LOCUS       NM_013473               1892 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus annexin A8 (Anxa8), transcript variant 1, mRNA.
ACCESSION   NM_013473
VERSION     NM_013473.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1892)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1892)
  AUTHORS   Heitzig,N., Kuhnl,A., Grill,D., Ludewig,K., Schloer,S., Galla,H.J.,
            Grewal,T., Gerke,V. and Rescher,U.
  TITLE     Cooperative binding promotes demand-driven recruitment of AnxA8 to
            cholesterol-containing membranes
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (4), 349-358 (2018)
   PUBMED   29306076
REFERENCE   4  (bases 1 to 1892)
  AUTHORS   Herriges,M.J., Tischfield,D.J., Cui,Z., Morley,M.P., Han,Y.,
            Babu,A., Li,S., Lu,M., Cendan,I., Garcia,B.A., Anderson,S.A. and
            Morrisey,E.E.
  TITLE     The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain
            lung development and homeostasis
  JOURNAL   Genes Dev 31 (9), 889-903 (2017)
   PUBMED   28546511
REFERENCE   5  (bases 1 to 1892)
  AUTHORS   Iglesias,J.M., Cairney,C.J., Ferrier,R.K., McDonald,L., Soady,K.,
            Kendrick,H., Pringle,M.A., Morgan,R.O., Martin,F., Smalley,M.J.,
            Blyth,K. and Stein,T.
  TITLE     Annexin A8 identifies a subpopulation of transiently quiescent
            c-kit positive luminal progenitor cells of the ductal mammary
            epithelium
  JOURNAL   PLoS One 10 (3), e0119718 (2015)
   PUBMED   25803307
  REMARK    GeneRIF: Annexin A8 identifies a subpopulation of transiently
            quiescent c-kit positive luminal progenitor cells of the ductal
            mammary epithelium.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1892)
  AUTHORS   Crotti,T.N., O'Sullivan,R.P., Shen,Z., Flannery,M.R., Fajardo,R.J.,
            Ross,F.P., Goldring,S.R. and McHugh,K.P.
  TITLE     Bone matrix regulates osteoclast differentiation and annexin A8
            gene expression
  JOURNAL   J Cell Physiol 226 (12), 3413-3421 (2011)
   PUBMED   21344395
  REMARK    GeneRIF: Define a distinct bone-dependent genetic program
            associated with terminal osteoclast differentiation and identified
            Anxa8 as a gene strongly induced late in osteoclast
            differentiation, regulating formation of the cell's characteristic
            actin ring.
REFERENCE   7  (bases 1 to 1892)
  AUTHORS   Runkel,F., Michels,M., Franken,S. and Franz,T.
  TITLE     Specific expression of annexin A8 in adult murine stratified
            epithelia
  JOURNAL   J Mol Histol 37 (8-9), 353-359 (2006)
   PUBMED   17082908
  REMARK    GeneRIF: ANXA8 protein is most abundant in stratified epithelia of
            the postnatal mouse. Its location in the suprabasal layers suggests
            that ANXA8 may be associated with the terminal differentiation of
            epithelial cells in these tissues.
REFERENCE   8  (bases 1 to 1892)
  AUTHORS   Stein,T., Price,K.N., Morris,J.S., Heath,V.J., Ferrier,R.K.,
            Bell,A.K., Pringle,M.A., Villadsen,R., Petersen,O.W., Sauter,G.,
            Bryson,G., Mallon,E.A. and Gusterson,B.A.
  TITLE     Annexin A8 is up-regulated during mouse mammary gland involution
            and predicts poor survival in breast cancer
  JOURNAL   Clin Cancer Res 11 (19 Pt 1), 6872-6879 (2005)
   PUBMED   16203777
  REMARK    GeneRIF: Annexin A8 is involved in mouse mammary gland involution
            and progression of human breast cancer
REFERENCE   9  (bases 1 to 1892)
  AUTHORS   Williams,T.M., Williams,M.E., Kuick,R., Misek,D., McDonagh,K.,
            Hanash,S. and Innis,J.W.
  TITLE     Candidate downstream regulated genes of HOX group 13 transcription
            factors with and without monomeric DNA binding capability
  JOURNAL   Dev Biol 279 (2), 462-480 (2005)
   PUBMED   15733672
REFERENCE   10 (bases 1 to 1892)
  AUTHORS   Fernandez,M.P., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Morgan,R.O.
  TITLE     The genetic origin of mouse annexin VIII
  JOURNAL   Mamm Genome 9 (1), 8-14 (1998)
   PUBMED   9434938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164099.3, AK075870.1, AK009085.1 and AJ002390.1.
            
            On Aug 8, 2013 this sequence version replaced NM_013473.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ002390.1, AK009085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC164099.3         198420-198486
            68-599              AK075870.1         2-533
            600-704             AK009085.1         562-666
            705-810             AK075870.1         639-744
            811-963             AJ002390.1         787-939
            964-964             AK009085.1         926-926
            965-1892            AJ002390.1         941-1868
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.8 cM"
     gene            1..1892
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /note="annexin A8"
                     /db_xref="GeneID:11752"
                     /db_xref="MGI:MGI:1201374"
     exon            1..98
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1061
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     annexin VIII; annexin 8"
                     /codon_start=1
                     /product="annexin A8 isoform 1"
                     /protein_id="NP_038501.2"
                     /db_xref="CCDS:CCDS26932.1"
                     /db_xref="GeneID:11752"
                     /db_xref="MGI:MGI:1201374"
                     /translation="MAWWKAWVEQEGVSVKGSSHFNPDPDAETLYKAMKGIGTNEQAI
                     IDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYSYEAKEL
                     HDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSTLEEDIQGDTSGYLERILV
                     CLLQGSRDDVSGFVDPGLVLQDAQALHEAGEKIMGTDEMKFITILCTRSATHLMRVFE
                     EYEKIANKCIEDSIKSETHGSLEEAMLTVVKCTRNVHSYFAERLYYAMKGAGTRDGTL
                     IRNIVSRSEIDLNLIKGQFKKMYGKTLSSMIMADTSGYYKTALLNLVGTDL"
     exon            99..189
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            190..284
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            285..398
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            399..489
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            490..569
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            570..629
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            630..723
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            724..819
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            820..878
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1001
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1882
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1859..1864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /note="hexamer: CATAAA"
     polyA_site      1882
                     /gene="Anxa8"
                     /gene_synonym="Anx8"
                     /note="major polyA site"
ORIGIN      
        1 ggggagtagc tgtgtccagt cactgagcag aggccaacta gtgtttcttc atctccctgg
       61 gaaaagcagc agacaggatg gcctggtgga aagcctgggt tgaacaggag ggcgtcagcg
      121 tgaagggtag ttctcatttc aacccagacc ctgatgcaga gaccctctac aaagccatga
      181 aggggattgg aaccaatgag caggccatca tagacgtgct caccaagagg agcaatgtgc
      241 agaggcagca gattgccaag tccttcaagg ctcaatttgg aaaggacctc actgagacct
      301 taaagtcaga gctgagtggc aaatttgaga gactcatcgt ggccctcatg tacccgccat
      361 acagctacga ggccaaggag ctgcacgatg ccatgaaggg cttaggaacc aaagaaggag
      421 tcatcattga gatcctagct tctcggacca agaaccagct gagagagata atgaaggcat
      481 atgaggaaga ctatggatct accctggaag aagacatcca aggagacacg agtggctatc
      541 tggagcggat tctggtgtgt ctcctgcagg gcagcagaga tgatgtgagc ggctttgtgg
      601 atccaggact ggtcctccaa gatgcacagg ccctgcatga agcgggtgag aagattatgg
      661 gaaccgatga gatgaagttc atcactatcc tgtgcacacg cagtgccact cacctgatga
      721 gagtgttcga ggaatatgaa aaaattgcca acaagtgcat tgaggatagc atcaagagtg
      781 agacccatgg ttcgctggag gaggccatgc tcactgtggt gaaatgcacc cggaacgtcc
      841 acagctactt tgcagagaga ctctactacg ccatgaaggg agcagggaca cgtgatggaa
      901 cgctgataag gaacattgtt tccaggagtg agattgactt aaatcttatc aagggtcagt
      961 ttaagaagat gtacggcaag actctcagca gcatgatcat ggccgacacc agtggttact
     1021 acaagactgc cctgctgaac cttgtgggca ctgacctctg aaaatgtcaa aaaatagaac
     1081 aagggcaaga agtgtgagcc cagcccctgc agcttcagcc ccgaccatgg gtgggggtag
     1141 gggacacctc atctggcttt tagtcttctg ttgcccagtt tctgatgctt ctcatcccat
     1201 gcttctgacc cggatgatga gaccagcctg ggtttccctt ccacctctcc cgtcagtcat
     1261 ttctaggtat gtgtataccg cccaccctag cattacctct gagcaaacgg aaacatcaac
     1321 atgaagaaag aagcttgcag tgtcctgtgg gtcattcctt ccccttcaca caaaatctcc
     1381 tgggcacagg gcacacagat gccttggctc tgacccatct actgagtcag ggtcttcaga
     1441 ggaagaacca aggaacatgg atttctagca gttgtcttag ctgctaagca tcattatcag
     1501 gcagccagtg agcatgtggg agagcacctc tatgagagga cacggccgtg gatctgagaa
     1561 agggtcacat agctctgcca atcgggacac tcacttaacg gaaattgtta ggctctaggt
     1621 ggaggaaaat tcttacacca tcctaatagc acgcattaga tgggattaca aatccccgtc
     1681 ctgacccaag tacgctgtgg tctgagaaac tcgggcttgt ccagtcattc cctccatgct
     1741 gaagcttgca gactagggag ccgcccagcc ctgagcatga atcccatcct ctgatcgtgg
     1801 tctccgagcc tgaagaacat gacagaactc ttctcaatat tcgttgggct ttcagaatca
     1861 taaacatttg tactttcaaa aaaaaaaaaa aa
//
