LOCUS       NM_010730               1395 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus annexin A1 (Anxa1), mRNA.
ACCESSION   NM_010730
VERSION     NM_010730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1395)
  AUTHORS   Fushiki,A., Ng,D., Lewis,Z.R., Yadav,A., Saraiva,T., Hammond,L.A.,
            Wirblich,C., Tasic,B., Menon,V., da Silva,J.A. and Costa,R.M.
  TITLE     A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor
            Deficits in Parkinson's Disease
  JOURNAL   bioRxiv (2024)
   PUBMED   39763754
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1395)
  AUTHORS   Carabana,C., Sun,W., Veludo Ramos,C., Huyghe,M., Perkins,M.,
            Maillot,A., Journot,R., Hartani,F., Faraldo,M.M., Lloyd-Lewis,B.
            and Fre,S.
  TITLE     Spatially distinct epithelial and mesenchymal cell subsets along
            progressive lineage restriction in the branching embryonic mammary
            gland
  JOURNAL   EMBO J 43 (12), 2308-2336 (2024)
   PUBMED   38760574
REFERENCE   3  (bases 1 to 1395)
  AUTHORS   You,Q., Ke,Y., Chen,X., Yan,W., Li,D., Chen,L., Wang,R., Yu,J. and
            Hong,H.
  TITLE     Loss of Endothelial Annexin A1 Aggravates Inflammation-Induched
            Vascular Aging
  JOURNAL   Adv Sci (Weinh) 11 (15), e2307040 (2024)
   PUBMED   38358087
  REMARK    GeneRIF: Loss of Endothelial Annexin A1 Aggravates
            Inflammation-Induched Vascular Aging.
REFERENCE   4  (bases 1 to 1395)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1395)
  AUTHORS   Singh,J., Jackson,K.L., Tang,F.S., Fu,T., Nowell,C., Salimova,E.,
            Kiriazis,H., Ritchie,R.H., Head,G.A., Woodman,O.L. and Qin,C.X.
  TITLE     The pro-resolving mediator, annexin A1 regulates blood pressure,
            and age-associated changes in cardiovascular function and
            remodeling
  JOURNAL   FASEB J 38 (3), e23457 (2024)
   PUBMED   38318648
  REMARK    GeneRIF: The pro-resolving mediator, annexin A1 regulates blood
            pressure, and age-associated changes in cardiovascular function and
            remodeling.
REFERENCE   6  (bases 1 to 1395)
  AUTHORS   Epifano,O., Liang,L.F. and Dean,J.
  TITLE     Mouse Zp1 encodes a zona pellucida protein homologous to egg
            envelope proteins in mammals and fish
  JOURNAL   J Biol Chem 270 (45), 27254-27258 (1995)
   PUBMED   7592984
REFERENCE   7  (bases 1 to 1395)
  AUTHORS   Wen,X.Y., Tang,S. and Breitman,M.L.
  TITLE     Genetic mapping of two mouse homeobox genes Tlx-1 and Tlx-2 to
            murine chromosomes 19 and 6
  JOURNAL   Genomics 24 (2), 388-390 (1994)
   PUBMED   7698766
REFERENCE   8  (bases 1 to 1395)
  AUTHORS   Horlick,K.R., Cheng,I.C., Wong,W.T., Wakeland,E.K. and Nick,H.S.
  TITLE     Mouse lipocortin I gene structure and chromosomal assignment: gene
            duplication and the origins of a gene family
  JOURNAL   Genomics 10 (2), 365-374 (1991)
   PUBMED   1676980
REFERENCE   9  (bases 1 to 1395)
  AUTHORS   Philipps,C., Rose-John,S., Rincke,G., Furstenberger,G. and Marks,F.
  TITLE     cDNA-cloning, sequencing and expression in
            glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse
            lipocortin I
  JOURNAL   Biochem Biophys Res Commun 159 (1), 155-162 (1989)
   PUBMED   2522299
REFERENCE   10 (bases 1 to 1395)
  AUTHORS   Sakata,T., Iwagami,S., Tsuruta,Y., Suzuki,R., Hojo,K., Sato,K. and
            Teraoka,H.
  TITLE     Mouse lipocortin I cDNA
  JOURNAL   Nucleic Acids Res 16 (24), 11818 (1988)
   PUBMED   2974946
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK167612.1.
            
            On Feb 7, 2007 this sequence version replaced NM_010730.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150564.1, AK150718.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1395              AK167612.1         3-1397
FEATURES             Location/Qualifiers
     source          1..1395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 13.83 cM"
     gene            1..1395
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /note="annexin A1"
                     /db_xref="GeneID:16952"
                     /db_xref="MGI:MGI:96819"
     exon            1..60
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..140
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1115
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /note="p35; annexin I; annexin-1; calpactin II; lipocortin
                     I; chromobindin-9; phospholipase A2 inhibitory protein;
                     calpactin-2; lipocortin 1"
                     /codon_start=1
                     /product="annexin A1"
                     /protein_id="NP_034860.2"
                     /db_xref="CCDS:CCDS29692.1"
                     /db_xref="GeneID:16952"
                     /db_xref="MGI:MGI:96819"
                     /translation="MAMVSEFLKQARFLENQEQEYVQAVKSYKGGPGSAVSPYPSFNV
                     SSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQENGKPLDEVLRKALTG
                     HLEEVVLAMLKTPAQFDADELRGAMKGLGTDEDTLIEILTTRSNEQIREINRVYREEL
                     KRDLAKDITSDTSGDFRKALLALAKGDRCQDLSVNQDLADTDARALYEAGERRKGTDV
                     NVFTTILTSRSFPHLRRVFQNYGKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPA
                     FFAEKLYEAMKGAGTRHKALIRIMVSRSEIDMNEIKVFYQKKYGISLCQAILDETKGD
                     YEKILVALCGGN"
     exon            141..249
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..344
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..458
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..549
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..629
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..686
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..780
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..876
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..935
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1058
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1395
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgaaacc atctgagcag agtctctctt cagtccccgg gaagacaagc aaatacaaag
       61 atacttctct aaaaatggca atggtatcag aattcctcaa gcaggcccgt tttcttgaaa
      121 atcaagaaca ggaatatgtt caagctgtaa aatcatacaa aggtggtcct gggtcagcag
      181 tgagccccta cccttccttc aatgtatcct cggatgttgc tgccttgcac aaagctatca
      241 tggttaaagg tgtggatgaa gcaaccatca ttgacattct taccaagagg accaatgctc
      301 agcgccagca gatcaaggcc gcgtacttac aggagaatgg aaagcccttg gatgaagtct
      361 tgagaaaagc ccttacaggc cacctggagg aggttgtttt ggctatgcta aaaactccag
      421 ctcagtttga tgcagatgaa ctccgtggtg ccatgaaggg acttggaaca gatgaagaca
      481 ctctcattga gattttgaca acaagatcta acgaacaaat cagagagatt aatagagtct
      541 acagagaaga gctgaaaaga gatctggcca aagacatcac ttcagataca tctggagact
      601 ttcggaaagc cttgcttgct cttgccaagg gtgaccgttg tcaggacttg agtgtgaatc
      661 aagatttggc tgatacagat gccagggctt tgtatgaagc tggagaaagg agaaagggga
      721 cagacgtgaa cgtcttcacc acaattctga ccagcaggag ctttcctcat cttcgcagag
      781 tgtttcagaa ttacggaaag tacagtcaac atgacatgaa caaagctctg gatctggaac
      841 tgaagggtga cattgagaag tgcctcacaa ccatcgtgaa gtgtgccacc agcactccag
      901 ctttctttgc cgagaagctg tacgaagcca tgaagggtgc cggaactcgc cataaggcat
      961 tgatcaggat tatggtctcc cgttcggaaa ttgacatgaa tgaaatcaaa gtattttacc
     1021 agaagaagta tggaatctct ctttgccaag ccatcctgga tgaaaccaaa ggagactatg
     1081 aaaaaatcct ggtggctctg tgtggtggaa actagacatc ccaactattc tgcaaggttc
     1141 tgaggagaat gtctcttagc tgttttcctt cgatggcatg ggcttaagta ggaaagttgc
     1201 tttggcagat aagtctaatt acctgctttg aataatatag cctataaata gattttacat
     1261 cattactctg tacaatagag aaatacttgt tttgttaatt atgtttatcc caaattataa
     1321 agccccataa gcaagtcact ttggtaccat tcctgagaaa gaagtttaca tataataaaa
     1381 taaaacaatt ttata
//
