LOCUS       NM_001281854             936 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus acyloxyacyl hydrolase (Aoah), transcript variant 2,
            mRNA.
ACCESSION   NM_001281854
VERSION     NM_001281854.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 936)
  AUTHORS   Wu,Z., Deng,B., Shen,Y., Li,X., Li,J., Li,Y., Ma,S., Pan,Y. and
            Ding,F.
  TITLE     Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition
            of Tubular CD74-Macrophage Crosstalk
  JOURNAL   Int J Biol Sci 20 (8), 3061-3075 (2024)
   PUBMED   38904010
  REMARK    GeneRIF: Acyloxyacyl Hydrolase Protects against Kidney Injury via
            Inhibition of Tubular CD74-Macrophage Crosstalk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 936)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 936)
  AUTHORS   Cheng,X., Jiang,W., Chen,Y., Zou,B., Wang,Z., Gan,L., Xiao,Z.,
            Li,C., Yu,C.Y., Lu,Y., Han,Z., Zeng,J., Gu,J., Chu,T., Fu,M.,
            Chu,Y., Zhang,W., Tang,J. and Lu,M.
  TITLE     Acyloxyacyl hydrolase promotes pulmonary defense by preventing
            alveolar macrophage tolerance
  JOURNAL   PLoS Pathog 19 (7), e1011556 (2023)
   PUBMED   37498977
  REMARK    GeneRIF: Acyloxyacyl hydrolase promotes pulmonary defense by
            preventing alveolar macrophage tolerance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 936)
  AUTHORS   Cheng,X., Song,X., Li,Z., Yuan,C., Lei,X., Feng,M., Hong,Z.,
            Zhang,L. and Hong,D.
  TITLE     Acyloxyacyl hydrolase deficiency induces chronic inflammation and
            bone loss in male mice
  JOURNAL   J Mol Med (Berl) 100 (11), 1599-1616 (2022)
   PUBMED   36112153
  REMARK    GeneRIF: Acyloxyacyl hydrolase deficiency induces chronic
            inflammation and bone loss in male mice.
REFERENCE   5  (bases 1 to 936)
  AUTHORS   Rahman-Enyart,A., Yang,W., Yaggie,R.E., White,B.A., Welge,M.,
            Auvil,L., Berry,M., Bushell,C., Rosen,J.M., Rudick,C.N.,
            Schaeffer,A.J. and Klumpp,D.J.
  TITLE     Acyloxyacyl hydrolase is a host determinant of gut
            microbiome-mediated pelvic pain
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 321 (3), R396-R412 (2021)
   PUBMED   34318715
REFERENCE   6  (bases 1 to 936)
  AUTHORS   Lu,M., Varley,A.W., Ohta,S., Hardwick,J. and Munford,R.S.
  TITLE     Host inactivation of bacterial lipopolysaccharide prevents
            prolonged tolerance following gram-negative bacterial infection
  JOURNAL   Cell Host Microbe 4 (3), 293-302 (2008)
   PUBMED   18779055
  REMARK    GeneRIF: Recovery from the tolerant state induced by Gram-negative
            bacteria is greatly delayed in in mice that lack AOAH, a lipase
            that partially deacylates the bacterial cell-wall
            lipopolysaccharide.
REFERENCE   7  (bases 1 to 936)
  AUTHORS   Shao,B., Lu,M., Katz,S.C., Varley,A.W., Hardwick,J., Rogers,T.E.,
            Ojogun,N., Rockey,D.C., Dematteo,R.P. and Munford,R.S.
  TITLE     A host lipase detoxifies bacterial lipopolysaccharides in the liver
            and spleen
  JOURNAL   J Biol Chem 282 (18), 13726-13735 (2007)
   PUBMED   17322564
REFERENCE   8  (bases 1 to 936)
  AUTHORS   Lu,M., Zhang,M., Takashima,A., Weiss,J., Apicella,M.A., Li,X.H.,
            Yuan,D. and Munford,R.S.
  TITLE     Lipopolysaccharide deacylation by an endogenous lipase controls
            innate antibody responses to Gram-negative bacteria
  JOURNAL   Nat Immunol 6 (10), 989-994 (2005)
   PUBMED   16155573
REFERENCE   9  (bases 1 to 936)
  AUTHORS   Feulner,J.A., Lu,M., Shelton,J.M., Zhang,M., Richardson,J.A. and
            Munford,R.S.
  TITLE     Identification of acyloxyacyl hydrolase, a
            lipopolysaccharide-detoxifying enzyme, in the murine urinary tract
  JOURNAL   Infect Immun 72 (6), 3171-3178 (2004)
   PUBMED   15155618
  REMARK    GeneRIF: produced by renal cortical tubule cells and secreted into
            urine, where it can deacylate lipopolysaccharides, a mechanism to
            limit inflammatory response to gram-negative bacteria in urinary
            tract
REFERENCE   10 (bases 1 to 936)
  AUTHORS   Lu,M., Zhang,M., Kitchens,R.L., Fosmire,S., Takashima,A. and
            Munford,R.S.
  TITLE     Stimulus-dependent deacylation of bacterial lipopolysaccharide by
            dendritic cells
  JOURNAL   J Exp Med 197 (12), 1745-1754 (2003)
   PUBMED   12810692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC165956.4, AK084452.1,
            AK150886.1 and AC123062.4.
            
            Summary: This genes encodes an enzyme that catalyzes the hydrolysis
            of acyloxylacyl-linked fatty acyl chains from bacterial
            lipopolysaccharides. The encoded protein modulates host
            inflammatory response to gram-negative bacteria. The proprotein is
            further cleaved into a large and small chain that interact in a
            heterodimer. Alternative splicing results in multiple transcript
            variants for this gene. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (2) lacks multiple 3' coding exons
            and contains an alternate 3' exon, resulting in a distinct 3'
            coding region and 3' UTR, compared to variant 1. The encoded
            isoform (2) is shorter and has a distinct C-terminus, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089580.1, AK152346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC165956.4         209593-209598
            7-164               AK084452.1         2-159
            165-934             AK150886.1         141-910
            935-936             AC123062.4         104737-104738       c
FEATURES             Location/Qualifiers
     source          1..936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.49 cM"
     gene            1..936
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /note="acyloxyacyl hydrolase"
                     /db_xref="GeneID:27052"
                     /db_xref="MGI:MGI:1350928"
     exon            1..405
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..719
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /EC_number="3.1.1.77"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="acyloxyacyl hydrolase isoform 2 preproprotein"
                     /protein_id="NP_001268783.1"
                     /db_xref="CCDS:CCDS88418.1"
                     /db_xref="GeneID:27052"
                     /db_xref="MGI:MGI:1350928"
                     /translation="MKFPWKVFKTTLLLLLLSHSLASVPSEDQPGDSYSHGQSCLGCV
                     VLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEAMK
                     ADVVCYALEFCKRGAVQPQCHLYPLPQDNQLISRCPERFRDQY"
     exon            406..501
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            502..568
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            569..668
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            669..936
                     /gene="Aoah"
                     /gene_synonym="4930433E13Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatgtgcaa ctcgggtatt tctttttcct gaagtctttg ctcagaggga ctgccttact
       61 agaacttctc cagcccttcc agatctggac atctgaactt ctctcagaca tggcagaata
      121 gctactgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttgcaca gtgtgctcga
      181 ggcagtgtgc attggggtgt ggtaactaca gaggggccaa gcaacattga gaagtggagt
      241 gatcttgtgg tccaagagtg tggttcctgg tacagctcag gatgaagttt ccctggaaag
      301 tcttcaagac cacccttctg cttcttctgc tctctcactc attggcctct gtgccctctg
      361 aggaccagcc aggtgacagc tactcccatg gccaaagctg tttagggtgt gtggtactgg
      421 tatctgtgat tgagcaactg gctgaagttc acaactcttc agtccaggtg gcgatggaga
      481 gactctgcag ctacctgcct gaaaagctgt tcttgaagac cgcctgctat ttcttggttc
      541 agacatttgg ctcagacatc ataaaactac tcgatgaagc tatgaaggct gatgtggtgt
      601 gctatgctct ggaattttgc aagcggggtg ctgtccaacc acagtgtcat ctctacccac
      661 ttccccagga caaccaactc atctcaagat gtccagaacg tttcagggat cagtactaaa
      721 aattccacat cctaagaaaa tctgatcagc tggtatctct catccaagct tacctatcct
      781 tactcaaaag atgactataa taaaatatta ccctcacaac tttcttaagt aaaacaagta
      841 tatatatata tatatatata tatatatatg atcagcatgt taccaaccat actatacaca
      901 gataatacat taaaatatta ctaaaatgaa atctaa
//
