LOCUS       NM_001008419            4776 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus aldehyde oxidase 2 (Aox2), mRNA.
ACCESSION   NM_001008419 XM_136626
VERSION     NM_001008419.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4776)
  AUTHORS   Cerqueira,N.M., Coelho,C., Bras,N.F., Fernandes,P.A., Garattini,E.,
            Terao,M., Romao,M.J. and Ramos,M.J.
  TITLE     Insights into the structural determinants of substrate specificity
            and activity in mouse aldehyde oxidases
  JOURNAL   J Biol Inorg Chem 20 (2), 209-217 (2015)
   PUBMED   25287365
  REMARK    GeneRIF: Although mAOX2 and mAOX3 are very similar to each other,
            we propose the following pairs of overlapping substrate
            specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
REFERENCE   2  (bases 1 to 4776)
  AUTHORS   Kurosaki,M., Bolis,M., Fratelli,M., Barzago,M.M., Pattini,L.,
            Perretta,G., Terao,M. and Garattini,E.
  TITLE     Structure and evolution of vertebrate aldehyde oxidases: from gene
            duplication to gene suppression
  JOURNAL   Cell Mol Life Sci 70 (10), 1807-1830 (2013)
   PUBMED   23263164
REFERENCE   3  (bases 1 to 4776)
  AUTHORS   Kurosaki,M., Terao,M., Barzago,M.M., Bastone,A., Bernardinello,D.,
            Salmona,M. and Garattini,E.
  TITLE     The aldehyde oxidase gene cluster in mice and rats. Aldehyde
            oxidase homologue 3, a novel member of the molybdo-flavoenzyme
            family with selective expression in the olfactory mucosa
  JOURNAL   J Biol Chem 279 (48), 50482-50498 (2004)
   PUBMED   15383531
  REMARK    GeneRIF: selectively expressed in Bowman's glands of the olfactory
            mucosa
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163498.3 and AC121091.10.
            
            On Aug 13, 2009 this sequence version replaced NM_001008419.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY187018.2, AY665589.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC163498.3         134234-134383
            151-208             AC163498.3         137085-137142
            209-305             AC163498.3         138574-138670
            306-414             AC163498.3         139395-139503
            415-541             AC163498.3         141479-141605
            542-603             AC163498.3         143600-143661
            604-687             AC163498.3         145816-145899
            688-768             AC163498.3         148106-148186
            769-913             AC163498.3         150209-150353
            914-1006            AC163498.3         151771-151863
            1007-1158           AC163498.3         155671-155822
            1159-1252           AC163498.3         156523-156616
            1253-1362           AC163498.3         159435-159544
            1363-1547           AC163498.3         160337-160521
            1548-1734           AC163498.3         161112-161298
            1735-1827           AC163498.3         163258-163350
            1828-1997           AC163498.3         164767-164936
            1998-2112           AC163498.3         165889-166003
            2113-2235           AC163498.3         168183-168305
            2236-2332           AC163498.3         178687-178783
            2333-2457           AC163498.3         186678-186802
            2458-2591           AC163498.3         188451-188584
            2592-2679           AC163498.3         190588-190675
            2680-2766           AC121091.10        16984-17070
            2767-2958           AC121091.10        17719-17910
            2959-3186           AC121091.10        19843-20070
            3187-3282           AC121091.10        24040-24135
            3283-3411           AC121091.10        26609-26737
            3412-3486           AC121091.10        29437-29511
            3487-3539           AC121091.10        30621-30673
            3540-3654           AC121091.10        31539-31653
            3655-3720           AC121091.10        34546-34611
            3721-3909           AC121091.10        34694-34882
            3910-4077           AC121091.10        39302-39469
            4078-4152           AC121091.10        56646-56720
            4153-4776           AC121091.10        59025-59648
FEATURES             Location/Qualifiers
     source          1..4776
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.0 cM"
     gene            1..4776
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /note="aldehyde oxidase 2"
                     /db_xref="GeneID:213043"
                     /db_xref="MGI:MGI:3529596"
     exon            1..150
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..4131
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /EC_number="1.2.3.1"
                     /note="aldehyde oxidase-like protein 3; aldehyde oxidase
                     3-like 1; aldehyde oxidase homolog 3; azaheterocycle
                     hydroxylase 2"
                     /codon_start=1
                     /product="aldehyde oxidase 2"
                     /protein_id="NP_001008419.1"
                     /db_xref="CCDS:CCDS35576.1"
                     /db_xref="GeneID:213043"
                     /db_xref="MGI:MGI:3529596"
                     /translation="MPCPAQISDDLEFFVNGRKVTEKNVDPEVTLLAFLRKNLCLTGT
                     KDACGTGGCGACTVMVSQHDPVCKKTRHFSVMACLVPLCSLHGAAVTTVEGVGSIKTR
                     LHPVQERIAKSHGTQCGFCTPGMVMSIYTLLRNHPQPSEEQLMEALGGNLCRCTGYRP
                     ILESGRTFCMEPDGCPQKGTGQCCLDQKESDSSGSKSDICTKLFVKDEFQPLDPTQEL
                     IFPPELLRMAENPEKQTLTFYGERITWIAPGTLQELLVLKAKYPEAPLISGNTALGPA
                     MKSQGHFYPVLLSPARIPDLRMVTKTSGGLTIGACCSLAQVKDILAESISELPQEKTQ
                     TYRALLKHLRSLAGQQIRNMASLGGHVISRHCYSDLNPILSVGNTTLNLLSEEGPRQI
                     PLSGHFLAGLASADLKPEEILGSVYIPHSQKREFVSAFRQAQCHQNALPDVNAGMRVL
                     FREGTDVIEELSIAYGGVGPTTVSAQRSCQQLLGRRWNALMLDEACRLLLDEVSLPGS
                     ALGGKVEFRRTLIVSLFFKFYLEVLQELKADQKLPPESTDSQRYPEIADRFLSSLGDF
                     QVTLPRGVQTYQRVDSHQPLQDPVGRPIMHLSGLKHATGEAVFCDDIPRVDKELFMAL
                     VTSTRAHARIISIDSSEVLDLPGVVDVITAEDIPGNNGEEDDKLLAVDKVLCVGQVIC
                     AVVAETDVQAKRATEKIKITYEDLKPVIFTIEDAIKHNSFLCPEKKLEQGNIEEAFEN
                     VDQVAEGTVHVGGQEHFYMETQRVLVIPKTEDKELDMYVSTQDPAHVQKTVSSTLNIP
                     ISRITCHVKRVGGGFGGKVGRPAVFGAIAAVGAVKTGHPIRLVLDREDDMLITGGRHP
                     LFAKYKVGFMNSGRIKALDIECYINGGCTLDDSELVTEFLVLKLENAYKIRNLRLRGR
                     ACMTNLPSNTAFRGFGFPQGALVTESCITAVAAKCGLPPEKIREKNMYKTVDKTIYKQ
                     AFNPDPLIRCWNECLDKSSFHIRRTRVDEFNKKSYWKKRGIAIVPMKFSVGFAATSYH
                     QAAALVHIYTDGSVLVAHGGNELGQGIHTKMLQVASRELKIPLSYLHICETSTTTVPN
                     TIATAASVGADVNGRAVQNACQILLKRLEPVIKKNPEGTWRDWIEAAFEKRISLSATG
                     YFRGYKAFMDWEKGEGDPFPYYVYGAACSEVEIDCLTGAHKKIRTDIVMDACCSLNPA
                     IDIGQIEGAFIQGMGLYTTEELLYSPEGVLYSRSPDKYKIPTVTDVPEQFNVSLLPSS
                     QTPLTLYSSKGLGESGMFLGSSVFFAIVDAVAAARRQRDIAEDFTVKSPATPEWVRMA
                     CADRFTDMIPRDDPKTFKPWSIPIA"
     exon            151..208
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..305
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..414
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..541
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..603
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..687
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..768
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..913
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1006
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1158
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1252
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1362
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1547
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1734
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1827
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1997
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2112
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2235
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2332
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2457
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2591
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2679
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2766
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2958
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3186
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3282
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3411
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3486
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3539
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3654
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3720
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3909
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3910..4077
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4152
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4776
                     /gene="Aox2"
                     /gene_synonym="Aoh3; Aox3l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctggggct ccaggctgcc cgcttccacc tcaatccttt ctgttcattt ctgtagctgg
       61 tatccgagcc aagaggccaa actcaccaga gccatgcctt gcccagccca gatttcggat
      121 gatctggagt tctttgtgaa cgggaggaag gtgacggaga agaatgtgga cccagaagtc
      181 actctgctgg ccttcctgag aaagaactta tgcctcacag gaactaagga tgcgtgtgga
      241 acaggaggct gtggggcctg cacagtgatg gtgtcacaac acgatccggt gtgcaagaag
      301 acaagacact tctccgtcat ggcatgcctg gtgcccctgt gctccctgca tggggctgct
      361 gtcaccaccg tggaaggtgt gggaagcatc aagaccaggc tccaccccgt gcaggagagg
      421 atcgccaaga gccacggcac ccagtgtggc ttctgcaccc ctgggatggt gatgtccatc
      481 tacacactgc tcaggaacca cccgcagccc tcagaggaac agctcatgga ggccttggga
      541 gggaacctct gccgctgtac tgggtatcgg ccaattctgg agagcggcag gaccttctgc
      601 atggagccag acggttgtcc acagaaagga acaggacagt gttgcttgga tcagaaggaa
      661 agtgactcat cgggaagcaa aagtgatatt tgcacgaagc tatttgtgaa agacgagttc
      721 cagcccttgg acccgaccca ggagctcata tttcccccag aactcctgag gatggctgag
      781 aacccagaga agcaaaccct aaccttttat ggagagagaa tcacctggat cgccccagga
      841 accctccaag aactcttggt gctgaaagct aagtaccctg aagctcctct catctcgggc
      901 aacacagccc tgggaccagc catgaagtct caaggacact tttaccctgt cctcctgtct
      961 cctgctagaa ttcctgatct aagaatggtg actaaaacca gtggaggact gaccataggt
     1021 gcctgctgca gcctggctca ggtgaaggac atcttggctg agagcatctc tgagctccca
     1081 caggagaaaa ctcagaccta ccgagcactc ctgaaacacc tccggagctt ggcgggacag
     1141 cagatccgga acatggcgtc cttaggagga catgttataa gcaggcattg ctactcggac
     1201 ctgaatccta tcctctctgt gggcaacacc acactcaatc tgctgtcaga agaaggcccg
     1261 cggcagattc ccctcagtgg acattttctt gctgggttgg caagtgcaga cctgaagccc
     1321 gaggagattc tggggtctgt gtacatccca cactctcaga agcgggagtt cgtgtctgcc
     1381 ttccggcagg cccagtgcca tcagaacgcc ttgcctgatg taaatgctgg catgagagtc
     1441 ctgttcagag aaggcacaga cgtcattgag gagctgagca ttgcctatgg aggggtgggg
     1501 cccaccaccg tcagcgcaca aaggtcctgc cagcagcttc tgggccggcg ctggaacgca
     1561 ctgatgctag acgaggcttg cagactgctt ctggatgaag tctcccttcc aggctcagcc
     1621 ctgggaggca aagtggaatt caggaggact ctgattgtca gcctcttctt caagttctac
     1681 ctggaggttc tgcaggaact gaaggctgac cagaagctgc ccccggagtc caccgacagc
     1741 cagcgttatc cagagatcgc agaccggttc ctaagctctc tgggagattt ccaggtcacg
     1801 ctaccccggg gagtccaaac ataccagaga gtagattctc accaacctct ccaagatcca
     1861 gttggacgtc ccatcatgca cctgtcaggt cttaaacatg ccacggggga agctgtattt
     1921 tgtgatgaca tccctagggt ggataaagaa ctcttcatgg ctttagtcac cagtaccaga
     1981 gctcatgcaa gaatcatatc aatcgactca tctgaggtcc ttgacctgcc tggtgtggtt
     2041 gatgtaataa cagctgaaga cattccaggc aacaatggtg aagaggatga caaattgctg
     2101 gctgtagata aggttctctg tgtgggccag gtcatctgtg ccgtggtggc agagactgat
     2161 gttcaggcaa aacgagcaac tgagaagata aaaatcacct acgaggatct gaaacctgtg
     2221 attttcacca tcgaggatgc cataaagcac aattcgttcc tgtgccctga aaaaaagctt
     2281 gaacaaggaa acatcgagga ggcctttgag aacgtggatc aggtagctga agggacagtc
     2341 catgttggag gacaagaaca cttctacatg gaaacacaga gagtgcttgt tattccgaag
     2401 acagaagaca aagagctaga catgtatgtg tccacacagg acccagccca cgtacagaaa
     2461 acagtgtcct ctaccttaaa catcccgatc agcaggatca cctgccatgt gaaaagagtg
     2521 ggtggaggct ttggaggaaa ggtggggagg ccagctgtgt tcggagcaat tgctgcggtg
     2581 ggggctgtca aaactggcca tcccattcgt cttgttctgg atcgtgaaga tgatatgcta
     2641 ataactgggg gacgacaccc attatttgca aaatacaaag tgggattcat gaacagtgga
     2701 cggatcaaag ccctagacat tgaatgctac atcaatggag gctgcacatt ggatgactcg
     2761 gagctggtaa cagaatttct tgtactaaaa ctggaaaatg catacaaaat ccgaaacctc
     2821 agactccgag gtcgtgcctg catgacaaac ttaccatcca atacagcttt tcgtgggttt
     2881 ggcttccctc agggagccct ggtaacagaa tcctgcatca cagctgtggc agccaaatgt
     2941 gggcttccac cagaaaagat tagggagaaa aacatgtaca aaacagttga taaaaccatc
     3001 tacaagcaag cgttcaaccc tgaccccctg ataaggtgtt ggaatgagtg tctggacaag
     3061 tcttcctttc acatcagaag gacaagagtg gacgagttca ataagaagag ttactggaag
     3121 aagcgaggca ttgctattgt ccccatgaag ttttcagttg gctttgctgc gacaagctac
     3181 catcaggcgg ctgcgctcgt ccatatctac accgatggct ctgtgttggt ggcacatgga
     3241 ggcaatgaac tggggcaagg tattcacacc aaaatgttac aggtggccag ccgtgaactg
     3301 aaaatacccc tgtcttatct gcatatctgt gaaacaagta caacaacagt gcccaataca
     3361 atcgctacag ccgcgtccgt tggagcggat gtcaacggca gggctgtgca gaatgcctgt
     3421 caaatccttc tcaaacgtct tgagcccgtc attaagaaaa acccagaagg gacatggaga
     3481 gactggatag aagcagcttt tgaaaaaaga atcagtcttt cagccactgg atacttcagg
     3541 ggctacaagg ccttcatgga ctgggagaaa ggagagggag acccattccc gtactatgtc
     3601 tatggagctg catgttctga ggttgaaatc gactgcctga caggtgctca caagaaaatc
     3661 agaaccgaca ttgtcatgga tgcatgttgc agcctgaatc cggccattga tattgggcag
     3721 atcgaaggtg catttattca aggaatgggc ctttatacca ccgaggagct actctactct
     3781 ccagagggcg tcctgtactc tcggagcccg gacaagtaca aaatcccaac tgtcactgat
     3841 gtcccagagc agtttaacgt gtccttgctg ccgtcctctc agaccccgct caccctctat
     3901 tcgtcaaagg gcctcgggga gtctgggatg ttcctagggt catctgtgtt ttttgccatt
     3961 gttgatgcgg tggctgcggc acggagacaa agagacatag cggaggactt cacagtgaag
     4021 agcccagcaa ccccagagtg ggtgcggatg gcctgtgcag atcggttcac ggacatgatc
     4081 ccgagagatg acccaaaaac gtttaaacct tggtctatac ctatagctta agcagctgtc
     4141 atttcctaag agatatttta gtacccaagt gaaaagccag cttcttactc ctgactggac
     4201 tgcatactgt atttgtacgc tgctgggcgg gagggagggg tgagccttgt cacaaaattt
     4261 agaatcacta ttcaaatcta accacattag agagatgagg catcttacaa attgtttact
     4321 tagggtcctc agcttagagg ccaccagata agcactgcaa tgtttgaagc acttttaatg
     4381 atttgtcttt gaaaacactg agtaaatgtt gctgcagatg gagggaaagg aaaggagacc
     4441 tggtgtgcag acgccatttt tgcctgaaag agcctgccag caactatcat gatgcctttg
     4501 accaggagcc actgagcctt agcagggcga ggtttctgca aggatttttt tcctttttat
     4561 ccccctcacc aggaataggc tgtgggtcta tgtatgtgta gttaacagaa aagaagtgat
     4621 attttccttg tgttagatga ttgttcagca agtgaacatc cctttggaat ttgaagggga
     4681 aaacagtgta caattttgaa tgcattatca caagatgttt ttgtttttat ttgtatgggg
     4741 ctttttttgt ttgcttttgt tttgtttgac ttttta
//
