LOCUS       NM_009675               4396 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus amine oxidase, copper containing 3 (Aoc3), mRNA.
ACCESSION   NM_009675
VERSION     NM_009675.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4396)
  AUTHORS   Ozcan,O., Akyol,O. and Akyol,A.
  TITLE     Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice Are More
            Prone to DSS-induced Colitis and Colonic Tumorigenesis
  JOURNAL   In Vivo 38 (5), 2300-2309 (2024)
   PUBMED   39187313
  REMARK    GeneRIF: Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice
            Are More Prone to DSS-induced Colitis and Colonic Tumorigenesis.
REFERENCE   2  (bases 1 to 4396)
  AUTHORS   Zhong,C., Que,D., Yu,W., Chen,D., Wang,Y., Zhang,X., Rui,B.,
            Yang,Y., Hong,Q., Huang,G., Yang,L., Yan,J. and Yang,P.
  TITLE     Amine oxidase copper-containing 3 aggravates cardiac remodelling by
            generating hydrogen peroxide after myocardial infarction
  JOURNAL   J Pathol 260 (2), 190-202 (2023)
   PUBMED   36825552
  REMARK    GeneRIF: Amine oxidase copper-containing 3 aggravates cardiac
            remodelling by generating hydrogen peroxide after myocardial
            infarction.
REFERENCE   3  (bases 1 to 4396)
  AUTHORS   Jargaud,V., Bour,S., Terce,F., Collet,X., Valet,P., Bouloumie,A.,
            Guillemot,J.C., Mauriege,P., Jalkanen,S., Stolen,C., Salmi,M.,
            Smith,D.J. and Carpene,C.
  TITLE     Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is
            reproduced in mice expressing a mutated vascular adhesion protein-1
            (VAP-1) devoid of amine oxidase activity
  JOURNAL   J Physiol Biochem 77 (1), 141-154 (2021)
   PUBMED   32712883
  REMARK    GeneRIF: Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion
            is reproduced in mice expressing a mutated vascular adhesion
            protein-1 (VAP-1) devoid of amine oxidase activity.
REFERENCE   4  (bases 1 to 4396)
  AUTHORS   Kubota,R., Reid,M.J., Lieu,K.L., Orme,M., Diamond,C., Tulberg,N.
            and Henry,S.H.
  TITLE     Comparison of Inhibitor and Substrate Selectivity between Rodent
            and Human Vascular Adhesion Protein-1
  JOURNAL   Mediators Inflamm 2020, 3270513 (2020)
   PUBMED   32410850
  REMARK    GeneRIF: Comparison of Inhibitor and Substrate Selectivity between
            Rodent and Human Vascular Adhesion Protein-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4396)
  AUTHORS   Yang,H., Ralle,M., Wolfgang,M.J., Dhawan,N., Burkhead,J.L.,
            Rodriguez,S., Kaplan,J.H., Wong,G.W., Haughey,N. and Lutsenko,S.
  TITLE     Copper-dependent amino oxidase 3 governs selection of metabolic
            fuels in adipocytes
  JOURNAL   PLoS Biol 16 (9), e2006519 (2018)
   PUBMED   30199530
  REMARK    GeneRIF: The results establish a role for Copper homeostasis in
            adipocyte metabolism and identify SSAO as a regulator of energy
            utilization processes in adipocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4396)
  AUTHORS   Nordquist,J.E., Gokturk,C. and Oreland,L.
  TITLE     Semicarbazide-sensitive amine oxidase (SSAO) gene expression in
            alloxan-induced diabetes in mice
  JOURNAL   Mol Med 8 (12), 824-829 (2002)
   PUBMED   12606817
  REMARK    GeneRIF: the increased enzyme activity observed in diabetes is not
            a result of increased SSAO gene transcription. It is controlled by
            posttranslational modifications of the protein, and the catalytic
            activity controls the gene expression
REFERENCE   7  (bases 1 to 4396)
  AUTHORS   Yu,P.H., Wang,M., Deng,Y.L., Fan,H. and Shira-Bock,L.
  TITLE     Involvement of semicarbazide-sensitive amine oxidase-mediated
            deamination in atherogenesis in KKAy diabetic mice fed with high
            cholesterol diet
  JOURNAL   Diabetologia 45 (9), 1255-1262 (2002)
   PUBMED   12242458
  REMARK    GeneRIF: Enzyme is in involved in deamination in atherogenesis in
            KKAy diabetic mice fed with high cholesterol diet.
REFERENCE   8  (bases 1 to 4396)
  AUTHORS   Moldes,M., Feve,B. and Pairault,J.
  TITLE     Molecular cloning of a major mRNA species in murine 3T3 adipocyte
            lineage. differentiation-dependent expression, regulation, and
            identification as semicarbazide-sensitive amine oxidase
  JOURNAL   J Biol Chem 274 (14), 9515-9523 (1999)
   PUBMED   10092636
REFERENCE   9  (bases 1 to 4396)
  AUTHORS   Bono,P., Salmi,M., Smith,D.J., Leppanen,I., Horelli-Kuitunen,N.,
            Palotie,A. and Jalkanen,S.
  TITLE     Isolation, structural characterization, and chromosomal mapping of
            the mouse vascular adhesion protein-1 gene and promoter
  JOURNAL   J Immunol 161 (6), 2953-2960 (1998)
   PUBMED   9743358
REFERENCE   10 (bases 1 to 4396)
  AUTHORS   Bono,P., Salmi,M., Smith,D.J. and Jalkanen,S.
  TITLE     Cloning and characterization of mouse vascular adhesion protein-1
            reveals a novel molecule with enzymatic activity
  JOURNAL   J Immunol 160 (11), 5563-5571 (1998)
   PUBMED   9605161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590969.12.
            
            On Apr 25, 2009 this sequence version replaced NM_009675.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF054831.1, AF115411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1934              AL590969.12        56987-58920         c
            1935-2220           AL590969.12        53524-53809         c
            2221-2350           AL590969.12        53048-53177         c
            2351-4396           AL590969.12        50096-52141         c
FEATURES             Location/Qualifiers
     source          1..4396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.72 cM"
     gene            1..4396
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /note="amine oxidase, copper containing 3"
                     /db_xref="GeneID:11754"
                     /db_xref="MGI:MGI:1306797"
     exon            1..1934
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..2632
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /EC_number="1.4.3.21"
                     /note="membrane primary amine oxidase; VAP-1; copper amine
                     oxidase; vascular adhesion protein 1;
                     semicarbazide-sensitive amine oxidase"
                     /codon_start=1
                     /product="amine oxidase [copper-containing] 3"
                     /protein_id="NP_033805.1"
                     /db_xref="CCDS:CCDS25465.1"
                     /db_xref="GeneID:11754"
                     /db_xref="MGI:MGI:1306797"
                     /translation="MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGGLSQPLHCPSV
                     LPSVQPRTHPSQSQPFADLSPEELTAVMSFLTKHLGPGLVDAAQARPSDNCVFSVELQ
                     LPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERH
                     GGPLPYYRRPVLDREYQDIEEMIFHRELPQASGLLHHCCFYKHQGQNLLTMTTAPRGL
                     QSGDRATWFGLYYNLSGAGFYPHPIGLELLIDHKALDPALWTIQKVFYQGRYYESLTQ
                     LEDQFEAGLVNVVLVPNNGTGGSWSLKSSVPPGPAPPLQFHPQGPRFSVQGSQVSSSL
                     WAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYVDGSFGIG
                     KYSTPLIRGVDCPYLATYVDWHFLLESQAPKTLRDAFCVFEQNQGLPLRRHHSDFYSH
                     YFGGVVGTVLVVRSVSTLLNYDYIWDMVFHPNGAIEVKFHATGYISSAFFFGAGEKFG
                     NRVGAHTLGTVHTHSAHFKVDLDVAGLKNWAWAEDMAFVPTIVPWQPEYQMQRLQVTR
                     KLLETEEEAAFPLGGATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKA
                     FTWGRYHLAVTQRKEEEPSSSSIFNQNDPWTPTVNFTDFISNETIAGEDLVAWVTAGF
                     LHIPHAEDIPNTVTAGNSVGFFLRPYNFFDEDPSFHSADSIYFREGQDATACEVNPLA
                     CLSQTATCAPEIPAFSHGGFAYRDN"
     exon            1935..2220
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2350
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..4396
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4372..4377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /note="hexamer: AATAAA"
     regulatory      4376..4381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /note="hexamer: AATAAG"
     polyA_site      4390
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /note="major polyA site"
     polyA_site      4396
                     /gene="Aoc3"
                     /gene_synonym="SSAO; VAP1"
                     /note="major polyA site"
ORIGIN      
        1 aagttagtct gtggggcaga cccggctact ttttggcagt ggatttccat acacagacga
       61 gatccctccc ccttccccca accccagctc tcccccaatc ccaaccctga cccagagagc
      121 actctgattt ggaaactgga ggacaaagcc atgtaaggtc tgtggatatc actgcagcca
      181 gctcagaccc gcctcccaac cctagctccg gcttccctgc tccttcccac cctggcaaaa
      241 gcagactaca aagaagctct gctattgcct agcgcctggg agaccccagc caaaaggagt
      301 ccatttctgg tagaagcctg tccatcaaga agcaatgacc cagaagacca ccctagtgct
      361 cctggctctg gctgtcatca ccatctttgc tttggtttgt gtcttgctag ctggcaggag
      421 cggagatggg ggtggactga gccaacctct tcattgcccc tctgttcttc ctagtgtcca
      481 gccccggaca caccctagcc agagccagcc gtttgcagac ctgagcccag aggagctgac
      541 agctgtgatg agcttcctga ccaagcacct ggggccaggg ctggtggatg cagcccaggc
      601 tcgaccctcg gacaactgtg tcttctcagt agagttgcag ctgcctgcca aggctgcagc
      661 cctggcccac ttggacagag gggggccccc acctgtgaga gaggcattgg ccatcatctt
      721 ctttggtgga caacccaagc ccaacgtgag tgagctggtg gtggggcccc tgcctcaccc
      781 ctcctacatg cgggatgtga ctgtggagcg ccacggcggc cccctgccct attaccggcg
      841 tcctgtgttg gacagagagt atcaggatat cgaggagatg atcttccaca gagagctgcc
      901 ccaagcttct ggactcctcc atcactgttg cttctacaaa caccagggac agaacctgct
      961 aacaatgact acagcccccc gtggtttgca atcaggggac cgggccacct ggtttggctt
     1021 gtattacaat ctctcagggg ctgggtttta ccctcacccc attggcttgg agcttctgat
     1081 agatcataag gccctggatc ctgccctgtg gaccatccag aaggtattct atcaaggccg
     1141 ttactatgag agtctcactc agctggagga ccagtttgag gctggcctgg tgaatgtggt
     1201 attggtccca aacaatggta caggtgggtc ctggtctcta aagtcctcag tgccaccggg
     1261 cccagctccc cctctgcagt tccatcccca gggaccccgg ttcagtgtcc aggggagcca
     1321 agtgtcttct tccttgtggg ctttttcttt tggccttgga gctttcagtg gcccaaggat
     1381 ctttgatatc cgctttcaag gggagagggt ggcctatgaa atcagtgtcc aggaggccat
     1441 agccctctac ggtggaaatt ccccagcatc aatgtcgacc tgctacgtgg acggtagctt
     1501 tggcattggc aaatactcta cccccctgat ccgaggggta gactgtcctt acctcgccac
     1561 ctatgtggac tggcacttcc ttctggaatc tcaggccccc aagacactac gtgatgcatt
     1621 ttgtgtgttt gaacagaacc agggcctccc actccggcgg caccactcag atttctactc
     1681 ccattatttt gggggtgttg tggggacggt gcttgtggtc agatccgtgt ctaccttgct
     1741 caattacgac tacatatggg acatggtctt ccaccccaat ggggccatag aagtcaaatt
     1801 ccacgccaca ggctatatca gctcagcttt cttcttcggt gctggtgaga agtttgggaa
     1861 ccgagttggg gcgcacacgc tgggcacggt acacacccac agcgctcact tcaaagtgga
     1921 tctggatgtg gcagggctga agaactgggc ctgggcagag gatatggctt ttgtccccac
     1981 gattgtacct tggcaaccgg agtaccagat gcagaggctg caggtgactc ggaagctgct
     2041 ggagacagag gaggaggctg ccttcccact ggggggcgcc accccacgct acctgtacct
     2101 ggccagtaac cacagcaaca agtggggtca taggcggggc taccgcatcc agatactcag
     2161 ctttgctgga aagcccttgc cccaggaaag tcccatagag aaagccttca cctgggggag
     2221 gtatcacttg gctgtgaccc agaggaagga ggaggagcct agcagctcta gcatcttcaa
     2281 ccagaacgac ccgtggaccc ccactgtgaa cttcaccgac ttcatcagca atgagaccat
     2341 tgctggagag gacttggtag cctgggtgac ggctggcttt ttgcacatcc ctcatgcaga
     2401 agatatcccc aacacggtga ctgcggggaa ctcagtgggc ttcttcctcc ggccgtataa
     2461 cttctttgac gaggacccct cctttcattc tgctgactcc atctatttcc gggagggcca
     2521 ggatgccacg gcctgtgagg ttaacccctt ggcttgcctg tcccagactg ccacctgtgc
     2581 ccccgaaatt cctgccttct cccatggggg ctttgcttac agagacaatt gaactgtttc
     2641 taagtatccc tccctcgctc ctgctcagac catgtgctca cttccccacg ccattaagtg
     2701 tccccaagat ggacaatcta gctaagagct gggaagtagc gcaacagccg ggcagtacac
     2761 agagcaattc gattgaagat ctggttcctt ctgtccccac atctttgatg tcccctctct
     2821 cttctgctgc cctccttgtc tctccctctc tgcttggagc atcctgagcc catggaaacc
     2881 tgatgcacag ggacactgaa ctttgttggt tgtgcctgta ctgagttcct gccttgggag
     2941 aatagccttg ttggagcctg gagtaatggc tatgttttgt tttgctttga atatggctcc
     3001 ttttccccac ccccaccgca ccccctattt ggctttcatt taaaagctta tgatagcttt
     3061 gaggactctg caatgaggat aactctctag agacccccaa agtagggtct ctctgagtct
     3121 ctcacatcca cagattcttc atctacatcc ctttcctact taagcctctt tcatttccat
     3181 tctctccctc tccctccccg ccccctctcc tttcctccct cccccctccc tcccctcttc
     3241 ctggagttcc tgcttgctca tacatgctag gattcctact cagtccaaaa gcgatgtccg
     3301 tcctaagagt tctctgagcc ctcattctca aactgcagtc tcttctcctg gacccgagtc
     3361 tgtggaaatc tcaaagatgt aatgcaaagc ctcatgggag aggaccaggc ttttctatct
     3421 cctaacgttc gtcacatatc aggaaggagt agggcttgtc cctgcggtag ccctgctttg
     3481 ccctctttac aagaagatgg aggtgctatg attatgacga atggttattt tattctatgg
     3541 ctctgctcca ctaatggctc tggtctctgt gcagtagcct gcaggagcca gctcgggaca
     3601 gtgagatagg atggggtctg cccaatcaga agcaggcatg caaatgagcc tgagtctgat
     3661 ctgccttggt gggacctgtt tcagggtttc tctttgctgc ttgtctttgc tgagacctgg
     3721 acaggggctg gtacacacat gactcaaaac aacagataca tcattcccta gcagtctggc
     3781 cagccccgtt gttaactaat gttattactg tagttaatgg aagaaaggct ggaaagatgt
     3841 gtgtgcactg ttcttgcaag gggcccaaat tccgttccca gcatccttat taaggtgctc
     3901 acaacaatct ataactctat ctccaggaga gccggtgccc tcttcagggg cacctaaact
     3961 taatgcacat accttcacac agacacatac atataaatac aaaataaaag aactcagcct
     4021 ggcacggtga cacatgactt taatcccagc attggaagtc agaggtagac agatctctga
     4081 gcatgagtcc agcctggtct acagagtgag ttccaggaca gccatagcta tacagagaaa
     4141 ccctgtcttg caaaacaaaa acaaacaaac caaaagagag ttctttaaag acaaaagaaa
     4201 agctaaaaat gagtaggcga taagtgtaca tttgtttatt tctgctgcat tccttgagaa
     4261 ctgagtaaga ccagttacct ctgaggagga agacagctga gagggaatca ggttctgcct
     4321 gcccttctga acatcatgga ttggaaccat gtgatcatat tgccccgtca aaataaataa
     4381 gtgggctata cactaa
//
