LOCUS       NM_001289926            6778 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus aminopeptidase O (Aopep), transcript variant 2, mRNA.
ACCESSION   NM_001289926 XM_006517378
VERSION     NM_001289926.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6778)
  AUTHORS   Piasecka,A., Szczesniak,M.W., Sekrecki,M., Kajdasz,A.,
            Sznajder,L.J., Baud,A. and Sobczak,K.
  TITLE     MBNL splicing factors regulate the microtranscriptome of skeletal
            muscles
  JOURNAL   Nucleic Acids Res 52 (19), 12055-12073 (2024)
   PUBMED   39258536
REFERENCE   2  (bases 1 to 6778)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6778)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 6778)
  AUTHORS   Jiang,Y.H., Man,Y.Y., Liu,Y., Yin,C.J., Li,J.L., Shi,H.C., Zhao,H.
            and Zhao,S.G.
  TITLE     Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via
            Glycolysis Pathway in Mice
  JOURNAL   Int J Mol Sci 22 (2), 550 (2021)
   PUBMED   33430468
  REMARK    GeneRIF: Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance
            via Glycolysis Pathway in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6778)
  AUTHORS   Zhang,Y., Han,J.J., Liang,X.Y., Zhao,L., Zhang,F., Rasouli,J.,
            Wang,Z.Z., Zhang,G.X. and Li,X.
  TITLE     miR-23b Suppresses Leukocyte Migration and Pathogenesis of
            Experimental Autoimmune Encephalomyelitis by Targeting CCL7
  JOURNAL   Mol Ther 26 (2), 582-592 (2018)
   PUBMED   29275848
  REMARK    GeneRIF: our results characterize a novel aspect of miR-23b
            function in leukocyte migration, and they identify miR-23b as a
            potential therapeutic target in the amelioration of MS and likely
            other autoimmune diseases.
REFERENCE   6  (bases 1 to 6778)
  AUTHORS   Kong,X., Yu,J., Bi,J., Qi,H., Di,W., Wu,L., Wang,L., Zha,J., Lv,S.,
            Zhang,F., Li,Y., Hu,F., Liu,F., Zhou,H., Liu,J. and Ding,G.
  TITLE     Glucocorticoids transcriptionally regulate miR-27b expression
            promoting body fat accumulation via suppressing the browning of
            white adipose tissue
  JOURNAL   Diabetes 64 (2), 393-404 (2015)
   PUBMED   25187367
  REMARK    GeneRIF: These results indicate that miR-27b functions as a central
            target of glucocorticoids and as an upstream regulator of Prdm16.
REFERENCE   7  (bases 1 to 6778)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 6778)
  AUTHORS   Kozomara,A. and Griffiths-Jones,S.
  TITLE     miRBase: integrating microRNA annotation and deep-sequencing data
  JOURNAL   Nucleic Acids Res 39 (Database issue), D152-D157 (2011)
   PUBMED   21037258
REFERENCE   9  (bases 1 to 6778)
  AUTHORS   Axton,R., Wallis,J.A., Taylor,H., Hanks,M. and Forrester,L.M.
  TITLE     Aminopeptidase O contains a functional nucleolar localization
            signal and is implicated in vascular biology
  JOURNAL   J Cell Biochem 103 (4), 1171-1182 (2008)
   PUBMED   17803194
  REMARK    GeneRIF: Alternative splicing predictably produces protein products
            with or without the catalytic domain and/or a nucleolar
            localisation signal and represents mechanism in regulating activity
            of APO.
REFERENCE   10 (bases 1 to 6778)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044477.1, AK141931.1, CT009757.28 and BX520155.1.
            
            On Feb 8, 2014 this sequence version replaced XM_006517378.1.
            
            Transcript Variant: This variant (2) contains an alternate segment
            in the 3' UTR. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.14913.1,
                                           SRR13422597.71121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AK044477.1         2-130
            130-3544            AK141931.1         96-3510
            3545-6413           CT009757.28        20031-22899         c
            6414-6778           BX520155.1         1-365
FEATURES             Location/Qualifiers
     source          1..6778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.8 cM"
     gene            1..6778
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /note="aminopeptidase O"
                     /db_xref="GeneID:72061"
                     /db_xref="MGI:MGI:1919311"
     exon            1..127
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            128..1065
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..2740
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /codon_start=1
                     /product="aminopeptidase O"
                     /protein_id="NP_001276855.1"
                     /db_xref="CCDS:CCDS36699.1"
                     /db_xref="GeneID:72061"
                     /db_xref="MGI:MGI:1919311"
                     /translation="MDIKLDPSRDDLPLMANTSHMLVKHYILDLDVDFGNQVIEGNIV
                     LFFGDGNRFKNQSRSTQETFQMESEEADIFRTAEPCHVPEMDSSTFSPKMGHRECAVC
                     GKGDQDAFDNDGNHDNQERDSEISSSKYCCDTGNHGKRDFLLVLDCCDLSVLKVEEVD
                     VAAVPGLEKFTKAPKLLATPEKLRCEIVRDLVALPADAWREQLDCYTRCSQAPGCGEL
                     LIDSDNWSLRIRKTGTSTPADFPRAIRIWYKTKPEGQSVAWTTDQNGRPCVYTMGSPI
                     NNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTPLREGYMSWHYYVTMPM
                     PASTFAIAVGCWTEMKPKASPPDDLMTEHSLPLSPSEADLRYDNTCNHMEYPCRFQSA
                     SAASQDIIPYRVFAPVCLEGACQEALLWLIPSCLSAAHSVLGTHPFSRLDILIVPTNF
                     PSLGMASPHIIFLSQSTLTGTSHLCGTRLCHEIAHSWFGLAIGARDWTEEWLSEGFAT
                     HLEDIFWAEAQQLPPHEALEQQELRACLRWHRLQDELRNSPEGMQVLRPNKEETGHVS
                     ASGASVVKHGLNPEKGFMQVHYLKGYFLLRFLTRTLGEKIYFPFLRKFVHLFHGQLIL
                     SQDFLQMLLENIPENKRLGLSVENIVRDWLECSGIPKALQEERKAEDCSPSRLARQVG
                     SEVAKWIRVNRRPRKRKRGKREVAFEKLSPDQIVLLLEWLLEQKTLSPQTLHCLQQTY
                     HLPEQDAEVRHRWCELVIKHKYTKAYNQVERFLLEDQAMGIYLYGELMVSEDARLQQL
                     AHRCFELVKEHMDRASAQVVTEMLF"
     exon            1066..1232
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1392
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1638
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1828
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1935
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2038
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2146
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2190
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2251
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2320
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2395
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2512
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2599
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..6765
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3521..3526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /note="hexamer: ATTAAA"
     polyA_site      3560
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /note="major polyA site"
     regulatory      6149..6154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /note="hexamer: AATAAA"
     polyA_site      6172
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /note="major polyA site"
     regulatory      6729..6734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /note="hexamer: AATAAA"
     polyA_site      6765
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
ORIGIN      
        1 gtggtaaccc ggagtctgcg gaagtgtagc tgcagcagca ccgcagctga gacaggtaac
       61 ctgcagctcc ggtgtcaagc agccgctccg ggttatgcgg acccacgacc tctggtgggg
      121 tgagcaggga attgaaagtt gtggaaagat aacgagtgcc agtgggtgct tcttatttgg
      181 taaaccagcc atttgtgatt ctgagctact acaggagatt agaagcttca gctgagattc
      241 agcaaagcta ccaactgcag actacaccat ggacataaag ctggaccctt cccgggatga
      301 tctgcctctc atggccaaca ccagccacat gcttgtgaag cactacatac tggatttgga
      361 tgtggacttt ggaaatcaag tcattgaggg caacatagtg cttttctttg gagatggaaa
      421 cagatttaaa aaccagtcgc gttctaccca ggaaaccttc cagatggagt cagaggaggc
      481 tgacatattt aggacagctg aaccctgcca tgttcctgag atggattcga gtaccttctc
      541 acctaagatg ggacatagag aatgtgcagt ctgtggtaaa ggtgatcaag atgcctttga
      601 taacgatggt aaccatgaca accaggaacg tgattctgag atctctagct caaagtactg
      661 ctgtgacaca gggaatcatg ggaaaaggga tttcttgcta gtgttggact gctgtgattt
      721 atctgtgcta aaggtagagg aggtggatgt ggctgctgtg ccaggccttg agaaatttac
      781 taaagctcca aagctcttgg ctactcctga gaagctcagg tgtgagattg tccgtgacct
      841 tgtggctctg cctgcagatg cttggaggga gcagttagac tgctacactc gttgcagcca
      901 ggctcctggc tgtggggagc tcttgattga ctctgacaat tggagcttac ggatcaggaa
      961 gacggggact tcgacacctg ctgactttcc tcgtgccatc agaatatggt ataaaactaa
     1021 acctgagggg cagtcagtag cttggacaac agaccagaat ggcaggccat gtgtttatac
     1081 tatgggatcc cccatcaaca acagggccct ttttccatgc caggaaccac ccgttgccat
     1141 gtcaacatgg caggctacag ttcgagcagc tgcatctttt gttgttttaa tgagtggaga
     1201 aaattctgcc aagcccacac cacttcgaga aggatacatg agctggcatt actatgtgac
     1261 catgccaatg ccggcctcta cctttgcaat tgcagtgggg tgctggacag aaatgaagcc
     1321 caaggcatcc ccaccagatg atctgatgac tgagcactct ctccccctct cgccatcgga
     1381 agcggacttg aggtatgata acacctgcaa tcatatggaa tacccttgca ggttccagag
     1441 tgcgtccgct gcctcccagg acatcattcc ttatcgagtg tttgccccag tgtgccttga
     1501 gggtgcctgc caagaggccc tgctgtggct gatcccttct tgcctctcag ctgcacactc
     1561 tgtcctggga acacaccctt tctcccggct ggacatactc attgtcccca ccaactttcc
     1621 aagtctggga atggccagcc cacacatcat cttcctctct cagagcacct taacaggcac
     1681 gagccatctc tgtgggaccc gtctttgcca tgaaattgct cactcctggt ttggcctagc
     1741 cattggggcc cgagactgga cagaggagtg gctcagtgaa ggatttgcca cgcatttgga
     1801 agatatattt tgggctgagg cacagcagct gcccccccat gaggccctgg agcagcagga
     1861 gctgagggct tgcctgcgct ggcaccgcct gcaggatgag cttcggaact ccccagaggg
     1921 aatgcaggtg ttaagaccca acaaagaaga gactggccat gtgagtgctt caggtgcatc
     1981 tgttgtcaag catggactca atccagagaa gggcttcatg caggttcatt acttaaaggg
     2041 ctacttcctt cttcggttcc taaccagaac acttggagag aaaatttatt ttccgttttt
     2101 aagaaaattt gtgcatctgt ttcatgggca gctgattctt tcccaggatt ttcttcaaat
     2161 gctgttggag aacattccag aaaacaaaag gctcggcctg tctgttgaga acatcgtccg
     2221 agattggctt gagtgttccg gaatacctaa ggcgctgcag gaggagcgca aggccgagga
     2281 ctgctcgccg agtaggctcg cacggcaagt aggctccgag gtggcgaaat ggattcgagt
     2341 caaccgcaga ccccgaaaac gcaaacgagg gaagcgagaa gtcgcctttg aaaagctttc
     2401 tccagaccag atcgtcttgc ttttggagtg gctcttagag cagaagacgc tgagccctca
     2461 gacactgcac tgtctccagc agacttacca tctcccagag caggatgcag aggttcgcca
     2521 tcgatggtgt gaactggtta ttaagcacaa gtacacaaag gcatacaatc aggtggagag
     2581 gttcctactg gaggaccagg ccatgggcat atacctgtat ggggagctga tggtgagtga
     2641 ggacgccagg ctgcagcagc tagcccacag gtgctttgag ctggtgaagg aacacatgga
     2701 cagagcatcg gcccaggtgg tgactgaaat gctgttctaa agaggtaatt ctcttttctt
     2761 tcttctaacc atccatgtca attggtaagc cacatgatga gccacagcac cagagggctg
     2821 ccaaacggtc ttggggagga agcagcaagg tgggtcctca ggaacaggaa gaaggctcag
     2881 gatctctgga gcacctcacc tgctggaagc atgggtgtga agcaggtaca gctgaaggag
     2941 caacagatct ggcactgctt tagccaccct ggattttgca caggtccaca ggctccaggg
     3001 tcaaggtcaa cacagcggtc catggcctca ttgctccagg cttcagcatg caggcatctc
     3061 tcctagaggc tgtgtaaacc tgagactcct tggcctctgg ttctctgacc tgtagagtag
     3121 gcagcaggtc ttctctgccc ctccatccaa gtgacacttg cgtcctaaag gcaagtctgt
     3181 ttccatctcg tgctggaaca ggatttacgc tggctcccag agtccttggc tgtggtgtaa
     3241 cttgcctcct ctgtagccag cttgtggacc agtaatgcag ttcagccaca gggcgtggag
     3301 ttctgagaca ggtgtgggct agtgcgtctc tttcatagtc gccagtcatc atctctacat
     3361 catcccagga cattatcgct tgccatggtg gtacatatga tgtttacttt tgtatatgtt
     3421 tgaaatttta catcaatcac tgtgttactc tgttgttctc tatgattacc aattaatgaa
     3481 tatttagaat tgtgttgcta atcttaaccc attgtcagac attaaattta cattttcaca
     3541 tttcactttt ataaaaccca cttctgtgta atgtttattt ttctgaagaa ctacactgat
     3601 gaagggaaaa catgttacta tgtatgacca tgttgttgca gaagagctgg ggaccgccac
     3661 agtcaagcag gggagatagt gggctggagt aagcaggtac agcctgctaa gcctgcacac
     3721 tacaagctag gacggtggcc tgtgtggata gacagagtcg gtcggggcgc ctcttcactg
     3781 cctcctgcag acatttctct agaaacttgt aagctgaggg attgttggta tgtggtgtgt
     3841 gaaggtcaca cagtaaagcc actgttccct ttttaggtcc ctaggccttc acttaggaaa
     3901 gccatagtca catagtggtc ctagtgactc ttctaagagt atttttgccc cctgagtgag
     3961 caaatcctca acttgctagg tcccctatga gctctgtgct atgcctcagc ttatccaacc
     4021 aaatgcttgg tcacaggcaa gccagagaga tgctccctcc ctacacacca cacctgctgt
     4081 ctgaggggcc cagagacatc ccaacccatt cagtctgcaa ttggagaaca gggtgtgtcc
     4141 cagggttaaa ggccacatac tcagagcaag gatggtccct aaggtattgg tctcatagct
     4201 gataagtgtg tcctttgtct cccagtcccc tatgctcctc tatacagtgc agccagcgcg
     4261 ctgaaggaca gcaggctgca ctgctagcgt ggtgggctca gaggcggttt ggaggacact
     4321 cagcacatgt ggatgggagt ggttgggcat ggtgctgccc tcacctgctc tggctgcttg
     4381 ggttcctggc atgctgattt gtgacttgag attaaaatca cattgccagg gattaccacg
     4441 caaccatgac cttggctgct cctgcagaac cgtggctact ttctctctgc agtttggaga
     4501 acagaggcgc cttgtggctc tttggaaaca aaagaagcca acagccttcg aagatgctca
     4561 ccagcccttt aattatggcc ggcgatgacc tctctaacaa ggtgcagagc ttagctgatt
     4621 ggtgaacagt gattggtttc cgctttgttc acagtggcta agttctgcac ctgaagagaa
     4681 ggtgagatgg ggacagttaa cttgcagctg ccaggcagag gccactgcct ggtggtcact
     4741 ccagaggagg agagaccagc ctgcctcaag gctgtgttgt caagagtgca aacagcgtgc
     4801 tgaccaccct taagtgtgtc tacagaaaat acagttctac tgctaattag ttcactgtaa
     4861 tgtcaagtgt attgggagtc acagaaaact aaacccaggt gcatcaagga aactgagcca
     4921 accttgtctc agctgatgcc acacgtgatg ggtgggggtg tggttctttg tccctgctgg
     4981 gcgtggtgaa ctctttcttg tatttgcagt ccaggtctcc atgtctccac agtcgctggc
     5041 aagatgatgc ccagggcacg ccaggaggca ctgcccagct gtgattggac ccgccctccg
     5101 gtgcctactg agctgatatc agttctcatt tcacacactg gctcagttca gcaggaacag
     5161 gagtcgagcc cttgagcaaa aagcctaccc atctgtaagt gcctgaggca ggcctcccac
     5221 ggagaagaag atgaagggcc tgagtgtctg gtaccagacc caacagcagt ggtatccctc
     5281 tgtatgtgct cccgaggtgg ggatttgtag agtgcagagc taaccttgga aagtttgcat
     5341 tccctagaag caggtagggc aggcgctgag catttgccac gtgttggggc agagcacacc
     5401 atgtcaccgc tgccttgagc agtgagaatg cctgtctgaa gggccttgtc tgtagagcct
     5461 ttctgaacct ctctgggctt cacagccctg catggcctgt gccgtgactg tgcaccccag
     5521 acccaggatt gtgaggtgtg gcttcagtgt tgcccctgtc ctcccatgaa aagttccctc
     5581 tcaagtggag gtcagaggct gggaggactc ctgttggaat ggctgtggtg actgggtaat
     5641 aaattttatt gctgtttcct ccacaggaca gatcacagtg agattctcat ataccttctc
     5701 ctagccctgg tggggccagg actgcactga ccctggacat caaagggagg attatgtggc
     5761 tgctaaggcc atcagcccac agcagtggtt ggtccatctt gggcttccag agactgggct
     5821 cccgtggcat atataaaagg cggagcctca taaactgttg cacctggcag ctgcctttgt
     5881 tcccagtcct agagagactg agtctacaca ctggaattga gctgtgactt taaggcagtc
     5941 attcaatgaa ggacaccctc ccctaggcag atggagagcc ggttgcctgc ttcctgtgat
     6001 tgcaaaaact agctgccatg ctctgagact gcagaatcat gtgacacctc ctgtggctgg
     6061 tccccaagga ttctgcaaag cccttttgat gtgttcagtc aacagagcat tcctgttttt
     6121 gaaaatgcag gaaagcctaa aatgtcttaa taaagtacca gatttgctag tgttccagtt
     6181 tgcttctgaa tttgatgctc cttaaaagca aagaagaacg tgtgtcagaa caggcacttt
     6241 ccacacactt cctacctcca ggtaatgtta attctaaaaa ggttggaagt aaagggaaat
     6301 tagtgtggct tgggactctg ctctcttcca aatgtggagt ttcagccagc ctggtactag
     6361 cggagtctca gaacaagctc taagctcttt cagtcactgt ctagagaacg gtgcttgaga
     6421 ctgagccatc agtgcagtca catgagccca gccaaggcag agcggtggac agaggaacca
     6481 gaaggagcat cccactggct ggccaggctt ctgcacccag acctgctggg tgacaaaggc
     6541 tctaggacag actgagagga gcgtccgcac agaaccattg gttttcagag cctgggctgt
     6601 agcagtgact gcatttggat ggttgcaggg gacttgcaaa tggttatctg ctttgtatac
     6661 cacaatggta caagtatcaa agtgtgttaa ttctacttaa tgttaccctg atttctgtga
     6721 agacttgaaa taaatggctg agtctatgcc ttcctgctct cagaaaaaaa aaaaaaaa
//
