.1         2-589
            631-734             BX633666.1         1-104               c
            735-1077            BB616838.1         274-616
            1078-1182           AC025116.14        130151-130255       c
            1183-1206           AC025116.14        129509-129532       c
            1207-4347           AK004700.1         3-3143
            4348-4360           AV275739.1         205-217
FEATURES             Location/Qualifiers
     source          1..4360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.96 cM"
     gene            1..4360
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /note="aldehyde oxidase 3"
                     /db_xref="GeneID:71724"
                     /db_xref="MGI:MGI:1918974"
     exon            1..177
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            178..235
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            236..332
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..441
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..568
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..630
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..711
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..792
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..937
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1030
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1182
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1276
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1386
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1571
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1734
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1827
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1997
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2112
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2235
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2332
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2457
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2591
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2679
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2766
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2958
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3186
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3282
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3411
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3486
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3539
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3654
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3720
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3909
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3910..4077
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4360
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4333..4338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /note="putative"
     polyA_site      4347
                     /gene="Aox3"
                     /gene_synonym="1200011D03Rik; Aoh1; Aoh2"
                     /note="putative"
ORIGIN      
        1 acagagcaga tttaaatcct gtagggcaat tcggtctcct gcagagcaca gcagttcatc
       61 tgagaggtgg acttagacac attaggtaca gttgcacaga gtgtggacga ctatcctcaa
      121 gtaatgtctc cttctaagga gtcagatgag cttattttct ttgtgaatgg aaaaaaggtc
      181 accgagagga atgcagaccc tgaggttaat ttattgttct acttgagaaa agtcatccga
      241 ctcacaggga caaagtatgg ctgtggagga ggtgactgtg gcgcctgcac agtgatgatc
      301 tcaagatacg accccatctc caaaaggatc agtcatttct ctgccactgc ctgcctggtt
      361 cccatctgct ctctccatgg ggctgctgtc actacagtag aaggcatagg aagcaccaaa
      421 accaggatac accctgtcca ggaaaggatt gccaaaggcc atggtaccca gtgtgggttc
      481 tgcactcccg ggatggtgat gagcatctat actctcctga ggaaccaccc agagccctcc
      541 acagaacaga taatggaaac cctgggcggg aatctatgcc gctgcactgg atacaggccc
      601 attgtggaga gtgcgaaaag tttctgcccg agttcaactt gctgccagat gaatggggaa
      661 gggaaatgtt gcttggatga agaaaaaaac gagcctgaga gaaaaaacag tgtttgcacc
      721 aagttgtatg aaaaaaaaga atttcagccc ttggatccaa ctcaggagct tatatttcca
      781 cctgagctga tgaggatggc cgaggagtcc caaaatacag ttctgacttt tcgtggggaa
      841 aggactacct ggattgcccc aggaacccta aatgaccttc tggaactgaa aatgaagcat
      901 cccagcgctc cacttgtgat tggcaacacc tatctggggc ttcatatgaa gttcacagac
      961 gtatcttatc caattatcat ctctcctgca aggatcttag aattatttgt ggtgactaat
     1021 acaaagcaag ggctgacact gggcgcaggc ctcagcctga cccaggtgaa gaacgtcttg
     1081 tctgacgtgg tctccagact ccctaaggag aagacgcaga tatactgtgc tctcctgaag
     1141 cagctgaaga ccctggctgg gcagcagatc aggaatgtgg cctccttagg tggtcatatt
     1201 atcagtagac tgccgacctc tgacctcaac cctattttgg gcataggcaa ttgcatcctc
     1261 aatgttgcct caacagaagg aatacagcaa atccctctga atgatcattt tctcgctgga
     1321 gttccagatg caatcctgaa gccagagcaa gtgctcatct ccgtttttgt gccacgctcc
     1381 agcaagtggg agtttgtatc agccttcaga caggcccctc gtcagcaaaa cgcgtttgca
     1441 acagtgaatg ctggaatgaa agtcgttttc aaggaggaca caaacaccat tacagacttg
     1501 gggatcttat atggagggat tggtgccacc gtaatcagcg cagataagtc ctgccggcag
     1561 ctgattggaa ggtgctggga tgaagaaatg ctggatgatg ctggcaagat gatttgtgag
     1621 gaagtctccc tcctgatggc agcccctgga gggatggagg aataccgaaa gactcttgcc
     1681 atcagtttcc tcttcatgtt ttacttagac gtgttgaagc agttaaagac gagggacccc
     1741 cacaagtacc ctgacatctc acagaaactc ctacacattc tggaagactt ccctttaacc
     1801 atgccttatg ggatgcagtc atttcaggat gtagacttcc aacagcctct gcaagaccca
     1861 atcggacgtc ccatcatgca tcagtctggc attaaacacg ccacaggaga ggcagtattt
     1921 tgtgatgata tgtctgtgtt gcctggggaa ctcttcttgg cagtggtaac cagcagcaag
     1981 tcacatgcta aaatcatctc tcttgatgcc tccgaggcct tggcgtcact tggtgtggtt
     2041 gatgtggtaa cagctcgaga tgtgcctggt gacaatggca gagaagagga aagcctatat
     2101 gcacaggatg aggtgatctg cgtgggtcaa attgtgtgtg ctgtggccgc tgactcttat
     2161 gctcatgccc agcaggccgc aaaaaaagtg aagattgtct atcaagacat agagcccatg
     2221 attgtgacag tgcaggatgc actgcaatat gaatcattca ttggacctga aagaaaacta
     2281 gaacaaggaa atgttgagga agcatttcaa tgtgccgatc aaatcctcga aggggaggtg
     2341 cacttgggag gccaggagca tttttacatg gagactcaaa gcgtacgtgt ggtccccaag
     2401 ggagaggata aggagatgga catctatgtg tcaagccagg atgctgcatt tacacaggaa
     2461 atggtggctc gcaccttggg catcccaaag aataggatca actgccatgt gaaaagggtt
     2521 ggtggagcct tcggagggaa agcaagcaag cctgggctcc tggcatccgt ggcagctgta
     2581 gccgcacaga agaccggccg cccaatacgt ttcattctag agcgtaggga tgacatgttg
     2641 ataactggag gacgtcaccc actactcggg aaatacaaga ttggcttcat gaacaatggg
     2701 aaaatcaagg cggcagacat ccagctttat atcaatggag gctgcacccc agatgattct
     2761 gaactggtga tagaatatgc tttgctcaaa ctggaaaatg cttacaagat ccccaacctc
     2821 cgtgtccgag gtcgagtctg taagaccaac ttgccttcca atacagcgtt tcgaggattt
     2881 ggctttcccc agggggcatt tgtaacagaa acctgtatgt ccgctgtggc agccaaatgc
     2941 cgcttaccac cagagaaggt tcgagagcta aacatgtaca gaacaatcga taggacaatt
     3001 cacaaccaag agtttgaccc aacgaatctg ctacagtgct gggaggcatg tgtggaaaat
     3061 tcttcctact ataacaggaa aaaagctgtg gatgaattta accaacagag attttggaag
     3121 aagagaggaa ttgccatcat ccccatgaaa ttctcagttg gatttccaaa gacattttat
     3181 tatcaggctg ccgctttggt ccagatctac acagatgggt ctgtactagt tgctcatggt
     3241 ggtgttgaac tgggacaagg tattaacacc aaaatgatac aggtggccag ccgtgaatta
     3301 aagataccta tgtcttatat acacctggat gagatgagca ctgtgaccgt ccccaacacg
     3361 gttaccactg gagcatccac cggtgccgat gtcaacggga gagctgttca gaatgcctgt
     3421 cagatcctta tgaagcgtct ggaacccatc atcaagcaga atcctagtgg tacctgggaa
     3481 gaatgggtta aggaagcttt tgttcaaagc attagcctct cggccactgg atattttagg
     3541 ggttaccaag ctgacatgga ctgggagaag ggagaaggtg acatttttcc ctattttgtt
     3601 tttggagctg cctgttctga ggttgaaatt gattgtctga cgggagctca caagaacatt
     3661 agaaccgaca ttgttatgga tggatcattc agtataaatc ctgctgtgga cataggccag
     3721 attgaagggg catttgttca aggtcttgga ctgtatactc tagaggaact gaaatattca
     3781 cctgaaggag tcctatacac tcgtggtcca caccagtaca aaatagcatc agttaccgac
     3841 atcccagaag aattccatgt atcactgttg acaccaaccc caaacccaaa agccatctac
     3901 tcttctaagg gccttggcga agctggaacg tttctgggct gttctgtgtt cttcgctatt
     3961 gccgcggccg tggctgcagc tcgagaggag agaggcttgt ccccaatttg ggccataaac
     4021 agccctgcca cagcagaagt gatccgcatg gcctgtgagg accagttcac gaacctggtt
     4081 ccacaaacgg attctaaatg ctgtaagccg tggtccatcc cagttgccta gtgcttgggg
     4141 ttccagcaca aaagcagatg gacttaaaac ttccacaggt cacaaatata aatatctata
     4201 tctaaaatat gtagaaaatt agaggcaatt cttaaatttt catatttaca aaatattgta
     4261 atctttaatc acatgcacta taagcaacga tgtttacgga gcttcagcca aaggtcatgt
     4321 ttaattcaat atattaaacg gaattttcca ctgtgtgaag
//
