LOCUS       NM_001409577            1393 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus annexin A2 (Anxa2), transcript variant 2, mRNA.
ACCESSION   NM_001409577 XM_006510796
VERSION     NM_001409577.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Luo,M., Almeida,D., Dallacasagrande,V., Hedhli,N., Gupta,M.,
            D'Amico,D.J., Kiss,S. and Hajjar,K.A.
  TITLE     Annexin A2 promotes proliferative vitreoretinopathy in response to
            a macrophage inflammatory signal in mice
  JOURNAL   Nat Commun 15 (1), 8757 (2024)
   PUBMED   39384746
  REMARK    GeneRIF: Annexin A2 promotes proliferative vitreoretinopathy in
            response to a macrophage inflammatory signal in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Nakamura,Y., Ito,M.A., Hoshino,Y., Matsuoka,I., Okada,T., Okada,Y.
            and Nakanishi,T.
  TITLE     Modulation of prostaglandin transport activity of SLCO2A1 by
            annexin A2 and S100A10
  JOURNAL   Am J Physiol Cell Physiol 326 (4), C1042-C1053 (2024)
   PUBMED   38372137
  REMARK    GeneRIF: Modulation of prostaglandin transport activity of SLCO2A1
            by annexin A2 and S100A10.
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Qiu,Y., Pei,D., Wang,M., Wang,Q., Duan,W., Wang,L., Liu,K., Guo,Y.,
            Luo,L., Guo,Z., Guan,F., Wang,Z., Xing,A., Liu,Z., Ma,Z., Jiang,G.,
            Yan,D., Liu,X., Zhang,Z. and Wang,W.
  TITLE     Nuclear autoantigenic sperm protein facilitates glioblastoma
            progression and radioresistance by regulating the ANXA2/STAT3 axis
  JOURNAL   CNS Neurosci Ther 30 (4), e14709 (2024)
   PUBMED   38605477
  REMARK    GeneRIF: Nuclear autoantigenic sperm protein facilitates
            glioblastoma progression and radioresistance by regulating the
            ANXA2/STAT3 axis.
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   He,J., Hou,X., Wu,J., Wang,K., Qi,X., Wei,Z., Sun,Y., Wang,C.,
            Yao,H. and Liu,K.
  TITLE     Hspb1 protects against severe acute pancreatitis by attenuating
            apoptosis and ferroptosis via interacting with Anxa2 to restore the
            antioxidative activity of Prdx1
  JOURNAL   Int J Biol Sci 20 (5), 1707-1728 (2024)
   PUBMED   38481805
  REMARK    GeneRIF: Hspb1 protects against severe acute pancreatitis by
            attenuating apoptosis and ferroptosis via interacting with Anxa2 to
            restore the antioxidative activity of Prdx1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Werren,E.A., LaForce,G.R., Srivastava,A., Perillo,D.R., Li,S.,
            Johnson,K., Baris,S., Berger,B., Regan,S.L., Pfennig,C.D., de
            Munnik,S., Pfundt,R., Hebbar,M., Jimenez-Heredia,R.,
            Karakoc-Aydiner,E., Ozen,A., Dmytrus,J., Krolo,A., Corning,K.,
            Prijoles,E.J., Louie,R.J., Lebel,R.R., Le,T.L., Amiel,J.,
            Gordon,C.T., Boztug,K., Girisha,K.M., Shukla,A., Bielas,S.L. and
            Schaffer,A.E.
  TITLE     TREX tetramer disruption alters RNA processing necessary for
            corticogenesis in THOC6 Intellectual Disability Syndrome
  JOURNAL   Nat Commun 15 (1), 1640 (2024)
   PUBMED   38388531
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Horlick,K.R., Cheng,I.C., Wong,W.T., Wakeland,E.K. and Nick,H.S.
  TITLE     Mouse lipocortin I gene structure and chromosomal assignment: gene
            duplication and the origins of a gene family
  JOURNAL   Genomics 10 (2), 365-374 (1991)
   PUBMED   1676980
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Amiguet,P., D'Eustachio,P., Kristensen,T., Wetsel,R.A., Saris,C.J.,
            Hunter,T., Chaplin,D.D. and Tack,B.F.
  TITLE     Structure and chromosome assignment of the murine p36 (calpactin I
            heavy chain) gene
  JOURNAL   Biochemistry 29 (5), 1226-1232 (1990)
   PUBMED   2138915
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Huebner,K., Cannizzaro,L.A., Frey,A.Z., Hecht,B.K., Hecht,F.,
            Croce,C.M. and Wallner,B.P.
  TITLE     Chromosomal localization of the human genes for lipocortin I and
            lipocortin II
  JOURNAL   Oncogene Res 2 (4), 299-310 (1988)
   PUBMED   2969496
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Saris,C.J., Kristensen,T., D'Eustachio,P., Hicks,L.J., Noonan,D.J.,
            Hunter,T. and Tack,B.F.
  TITLE     cDNA sequence and tissue distribution of the mRNA for bovine and
            murine p11, the S100-related light chain of the protein-tyrosine
            kinase substrate p36 (calpactin I)
  JOURNAL   J Biol Chem 262 (22), 10663-10671 (1987)
   PUBMED   3038891
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Saris,C.J., Tack,B.F., Kristensen,T., Glenney,J.R. Jr. and
            Hunter,T.
  TITLE     The cDNA sequence for the protein-tyrosine kinase substrate p36
            (calpactin I heavy chain) reveals a multidomain protein with
            internal repeats
  JOURNAL   Cell 46 (2), 201-212 (1986)
   PUBMED   3013423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009708.6.
            
            On Jul 20, 2022 this sequence version replaced XM_006510796.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.725286.1,
                                           ERR3835354.13158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                CT009708.6         128955-129023       c
            70-134              CT009708.6         118592-118656       c
            135-234             CT009708.6         115726-115825       c
            235-329             CT009708.6         106969-107063       c
            330-443             CT009708.6         103325-103438       c
            444-534             CT009708.6         100052-100142       c
            535-614             CT009708.6         99257-99336         c
            615-674             CT009708.6         97859-97918         c
            675-768             CT009708.6         96553-96646         c
            769-864             CT009708.6         95468-95563         c
            865-923             CT009708.6         95003-95061         c
            924-1046            CT009708.6         93342-93464         c
            1047-1393           CT009708.6         91324-91670         c
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 38.58 cM"
     gene            1..1393
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /note="annexin A2"
                     /db_xref="GeneID:12306"
                     /db_xref="MGI:MGI:88246"
     exon            1..69
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            70..134
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1106
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /note="annexin-2; protein I; chromobindin-8; placental
                     anticoagulant protein IV; calpactin-1 heavy chain; 33kDa
                     lymphocyte Ca<2+>- binding protein; calpactin I heavy
                     chain; annexin II; lipocortin II; 33-kDa calcimedin;
                     36-kDa calelectrin; 33-kDa lymphocyte Ca<2+>- binding
                     protein"
                     /codon_start=1
                     /product="annexin A2"
                     /protein_id="NP_001396506.1"
                     /db_xref="GeneID:12306"
                     /db_xref="MGI:MGI:88246"
                     /translation="MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIET
                     AVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGL
                     LKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDII
                     SDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMT
                     ERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYD
                     SMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYL
                     CGGDD"
     exon            135..234
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            235..329
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            330..443
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            444..534
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            535..614
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            615..674
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            675..768
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            769..864
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            865..923
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1046
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1393
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /note="hexamer: AATAAA"
     polyA_site      1393
                     /gene="Anxa2"
                     /gene_synonym="Cal1h; p36; PAP-IV"
                     /note="major polyA site"
ORIGIN      
        1 agtgagaagt cccacttcgc tttccgcact gcgttctctc actctggacc gtaacttctg
       61 caatttcagc tttttttttc ttcaaaatgt ctactgtcca cgaaatcctg tgcaagctca
      121 gcctggaggg tgatcattct acacccccaa gtgcctacgg gtcagtcaaa ccctacacca
      181 acttcgatgc tgagagggat gctctgaaca ttgagacagc agtcaagacc aaaggagtgg
      241 atgaggtcac cattgtcaac atcctgacaa accgcagcaa tgtgcagagg caggacattg
      301 ccttcgccta tcagagaagg accaaaaagg agctcccgtc agcgctgaag tcagccttat
      361 ctggccacct ggagacggtg attttgggcc tattgaagac acctgcccag tatgatgctt
      421 cggaactaaa agcttccatg aagggcctgg ggactgacga ggactccctc attgagatca
      481 tctgctcacg aaccaaccag gagctgcaag agatcaacag agtgtacaag gaaatgtaca
      541 agactgatct ggagaaggac atcatctctg acacatctgg agacttccga aagctgatgg
      601 tcgcccttgc aaagggcaga cgagcagagg atggctcagt tattgactac gagctgattg
      661 accaggatgc ccgggagctc tatgatgccg gggtgaagag gaaaggaacc gacgtcccca
      721 agtggatcag catcatgact gagcgcagtg tgtgccacct ccagaaagtg ttcgaaaggt
      781 acaagagcta cagcccttat gacatgctgg agagcatcaa gaaagaggtc aaaggggacc
      841 tggagaacgc cttcctgaac ctggtccagt gcatccagaa caagcccctg tacttcgctg
      901 accggctgta cgactccatg aagggcaagg ggactcgaga caaggtcctg attagaatca
      961 tggtctctcg cagtgaagtg gacatgctga aaatcagatc tgaattcaag aggaaatatg
     1021 gcaagtccct gtactactac atccagcaag acaccaaggg tgactaccag aaggcactgc
     1081 tgtacctgtg tggtggggat gactgaaggg ctcagcacag tggatcaccc agaagtggct
     1141 ctacctgtgc cccaacctgg cgttctagag acttcgctct ccactaatgg acccctgagc
     1201 tcctccctgt gaggatgatg acagggctgc cgaccctttc cccatcttag ctgcccttgc
     1261 ctggctttct cctcattctc tcctttatgc caaagaagtg aacattccag ggagtggggc
     1321 gtagcgtctg tgacatgaga cacttcctct tatgtactgt gtcgtgaata aaccgttttt
     1381 actttagaaa caa
//
