LOCUS       NM_001379545            2225 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus annexin A9 (Anxa9), transcript variant 3, mRNA.
ACCESSION   NM_001379545 XM_011240235
VERSION     NM_001379545.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2225)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2225)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2225)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2225)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   5  (bases 1 to 2225)
  AUTHORS   Boczonadi,V. and Maatta,A.
  TITLE     Annexin A9 is a periplakin interacting partner in membrane-targeted
            cytoskeletal linker protein complexes
  JOURNAL   FEBS Lett 586 (19), 3090-3096 (2012)
   PUBMED   22841549
REFERENCE   6  (bases 1 to 2225)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   7  (bases 1 to 2225)
  AUTHORS   Chlystun,M., Markoff,A. and Gerke,V.
  TITLE     Structural and functional characterisation of the mouse annexin A9
            promoter
  JOURNAL   Biochim Biophys Acta 1742 (1-3), 141-149 (2004)
   PUBMED   15590064
REFERENCE   8  (bases 1 to 2225)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140190.3.
            
            On Apr 9, 2020 this sequence version replaced XM_011240235.2.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longer isoform (a). Variants 1-3 all
            encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.351779.1,
                                           SRR13422590.441256.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AC140190.3         201239-201616       c
            379-474             AC140190.3         193510-193605       c
            475-565             AC140190.3         192768-192858       c
            566-662             AC140190.3         192298-192394       c
            663-757             AC140190.3         189422-189516       c
            758-871             AC140190.3         189102-189215       c
            872-962             AC140190.3         188771-188861       c
            963-1042            AC140190.3         187747-187826       c
            1043-1102           AC140190.3         187528-187587       c
            1103-1187           AC140190.3         186967-187051       c
            1188-1283           AC140190.3         186738-186833       c
            1284-1342           AC140190.3         186589-186647       c
            1343-1465           AC140190.3         183673-183795       c
            1466-2225           AC140190.3         182529-183288       c
FEATURES             Location/Qualifiers
     source          1..2225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..2225
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /note="annexin A9"
                     /db_xref="GeneID:71790"
                     /db_xref="MGI:MGI:1923711"
     exon            1..378
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            379..474
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            475..565
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..1528
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /note="isoform a is encoded by transcript variant 3;
                     annexin-9; annexin-31; annexin XXXI"
                     /codon_start=1
                     /product="annexin A9 isoform a"
                     /protein_id="NP_001366474.1"
                     /db_xref="GeneID:71790"
                     /db_xref="MGI:MGI:1923711"
                     /translation="MSASCGPLGTSLTQEILSSLGLADKTAAWGTLGTLRTFLSFSVD
                     KDVQRLLKAIAGQGVDYDTIVDVLTNRSREQRQLISRAFQERTKQDLLKSLQAALSGN
                     LEKIVVALLQPAAQFDAQELRTALKTSGSAEDVALEILATRAAPGLQACLAVYKHDFQ
                     VEAEEDIRTETNGILQDLLLALSKGDRESYSGIIDYNLEEQDVRALQQAGESSTAGQW
                     VLLLTQRSPEHLIRVFDQYRRCTGQELEDAIRNCFHGDAQLALISLASMLRNTALYFA
                     NKLHQALQETEPNFQVLTRVLISRSESDLLSIRAEFKKKFGKSLYSSLQDVVRGDCRS
                     ALLALCRAEDI"
     exon            566..662
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            663..757
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            758..871
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            872..962
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1042
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1102
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1187
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1283
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1342
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1465
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..2225
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2002..2007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      2022
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /note="major polyA site"
     regulatory      2201..2206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2225
                     /gene="Anxa9"
                     /gene_synonym="1110003P15Rik; 2310069F17Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggccgagcc cagtagcgga gctgagttgg gtgtgggccg cggccgggcg gggcccggtg
       61 cccggaaccc tgcgctgcgc ctatggagcg gaggagcccc gacggggcgg gtggcacgtg
      121 ccccgcaggg cgcctgggtc tctgagtggc gcggttgcgg cccacccgga cattggtcag
      181 ggaccccctg gtgcttgagc ccagagcagt tcagagctgg ctgcctctgc ccaaccccgc
      241 ggccctggtg tggtcggcga cctcagccca tgatttaccc ccgggttgaa tgctacaatc
      301 ccatcgtccg gcttcactgg gcatcagagg aagggtgcac gcggagaaaa ccctgcacag
      361 atcccgatgc tccctacggc tgtccactcc tcctcttctc tgcccggcta ctccggagct
      421 ggtgccttca cgacgctgaa ccataacacc catcttattt tcagcacctt tcagggaagc
      481 cagctgcacc atgtctgcga gctgtggacc actgggaaca tctctgactc aggagatcct
      541 cagctccctg ggtcttgccg acaagaccgc agcctggggg accctgggca ccctcaggac
      601 gttcttgagt ttcagtgtgg acaaggatgt acaaagactg ctgaaggcta tcgcaggcca
      661 aggtgtggac tatgatacca ttgtggatgt actgaccaat cggagcagag agcaaagaca
      721 gctcatttct cgagcctttc aagagcgcac caaacaggat ctattgaagt ccttgcaggc
      781 agcgctctct ggcaatctgg agaaaatcgt ggtggctctc ctacagcctg cagcccaatt
      841 tgatgcccag gaactgagga cagccttgaa gacctctggt tctgctgagg atgtagcctt
      901 ggaaatcctg gccacccgag cagcgcccgg actgcaggca tgcctggcag tatataagca
      961 tgacttccag gtggaggctg aggaagatat caggactgag accaatggta tcctgcagga
     1021 cctgcttctg gccctgagca agggggaccg tgagagctat tctggaatta ttgattacaa
     1081 cttggaagaa caagatgtcc gggcacttca gcaggctgga gaatccagta cagcagggca
     1141 atgggtcctg ctccttacac aacgcagtcc tgaacacctc atccgagtgt ttgatcagta
     1201 ccggagatgc actggccagg aactggagga tgctatccgg aactgtttcc atggagatgc
     1261 ccagctggct ctgatcagcc tagcttccat gttgagaaac acagcgctgt actttgctaa
     1321 caaactccac caagcccttc aggaaactga gcctaatttc caagtgctga cgcgggtcct
     1381 tatctcccga agcgagagtg accttctaag cattcgggct gagttcaaga agaaatttgg
     1441 gaagtctctc tattcttctc ttcaggatgt agtcagaggg gattgtcgtt cagcactact
     1501 ggccctgtgt agagctgaag atatctgaga ccttcctgac ccaccctgac gcgacactcg
     1561 aaaccgctga gattcccata tttggttgaa aacatggaag aaccccaagg aacaccatgc
     1621 accctggcct cctctcgagg ctggacctct gagttccttt ggatttccct cttctcagac
     1681 tggcatcttc cagctccatt ctagagagga gtaacgggag ttctctgaca gtctctgccc
     1741 tgctcaatcc ctcctaaggc cagaacatct ccctgggagt caaatgtttt ggcagttcac
     1801 catctttttg tttcctggtt aaagtctggg tggaggaggc catggatcag gaggaggcca
     1861 tggagttgag gtgcctttga agtatgctca gccattcaac aggaatcctg tttttacccc
     1921 agtactgcac ttaacagtta ccaacacacc ccactcctgg atcttctccc caggaaatct
     1981 cacgtaatta agaacagtaa aaagaaagag cggaagagcc aacatttggg ttccccctgc
     2041 tggctctgtg agaaatgaca ggcaacctgt cgcctccctg gctcctcccc tgttcacatt
     2101 cctcaaccgg gtcaaatatt ttactcccct gctccaaggt aggaacgcaa atctcaggaa
     2161 agaagtttta tttccaaacc tctaggaagg cattaaaaat aataaagata gaaactcaaa
     2221 ccaaa
//
