LOCUS       NM_001374757            2824 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus annexin A7 (Anxa7), transcript variant 3, mRNA.
ACCESSION   NM_001374757 XM_006518453
VERSION     NM_001374757.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2824)
  AUTHORS   Manke,M.C., Geue,S., Coman,C., Peng,B., Kollotzek,F., Munzer,P.,
            Walker,B., Huber,S.M., Rath,D., Sickmann,A., Stegner,D.,
            Duerschmied,D., Lang,F., Nieswandt,B., Gawaz,M., Ahrends,R. and
            Borst,O.
  TITLE     ANXA7 Regulates Platelet Lipid Metabolism and Ca2+ Release in
            Arterial Thrombosis
  JOURNAL   Circ Res 129 (4), 494-507 (2021)
   PUBMED   34176316
  REMARK    GeneRIF: ANXA7 Regulates Platelet Lipid Metabolism and Ca(2+)
            Release in Arterial Thrombosis.
REFERENCE   2  (bases 1 to 2824)
  AUTHORS   Gilhooley,M.J., Hickey,D.G., Lindner,M., Palumaa,T., Hughes,S.,
            Peirson,S.N., MacLaren,R.E. and Hankins,M.W.
  TITLE     ON-bipolar cell gene expression during retinal degeneration:
            Implications for optogenetic visual restoration
  JOURNAL   Exp Eye Res 207, 108553 (2021)
   PUBMED   33811915
  REMARK    GeneRIF: ON-bipolar cell gene expression during retinal
            degeneration: Implications for optogenetic visual restoration.
REFERENCE   3  (bases 1 to 2824)
  AUTHORS   Alauddin,M., Salker,M.S., Umbach,A.T., Rajaxavier,J., Okumura,T.,
            Singh,Y., Wagner,A., Brucker,S.Y., Wallwiener,D., Brosens,J.J. and
            Lang,F.
  TITLE     Annexin A7 Regulates Endometrial Receptivity
  JOURNAL   Front Cell Dev Biol 8, 770 (2020)
   PUBMED   32923441
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2824)
  AUTHORS   Deng,Q., Li,L. and Jin,Y.
  TITLE     Long Noncoding RNAs Coregulated by Annexin A7 and JNK in
            Hepatocellular Carcinoma Cells Identified by Whole-Genome
            Expression Profiling
  JOURNAL   Biomed Res Int 2020, 5747923 (2020)
   PUBMED   32775428
  REMARK    GeneRIF: Long Noncoding RNAs Coregulated by Annexin A7 and JNK in
            Hepatocellular Carcinoma Cells Identified by Whole-Genome
            Expression Profiling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2824)
  AUTHORS   Wang,J., Huang,Y., Zhang,J., Xing,B., Xuan,W., Wang,H., Huang,H.,
            Yang,J. and Tang,J.
  TITLE     High co-expression of the SDF1/CXCR4 axis in hepatocarcinoma cells
            is regulated by AnnexinA7 in vitro and in vivo
  JOURNAL   Cell Commun Signal 16 (1), 22 (2018)
   PUBMED   29783989
  REMARK    GeneRIF: AnnexinA7 positively regulates expression levels of
            SDF1/CXCR4
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2824)
  AUTHORS   Fernandez,M.P., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Morgan,R.O.
  TITLE     Sequence and chromosomal localization of mouse annexin XI
  JOURNAL   Genomics 37 (3), 366-374 (1996)
   PUBMED   8938449
REFERENCE   7  (bases 1 to 2824)
  AUTHORS   Selbert,S., Fischer,P., Pongratz,D., Stewart,M. and Noegel,A.A.
  TITLE     Expression and localization of annexin VII (synexin) in muscle
            cells
  JOURNAL   J Cell Sci 108 (Pt 1), 85-95 (1995)
   PUBMED   7738119
REFERENCE   8  (bases 1 to 2824)
  AUTHORS   Zhang-Keck,Z.Y., Srivastava,M., Kozak,C.A., Caohuy,H., Shirvan,A.,
            Burns,A.L. and Pollard,H.B.
  TITLE     Genomic organization and chromosomal localization of the mouse
            synexin gene
  JOURNAL   Biochem J 301 (Pt 3) (Pt 3), 835-845 (1994)
   PUBMED   8053909
REFERENCE   9  (bases 1 to 2824)
  AUTHORS   Zhang-Keck,Z.Y., Burns,A.L. and Pollard,H.B.
  TITLE     Mouse synexin (annexin VII) polymorphisms and a phylogenetic
            comparison with other synexins
  JOURNAL   Biochem J 289 (Pt 3) (Pt 3), 735-741 (1993)
   PUBMED   7916616
REFERENCE   10 (bases 1 to 2824)
  AUTHORS   Magendzo,K., Shirvan,A., Cultraro,C., Srivastava,M., Pollard,H.B.
            and Burns,A.L.
  TITLE     Alternative splicing of human synexin mRNA in brain, cardiac, and
            skeletal muscle alters the unique N-terminal domain
  JOURNAL   J Biol Chem 266 (5), 3228-3232 (1991)
   PUBMED   1825209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121801.2.
            
            On Oct 11, 2019 this sequence version replaced XM_006518453.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.178384.1,
                                           SRR10662773.2537185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC121801.2         10242-10403
            163-217             AC121801.2         16854-16908
            218-422             AC121801.2         18611-18815
            423-524             AC121801.2         20694-20795
            525-589             AC121801.2         22248-22312
            590-655             AC121801.2         22660-22725
            656-758             AC121801.2         25237-25339
            759-853             AC121801.2         25480-25574
            854-967             AC121801.2         27163-27276
            968-1138            AC121801.2         27458-27628
            1139-1309           AC121801.2         29700-29870
            1310-1385           AC121801.2         29949-30024
            1386-1498           AC121801.2         31501-31613
            1499-2824           AC121801.2         33582-34907
FEATURES             Location/Qualifiers
     source          1..2824
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..2824
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /note="annexin A7"
                     /db_xref="GeneID:11750"
                     /db_xref="MGI:MGI:88031"
     exon            1..162
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            163..217
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1621
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /note="isoform 3 is encoded by transcript variant 3;
                     annexin-7; annexin VII"
                     /codon_start=1
                     /product="annexin A7 isoform 3"
                     /protein_id="NP_001361686.1"
                     /db_xref="CCDS:CCDS88585.1"
                     /db_xref="GeneID:11750"
                     /db_xref="MGI:MGI:88031"
                     /translation="MSYPGYPPTGYPPFPGYPPAGQESSFPTAGQYPYPSGFPPMGGG
                     AYPPAPSGGYPGAGGYPAPGGYPAPGGYPGALSPGGPPAYPGGQGFGAPPGGAGFSGY
                     PQPPAQSYGGGPAQVPVPGGFPGGQMPSQYPGGQAPYPSQINTESSSSYPAFPPVSLD
                     YSSDPASMTQGTQGTILPASNFDAMRDAEILRKAMKGFGTDEQAIVDVVSNRSNDQRQ
                     QIKAAFKTMYGKDLIKDLKSELSGNMEELILALFMPSTYYDAWSLRKAMQGAGTQERV
                     LIEILCTRTNQEIRDIVRCYQLEFGRDLEKDIRSDTSGHFERLLVSMCQGNRDERQSV
                     NHQMAQEDAQRLYQAGEGRLGTDESCFNMILATRSFPQLKATMEAYSRMANRDLLSSV
                     SREFSGYVESGLKTILQCALNRPAFFAERLYYSMKGAGTDDSTLVRIVVTRSEIDLVQ
                     IKQMFTQMYQKTLSTMIASDTSGDYRKLLLAIVGQ"
     exon            218..422
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            423..524
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            525..589
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            590..655
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            656..758
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            759..853
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            854..967
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1138
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1309
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1385
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1498
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..2824
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /note="hexamer: AATAAA"
     polyA_site      1932
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /note="major polyA site"
     regulatory      2795..2800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
                     /note="hexamer: AATAAA"
     polyA_site      2824
                     /gene="Anxa7"
                     /gene_synonym="Anx7; synexin"
ORIGIN      
        1 atattgcagg aaagcgggct agggtgtgac gctgctttct cgttcaggtg aggactcgca
       61 ccccctcccc ttgctgttct tccgtcggtc agtcagctcg ttcccagtcc ctggtctggt
      121 cttccaaccg tagtcgtaga gccccgcgcg tgtcctaacg agaatgtcat acccaggcta
      181 tccccccacc ggctacccgc ctttccctgg atatcctcct gcaggtcagg agtcatcttt
      241 ccccactgcg ggtcagtacc cgtaccctag tggctttcca ccaatgggag gaggtgctta
      301 cccaccagca ccaagtggtg ggtatccagg agctggaggc taccccgcac ctggaggtta
      361 tccagcccct gggggctatc ctggagccct aagtccaggg ggtcctccag cctatcctgg
      421 aggccaaggc tttggggccc cacccggtgg agcaggcttt tctggctatc cacagccacc
      481 tgcacagtct tatggtggcg gaccagccca ggttccagta ccaggtggct ttcctggagg
      541 acagatgcca tctcagtacc ctggaggaca agctccctac cctagccaga tcaatacaga
      601 atcctcttct tcctatcctg ctttcccccc tgtttctttg gattatagca gtgatcccgc
      661 ttcgatgact cagggcaccc aaggaacaat cctcccagcc tccaactttg atgctatgag
      721 agatgcagaa attctccgca aagcaatgaa agggtttggg acagacgagc aagcaattgt
      781 ggatgttgtg tctaaccgtt ccaatgacca gaggcaacaa atcaaagcag cttttaagac
      841 catgtatggc aaggatttaa ttaaagatct caagtcagaa ttgagtggga atatggaaga
      901 attaatcctt gcgctgttca tgccttctac atactatgat gcctggagct tacggaaggc
      961 aatgcaggga gcaggaactc aagaacgtgt attgatagag attttgtgca caagaacaaa
     1021 tcaagaaatt cgagacattg ttagatgtta ccaattagaa tttggacgag accttgagaa
     1081 ggacattagg tcagatacct cgggacattt tgaacgtctc ctcgtgtcca tgtgccaggg
     1141 aaaccgtgac gagaggcaga gcgtgaacca ccagatggcc caggaggacg ctcagcgtct
     1201 ctatcaggcc ggggagggga gactgggaac ggatgaatcc tgtttcaaca tgattctcgc
     1261 cacaaggagc ttccctcagc tgaaggccac tatggaggct tattccagga tggctaatcg
     1321 cgatttgcta agcagtgtaa gccgagaatt ttcgggatac gttgaaagtg gtttgaagac
     1381 catcttgcag tgcgccctca accgccctgc cttctttgct gaacgactct actattccat
     1441 gaaaggcgct ggcacggacg actccaccct ggtcaggatt gtggtcactc gaagtgagat
     1501 tgaccttgtt cagataaaac agatgttcac ccagatgtat cagaagaccc taagcacaat
     1561 gatcgcaagt gacacgagtg gagattacag gaagctgctc ctggccatcg ttggccagtg
     1621 agaagggtcc ttttcccctt taaggaatga agctcttcag gacctatcct tccatgcaat
     1681 gagacctgca tgcagccatg tcagatacca cctgaccaga gtagttttct actgaagact
     1741 gtcagggggt gtgctgggtt tgcacatgtt gttactgcct taattctaat gttaggtttt
     1801 tttttttcct gtatccaatc agtgtaaaag ccatatcaat gacgtagtaa tgtaatattt
     1861 gtaaagcttt gctctcactg cttttatttt aatccggatt tcaaattgaa taaaagtcac
     1921 aacaatctct aattctgttt aatgttaaaa gaatgagagg atgggaacgg agtttgttaa
     1981 aacacgctgt tctggttgat tgcagagtgt gattttcagc tcaggaataa gccacagtaa
     2041 ctcgggtcga tggctgaagt ttcctggtac aagtggaata aaactctcag ctagtagtgt
     2101 aggactgaca ggccatgtag tgttcaccta aataacgtag tctatgcaag caagattgaa
     2161 acccctctgc ctcccaaggc tagctggtgg cagctgttag taatgaatcc cactgtgtgg
     2221 tgggagtgcc ttgtggaaca ccacacagct ctgacagtga cgtcctgtgc aaggctggcc
     2281 ttctaagcca ctgagacccc agatgttaca ttatcatggt aaccagaatg ctcctgaggc
     2341 agcaggagct taactggaag cacaggaaac tgccttctcc tcttcctctt cctccccatc
     2401 cacggcccag gcccatgagt aacctgatta cttctgtgtc tctacccaat tcccatggat
     2461 aagggcaaaa gcaagcacca ttctacattt aattgtcaca gggaaaatca cttataaaag
     2521 cctctgtttt ctatcttgta aaaacagatt ttatgtgcac gagtgtttac gtgcaaacat
     2581 gtacatgcac ccagccactt gcatgcctat ttttctcaca gagactggga gagggtgttg
     2641 gaaaccctaa aatggaagct acagatgctt gtgaactatt gtgtgagtgc tggtatctga
     2701 acccaggtcc tctgtgttta gtttattaga gtagagcttt aattttaaga taaatgttta
     2761 aacagtaagt ttggtcctgt gactttacag aaacaataaa attgtacact tcttaaaaac
     2821 caca
//
