LOCUS       NM_009673               1738 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus annexin A5 (Anxa5), mRNA.
ACCESSION   NM_009673
VERSION     NM_009673.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1738)
  AUTHORS   Baur,K., Carrillo-Garcia,C., San,S., von Hahn,M., Strelau,J.,
            Holzl-Wenig,G., Mandl,C. and Ciccolini,F.
  TITLE     Growth/differentiation factor 15 controls ependymal and stem cell
            number in the V-SVZ
  JOURNAL   Stem Cell Reports 19 (3), 351-365 (2024)
   PUBMED   38366596
REFERENCE   2  (bases 1 to 1738)
  AUTHORS   Chen,H., Bai,Y., Kobayashi,M., Xiao,S., Cai,W., Barajas,S.,
            Chen,S., Miao,J., Meke,F.N., Vemula,S., Ropa,J.P., Croop,J.M.,
            Boswell,H.S., Wan,J., Jia,Y., Liu,H., Li,L.S., Altman,J.K.,
            Eklund,E.A., Ji,P., Tong,W., Band,H., Huang,D.T., Platanias,L.C.,
            Zhang,Z.Y. and Liu,Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
  REMARK    Erratum:[Blood. 2024 Jan 25;143(4):376. doi:
            10.1182/blood.2023023174.. PMID: 38270941]
REFERENCE   3  (bases 1 to 1738)
  AUTHORS   Gao,Y., Zhang,H., Wang,J., Li,F., Li,X., Li,T., Wang,C., Li,L.,
            Peng,R., Liu,L., Cui,W., Zhang,S. and Zhang,J.
  TITLE     Annexin A5 ameliorates traumatic brain injury-induced
            neuroinflammation and neuronal ferroptosis by modulating the
            NF-kB/HMGB1 and Nrf2/HO-1 pathways
  JOURNAL   Int Immunopharmacol 114, 109619 (2023)
   PUBMED   36700781
  REMARK    GeneRIF: Annexin A5 ameliorates traumatic brain injury-induced
            neuroinflammation and neuronal ferroptosis by modulating the
            NF-kB/HMGB1 and Nrf2/HO-1 pathways.
REFERENCE   4  (bases 1 to 1738)
  AUTHORS   Babochkina,T.I., Gerlinskaya,L.A., Anisimova,M.V., Kontsevaya,G.V.,
            Feofanova,N.A., Stanova,A.K., Moshkin,M.P. and Moshkin,Y.M.
  TITLE     Mother-Fetus Immune Cross-Talk Coordinates 'Extrinsic'/'Intrinsic'
            Embryo Gene Expression Noise and Growth Stability
  JOURNAL   Int J Mol Sci 23 (20), 12467 (2022)
   PUBMED   36293324
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1738)
  AUTHORS   Cserep,C., Schwarcz,A.D., Posfai,B., Laszlo,Z.I., Kellermayer,A.,
            Kornyei,Z., Kisfali,M., Nyerges,M., Lele,Z., Katona,I. and
            Adam,Denes.
  TITLE     Microglial control of neuronal development via somatic purinergic
            junctions
  JOURNAL   Cell Rep 40 (12), 111369 (2022)
   PUBMED   36130488
REFERENCE   6  (bases 1 to 1738)
  AUTHORS   van Schaick,H.S., Smidt,M.P., Rovescalli,A.C., Luijten,M., van der
            Kleij,A.A., Asoh,S., Kozak,C.A., Nirenberg,M. and Burbach,J.P.
  TITLE     Homeobox gene Prx3 expression in rodent brain and extraneural
            tissues
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 12993-12998 (1997)
   PUBMED   9371788
REFERENCE   7  (bases 1 to 1738)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   8  (bases 1 to 1738)
  AUTHORS   Denny,P., Lord,C.J., Hill,N.J., Goy,J.V., Levy,E.R., Podolin,P.L.,
            Peterson,L.B., Wicker,L.S., Todd,J.A. and Lyons,P.A.
  TITLE     Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the
            interleukin-2 gene
  JOURNAL   Diabetes 46 (4), 695-700 (1997)
   PUBMED   9075813
REFERENCE   9  (bases 1 to 1738)
  AUTHORS   Rodriguez-Garcia,M.I., Kozak,C.A., Morgan,R.O. and Fernandez,M.P.
  TITLE     Mouse annexin V chromosomal localization, cDNA sequence
            conservation, and molecular evolution
  JOURNAL   Genomics 31 (2), 151-157 (1996)
   PUBMED   8824796
REFERENCE   10 (bases 1 to 1738)
  AUTHORS   Chepenik,K.P., Shipman-Appasamy,P., Ahn,N. and Goldowitz,D.
  TITLE     Developmental regulation of various annexins in the embryonic
            palate of the mouse: dexamethasone affects expression of annexin-1
  JOURNAL   J Craniofac Genet Dev Biol 15 (4), 171-181 (1995)
   PUBMED   8719346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY297767.1, CX218962.1, AK153388.1, AK152185.1 and AI845042.1.
            
            On Dec 17, 2008 this sequence version replaced NM_009673.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152185.1, AK153388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY297767.1         1-44
            45-219              CX218962.1         1-175
            220-1194            AK153388.1         1-975
            1195-1616           AK152185.1         1030-1451
            1617-1738           AI845042.1         1-122               c
FEATURES             Location/Qualifiers
     source          1..1738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.46 cM"
     gene            1..1738
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /note="annexin A5"
                     /db_xref="GeneID:11747"
                     /db_xref="MGI:MGI:106008"
     exon            1..315
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            316..346
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1303
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /note="PP4; CBP-I; PAP-I; VAC-alpha; annexin-5; anchorin
                     CII; endonexin II; lipocortin V; calphobindin I;
                     thromboplastin inhibitor; vascular anticoagulant-alpha;
                     placental anticoagulant protein 4; placental anticoagulant
                     protein I; annexin V"
                     /codon_start=1
                     /product="annexin A5"
                     /protein_id="NP_033803.1"
                     /db_xref="CCDS:CCDS38416.1"
                     /db_xref="GeneID:11747"
                     /db_xref="MGI:MGI:106008"
                     /translation="MATRGTVTDFPGFDGRADAEVLRKAMKGLGTDEDSILNLLTSRS
                     NAQRQEIAQEFKTLFGRDLVDDLKSELTGKFEKLIVAMMKPSRLYDAYELKHALKGAG
                     TDEKVLTEIIASRTPEELSAIKQVYEEEYGSNLEDDVVGDTSGYYQRMLVVLLQANRD
                     PDTAIDDAQVELDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRRVFDKYMTISGFQ
                     IEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVVVSRSE
                     IDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGGEDD"
     exon            347..431
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            432..526
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            527..640
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            641..731
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            732..811
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            812..868
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            869..962
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1058
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1117
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1240
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1724
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1699..1704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /note="hexamer: AATAAA"
     polyA_site      1724
                     /gene="Anxa5"
                     /gene_synonym="Anx5; CPB-I"
                     /note="major polyA site"
ORIGIN      
        1 gatgggggcg cggcccgggc tgggacctaa ttagggaggt ggccatggta ggggggtggc
       61 cttgtctgag gaaagtaccg tatccaggga tgtggcagct gcctgggaca aggcggggct
      121 tatagtgcag cgtctctggg ggcgggaccc tggtgggtgt gtgatcttgg caggggcgtg
      181 gcgtggcggg gccaggtcgg gctaggctgg gctgcccagg gcgtttccgt tgcacggagt
      241 tgtgaagagt actgccttgt cctttggcgt gtgcatcggt cctgctctca cccgcagcct
      301 gcgctctact gcctgctcca gtccactcct gaccgacagc atcatggcta cgagaggcac
      361 tgtgactgac ttccctggat ttgatggcag ggctgatgca gaagtccttc ggaaggccat
      421 gaaaggcttg ggtaccgatg aggacagcat cctgaacctg ttgacatccc gaagcaatgc
      481 tcagcgccag gaaattgctc aggagtttaa gactctgttt ggcagggacc ttgtggatga
      541 cctgaagtct gaactgactg gaaagtttga gaagttaatt gtggctatga tgaagccctc
      601 acgactctac gatgcctacg agctgaagca tgctcttaag ggagctggta cagacgagaa
      661 agtattgacc gagattattg cttcaaggac acctgaagaa ctcagtgcca taaaacaagt
      721 ttatgaagaa gaatatggtt ccaacctgga agatgatgtg gtgggggata cttcagggta
      781 ctaccagagg atgttggtgg tcctccttca ggcgaataga gaccctgata ctgcaattga
      841 tgatgctcaa gttgaactgg atgctcaggc attgttccag gctggagagc tgaagtgggg
      901 gacagatgaa gaaaaattca tcaccatctt tgggacacgc agtgtgtctc atttaagaag
      961 agtgtttgac aagtacatga ccatatcagg atttcagatt gaggaaacca ttgatcgaga
     1021 gacctcgggg aacttggagc agctgctcct ggctgtcgtg aagtctattc ggagcatacc
     1081 tgcctacctt gcagagaccc tctactatgc catgaagggt gctgggacgg acgatcacac
     1141 cctcatcaga gtcgtggtgt cgaggagtga gattgacctg tttaacataa ggaaggagtt
     1201 taggaagaac ttcgccacct ccctgtattc tatgatcaag ggcgacacat ctggagacta
     1261 taagaaggcc ctgctgctgc tctgcggggg cgaggatgac tgagagccgc ctggagcgcc
     1321 ctgtgcctgc tgcccaccat cagctttcct cagcaccaca cttgcttgca ttctgtgcct
     1381 gccgcgctgc cttacactag tatgctaatg accaaaggtg tcttagatga aagcagtgtc
     1441 ccgcccttct gatgttctgt ctacagtagg tagtgacctt cccatatctc tcagtccaat
     1501 gtctgagtta ttaatattgt ctatgaattg ctttttatat ccttttttaa agcttcattt
     1561 atattaagtt aataacccta ttatcttgat tggaacctta gcggtgaaat tgtgaactct
     1621 tggaaatgct gtcaatcaag cttactgctc tagcagacct gcaaaattat gatggtagta
     1681 tccaaaacat tggcgacaaa taaaaacatt cccttccctc caaaaaaaaa aaaaaaaa
//
