LOCUS       NM_012054               2923 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus acyloxyacyl hydrolase (Aoah), transcript variant 1,
            mRNA.
ACCESSION   NM_012054
VERSION     NM_012054.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2923)
  AUTHORS   Wu,Z., Deng,B., Shen,Y., Li,X., Li,J., Li,Y., Ma,S., Pan,Y. and
            Ding,F.
  TITLE     Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition
            of Tubular CD74-Macrophage Crosstalk
  JOURNAL   Int J Biol Sci 20 (8), 3061-3075 (2024)
   PUBMED   38904010
  REMARK    GeneRIF: Acyloxyacyl Hydrolase Protects against Kidney Injury via
            Inhibition of Tubular CD74-Macrophage Crosstalk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2923)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2923)
  AUTHORS   Cheng,X., Jiang,W., Chen,Y., Zou,B., Wang,Z., Gan,L., Xiao,Z.,
            Li,C., Yu,C.Y., Lu,Y., Han,Z., Zeng,J., Gu,J., Chu,T., Fu,M.,
            Chu,Y., Zhang,W., Tang,J. and Lu,M.
  TITLE     Acyloxyacyl hydrolase promotes pulmonary defense by preventing
            alveolar macrophage tolerance
  JOURNAL   PLoS Pathog 19 (7), e1011556 (2023)
   PUBMED   37498977
  REMARK    GeneRIF: Acyloxyacyl hydrolase promotes pulmonary defense by
            preventing alveolar macrophage tolerance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2923)
  AUTHORS   Cheng,X., Song,X., Li,Z., Yuan,C., Lei,X., Feng,M., Hong,Z.,
            Zhang,L. and Hong,D.
  TITLE     Acyloxyacyl hydrolase deficiency induces chronic inflammation and
            bone loss in male mice
  JOURNAL   J Mol Med (Berl) 100 (11), 1599-1616 (2022)
   PUBMED   36112153
  REMARK    GeneRIF: Acyloxyacyl hydrolase deficiency induces chronic
            inflammation and bone loss in male mice.
REFERENCE   5  (bases 1 to 2923)
  AUTHORS   Rahman-Enyart,A., Yang,W., Yaggie,R.E., White,B.A., Welge,M.,
            Auvil,L., Berry,M., Bushell,C., Rosen,J.M., Rudick,C.N.,
            Schaeffer,A.J. and Klumpp,D.J.
  TITLE     Acyloxyacyl hydrolase is a host determinant of gut
            microbiome-mediated pelvic pain
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 321 (3), R396-R412 (2021)
   PUBMED   34318715
REFERENCE   6  (bases 1 to 2923)
  AUTHORS   Lu,M., Varley,A.W., Ohta,S., Hardwick,J. and Munford,R.S.
  TITLE     Host inactivation of bacterial lipopolysaccharide prevents
            prolonged tolerance following gram-negative bacterial infection
  JOURNAL   Cell Host Microbe 4 (3), 293-302 (2008)
   PUBMED   18779055
  REMARK    GeneRIF: Recovery from the tolerant state induced by Gram-negative
            bacteria is greatly delayed in in mice that lack AOAH, a lipase
            that partially deacylates the bacterial cell-wall
            lipopolysaccharide.
REFERENCE   7  (bases 1 to 2923)
  AUTHORS   Shao,B., Lu,M., Katz,S.C., Varley,A.W., Hardwick,J., Rogers,T.E.,
            Ojogun,N., Rockey,D.C., Dematteo,R.P. and Munford,R.S.
  TITLE     A host lipase detoxifies bacterial lipopolysaccharides in the liver
            and spleen
  JOURNAL   J Biol Chem 282 (18), 13726-13735 (2007)
   PUBMED   17322564
REFERENCE   8  (bases 1 to 2923)
  AUTHORS   Lu,M., Zhang,M., Takashima,A., Weiss,J., Apicella,M.A., Li,X.H.,
            Yuan,D. and Munford,R.S.
  TITLE     Lipopolysaccharide deacylation by an endogenous lipase controls
            innate antibody responses to Gram-negative bacteria
  JOURNAL   Nat Immunol 6 (10), 989-994 (2005)
   PUBMED   16155573
REFERENCE   9  (bases 1 to 2923)
  AUTHORS   Feulner,J.A., Lu,M., Shelton,J.M., Zhang,M., Richardson,J.A. and
            Munford,R.S.
  TITLE     Identification of acyloxyacyl hydrolase, a
            lipopolysaccharide-detoxifying enzyme, in the murine urinary tract
  JOURNAL   Infect Immun 72 (6), 3171-3178 (2004)
   PUBMED   15155618
  REMARK    GeneRIF: produced by renal cortical tubule cells and secreted into
            urine, where it can deacylate lipopolysaccharides, a mechanism to
            limit inflammatory response to gram-negative bacteria in urinary
            tract
REFERENCE   10 (bases 1 to 2923)
  AUTHORS   Lu,M., Zhang,M., Kitchens,R.L., Fosmire,S., Takashima,A. and
            Munford,R.S.
  TITLE     Stimulus-dependent deacylation of bacterial lipopolysaccharide by
            dendritic cells
  JOURNAL   J Exp Med 197 (12), 1745-1754 (2003)
   PUBMED   12810692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC165956.4, AK084452.1 and
            AA763211.1.
            
            On Aug 8, 2013 this sequence version replaced NM_012054.3.
            
            Summary: This genes encodes an enzyme that catalyzes the hydrolysis
            of acyloxylacyl-linked fatty acyl chains from bacterial
            lipopolysaccharides. The encoded protein modulates host
            inflammatory response to gram-negative bacteria. The proprotein is
            further cleaved into a large and small chain that interact in a
            heterodimer. Alternative splicing results in multiple transcript
            variants for this gene. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084452.1, AK085343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC165956.4         209593-209598
            7-2921              AK084452.1         2-2916
            2922-2923           AA763211.1         334-335
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.49 cM"
     gene            1..2923
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /note="acyloxyacyl hydrolase"
                     /db_xref="GeneID:27052"
                     /db_xref="MGI:MGI:1350928"
     exon            1..405
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..2006
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /EC_number="3.1.1.77"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="acyloxyacyl hydrolase isoform 1 preproprotein"
                     /protein_id="NP_036184.1"
                     /db_xref="CCDS:CCDS26266.1"
                     /db_xref="GeneID:27052"
                     /db_xref="MGI:MGI:1350928"
                     /translation="MKFPWKVFKTTLLLLLLSHSLASVPSEDQPGDSYSHGQSCLGCV
                     VLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEAMK
                     ADVVCYALEFCKRGAVQPQCHLYPLPQEAWESALEKARQVLRRSSTMKYPRSGRNICS
                     LPFLTKICQKIELSIKKAVPFKDIDSDKHSVFPTLRGYHWRGRDCNDSDKTVYPGRRP
                     DNWDIHQDSNCNGIWGIDPKDGIPYEKKFCEGSQPRGIILLGDSAGAHFHIPPEWLTA
                     SQMSVNSFLNLPSALTDELNWPQLSGVTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQ
                     SISKNGASSRNLKNFIESLSRNQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMY
                     ANVMQTLTHLNSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFSFL
                     RCLQLNPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLFYVDFAFHEII
                     EDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQLQWPHVLGKENPFNSQIEE
                     VFGDQGGH"
     exon            406..501
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            502..568
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            569..668
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            669..728
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            729..799
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            800..860
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            861..931
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            932..980
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1029
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1124
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1216
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1299
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1336
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1411
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1584
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1643
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1703
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1800
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1877
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2923
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2919
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /note="major polyA site"
ORIGIN      
        1 caatgtgcaa ctcgggtatt tctttttcct gaagtctttg ctcagaggga ctgccttact
       61 agaacttctc cagcccttcc agatctggac atctgaactt ctctcagaca tggcagaata
      121 gctactgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttgcaca gtgtgctcga
      181 ggcagtgtgc attggggtgt ggtaactaca gaggggccaa gcaacattga gaagtggagt
      241 gatcttgtgg tccaagagtg tggttcctgg tacagctcag gatgaagttt ccctggaaag
      301 tcttcaagac cacccttctg cttcttctgc tctctcactc attggcctct gtgccctctg
      361 aggaccagcc aggtgacagc tactcccatg gccaaagctg tttagggtgt gtggtactgg
      421 tatctgtgat tgagcaactg gctgaagttc acaactcttc agtccaggtg gcgatggaga
      481 gactctgcag ctacctgcct gaaaagctgt tcttgaagac cgcctgctat ttcttggttc
      541 agacatttgg ctcagacatc ataaaactac tcgatgaagc tatgaaggct gatgtggtgt
      601 gctatgctct ggaattttgc aagcggggtg ctgtccaacc acagtgtcat ctctacccac
      661 ttccccagga ggcctgggag tctgcactgg agaaggcgag acaagtcctc aggaggtcct
      721 ctaccatgaa atatcccaga agtggtcgta acatttgttc cctaccattt ttgaccaaga
      781 tctgccagaa aattgaatta tctataaaga aggccgtgcc attcaaagac atagattcag
      841 acaagcacag tgttttccca acgctgcggg gctaccactg gcgagggcgt gactgtaatg
      901 acagtgacaa gacagtgtac ccgggcagaa ggccagacaa ctgggatatc catcaggact
      961 ccaactgtaa tggcatctgg ggtattgatc cgaaagatgg aattccatat gagaagaaat
     1021 tctgtgaagg ttcacagccc aggggaatca ttttgctggg agactcagct ggggctcatt
     1081 ttcacatccc ccctgaatgg ctgacagctt cacagatgtc tgtgaactcc ttcctcaacc
     1141 tgccgtccgc ccttaccgat gagctcaact ggccccaact ctctggtgta actggatttc
     1201 tggactccac gagtggaatt gaagaaaaat ccatttacca tcgtttgaga aagagaaacc
     1261 attgcaatca cagagactat cagagtatct caaaaaatgg tgcatcttcc agaaatctga
     1321 agaattttat tgaaagcttg tctaggaacc aggcatcaga ccatccagcc attgtccttt
     1381 atgccatgat tggaaacgat gtttgtaatt cgaaagctga cacagtacca gaaatgacca
     1441 ctcctgaaca aatgtacgcc aacgtcatgc agactctgac acatctaaat tctcacctgc
     1501 ccaatggcag ccacgttatt ttatacggct taccagatgg aacttttctc tgggatagct
     1561 tgcacaaccg ataccaccct ctaggccagc taaataaaga tgtgacctat gcacagttct
     1621 tctcctttct aagatgcctg cagctcaatc cctgtaacgg ctggatgtct tccaacaaga
     1681 ccctccggac tctcacttca gagagagccg aacaactctc caatacactg aaaaaaattg
     1741 caaccaccga gacgtttgca aacttcgatc ttttctacgt ggattttgcc ttccatgaaa
     1801 taatagagga ctggcagaaa agaggtggac agccatggca gcttattgaa cctgtggatg
     1861 gattccaccc caatgaggtg gcttcacttc tgcaagcaaa tcgtgtctgg gaaaagatac
     1921 agcttcaatg gcctcatgtc ctgggaaagg agaatccatt caactctcag attgaagagg
     1981 tgtttggaga ccaaggagga cactgagtct ccgcggaagg cgcatcactg ggggagagaa
     2041 aggtggataa accctcccac ctgctcattc caggggctgc tgtgcaacag gcccagaaga
     2101 ccttcttcag cagcctctct gcagaccact ttcctctcag ttggggacag accttaatgg
     2161 caatgtccat taacagcaat gtcctttgct tcccacagca agtcttctct gttcaactct
     2221 gaaacacttt ttccaatttt ttattaggta ttttcttcat ttatatttca gatgctatcc
     2281 cgaaaatccc ctttaagctg attatcttgg gtatttgtta tagtaatgaa aaacttacgt
     2341 cacaataaat aatctagaga tgattgaaag tacataggca tgtgtaggtt atatacaaat
     2401 actatatacc attttctaca aggatcctga tcagagttcc tgtgcatata tgaacttcaa
     2461 tctgtactag agtcttctct ccatctctgt gggcaattga ctccaggact tgcaaggata
     2521 ccagggtctg aggacattca agttccttgt aaagggaagt ctagcaatca ctttcttttc
     2581 tgtgtctcac tttcctcagc cttttctgag atgccacaga tttagggttc aatctttgta
     2641 cgcccagagg tacccctgtg cttggtgtag cccacaggta tgagacagtt ggccccacag
     2701 tggcaagtag gaactattga aatcatgcac aagtctcctc agttactggc atttggtgga
     2761 cttcttacat cagccccctt aacctacaac aatgacctga acacattctt atagcaatgc
     2821 tggcccaccc ccacccctta cagccctgat tctcttgtcc tgcttccaaa ataaactgtc
     2881 tgcactccaa tatttgcctc aataaagtca aagttctaag gtt
//
