LOCUS       NM_001136089            1840 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus annexin A10 (Anxa10), transcript variant 1, mRNA.
ACCESSION   NM_001136089
VERSION     NM_001136089.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Park,J., Wu,J., Szkop,K.J., Jeong,J., Jovanovic,P., Husmann,D.,
            Flores,N.M., Francis,J.W., Chen,Y.C., Benitez,A.M., Zahn,E.,
            Song,S., Ajani,J.A., Wang,L., Singh,K., Larsson,O., Garcia,B.A.,
            Topisirovic,I., Gozani,O. and Mazur,P.K.
  TITLE     SMYD5 methylation of rpL40 links ribosomal output to gastric cancer
  JOURNAL   Nature 632 (8025), 656-663 (2024)
   PUBMED   39048817
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Motomura,K., Matsuzaka,T., Shichino,S., Ogawa,T., Pan,H.,
            Nakajima,T., Asano,Y., Okayama,T., Takeuchi,T., Ohno,H., Han,S.I.,
            Miyamoto,T., Takeuchi,Y., Sekiya,M., Sone,H., Yahagi,N.,
            Nakagawa,Y., Oda,T., Ueha,S., Ikeo,K., Ogura,A., Matsushima,K. and
            Shimano,H.
  TITLE     Single-Cell Transcriptome Profiling of Pancreatic Islets From Early
            Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward
            beta-Cell Failure
  JOURNAL   Diabetes 73 (1), 75-92 (2024)
   PUBMED   37871012
  REMARK    GeneRIF: Single-Cell Transcriptome Profiling of Pancreatic Islets
            From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis
            Toward beta-Cell Failure.
REFERENCE   4  (bases 1 to 1840)
  AUTHORS   Wang,X., Zhou,Y., Ning,L., Chen,J., Chen,H. and Li,X.
  TITLE     Knockdown of ANXA10 induces ferroptosis by inhibiting
            autophagy-mediated TFRC degradation in colorectal cancer
  JOURNAL   Cell Death Dis 14 (9), 588 (2023)
   PUBMED   37666806
  REMARK    GeneRIF: Knockdown of ANXA10 induces ferroptosis by inhibiting
            autophagy-mediated TFRC degradation in colorectal cancer.
            Erratum:[Cell Death Dis. 2023 Oct 16;14(10):683. doi:
            10.1038/s41419-023-06151-x.. PMID: 37845204]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1840)
  AUTHORS   Lee,J.H., Kim,S., Han,S., Min,J., Caldwell,B., Bamford,A.D.,
            Rocha,A.S.B., Park,J., Lee,S., Wu,S.S., Lee,H., Fink,J.,
            Pilat-Carotta,S., Kim,J., Josserand,M., Szep-Bakonyi,R., An,Y.,
            Ju,Y.S., Philpott,A., Simons,B.D., Stange,D.E., Choi,E., Koo,B.K.
            and Kim,J.K.
  TITLE     p57Kip2 imposes the reserve stem cell state of gastric chief cells
  JOURNAL   Cell Stem Cell 29 (5), 826-839 (2022)
   PUBMED   35523142
REFERENCE   6  (bases 1 to 1840)
  AUTHORS   Sasaki,S., Ibi,T., Akiyama,T., Fukushima,M. and Sugimoto,Y.
  TITLE     Loss of maternal ANNEXIN A10 via a 34-kb deleted-type copy number
            variation is associated with embryonic mortality in Japanese Black
            cattle
  JOURNAL   BMC Genomics 17 (1), 968 (2016)
   PUBMED   27881083
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1840)
  AUTHORS   Lu,Y., Ni,S., He,L.N., Gao,Y.J. and Jiang,B.C.
  TITLE     Annexin A10 is involved in the development and maintenance of
            neuropathic pain in mice
  JOURNAL   Neurosci Lett 631, 1-6 (2016)
   PUBMED   27507697
  REMARK    GeneRIF: Spinal nerve ligation (SNL) induced persistent
            upregulation of annexin A10 mRNA and protein in the spinal cord of
            mice.  annexin A10 siRNA partially prevented SNL-induced mechanical
            allodynia and heat hyperalgesia. Findings suggest that annexin A10
            might be a novel target in the treatment of neuropathic pain.
REFERENCE   8  (bases 1 to 1840)
  AUTHORS   Yamamoto,A., Uchiyama,K., Nara,T., Nishimura,N., Hayasaka,M.,
            Hanaoka,K. and Yamamoto,T.
  TITLE     Structural abnormalities of corpus callosum and cortical axonal
            tracts accompanied by decreased anxiety-like behavior and lowered
            sociability in spock3- mutant mice
  JOURNAL   Dev Neurosci 36 (5), 381-395 (2014)
   PUBMED   25138526
REFERENCE   9  (bases 1 to 1840)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 1840)
  AUTHORS   Morgan,R.O., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Balsara,B.R., Testa,J.R. and Fernandez,M.P.
  TITLE     Novel human and mouse annexin A10 are linked to the genome
            duplications during early chordate evolution
  JOURNAL   Genomics 60 (1), 40-49 (1999)
   PUBMED   10458909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY083459.1, AK168715.1 and AK131880.1.
            
            On Oct 26, 2013 this sequence version replaced NM_001136089.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131880.1, AK008772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                BY083459.1         1-96
            97-1360             AK168715.1         1-1264
            1361-1840           AK131880.1         1281-1760
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 31.55 cM"
     gene            1..1840
                     /gene="Anxa10"
                     /note="annexin A10"
                     /db_xref="GeneID:26359"
                     /db_xref="MGI:MGI:1347090"
     exon            1..183
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1140
                     /gene="Anxa10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     annexin-10"
                     /codon_start=1
                     /product="annexin A10 isoform 1"
                     /protein_id="NP_001129561.1"
                     /db_xref="CCDS:CCDS52558.1"
                     /db_xref="GeneID:26359"
                     /db_xref="MGI:MGI:1347090"
                     /translation="MFCGEYVQGTIFPAPNFNPMMDAQMLGGALQGFDCNKDMLIDIL
                     TQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGLMYPPPSYDAHELWHAM
                     KGPGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNLVQ
                     ANREEGYSDPAMAAQDAMVLWEACQQKTGEHKTMMQMILCNKSYPQLWLVFQEFQNIS
                     GQDLVDAINDCYDGYFQELLVAIVRCIQDKPSYFAYKLYRAIHDFGFHNKTVIRILIA
                     RSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAICAGDVEDY"
     exon            184..265
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            266..360
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            361..474
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            475..565
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            566..645
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            646..699
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            700..793
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            794..889
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            890..948
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1071
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1840
                     /gene="Anxa10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1339..1344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa10"
                     /note="hexamer: ATTAAA"
     polyA_site      1367
                     /gene="Anxa10"
                     /note="major polyA site"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anxa10"
                     /note="hexamer: AATAAA"
     polyA_site      1786
                     /gene="Anxa10"
ORIGIN      
        1 tgatttgcct ctgtattttc ttgcctgaga tatttggtca ggcagatata tttaaatttg
       61 gaactgcagg gaacctcagc cattctggcc tcatagggaa caactctgaa gcaggacctt
      121 tactgaaatc ctggtgatct accctggtta cttcctctct tgaaaatgtt ttgcggggaa
      181 tatgtccaag gaaccatctt cccagctcca aatttcaatc ccatgatgga tgcccaaatg
      241 ctaggcggag cactccaagg atttgactgc aacaaagaca tgctgattga catcctaaca
      301 caacgcagca atgcacagcg gcagatgata gctgggacct atcagagcat gtatggccgg
      361 gacctgattt cagttctgaa ggaacaactt tcatctcact tcaaagaagt gatggtgggc
      421 ctgatgtatc ctccaccatc ttatgatgct catgagctct ggcatgccat gaagggacca
      481 ggaactgatg agaattgcct cattgaaata ttagcttcaa gaacaaatgg ggagattttc
      541 cagatgcgag aagcctactg tttacagtac agcaataacc ttcaagagga catttactca
      601 gaaacctcag gacacttcag ggatactctc atgaacttgg tccaggcaaa cagggaggaa
      661 ggatactctg atcctgcaat ggctgctcag gatgcaatgg tgctgtggga agcctgccag
      721 cagaagactg gggaacataa aaccatgatg cagatgatcc tgtgcaacaa gagctaccca
      781 caactttggc tggttttcca ggaatttcaa aatatttctg gccaagacct ggtggatgcc
      841 atcaatgact gttacgatgg ttatttccag gagctgctgg ttgctattgt tcgttgtatc
      901 caggacaaac caagctattt tgcttataaa ttatacaggg caatccatga ttttggcttc
      961 cataacaaaa ctgtcatcag gattctcatc gccagaagtg aaatagacct aatgaccata
     1021 aggaaacgtt acaaagagag atttggaaaa tccctctttc atgatatcaa aaattttgct
     1081 tcagggcact atgagaaagc actacttgcc atctgtgctg gtgatgtgga agactactga
     1141 aaagagggag agtttgaagg tgatgcgatc ttctttatag gcacccgaca tagactgctg
     1201 aacgcgtgct gtattcacac tgaaacagaa ctataaaatc aaatttttct tctatctcta
     1261 caattattct gagacaaaaa tctcctctgt tggaaatgtg taatcctaga tttgtagccc
     1321 ttattcaatt agtaatcaat taaactgtat atggtagaat aagaaaagca ctgcattgga
     1381 atcaatttta tttacatgtg aactgtcagt tcctacaaca agaaaatctg acaggactgt
     1441 tttaatatca gtctgaaatg tggaaaattg accactgtct gtgtgaccac catccatatt
     1501 atggtcacca ttagtgcctg atcaccctct gtgtgtgacc actgtcaatg tgaccaccat
     1561 ccatgttatg gtcaccatta gtgcctgatc accctctgtg tgtgaccact gtcagtgtga
     1621 ccaccgtcca tatgtgttca ccctcagtgt gtaataactc tcagtgcatg atcaccctca
     1681 aagaaattgc ctggactctt ggacaaacaa aacaaagctg aagcaagggc ctagaatagc
     1741 cttgtaatga aaatagataa tcacaaataa actataccaa gaggcatact ttctgaatta
     1801 gttgtactaa aacttgaata aaaagtaagg gtttgcgtgc
//
