LOCUS       NM_013472               2670 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus annexin A6 (Anxa6), transcript variant 1, mRNA.
ACCESSION   NM_013472
VERSION     NM_013472.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2670)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 2670)
  AUTHORS   Dautan,D., Monai,A., Maltese,F., Chang,X., Molent,C., Mauro,D.,
            Galbusera,A., Vecchia,D., Antonelli,F., Benedetti,A., Drago,F.,
            Leggio,G.M., Pagani,M., Fellin,T., Gozzi,A., Schumann,G., Manago,F.
            and Papaleo,F.
  TITLE     Cortico-cortical transfer of socially derived information gates
            emotion recognition
  JOURNAL   Nat Neurosci 27 (7), 1318-1332 (2024)
   PUBMED   38769153
REFERENCE   3  (bases 1 to 2670)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2670)
  AUTHORS   Wang,Y., Yang,Z., Wang,R., Zheng,Y., Han,Z., Fan,J., Yan,F., Liu,P.
            and Luo,Y.
  TITLE     Annexin A6 mitigates neurological deficit in ischemia/reperfusion
            injury by promoting synaptic plasticity
  JOURNAL   CNS Neurosci Ther 30 (2), e14639 (2024)
   PUBMED   38380783
  REMARK    GeneRIF: Annexin A6 mitigates neurological deficit in
            ischemia/reperfusion injury by promoting synaptic plasticity.
REFERENCE   5  (bases 1 to 2670)
  AUTHORS   Salamon,R.J., McKeon,M.C., Bae,J., Zhang,X., Paltzer,W.G.,
            Wanless,K.N., Schuett,A.R., Nuttall,D.J., Nemr,S.A., Sridharan,R.,
            Lee,Y., Kamp,T.J. and Mahmoud,A.I.
  TITLE     LRRC10 regulates mammalian cardiomyocyte cell cycle during heart
            regeneration
  JOURNAL   NPJ Regen Med 8 (1), 39 (2023)
   PUBMED   37507410
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2670)
  AUTHORS   Spicer,A.P., Roller,M.L., Camper,S.A., McPherson,J.D.,
            Wasmuth,J.J., Hakim,S., Wang,C., Turley,E.A. and McDonald,J.A.
  TITLE     The human and mouse receptors for hyaluronan-mediated motility,
            RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse
            chromosome 11
  JOURNAL   Genomics 30 (1), 115-117 (1995)
   PUBMED   8595891
REFERENCE   7  (bases 1 to 2670)
  AUTHORS   Kaetzel,M.A., Pula,G., Campos,B., Uhrin,P., Horseman,N. and
            Dedman,J.R.
  TITLE     Annexin VI isoforms are differentially expressed in mammalian
            tissues
  JOURNAL   Biochim Biophys Acta 1223 (3), 368-374 (1994)
   PUBMED   7918672
REFERENCE   8  (bases 1 to 2670)
  AUTHORS   Buckwalter,M.S., Testa,C.M., Noebels,J.L. and Camper,S.A.
  TITLE     Genetic mapping and evaluation of candidate genes for spasmodic, a
            neurological mouse mutation with abnormal startle response
  JOURNAL   Genomics 17 (2), 279-286 (1993)
   PUBMED   8406478
REFERENCE   9  (bases 1 to 2670)
  AUTHORS   Davies,A.A., Moss,S.E., Crompton,M.R., Jones,T.A., Spurr,N.K.,
            Sheer,D., Kozak,C. and Crumpton,M.J.
  TITLE     The gene coding for the p68 calcium-binding protein is localised to
            bands q32-q34 of human chromosome 5, and to mouse chromosome 11
  JOURNAL   Hum Genet 82 (3), 234-238 (1989)
   PUBMED   2731935
REFERENCE   10 (bases 1 to 2670)
  AUTHORS   Moss,S.E., Crompton,M.R. and Crumpton,M.J.
  TITLE     Molecular cloning of murine p68, a Ca2+-binding protein of the
            lipocortin family
  JOURNAL   Eur J Biochem 177 (1), 21-27 (1988)
   PUBMED   2972541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY316619.1, AK146509.1, AK147066.1 and BB033332.1.
            
            On Sep 8, 2016 this sequence version replaced NM_013472.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147066.1, AK146509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               BY316619.1         1-354
            355-2509            AK146509.1         323-2477
            2510-2661           AK147066.1         2476-2627
            2662-2670           BB033332.1         278-286
FEATURES             Location/Qualifiers
     source          1..2670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.13 cM"
     gene            1..2670
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /note="annexin A6"
                     /db_xref="GeneID:11749"
                     /db_xref="MGI:MGI:88255"
     exon            1..113
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            114..157
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..2161
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /note="isoform a is encoded by transcript variant 1; p68;
                     p70; CPB-II; annexin-6; lipocortin VI; calphobindin-II;
                     chromobindin-20; 67 kDa calelectrin; annexin VI, p68"
                     /codon_start=1
                     /product="annexin A6 isoform a"
                     /protein_id="NP_038500.2"
                     /db_xref="CCDS:CCDS24705.1"
                     /db_xref="GeneID:11749"
                     /db_xref="MGI:MGI:88255"
                     /translation="MAKIAQGAMYRGSVHDFPEFDANQDAEALYTAMKGFGSDKESIL
                     ELITSRSNKQRQEICQNYKSLYGKDLIEDLKYELTGKFERLIVNLMRPLAYCDAKEIK
                     DAISGVGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLESDIIGDTSGHFQKMLVV
                     LLQGTRENDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEY
                     LKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIR
                     IMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKALLKLCGGDDDAAGQFFPE
                     AAQVAYQMWELSAVSRVELKGTVCAANDFNPDADAKALRKAMKGIGTDEATIIDIVTH
                     RSNAQRQQIRQTFKSHFGRDLMADLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEG
                     AGTDEKTLIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGN
                     REEGGENRDQAQEDAQVAAEILEIADTPSGDKTSLETRFMTVLCTRSYPHLRRVFQEF
                     IKKTNYDIEHVIKKEMSGDVKDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTR
                     VMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFMKALLALCGGED"
     exon            158..248
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            249..343
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            344..457
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            458..548
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            549..628
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            629..685
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            686..779
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            780..875
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            876..934
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1057
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1116
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1195
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1277
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1372
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1486
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1577
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1657
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1711
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1729
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1823
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1919
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1978
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2101
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2670
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2515
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /note="major polyA site"
     regulatory      2580..2585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
                     /note="hexamer: AATAGA"
     polyA_site      2603
                     /gene="Anxa6"
                     /gene_synonym="Anx6; AnxVI; Cabm; Camb"
ORIGIN      
        1 gcgccacgtg tccccctcca ccgtgcgccc agcctgcgct gcggctgctg ctaggctaac
       61 gggcttcgag ctgcgtctgt ccatacgccc tgatctgagg cctccctagc gcgtggtttc
      121 tgctgcagaa cctgagacca tggccaaaat agcacagggt gccatgtacc gaggctctgt
      181 ccacgacttc ccagagtttg acgcaaatca ggatgctgag gccttgtaca cagccatgaa
      241 gggcttcggc agtgacaagg agtccatact ggagctgatc acctcccgca gcaacaagca
      301 gaggcaggag atctgccaga attacaagtc cctgtatggc aaggacctca tcgaagactt
      361 gaagtatgag ttgacgggga agttcgagcg gctgatagtg aacctgatga ggccacttgc
      421 ctattgtgac gccaaagaga ttaaagacgc catctcgggc gttggcacag atgagaagtg
      481 ccttattgaa attttggctt cccggaccaa tgagcagatg caccagctgg tggccgcata
      541 caaagacgcc tatgagcgag acctggaatc tgacatcatt ggagacactt ccggccactt
      601 ccagaagatg ctggtggtac tgctccaggg aacccgggag aatgacgatg ttgtgagcga
      661 ggatttggtc cagcaggatg tccaggacct gtatgaggca ggggaactga aatggggaac
      721 agatgaggcc cagttcatct acatcttggg aaaccgcagc aaacagcacc tacgactggt
      781 gtttgatgag tatctgaaga ccacagggaa gcccatcgaa gccagtatca gaggggagct
      841 gtctggagac tttgagaagc tgatgttggc cgtggtgaag tgcatccgaa gcaccccgga
      901 gtattttgcg gaaaggctgt tcaaagccat gaagggccta gggacccgag acaacactct
      961 gatccgcatc atggtctcca ggagcgagct ggatatgctt gacatccggg agatcttccg
     1021 gaccaagtat gagaagtcac tctacagcat gatcaagaat gatacttccg gtgaatacaa
     1081 gaaggctctg ctgaagctgt gtggaggaga tgatgatgcc gctggccagt tcttcccgga
     1141 ggcagcacag gtggcctatc agatgtggga acttagtgca gtgtcccgag tcgagctgaa
     1201 gggtactgtg tgtgcagcca atgatttcaa ccctgacgct gatgccaagg ccctgcggaa
     1261 agccatgaag ggaattggaa ctgatgaagc caccatcatc gacatcgtca cccaccggag
     1321 caacgcccag cggcagcaga tccggcagac cttcaaatct cactttggcc gggatttaat
     1381 ggctgacctg aagtcagaga tctcgggaga cctggcaagg ctgattctgg ggctcatgat
     1441 gccacctgcc cattacgatg ctaagcagct gaagaaagct atggagggag ccggcacaga
     1501 tgaaaagact ctcatagaaa tcctggccac ccggaccaat gctgaaatcc gggccatcaa
     1561 cgaggcctac aaggaggatt atcacaagtc cctggaggat gccttgagct cagacacatc
     1621 tggccacttc agaaggattc tcatttctct ggccacagga aatcgagagg aaggaggaga
     1681 aaaccgggac caggcccagg aagatgccca ggtggctgct gagatcttgg aaatagcaga
     1741 cacccccagc ggagacaaaa cttccttgga gacacgcttc atgaccgtcc tgtgcacccg
     1801 tagctatccc cacctgcgca gagtcttcca ggagttcatc aagaagacca actatgacat
     1861 agagcatgtc atcaagaagg agatgtctgg ggatgtcaag gacgcatttg tggccatcgt
     1921 tcagagtgtc aagaacaagc ctctcttctt tgctgataaa ctgtacaagt ccatgaaggg
     1981 tgctggcaca gatgagaaga ccctcaccag ggtgatggtg tctcggagtg agatagatct
     2041 gctcaacatc cggagggaat tcattgagaa atatgacaag tctctacacc aagccattga
     2101 gggtgacacc tctggagact tcatgaaggc tttgcttgct ctgtgtggcg gagaggacta
     2161 aagctcctga cctcagaggg ccccctctac caagcagtgg ccaactgcac cagctgccgc
     2221 cgtgacctga ccaagccatt gctccagctt caggatctaa ggaagacgca aggggtgggg
     2281 ttggactgtc catccagctg gggcactctc tagccattga gggtcccagg cggtcccttc
     2341 tgttatccct cccgctcatg gctaaggggc tggtgaacca cggccatata ctgcattcaa
     2401 ctctgatccc cttctaccta ctcctccgcc cgccctggtt tccatccctc cacataaccc
     2461 tgcctgactt gagctttgtc acatctcaag acataccaaa cctctgtcta tgaaatgagt
     2521 gatgtgtgtg ctttaaaggg cgggctgtgg tgcctggtgc caggcaagca ttctgggata
     2581 atagagatga cagattaatt tgactgacgg gtgatcatcc ccggctgtca ccgtccaatc
     2641 tgataaaagt accaagctag gaatttccac
//
