LOCUS       NM_009676               4382 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus aldehyde oxidase 1 (Aox1), mRNA.
ACCESSION   NM_009676
VERSION     NM_009676.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4382)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4382)
  AUTHORS   Wu,Y., Wei,F.Y., Kawarada,L., Suzuki,T., Araki,K., Komohara,Y.,
            Fujimura,A., Kaitsuka,T., Takeya,M., Oike,Y., Suzuki,T. and
            Tomizawa,K.
  TITLE     Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is
            Required for Mitochondrial Translation and Is Involved in
            Reversible Infantile Liver Injury
  JOURNAL   PLoS Genet 12 (9), e1006355 (2016)
   PUBMED   27689697
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4382)
  AUTHORS   Cerqueira,N.M., Coelho,C., Bras,N.F., Fernandes,P.A., Garattini,E.,
            Terao,M., Romao,M.J. and Ramos,M.J.
  TITLE     Insights into the structural determinants of substrate specificity
            and activity in mouse aldehyde oxidases
  JOURNAL   J Biol Inorg Chem 20 (2), 209-217 (2015)
   PUBMED   25287365
  REMARK    GeneRIF: Although mAOX2 and mAOX3 are very similar to each other,
            we propose the following pairs of overlapping substrate
            specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
REFERENCE   4  (bases 1 to 4382)
  AUTHORS   Kamli,M.R., Kim,J., Pokharel,S., Jan,A.T., Lee,E.J. and Choi,I.
  TITLE     Expressional studies of the aldehyde oxidase (AOX1) gene during
            myogenic differentiation in C2C12 cells
  JOURNAL   Biochem Biophys Res Commun 450 (4), 1291-1296 (2014)
   PUBMED   24996175
  REMARK    GeneRIF: findings suggest that AOX1 acts as a contributor to the
            process of myogenesis by influencing the level of H2O2
REFERENCE   5  (bases 1 to 4382)
  AUTHORS   Swenson,T.L. and Casida,J.E.
  TITLE     Aldehyde oxidase importance in vivo in xenobiotic metabolism:
            imidacloprid nitroreduction in mice
  JOURNAL   Toxicol Sci 133 (1), 22-28 (2013)
   PUBMED   23462233
REFERENCE   6  (bases 1 to 4382)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
REFERENCE   7  (bases 1 to 4382)
  AUTHORS   King,T.R., Lee,B.K., Behringer,R.R. and Eicher,E.M.
  TITLE     Mapping anti-mullerian hormone (Amh) and related sequences in the
            mouse: identification of a new region of homology between MMU10 and
            HSA19p
  JOURNAL   Genomics 11 (2), 273-283 (1991)
   PUBMED   1685136
REFERENCE   8  (bases 1 to 4382)
  AUTHORS   Ben-David,Y., Letwin,K., Tannock,L., Bernstein,A. and Pawson,T.
  TITLE     A mammalian protein kinase with potential for serine/threonine and
            tyrosine phosphorylation is related to cell cycle regulators
  JOURNAL   EMBO J 10 (2), 317-325 (1991)
   PUBMED   1825055
REFERENCE   9  (bases 1 to 4382)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics, ontogeny, and testosterone inducibility of aldehyde
            oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I
            and Aox-2) closely linked on chromosome 1
  JOURNAL   Biochem Genet 17 (5-6), 517-527 (1979)
   PUBMED   518535
REFERENCE   10 (bases 1 to 4382)
  AUTHORS   Lush,I.E.
  TITLE     Genetic variation of some aldehyde-oxidizing enzymes in the mouse
  JOURNAL   Anim Blood Groups Biochem Genet 9 (2), 85-96 (1978)
   PUBMED   742739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB017482.1, AC117562.6 and AC025116.14.
            
            On Jul 14, 2006 this sequence version replaced NM_009676.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017482.1, BC026132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1393              AB017482.1         67-1459
            1394-1394           AC117562.6         23372-23372         c
            1395-2618           AB017482.1         1461-2684
            2619-2619           AC117562.6         4069-4069           c
            2620-2906           AB017482.1         2686-2972
            2907-2907           AC117562.6         129-129             c
            2908-2996           AB017482.1         2974-3062
            2997-2997           AC117562.6         39-39               c
            2998-3836           AB017482.1         3064-3902
            3837-3837           AC025116.14        171756-171756       c
            3838-4382           AB017482.1         3904-4448
FEATURES             Location/Qualifiers
     source          1..4382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6 x CBA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.86 cM"
     gene            1..4382
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /note="aldehyde oxidase 1"
                     /db_xref="GeneID:11761"
                     /db_xref="MGI:MGI:88035"
     exon            1..90
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..4050
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /EC_number="1.2.3.1"
                     /note="retinal oxidase; aldehyde oxidase 2; azaheterocycle
                     hydroxylase 1"
                     /codon_start=1
                     /product="aldehyde oxidase 1"
                     /protein_id="NP_033806.2"
                     /db_xref="CCDS:CCDS35575.1"
                     /db_xref="GeneID:11761"
                     /db_xref="MGI:MGI:88035"
                     /translation="MDPIQLLFYVNGQKVVEKNVDPEMMLLPYLRKNLRLTGTKYGCG
                     GGGCGACTVMISRYNPSTKAIRHHPVNACLTPICSLHGTAVTTVEGLGNTRTRLHPIQ
                     ERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDAC
                     KTFCKASGCCQSKENGVCCLDQEINGLAESQEEDKTSPELFSEEEFLPLDPTQELIFP
                     PELMRIAEKQPPKTRVFYGERVTWISPVTLKELVEAKFKYPQAPIVMGYTSVGPEVKF
                     KGVFHPIIISPDRIEELGVISQARDGLTLGAGLSLDQVKDILADIVQKLPEEKTQTYR
                     ALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLNLLSKDGERRIPLS
                     EEFLRKCPEADLKPQEVLVSVNIPWSRKWEFVSAFRQAQRQQNALAIVNSGMRVLFRE
                     GGGVIEELSILYGGVGSTIISAKNSCQRLIGRPWNEGMLDTACRLVLDEVTLAASAPG
                     GKVEFKRTLIISFLFKFYLEVSQGLKREDPGHSPSLAGNHESALDDLHSKHPWRTLTH
                     QNVDPAQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIV
                     SIDLSEALSLPGVVDIITADHLQEANTFGTETFLATDEVHCVGHLVCAVIADSETRAK
                     QAAKQVKVVYQDLAPLILTIEEAIQHKSFFKSERKLECGNVDEAFKIVDQILEGEIHI
                     GGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKYIQDIVAATLKLSANKVMCHVRRV
                     GGAFGGKVGKTSILAAITAFAASKHGRAVRCILERGEDMLITGGRHPYLGKYKAGFMN
                     DGRILALDVEHYCNGGCSLDESLWVIEMGLLKLDNAYKFPNLRCRGWACRTNLPSNTA
                     LRGFGFPQAGLVTEACITEVAIKCGLSPEQVRTINMYKHVDTTHYKQEFSAKALSECW
                     RECMAKCSYFERKAAIGKFNAENSWKKRGMAVIPLKFPVGIGSVAMGQAAALVHIYLD
                     GSALVSHGGIEMGQGVHTKMIQVVSRELRMPMSSVHLRGTSTETVPNTNASGGSVVAD
                     LNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQTAFDQSISLSAVGYFRGYESNIDW
                     EKGEGHPFEYFVFGAACSEVEIDCLTGDHKNIRTNIVMDVGHSINPALDIGQVEGAFI
                     QGMGLYTIEELSYSPQGTLYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKG
                     LGESGVFLGCSVFFAIHDAVKAARQERGISGPWKLNSPLTPEKIRMACEDKFTKMIPR
                     DEPGSYVPWNIPV"
     exon            91..148
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            149..245
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            246..354
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            355..481
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            482..543
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            544..633
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            634..714
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            715..859
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            860..952
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1104
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1198
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1308
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1493
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1656
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1749
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1919
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2034
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2157
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2254
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2379
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2513
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2601
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2688
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2880
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3108
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3204
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3333
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3408
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3461
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3576
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3642
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3831
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..3999
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4382
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4246..4251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /note="hexamer: ATTAAA"
     polyA_site      4268
                     /gene="Aox1"
                     /gene_synonym="Ao; Aox-1; Aox-2; Aox2; Moro; Ro"
                     /note="major polyA site"
ORIGIN      
        1 ctctgcaagg actggcgctg ctagggacct gctagggacc tcggagtcat ggaccccatt
       61 cagctgctct tctacgtgaa tggccagaag gtggtagaaa aaaatgtcga tcctgaaatg
      121 atgcttttac catacctgag gaagaatctc cgactcacag gaactaagta tggctgtgga
      181 ggcgggggct gtggggcctg cacagtgatg atctcgcggt acaaccccag caccaaggcg
      241 atcaggcatc atcctgtcaa tgcctgtctg acccccatct gctctctaca tggtacagca
      301 gtcaccacgg tagaaggctt aggcaacacc aggaccaggc ttcatcctat tcaggagaga
      361 attgccaagt gtcacggcac ccagtgtgga ttctgtactc ctgggatggt gatgtccatg
      421 tacgcactgc tcaggaacca tccagagccc actctagatc agttaactga tgcccttggt
      481 gggaatctgt gccgctgcac tggatatagg cccataattg atgcctgcaa gactttctgt
      541 aaagcctctg gctgctgtca aagtaaagaa aatggggtgt gctgtttgga tcaagaaata
      601 aatggattgg cagaatccca ggaagaagat aagacaagtc cagaactgtt ctcagaagag
      661 gaatttctgc cactggaccc gacccaagag ctgatatttc ctcccgagct aatgagaata
      721 gctgagaaac agccaccaaa gaccagagtg ttttatggtg agagggtgac atggatttcc
      781 cccgtgactc tgaaggaact tgtggaagct aaattcaagt atccccaggc ccctattgtc
      841 atggggtaca cttctgtggg acctgaagta aagtttaaag gtgtcttcca ccccatcata
      901 atttctcctg acagaattga agagctgggt gtcataagcc aggccaggga tgggctgacc
      961 ctgggtgctg gcctcagcct ggatcaggtg aaggacattc tggctgatat agtccagaag
     1021 cttccagaag agaagacaca gacataccgt gctctcctga agcacctgag aactctggct
     1081 ggctcccaga tcaggaacat ggcttctcta gggggccaca ttgtgagcag acatctggac
     1141 tcagatctga atccccttct ggctgtgggt aactgtaccc tcaacttact gtccaaagat
     1201 ggagaacggc ggatcccttt aagtgaagag tttctccgaa agtgtcctga agcagatctt
     1261 aagcctcagg aagtcttggt ctcagtgaac atcccctggt ccaggaagtg ggagtttgtg
     1321 tcagccttcc gtcaagcgca aagacaacag aatgcactag caatagtcaa ctccggaatg
     1381 agagtccttt ttagagaagg aggtggcgtc attgaagagt tatccatttt gtatggaggt
     1441 gtcggttcaa ctatcatcag tgccaagaac tcctgtcaga gactcattgg gaggccctgg
     1501 aatgaaggga tgctggacac agcctgtagg ctggttttgg atgaagtcac ccttgcagcc
     1561 tcagctcctg gtgggaaggt ggagttcaag aggaccctca tcatcagctt ccttttcaag
     1621 ttctacctgg aggtgtcaca gggtttgaag agggaggacc caggtcactc tcctagcctg
     1681 gcaggcaacc atgagagtgc tttagatgat cttcattcaa aacatccctg gagaacatta
     1741 acccaccaga atgtagatcc agcacagctg cctcaggacc ccattggacg tcccatcatg
     1801 cacctttctg ggattaaaca tgccacgggc gaggccatct actgtgacga catgcctgca
     1861 gtagaccggg agcttttcct cacttttgta acaagttcaa gagcacacgc taagattgtg
     1921 tccattgatc tgtcggaagc tctcagcctg cctggtgtgg tggacatcat tactgcagat
     1981 catcttcagg aagcaaacac cttcggcaca gagacatttc tggccacaga tgaggtacac
     2041 tgcgtgggcc atcttgtctg tgctgtgatt gcagattctg agacacgggc aaagcaagcg
     2101 gcgaagcaag tgaaggtggt ctaccaagac ttggcgcctc tgatcctaac gattgaggaa
     2161 gctatacaac acaagtcctt cttcaagtca gaacggaagc tggagtgtgg gaatgttgac
     2221 gaagcattta aaatcgttga tcaaattctt gaaggtgaaa tacacatagg cggccaggaa
     2281 catttttata tggaaaccca aagcatgctt gttgttccca aaggagagga tggagagatt
     2341 gacatctatg tgtctacaca gtttcccaaa tatatacagg atatagtcgc tgcaaccttg
     2401 aagctctcag ccaacaaggt catgtgtcat gtaaggcgtg ttggcggggc atttggaggg
     2461 aaggtgggca agaccagcat cttggcagcc atcactgcat ttgctgctag caaacacggt
     2521 cgcgcagtcc gctgcattct ggaacgagga gaagacatgt taataactgg aggccgccat
     2581 ccttaccttg gaaagtataa agctggattc atgaatgacg gcagaatctt ggccctggac
     2641 gtggagcact actgcaatgg agggtgctcc ctggatgagt cactatgggt gatagaaatg
     2701 gggcttctga agctggacaa cgcttacaag tttcccaacc tacgctgccg gggctgggcc
     2761 tgcagaacca accttccatc caacactgct ctgcgtgggt ttggctttcc tcaggcaggg
     2821 ctggtcaccg aagcctgtat cacagaagtg gcaatcaaat gtggcctgtc ccctgagcag
     2881 gttcgaacca taaatatgta caagcacgtt gatactaccc attacaagca agagttcagc
     2941 gccaaggccc tctctgagtg ctggagagag tgcatggcca agtgttccta ctttgagagg
     3001 aaagcagcca taggaaaatt caacgcagag aattcctgga agaagagagg aatggctgtg
     3061 attcccctga agtttcctgt gggtattgga tcagtagcca tgggacaggc agctgccttg
     3121 gttcatattt atttggatgg ctctgcactg gtctctcatg gtggaattga gatggggcag
     3181 ggtgtgcaca ctaaaatgat tcaggtggtc agccgggaac taaggatgcc gatgtccagt
     3241 gtccacctgc gtgggacaag cacagaaacc gtccccaaca caaatgcctc tggaggctct
     3301 gtggtggcag atctcaatgg actggcagta aaggatgcct gtcagaccct tctaaaacgc
     3361 cttgaaccca tcatcagcaa gaatcctcag ggaacttgga aggattgggc ccagactgct
     3421 tttgaccaaa gcatcagtct ctcggctgtt ggatatttca ggggttatga gtcgaatata
     3481 gactgggaga aaggggaagg tcatcccttc gaatactttg tgtttggagc tgcctgctca
     3541 gaggttgaaa tagactgcct gactggggac cataagaata tcagaacaaa catcgtgatg
     3601 gatgttggcc acagcataaa cccagccctt gacataggtc aggttgaagg tgcatttatt
     3661 caaggaatgg gactttacac aatagaggag ctgagttact ctcctcaggg cactctatac
     3721 agtcgtggtc caaaccaata caagattcct gccatctgtg acatccccac ggaaatgcac
     3781 atttcttttt tgcccccatc tgaacactca aacaccctgt attcatctaa gggcctggga
     3841 gagtctgggg tgtttctggg atgttcggta ttttttgcca tccatgatgc agtgaaggca
     3901 gcgcggcagg agagaggcat ctctggacca tggaaactca acagtcctct gactccagag
     3961 aaaatcagaa tggcctgtga agataagttc accaaaatga tcccaagaga tgagcctgga
     4021 tcctatgttc cctggaacat acctgtgtga gtcaaacatg aacctctgga ggaattggct
     4081 gagcaactac agaccgtacc tcctgcctgc tctgctctaa gatgctaaat gcgaaagcca
     4141 gagtttcaca gcccagaatc atctacagca ctgctttaca tgaagccgac tcggaagatt
     4201 ctcttgagga tactccagat acacctgagc aattataaat catatattaa attgcacaaa
     4261 tatttaaatc gtttgctcta aggtggtttc aatcattatt ctgtcccttg gatccgtcaa
     4321 gctaactgga ctatatgaca cctgagcaat tataaatcat atattaaatt gcacaaatat
     4381 tt
//
