LOCUS       NP_001276855             823 aa            linear   ROD 26-NOV-2024
DEFINITION  aminopeptidase O [Mus musculus].
ACCESSION   NP_001276855 XP_006517441
VERSION     NP_001276855.1
DBSOURCE    REFSEQ: accession NM_001289926.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 823)
  AUTHORS   Piasecka,A., Szczesniak,M.W., Sekrecki,M., Kajdasz,A.,
            Sznajder,L.J., Baud,A. and Sobczak,K.
  TITLE     MBNL splicing factors regulate the microtranscriptome of skeletal
            muscles
  JOURNAL   Nucleic Acids Res 52 (19), 12055-12073 (2024)
   PUBMED   39258536
REFERENCE   2  (residues 1 to 823)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 823)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (residues 1 to 823)
  AUTHORS   Jiang,Y.H., Man,Y.Y., Liu,Y., Yin,C.J., Li,J.L., Shi,H.C., Zhao,H.
            and Zhao,S.G.
  TITLE     Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via
            Glycolysis Pathway in Mice
  JOURNAL   Int J Mol Sci 22 (2), 550 (2021)
   PUBMED   33430468
  REMARK    GeneRIF: Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance
            via Glycolysis Pathway in Mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 823)
  AUTHORS   Zhang,Y., Han,J.J., Liang,X.Y., Zhao,L., Zhang,F., Rasouli,J.,
            Wang,Z.Z., Zhang,G.X. and Li,X.
  TITLE     miR-23b Suppresses Leukocyte Migration and Pathogenesis of
            Experimental Autoimmune Encephalomyelitis by Targeting CCL7
  JOURNAL   Mol Ther 26 (2), 582-592 (2018)
   PUBMED   29275848
  REMARK    GeneRIF: our results characterize a novel aspect of miR-23b
            function in leukocyte migration, and they identify miR-23b as a
            potential therapeutic target in the amelioration of MS and likely
            other autoimmune diseases.
REFERENCE   6  (residues 1 to 823)
  AUTHORS   Kong,X., Yu,J., Bi,J., Qi,H., Di,W., Wu,L., Wang,L., Zha,J., Lv,S.,
            Zhang,F., Li,Y., Hu,F., Liu,F., Zhou,H., Liu,J. and Ding,G.
  TITLE     Glucocorticoids transcriptionally regulate miR-27b expression
            promoting body fat accumulation via suppressing the browning of
            white adipose tissue
  JOURNAL   Diabetes 64 (2), 393-404 (2015)
   PUBMED   25187367
  REMARK    GeneRIF: These results indicate that miR-27b functions as a central
            target of glucocorticoids and as an upstream regulator of Prdm16.
REFERENCE   7  (residues 1 to 823)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (residues 1 to 823)
  AUTHORS   Kozomara,A. and Griffiths-Jones,S.
  TITLE     miRBase: integrating microRNA annotation and deep-sequencing data
  JOURNAL   Nucleic Acids Res 39 (Database issue), D152-D157 (2011)
   PUBMED   21037258
REFERENCE   9  (residues 1 to 823)
  AUTHORS   Axton,R., Wallis,J.A., Taylor,H., Hanks,M. and Forrester,L.M.
  TITLE     Aminopeptidase O contains a functional nucleolar localization
            signal and is implicated in vascular biology
  JOURNAL   J Cell Biochem 103 (4), 1171-1182 (2008)
   PUBMED   17803194
  REMARK    GeneRIF: Alternative splicing predictably produces protein products
            with or without the catalytic domain and/or a nucleolar
            localisation signal and represents mechanism in regulating activity
            of APO.
REFERENCE   10 (residues 1 to 823)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044477.1, AK141931.1, CT009757.28 and BX520155.1.
            
            On Feb 8, 2014 this sequence version replaced XP_006517441.1.
            
            Transcript Variant: This variant (2) contains an alternate segment
            in the 3' UTR. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.14913.1,
                                           SRR13422597.71121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.8 cM"
     Protein         1..823
                     /product="aminopeptidase O"
                     /calculated_mol_wt=93448
     Region          <244..641
                     /region_name="GluZincin"
                     /note="Gluzincin Peptidase family (thermolysin-like
                     proteinases, TLPs) which includes peptidases M1, M2, M3,
                     M4, M13, M32 and M36 (fungalysins); cl14813"
                     /db_xref="CDD:472708"
     Site            588
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:P15144; propagated from
                     UniProtKB/Swiss-Prot (Q8BXQ6.3)"
     Region          693..703
                     /region_name="Nucleolar localization signal.
                     /evidence=ECO:0000269|PubMed:17803194"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BXQ6.3)"
     Region          710..822
                     /region_name="Leuk-A4-hydro_C"
                     /note="Leukotriene A4 hydrolase, C-terminal; pfam09127"
                     /db_xref="CDD:462686"
     CDS             1..823
                     /gene="Aopep"
                     /gene_synonym="2010111I01Rik; 2300006M17Rik; AP-O; ApO;
                     mir-23b; mir-24-1; mir-27b"
                     /coded_by="NM_001289926.1:269..2740"
                     /db_xref="CCDS:CCDS36699.1"
                     /db_xref="GeneID:72061"
                     /db_xref="MGI:MGI:1919311"
ORIGIN      
        1 mdikldpsrd dlplmantsh mlvkhyildl dvdfgnqvie gnivlffgdg nrfknqsrst
       61 qetfqmesee adifrtaepc hvpemdsstf spkmghreca vcgkgdqdaf dndgnhdnqe
      121 rdseisssky ccdtgnhgkr dfllvldccd lsvlkveevd vaavpglekf tkapkllatp
      181 eklrceivrd lvalpadawr eqldcytrcs qapgcgelli dsdnwslrir ktgtstpadf
      241 prairiwykt kpegqsvawt tdqngrpcvy tmgspinnra lfpcqeppva mstwqatvra
      301 aasfvvlmsg ensakptplr egymswhyyv tmpmpastfa iavgcwtemk pkasppddlm
      361 tehslplsps eadlrydntc nhmeypcrfq sasaasqdii pyrvfapvcl egacqeallw
      421 lipsclsaah svlgthpfsr ldilivptnf pslgmasphi iflsqstltg tshlcgtrlc
      481 heiahswfgl aigardwtee wlsegfathl edifwaeaqq lpphealeqq elraclrwhr
      541 lqdelrnspe gmqvlrpnke etghvsasga svvkhglnpe kgfmqvhylk gyfllrfltr
      601 tlgekiyfpf lrkfvhlfhg qlilsqdflq mllenipenk rlglsveniv rdwlecsgip
      661 kalqeerkae dcspsrlarq vgsevakwir vnrrprkrkr gkrevafekl spdqivllle
      721 wlleqktlsp qtlhclqqty hlpeqdaevr hrwcelvikh kytkaynqve rflledqamg
      781 iylygelmvs edarlqqlah rcfelvkehm drasaqvvte mlf
//
