LOCUS       NM_133738               3806 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus anthrax toxin receptor 2 (Antxr2), mRNA.
ACCESSION   NM_133738 XM_355624
VERSION     NM_133738.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3806)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3806)
  AUTHORS   Zuo,Z., Liu,J., Sun,Z., Cheng,Y.W., Ewing,M., Bugge,T.H.,
            Finkel,T., Leppla,S.H. and Liu,S.
  TITLE     ERK and c-Myc signaling in host-derived tumor endothelial cells is
            essential for solid tumor growth
  JOURNAL   Proc Natl Acad Sci U S A 120 (1), e2211927120 (2023)
   PUBMED   36574698
REFERENCE   3  (bases 1 to 3806)
  AUTHORS   Cryan,L.M., Tsang,T.M., Stiles,J., Bazinet,L., Lee,S.L.,
            Garrard,S., Madrian,E., Roberts,C., Payne,J., Jensen,A.,
            Frankel,A.E., Ackroyd,P.C., Christensen,K.A. and Rogers,M.S.
  TITLE     Capillary morphogenesis gene 2 (CMG2) mediates growth
            factor-induced angiogenesis by regulating endothelial cell
            chemotaxis
  JOURNAL   Angiogenesis 25 (3), 397-410 (2022)
   PUBMED   35212873
  REMARK    GeneRIF: Capillary morphogenesis gene 2 (CMG2) mediates growth
            factor-induced angiogenesis by regulating endothelial cell
            chemotaxis.
REFERENCE   4  (bases 1 to 3806)
  AUTHORS   Yang,N.J., Isensee,J., Neel,D.V., Quadros,A.U., Zhang,H.B.,
            Lauzadis,J., Liu,S.M., Shiers,S., Belu,A., Palan,S., Marlin,S.,
            Maignel,J., Kennedy-Curran,A., Tong,V.S., Moayeri,M., Roderer,P.,
            Nitzsche,A., Lu,M., Pentelute,B.L., Brustle,O., Tripathi,V.,
            Foster,K.A., Price,T.J., Collier,R.J., Leppla,S.H., Puopolo,M.,
            Bean,B.P., Cunha,T.M., Hucho,T. and Chiu,I.M.
  TITLE     Anthrax toxins regulate pain signaling and can deliver molecular
            cargoes into ANTXR2+ DRG sensory neurons
  JOURNAL   Nat Neurosci 25 (2), 168-179 (2022)
   PUBMED   34931070
REFERENCE   5  (bases 1 to 3806)
  AUTHORS   Merritt,C., Chun,E.M., Fattah,R.J., Silva,L.M., Ma,Q.Q.,
            Moayeri,M., Paliga,D., Neumann,S., Heumann,R., Leppla,S.H. and
            Bugge,T.H.
  TITLE     Imaging of anthrax intoxication in mice reveals shared and
            individual functions of surface receptors CMG-2 and TEM-8 in
            cellular toxin entry
  JOURNAL   J Biol Chem 298 (1), 101467 (2022)
   PUBMED   34871548
REFERENCE   6  (bases 1 to 3806)
  AUTHORS   Eng,S.R., Dykes,I.M., Lanier,J., Fedtsova,N. and Turner,E.E.
  TITLE     POU-domain factor Brn3a regulates both distinct and common programs
            of gene expression in the spinal and trigeminal sensory ganglia
  JOURNAL   Neural Dev 2, 3 (2007)
   PUBMED   17239249
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3806)
  AUTHORS   Rainey,G.J., Wigelsworth,D.J., Ryan,P.L., Scobie,H.M., Collier,R.J.
            and Young,J.A.
  TITLE     Receptor-specific requirements for anthrax toxin delivery into
            cells
  JOURNAL   Proc Natl Acad Sci U S A 102 (37), 13278-13283 (2005)
   PUBMED   16141341
  REMARK    GeneRIF: because protective antigen binds to CMG2 with much higher
            affinity than it does to TEM8, a lower pH is needed to attenuate
            CMG2 binding to allow pore formation; toxin can form pores at
            different points in the endocytic pathway
REFERENCE   8  (bases 1 to 3806)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
REFERENCE   9  (bases 1 to 3806)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   10 (bases 1 to 3806)
  AUTHORS   Takahashi,Y., Miyata,M., Zheng,P., Imazato,T., Horwitz,A. and
            Smith,J.D.
  TITLE     Identification of cAMP analogue inducible genes in RAW264
            macrophages
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 385-394 (2000)
   PUBMED   11004510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133519.3 and AC125131.4.
            
            On Dec 28, 2021 this sequence version replaced NM_133738.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076595.1, AK170655.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               AC133519.3         96695-97314
            621-692             AC133519.3         98057-98128
            693-764             AC133519.3         100170-100241
            765-846             AC133519.3         122772-122853
            847-954             AC133519.3         123340-123447
            955-1023            AC133519.3         123588-123656
            1024-1104           AC133519.3         124405-124485
            1105-1165           AC133519.3         147678-147738
            1166-1264           AC133519.3         150013-150111
            1265-1334           AC133519.3         152322-152391
            1335-1413           AC133519.3         161952-162030
            1414-1509           AC133519.3         167007-167102
            1510-1551           AC133519.3         178501-178542
            1552-1647           AC133519.3         179372-179467
            1648-1812           AC133519.3         189145-189309
            1813-1893           AC133519.3         189545-189625
            1894-3806           AC125131.4         126629-128541       c
FEATURES             Location/Qualifiers
     source          1..3806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.77 cM"
     gene            1..3806
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /note="anthrax toxin receptor 2"
                     /db_xref="GeneID:71914"
                     /db_xref="MGI:MGI:1919164"
     exon            1..620
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             469..1932
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /codon_start=1
                     /product="anthrax toxin receptor 2 precursor"
                     /protein_id="NP_598499.1"
                     /db_xref="CCDS:CCDS39177.1"
                     /db_xref="GeneID:71914"
                     /db_xref="MGI:MGI:1919164"
                     /translation="MVAGRSRARSPGSWLFPGLWLLAVGGPGSLLQAQEQPSCKKAFD
                     LYFVLDKSGSVANNWIEIYNFVHQLTERFVSPEMRLSFIVFSSQATIILPLTGDRYKI
                     GKGLEDLKAVKPVGETYIHEGLKLANEQIQNAGGLKASSIIIALTDGKLDGLVPSYAE
                     NEAKKSRSLGASVYCVGVLDFEQAQLERIADSKDQVFPVKGGFQALKGIINSILAQSC
                     TEILELSPSSVCVGEKFQVVLTGRAVTSISHDGSVLCTFTANSTYTKSEKPVSIQPSS
                     ILCPAPVLNKDGETLEVSISYNDGKSAVSRSLTITATECTNGIAAIVAILVLLLLLGA
                     ALMWWFWPLCCKVVIKDPPPPPSAPMEEEEEDPLPNKKWPTVDASYYGGRGVGGIKRM
                     EVRWGDKGSTEEGARLEKAKNAVVMVPEEEIPIPSRPPRPRPTHQAPQTKWYTPIKGR
                     LDALWALIMKQYDRVSLMRPQEGDEGRCINFSRVPHQ"
     exon            621..692
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..764
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..846
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            847..954
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1023
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1104
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1165
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1264
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1334
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1413
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1509
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1551
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1647
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1812
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1893
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..3806
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3786..3791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /note="hexamer: AATAAA"
     polyA_site      3806
                     /gene="Antxr2"
                     /gene_synonym="2310046B19Rik; cI-35; CMG-2; CMG2"
                     /note="major polyA site"
ORIGIN      
        1 gagttcccgc ggcgatcgtg gggtccgcgg gtgcctgtcc cgcagctcac caccgcagct
       61 agacgccagc ctttctgctc ccgggtgggc gccggagact cagcgggagg cgaggaactt
      121 gtcccgagag ctgtcgctgc gggcctcatt gtctgcagca actctccgga atccggagtg
      181 ggagaactgg actctgtcca ctgggatttg cccagagttc cggcggcagc tgtggcggct
      241 gcggagactc tctttgtcct cccaggacct cgctctctct cctcagtggc agctgttggg
      301 tggctctgag cttggagagg gcatcccagc cccgctcagc ctctgacccc cgggcgagtc
      361 cccggtgact ccgcctcttt cacgtctctg ctctgtgaag cccggagccc agaaccccga
      421 gcccaaggga ctgtgagcca gagagagctg ccgggccccg gccacaggat ggtggccggt
      481 cggtcccggg cgcgcagccc tgggagctgg ctgttccctg gcctgtggtt gttggctgtg
      541 ggcggtccgg ggtcgttgct gcaagcccag gagcagccct cttgcaaaaa agccttcgat
      601 ttgtacttcg tactggacaa gtctggcagt gtagcaaata actggattga aatttataat
      661 tttgtccacc agctgacaga gagatttgtg agccctgaaa tgagattgtc cttcattgtg
      721 ttttcttccc aagcaaccat tattttgcca ttaactggag acaggtacaa aattggcaaa
      781 ggactggagg atttaaaggc cgttaagcca gttggagaaa catacatcca tgaaggacta
      841 aagcttgcaa acgaacaaat tcaaaatgca ggaggcttaa aagcctccag tatcataatt
      901 gctttgacgg acggtaagct ggacggcctg gtaccatctt atgcagagaa cgaggcaaag
      961 aagtccaggt cacttggcgc tagtgtttac tgcgttgggg tccttgattt tgaacaagct
     1021 cagctggaaa gaattgctga ttccaaggac caggttttcc ctgtcaaagg tggatttcaa
     1081 gctctcaaag gcatcatcaa ctctatatta gctcaatcat gtactgaaat cctggaattg
     1141 agtccttcaa gtgtctgtgt aggggagaaa tttcaagttg ttctgactgg aagagcagtc
     1201 acgtcgatca gtcacgatgg cagtgtcctc tgtacattca ctgcaaacag cacatataca
     1261 aagagtgaga agccagtgag cattcagcca agttccatcc tttgtcctgc acctgtcctg
     1321 aacaaagatg gagaaactct tgaagtttca atcagctata atgatgggaa gtctgctgtc
     1381 tcaagatcct taacaatcac agccacagaa tgtaccaatg ggattgcagc catcgtagct
     1441 attttggtgt tgttgctgct cttgggtgct gccttgatgt ggtggttttg gcccctttgc
     1501 tgcaaagtgg ttatcaagga ccctccccca ccaccttctg caccaatgga ggaggaggag
     1561 gaggatcctt tgcccaacaa gaagtggccg actgtggacg cttcctacta cggaggtcga
     1621 ggtgttggag gaattaaaag gatggaggtc cgctggggag ataaaggatc tacagaggaa
     1681 ggtgcaaggc tagagaaagc aaaaaatgct gtggtgatgg tccctgaaga agagatcccc
     1741 atcccatcca gaccacctcg acccagaccc acacaccagg cacctcagac aaagtggtac
     1801 acgccaatca agggtcgttt ggatgcactc tgggctttga tcatgaagca gtatgaccgg
     1861 gtgtccttga tgagacccca ggaaggtgat gagggccgat gcataaactt ctcccgggtt
     1921 ccacatcaat aagacgggag aacaaagaat gagaagataa gaagacagtg tgacagtgta
     1981 tcttcatgat gctgatttcc aacagaaccg acagtccggt gcatctcaga agttcttggg
     2041 acaacagccc attttctctc tgtcaggaaa tgtttcctct gccttctgct ttctgtgcac
     2101 taaacatttt ccaacacttg ttctgccatc gacatgagag gtgatgaaag tcatcggcga
     2161 tagcccatga ttcacgacac tgaaaatccc gaggaatgtt agtttgcatg ctagggttta
     2221 tgcaaagctc gttttgacta tgtaagagga caaagcagac acatcgatga tgtaatgata
     2281 ccaaagctag gactgcaaat ccaccagcca cagaggtttg caatggagac tggtgattct
     2341 gccatgaatg tgtggcccct gtgcttttgt ttggcaagat ctttagctac aagcaaaaca
     2401 tgaagtttcc tcccaggcta aacagataat ggagtccact gccttgtagc tatgtcagat
     2461 agcaaagcct ttccaagtcc tccattactt tgtgccttac aggaaatttc tgactagaaa
     2521 atcttgtcac tgttacactg aaagtgcaca cgcatgacaa aatgtagacg agacgcctca
     2581 aggtactgga tgcaagcagg atttttgccc tttagttttc caagacacct ttcttttatt
     2641 atgcacttga gacaagagaa ttaatagagc gttaattcaa caggaagacc gcctccaacc
     2701 aaagacctgg agcgcagcat aaggacttgt gatttgagac gttgtcccca gcctggtaga
     2761 tccccctttc tcagcatttg ggatttagca gtgcataaag cattaatatc tgtaaaaaca
     2821 cctagatgtt tgtttggctt ttaatttaag gaagctgcaa ccacaaagct tccgctcagg
     2881 gttttttctt ccttcaagtc tccaagggct cttcagcgtc acaagccagc aactctcttt
     2941 gcatgaaaat ttcaaagttt aattaatata attaaaggca acagcaagca gcagcctgtg
     3001 aagattttgc tcatcttttt tatgcctttt gacattgagt gacctatcac tgtatgcatg
     3061 ttacttagaa attgaggagc accacacctt ggttgtggtt cagcctggga aagagacctc
     3121 cttccttctg tttataaatt aaaatcagga ggggcgccat cagaaagcat ggacaatata
     3181 catactataa atttttagaa atatcaccat cgtgtcacgt caacgatgcc aaattatgtt
     3241 agtgtgagca gaaacccggt gggggaggaa ggcggcagca gccgaaggaa atagctcaga
     3301 taatctagtc actttcgata ctgtacttca gatgcgaaat ggatattcga ctggaaacct
     3361 gacaaagcgc gcctgctttg atgtgaactg ttatagacaa tgaccagtgg ccgggtcagt
     3421 gggatgtctc tctgcgagca caaaggctta tcaaatgaca ctaaaaataa gttcaacaac
     3481 catcactttg gaagggagaa ggcgaacatt tcatgtttgg cgggcatgtg agtgcaggag
     3541 atggaaagag ccatttagag catcctcata taattgcccg cattgtactc ttcatggaaa
     3601 tttcaaagga cggcagtgat atttttcatt ggtgtccacg tttgtggcac tgctccaaga
     3661 agccttatgc acacatacaa atatacaaat gcacacacct acactctcta gctttaatct
     3721 ttttgctcaa ccttatttat atcactgact ggctggatcc aaagtcacac ctccacatat
     3781 tagtgaataa aaaattttta cctgtg
//
