LOCUS       NM_029638               2673 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus amine oxidase, copper-containing 1 (Aoc1), transcript
            variant 3, mRNA.
ACCESSION   NM_029638
VERSION     NM_029638.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2673)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2673)
  AUTHORS   Karer,M., Rager-Resch,M., Haider,T., Petroczi,K., Gludovacz,E.,
            Borth,N., Jilma,B. and Boehm,T.
  TITLE     Diamine oxidase knockout mice are not hypersensitive to orally or
            subcutaneously administered histamine
  JOURNAL   Inflamm Res 71 (4), 497-511 (2022)
   PUBMED   35303133
REFERENCE   3  (bases 1 to 2673)
  AUTHORS   Boehm,T., Karer,M., Gludovacz,E., Petroczi,K., Resch,M.,
            Schuetzenberger,K., Klavins,K., Borth,N. and Jilma,B.
  TITLE     Simple, sensitive and specific quantification of diamine oxidase
            activity in complex matrices using newly discovered fluorophores
            derived from natural substrates
  JOURNAL   Inflamm Res 69 (9), 937-950 (2020)
   PUBMED   32488317
REFERENCE   4  (bases 1 to 2673)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2673)
  AUTHORS   Kirschner,K.M., Braun,J.F., Jacobi,C.L., Rudigier,L.J.,
            Persson,A.B. and Scholz,H.
  TITLE     Amine oxidase copper-containing 1 (AOC1) is a downstream target
            gene of the Wilms tumor protein, WT1, during kidney development
  JOURNAL   J Biol Chem 289 (35), 24452-24462 (2014)
   PUBMED   25037221
  REMARK    GeneRIF: findings suggest that WT1-dependent control of polyamine
            breakdown, which is mediated by changes in AOC1 expression, has a
            role in kidney organogenesis
REFERENCE   6  (bases 1 to 2673)
  AUTHORS   Garcia-Lopez,A., Llamusi,B., Orzaez,M., Perez-Paya,E. and
            Artero,R.D.
  TITLE     In vivo discovery of a peptide that prevents CUG-RNA hairpin
            formation and reverses RNA toxicity in myotonic dystrophy models
  JOURNAL   Proc Natl Acad Sci U S A 108 (29), 11866-11871 (2011)
   PUBMED   21730182
REFERENCE   7  (bases 1 to 2673)
  AUTHORS   Liang,X.H., Zhao,Z.A., Deng,W.B., Tian,Z., Lei,W., Xu,X.,
            Zhang,X.H., Su,R.W. and Yang,Z.M.
  TITLE     Estrogen regulates amiloride-binding protein 1 through
            CCAAT/enhancer-binding protein-beta in mouse uterus during embryo
            implantation and decidualization
  JOURNAL   Endocrinology 151 (10), 5007-5016 (2010)
   PUBMED   20668027
  REMARK    GeneRIF: Abp1 may be essential for mouse embryo implantation and
            decidualization.
REFERENCE   8  (bases 1 to 2673)
  AUTHORS   Lundwall,A., Malm,J., Clauss,A., Valtonen-Andre,C. and Olsson,A.Y.
  TITLE     Molecular cloning of complementary DNA encoding mouse seminal
            vesicle-secreted protein SVS I and demonstration of homology with
            copper amine oxidases
  JOURNAL   Biol Reprod 69 (6), 1923-1930 (2003)
   PUBMED   12930721
REFERENCE   9  (bases 1 to 2673)
  AUTHORS   Hou,P., Estrada,L., Kinley,A.W., Parsons,J.T., Vojtek,A.B. and
            Gorski,J.L.
  TITLE     Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia,
            directly interacts with cortactin and mAbp1 to modulate cell shape
  JOURNAL   Hum Mol Genet 12 (16), 1981-1993 (2003)
   PUBMED   12913069
REFERENCE   10 (bases 1 to 2673)
  AUTHORS   Anderson,M.G., Smith,R.S., Hawes,N.L., Zabaleta,A., Chang,B.,
            Wiggs,J.L. and John,S.W.
  TITLE     Mutations in genes encoding melanosomal proteins cause pigmentary
            glaucoma in DBA/2J mice
  JOURNAL   Nat Genet 30 (1), 81-85 (2002)
   PUBMED   11743578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY131896.1, AK146078.1 and AC159547.4.
            
            On Jun 6, 2009 this sequence version replaced NM_029638.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant (1). All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034215.1, AK144567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               BY131896.1         1-118
            119-1810            AK146078.1         278-1969
            1811-1811           AC159547.4         107742-107742       c
            1812-2673           AK146078.1         1971-2832
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.78 cM"
     gene            1..2673
                     /gene="Aoc1"
                     /gene_synonym="1600012D06Rik; Abp1; DAO"
                     /note="amine oxidase, copper-containing 1"
                     /db_xref="GeneID:76507"
                     /db_xref="MGI:MGI:1923757"
     exon            1..44
                     /gene="Aoc1"
                     /gene_synonym="1600012D06Rik; Abp1; DAO"
                     /inference="alignment:Splign:2.1.0"
     exon            45..1633
                     /gene="Aoc1"
                     /gene_synonym="1600012D06Rik; Abp1; DAO"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2319
                     /gene="Aoc1"
                     /gene_synonym="1600012D06Rik; Abp1; DAO"
                     /EC_number="1.4.3.22"
                     /note="amiloride-sensitive amine oxidase; ABP;
                     histaminase; amiloride binding protein 1 (amine oxidase,
                     copper-containing); amiloride-binding protein 1; amine
                     oxidase copper domain-containing protein 1; diamine
                     oxidase"
                     /codon_start=1
                     /product="diamine oxidase [copper-containing] precursor"
                     /protein_id="NP_083914.2"
                     /db_xref="CCDS:CCDS51767.1"
                     /db_xref="GeneID:76507"
                     /db_xref="MGI:MGI:1923757"
                     /translation="MRLAQMSLAFGWAAVILLLQTADTASAVTTPHDKARIFADLSPQ
                     EIKAVHSFLMSRKELGLESSKNLTLAKNSVFLIEMLLPKKKNVLKFLDEGRKSPVREA
                     RAIIFFGAQDHPNVTEFAVGPLPRPCYVQALSPRPGHHLSWSSRPISTAEYDLLYHML
                     NRAITPLHQFFLDTTGFSFLGCDDRFLTFTDVAPRGVESGQRRSWLIVQRYVEGYFLH
                     PTGLEILVDHSSTDVQDWRVEQLWYNGKFYNSPEELAQKYAVGEVEAVVLEEVVLEDP
                     LPGATEQPPLFSSYKPRGEFHTPVTVAGPHVVQPSGPRYKLEGNVVLYGDWSFSYRLR
                     SSSGLQIFNVLFGGERVAYEVSVQEAVALYGGHTPAGMQTKYIDVGWGLGSVTHELAP
                     GIDCPETATFLDAFHYYDSDGPVLYPRALCLFEMPTGVPLRRHFDSNFKGGFNFYAGL
                     KGYVLVLRTTSTVYNYDYIWDFIFYPNGVMETKMHATGYVHATFYTPEGLRHGTRLQT
                     HLLGNIHTHLVHYRVDLDVAGTKNSFRTLKTKLENITNPWSPSHSLVQPTLEQTQYSH
                     EHQAAFRFGQTLPKYLLFSSPQKNRWGHRRSYRLQIHSMAEQVLPPGWQEERAVTWAR
                     YPLAVTKYRESERYSSSLYNQNDPWDPPVVFEEFLRNNENIENEDLVAWVTVGFLHIP
                     HSEDVPNTATPGNCVGFLIRPFNFFEEDPSLASRDTVIVWPQDNGLNHVQRWIPENRD
                     CLVSPPFSYNGTYKPV"
     exon            1634..1919
                     /gene="Aoc1"
                     /gene_synonym="1600012D06Rik; Abp1; DAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2052
                     /gene="Aoc1"
                     /gene_synonym="1600012D06Rik; Abp1; DAO"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2673
                     /gene="Aoc1"
                     /gene_synonym="1600012D06Rik; Abp1; DAO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacaaagtc tgggagctgg ggagcgacgg agcagagcac acagagccat gaggctggca
       61 cagatgagtc tggccttcgg ctgggcagct gtcatattac ttctacagac ggcagacaca
      121 gcatctgctg tgacgactcc tcatgacaaa gcaaggatat ttgcagacct gagcccccag
      181 gagataaagg ctgtgcacag cttcctgatg agcagaaagg agctggggct ggagtcatcc
      241 aagaatctga ctttggccaa gaactccgtg tttctcattg agatgctact gccaaaaaag
      301 aagaatgtgc tgaaattttt ggatgaagga agaaaaagtc ctgtccggga agccagggcc
      361 atcatcttct tcggtgccca ggatcacccc aatgtcactg agtttgctgt ggggcccctg
      421 ccacggccct gctatgttca agcactgtcc cccaggccag ggcaccatct gtcctggtca
      481 tcaagaccca tctccacagc ggagtatgac ctcctctacc acatgctgaa cagagccatc
      541 acgcctctgc accagttttt ccttgacact actggcttct cattcctagg ctgcgatgac
      601 cggttcttga cttttacgga tgtagcgccg cgtggtgtgg agtctggtca gcgtagaagc
      661 tggcttatcg tgcagcgcta tgtggaaggc tacttcctgc atcccacagg gctggagatc
      721 cttgtagatc atagcagcac agatgtccag gactggagag tggaacagct ctggtataac
      781 ggcaagttct acaacagccc agaggaactg gctcagaaat acgcagttgg agaagtggag
      841 gcagtggttc tggaggaagt ggttctcgag gacccactgc cgggtgccac agagcagcca
      901 ccactcttct cttcctacaa gccccggggg gaattccaca cgccagtcac tgttgcaggc
      961 ccccacgttg tccagcccag tggccccaga tataagctag agggcaacgt tgtgctctac
     1021 ggagactgga gcttctctta ccggctaaga tcctcttctg ggctgcagat ctttaatgta
     1081 ctctttggag gtgagcgtgt tgcctatgag gtcagcgtgc aggaggctgt ggcactatat
     1141 ggaggacaca cacctgcagg catgcagact aagtatattg atgttggttg gggcctgggc
     1201 agtgtcactc acgagctggc ccctggtatt gactgtccag agaccgctac tttcctggat
     1261 gctttccact attatgacag cgatggccct gtcctttatc cacgcgctct gtgcctcttt
     1321 gagatgccca caggggtacc ccttaggcgc cactttgact caaactttaa aggtggcttc
     1381 aacttctatg cgggtttgaa aggatatgtg ctggtgctac ggacgacatc gacagtctat
     1441 aattatgact atatctggga tttcatcttc taccctaatg gtgtgatgga gaccaagatg
     1501 catgccactg gatatgtcca cgcaaccttc tacacccctg agggactgcg ccatggcact
     1561 cgcttacaaa cccacctgct tggcaacatc cacacccacc tggtgcacta ccgtgttgac
     1621 ctggacgtgg caggcaccaa gaacagcttc cggacactga agacaaagct ggaaaacatc
     1681 accaatccct ggagcccaag tcactcccta gtccagccca cacttgagca gacccagtac
     1741 tcccacgagc accaggctgc attccgcttt ggacagactc tgcccaagta cctgctcttt
     1801 agcagccccc aaaagaaccg ttggggccac aggcggagct accgcctgca gatccactct
     1861 atggctgagc aggtgctacc accaggttgg caggaggagc gggctgtcac ttgggccagg
     1921 tatcccttgg ctgtgacaaa gtatcgggaa tctgaacgct acagcagcag cctctacaac
     1981 cagaatgacc cctgggatcc ccctgtggtt tttgaggagt tccttcggaa caacgagaac
     2041 attgaaaatg aggatctggt ggcctgggtg acagtaggct tcctgcacat ccctcactca
     2101 gaggatgtcc ccaacacagc cacacctgga aattgtgtgg gcttcttgat ccggccattc
     2161 aacttcttcg aggaggatcc atccctggca tctagagaca ctgtgatagt gtggccccag
     2221 gacaacggtc tcaaccatgt tcagcgctgg atccctgaga acagggactg cttggtgtct
     2281 cctcctttta gctacaatgg gacctacaag cctgtgtgat gggtctgacc ccagcctctg
     2341 aagcatatcc ccagattctc acaaacactg gaaaatcaaa cacacaaaca aacaaacaaa
     2401 caaaacttct gtttctaccc tgcaggctgc tttttagcag catgtgaggg ctggctctac
     2461 tcctgtttta ttaccatacc tgccaaagac ttccatgacc aatgcaaagg aagatcacag
     2521 aattctcttc aggtgggttg tgggggtggt ggttaaaaca tttgaggatt ttctcttcct
     2581 gtaaggagac tttgggggaa attgtctcac ctcaacgatg ggcaggagta aagaaactca
     2641 tgtgaaaatc taataaaatg acctttgccc ttt
//
