LOCUS       NM_054041               5280 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus anthrax toxin receptor 1 (Antxr1), mRNA.
ACCESSION   NM_054041
VERSION     NM_054041.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5280)
  AUTHORS   Hsu,K.S., Dunleavey,J.M., Szot,C., Yang,L., Hilton,M.B., Morris,K.,
            Seaman,S., Feng,Y., Lutz,E.M., Koogle,R., Tomassoni-Ardori,F.,
            Saha,S., Zhang,X.M., Zudaire,E., Bajgain,P., Rose,J., Zhu,Z.,
            Dimitrov,D.S., Cuttitta,F., Emenaker,N.J., Tessarollo,L. and St
            Croix,B.
  TITLE     Cancer cell survival depends on collagen uptake into
            tumor-associated stroma
  JOURNAL   Nat Commun 13 (1), 7078 (2022)
   PUBMED   36400786
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5280)
  AUTHORS   Merritt,C., Chun,E.M., Fattah,R.J., Silva,L.M., Ma,Q.Q.,
            Moayeri,M., Paliga,D., Neumann,S., Heumann,R., Leppla,S.H. and
            Bugge,T.H.
  TITLE     Imaging of anthrax intoxication in mice reveals shared and
            individual functions of surface receptors CMG-2 and TEM-8 in
            cellular toxin entry
  JOURNAL   J Biol Chem 298 (1), 101467 (2022)
   PUBMED   34871548
REFERENCE   3  (bases 1 to 5280)
  AUTHORS   Gong,Q., Deng,J., Zhang,L., Zhou,C., Fu,C., Wang,X. and Zhuang,L.
  TITLE     Targeted silencing of TEM8 suppresses non-small cell lung cancer
            tumor growth via the ERK/Bcl-2 signaling pathway
  JOURNAL   Mol Med Rep 24 (2) (2021)
   PUBMED   34165155
  REMARK    GeneRIF: Targeted silencing of TEM8 suppresses nonsmall cell lung
            cancer tumor growth via the ERK/Bcl2 signaling pathway.
REFERENCE   4  (bases 1 to 5280)
  AUTHORS   Jiang,Q., Qin,X., Yoshida,C.A., Komori,H., Yamana,K., Ohba,S.,
            Hojo,H., Croix,B.S., Kawata-Matsuura,V.K.S. and Komori,T.
  TITLE     Antxr1, Which is a Target of Runx2, Regulates Chondrocyte
            Proliferation and Apoptosis
  JOURNAL   Int J Mol Sci 21 (7), 2425 (2020)
   PUBMED   32244499
  REMARK    GeneRIF: Antxr1, Which is a Target of Runx2, Regulates Chondrocyte
            Proliferation and Apoptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5280)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   6  (bases 1 to 5280)
  AUTHORS   Liu,S., Crown,D., Miller-Randolph,S., Moayeri,M., Wang,H., Hu,H.,
            Morley,T. and Leppla,S.H.
  TITLE     Capillary morphogenesis protein-2 is the major receptor mediating
            lethality of anthrax toxin in vivo
  JOURNAL   Proc Natl Acad Sci U S A 106 (30), 12424-12429 (2009)
   PUBMED   19617532
  REMARK    GeneRIF: Data show that the lethality of anthrax toxin for mice is
            mostly mediated by CMG2 and that TEM8 plays only a minor role.
REFERENCE   7  (bases 1 to 5280)
  AUTHORS   Xu,Q., Hesek,E.D. and Zeng,M.
  TITLE     Transcriptional stimulation of anthrax toxin receptors by anthrax
            edema toxin and Bacillus anthracis Sterne spore
  JOURNAL   Microb Pathog 43 (1), 37-45 (2007)
   PUBMED   17459655
  REMARK    GeneRIF: The mRNA transcripts of both receptors, ANTXR1 and ANTXR2
            were detected in J774A.1 cells and mouse tissues suggesting that
            anthrax edema toxin and B. anthracis Sterne spore are involved in
            the ANTXR mRNA regulation in host cells.
REFERENCE   8  (bases 1 to 5280)
  AUTHORS   Michaud,E.J., Culiat,C.T., Klebig,M.L., Barker,P.E., Cain,K.T.,
            Carpenter,D.J., Easter,L.L., Foster,C.M., Gardner,A.W., Guo,Z.Y.,
            Houser,K.J., Hughes,L.A., Kerley,M.K., Liu,Z., Olszewski,R.E.,
            Pinn,I., Shaw,G.D., Shinpock,S.G., Wymore,A.M., Rinchik,E.M. and
            Johnson,D.K.
  TITLE     Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice
  JOURNAL   BMC Genomics 6, 164 (2005)
   PUBMED   16300676
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5280)
  AUTHORS   Bonuccelli,G., Sotgia,F., Frank,P.G., Williams,T.M., de
            Almeida,C.J., Tanowitz,H.B., Scherer,P.E., Hotchkiss,K.A.,
            Terman,B.I., Rollman,B., Alileche,A., Brojatsch,J. and Lisanti,M.P.
  TITLE     ATR/TEM8 is highly expressed in epithelial cells lining Bacillus
            anthracis' three sites of entry: implications for the pathogenesis
            of anthrax infection
  JOURNAL   Am J Physiol Cell Physiol 288 (6), C1402-C1410 (2005)
   PUBMED   15689409
  REMARK    GeneRIF: This is the first demonstration that the ATR/TEM8 protein
            is highly expressed in epithelial cells, suggesting that the
            ATR/TEM8 expression pattern is highly relevant for understanding
            the pathogenesis of anthrax infection.
REFERENCE   10 (bases 1 to 5280)
  AUTHORS   Carson-Walter,E.B., Watkins,D.N., Nanda,A., Vogelstein,B.,
            Kinzler,K.W. and St Croix,B.
  TITLE     Cell surface tumor endothelial markers are conserved in mice and
            humans
  JOURNAL   Cancer Res 61 (18), 6649-6655 (2001)
   PUBMED   11559528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB649806.1 and BC094544.1.
            
            On Apr 5, 2007 this sequence version replaced NM_054041.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094544.1, AF378762.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BB649806.1         48-102
            56-5280             BC094544.1         1-5225
FEATURES             Location/Qualifiers
     source          1..5280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.94 cM"
     gene            1..5280
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /note="anthrax toxin receptor 1"
                     /db_xref="GeneID:69538"
                     /db_xref="MGI:MGI:1916788"
     exon            1..479
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..2022
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /note="tumor endothelial marker 8"
                     /codon_start=1
                     /product="anthrax toxin receptor 1 precursor"
                     /protein_id="NP_473382.1"
                     /db_xref="CCDS:CCDS20318.1"
                     /db_xref="GeneID:69538"
                     /db_xref="MGI:MGI:1916788"
                     /translation="MDRAGRLGAGLRGLCVAALVLVCAGHGGRREDGGPACYGGFDLY
                     FILDKSGSVLHHWNEIYYFVEQLAHRFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQ
                     GLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSE
                     REANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSC
                     IEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFAVEDTY
                     LLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLVLFLLLAL
                     ALLWWFWPLCCTVIIKEVPPPPVEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRM
                     EVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKG
                     KLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNSQPAKYPLNNTYHPSSPPPAP
                     IYTPPPPAPHCPPPAPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV"
     exon            480..551
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            552..623
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            624..705
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            706..739
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            740..819
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            820..888
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            889..969
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1030
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1129
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1199
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1278
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1374
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1416
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1512
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1680
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1761
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..5264
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4466..4471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
                     /note="hexamer: AATAAA"
     polyA_site      4489
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
     polyA_site      5248
                     /gene="Antxr1"
                     /gene_synonym="2310008J16Rik; 2810405N18Rik; Antrx1; Tem8"
ORIGIN      
        1 aagaacaatt tgaaaaccca ccccatcata cttaaaatct aggacaaaga gccatcggga
       61 cggaactgct tcgactgcaa agcttcaagc gcagcctggg agcggcctgg tggccctatc
      121 ccggcagctc cacacagcag aacgccctgg gtccctgaaa ctcgaaaccc gggctcagaa
      181 ccagcggaaa ccaaagcgaa atccttgaac ttctctgaac aattgcttcc gggcgtttgc
      241 tgagagccgg gggacctgac cggagcccag gccgcgtatg gcgcgcccct gatgtcacac
      301 ggacgccagc gaggccagcg ctccggctgc agcatggacc gcgcggggcg cctgggtgcg
      361 ggcctgcggg gactctgcgt ggctgcactc gtgctcgtgt gcgccggaca cgggggccgc
      421 cgcgaggatg ggggaccagc ttgctacgga ggattcgacc tctacttcat cctggacaag
      481 tcaggaagtg tgctgcacca ctggaatgaa atctactact tcgtggagca gttggctcat
      541 agattcatca gcccacagct aaggatgtcc ttcattgtct tctctactcg agggacaact
      601 ttaatgaaac taactgagga cagggaacag atccgacaag gcctagaaga gctccagaaa
      661 gttctgccag gaggagacac ttacatgcac gaaggattcg agagggccag tgagcagatt
      721 tactatgaga acagtcaagg atacaggacg gcgagcgtca tcatcgcgtt gacggatggg
      781 gagctgcacg aggacctctt cttctactca gagagggagg ctaaccgatc ccgagacctt
      841 ggtgcgattg tttactgcgt tggcgtgaag gatttcaatg aaactcagtt ggctcggatt
      901 gcagacagta aggaccacgt gtttcctgtg aacgacggct tccaggctct ccaaggcatt
      961 atccactcaa ttttaaagaa atcctgcatc gaaattctgg cggctgaacc atccaccatc
     1021 tgcgcgggag agtcctttca agtggtcgta agaggaaatg gcttccgaca tgcccgcaat
     1081 gtggacaggg tcctctgcag cttcaaaatc aatgactcag tcacgctcaa tgagaagccc
     1141 tttgctgtgg aagacactta tttgctgtgc ccagcaccaa tcttgaaaga agttggcatg
     1201 aaagctgcac tgcaggtcag catgaacgac ggcctgtcct tcatctccag ttctgtcatc
     1261 atcaccacca cacactgttc agacggctcc atcctggcga ttgctctgct ggtcctcttc
     1321 ctgctgctgg ccctggcgct gctctggtgg ttctggcccc tctgctgcac agtgatcatc
     1381 aaggaggtcc ctccaccccc tgttgaggag agtgaggaag aagacgatga tggtttgcca
     1441 aagaagaaat ggcccacagt agatgcctct tattatggtg gacgcggtgt gggaggcatt
     1501 aaaagaatgg aggtccgctg gggagaaaag ggctccacag aagaaggggc gaagttagaa
     1561 aaggcaaaga atgcacgagt caagatgcca gagcaagaat atgagttccc agaaccccga
     1621 aacctcaaca acaacatgcg ccggccttcc tcgcctcgga agtggtactc gcccatcaag
     1681 ggaaaactcg atgccttgtg ggttctgctg agaaaaggat atgaccgagt gtctgtgatg
     1741 aggccacagc caggagacac gggacgctgt atcaacttca ccagagtgaa gaacagtcag
     1801 ccagccaagt atcccctgaa caacacctac caccccagct ccccacctcc cgctcctatc
     1861 tacacacccc caccccctgc tccccactgc cctcccccag cccccagtgc ccccactcct
     1921 cccattcctt ccccaccatc cactctcccc cctcctcctc aggccccacc ccctaacagg
     1981 gcacctcccc cctcccgacc tcctccaagg ccttctgtct agaacccaaa gtccgagctc
     2041 tgggctgcct gagcaactcc agcaggaggc ttctctgctg aaagaaagat ctgcccagcc
     2101 tatgtggtga gtggcacctg atgtttgcac gatttaaaag caagtcgtga tgggcagaac
     2161 aaaatgggca ttttgaactg cctgaagaca gacaatgaga caataacagt cacattatag
     2221 cctgtgaccc ctcacctcta gaggaaggtt cccgagatgg ccacattgcc acagtgctct
     2281 cagccagatt atgtcccatg aagaccagga agaaagtgac ttccaagaat ggaatgcagc
     2341 attggataag aagcacctgg ctgagattct gacctcactg atttgactct tgattcttgg
     2401 actgggagcc aggccatctc cacccctggt accacccagc aactctgaaa atgtgcagtg
     2461 tccctagtat gcatcgaata ggtatccaac tgggatctgc aggttgcctt ataaagagca
     2521 tatgctctat tctctttccc gaacttcctg gtttcccagt gatgagggaa ggggaaaggt
     2581 gttgccatgc ttagaagtta gaggacgtca gtgctcagca ctgatggaga agcgttgatg
     2641 ggagtgtcca gctcttacat ctagaaatgg ctggcttcag caggcacagt tcctaaacca
     2701 acaagccttg tcattgtcaa aggcaaccta ctaatgattc accttaaaca tcaaggttga
     2761 ctgtggcata ggtcagagct gatcacacag aaccttcccc atgaaatcgc aaggttcctc
     2821 atcttcaaat acccaggacc ccagagattt ctaaatccag ctaagagaca gtagtcctga
     2881 cttggcaaga aaaccattcc cagttgtttt actctgaaac aggccgttgt atgtatggta
     2941 tatctctcct tggcctttca acctgctcac aagtattacc agttatgaag caaggagaaa
     3001 tacatccagt gtgtaataga aaagctctgc ccgcaatccc catgtcactc ctctacatta
     3061 ttctgaagct gcttggtcag tgagcccttt aacctcatgt agactctgga cactgtcacc
     3121 caatcatgaa aacagaggtc attgtcaaag gcagtgtata gcctgtacaa aaatgatgct
     3181 tccttcctca gtttccacag gccccaaaat tcctgtctta ggctcctaaa cctctaaact
     3241 ttttcctgga acaaaagata taaaacgggc ataagttttt atgttttggg ctgtgatctc
     3301 caaagatcct tcaagaactc aagttagcct cattcttcca gcttgtttag aacagaggca
     3361 tccaggtgtc atgcactcca tagacaccaa tccttgttcc caaggcagac attattaatc
     3421 aatctcagca ctagttctca atttaatcca attatatttt tccacagtac ttcacatctc
     3481 ttatgacctg ttggtcatca gttagaattg agagagataa acactgtttg taatccctac
     3541 cttagaaaga aaagcagagg agaatggggg aaccaccagc ataaaagtta ttatctgggg
     3601 aaaatcgacc tgaaagaacg cccaagtcca agacctatgg tgctgacacc aaagtaacac
     3661 tttcccaagt gtaccccaga ccccactctt ctccctgtgg ccaccactcc ctgcttttca
     3721 ggagttgtga aaaagatctc cttcaccctt actgtgcccc catattagaa caaggcttgt
     3781 ttagtgtagt ccttgttaaa caggtgccag aatgtctcag ccacctgaga tgacattgct
     3841 gggccccaga aaaccattcc aaggagaatg ggctccccag gctcagagca tgcaactatg
     3901 agcccatggc aactgttttg actgctggca gtacaaaacg ggccacccca cattacagct
     3961 gcaggatttg tgcagccata agaaagtacg aaccaagatg ctggcgttgc tgttcaacaa
     4021 gcatgggctt cggggaaggc agcagactcc gagagcaggc cttgtgcagt gtcccaaggg
     4081 gctgtggtga agtgtctgag gaaaaatgaa tgctgataca tggtgattct gagaagaatt
     4141 tgcaaggttt gaccttagaa tttatggaat gtcttccctg gtcattcaga attatggcta
     4201 gaagtttcta gaaaccgtca aggttaatac ctttcagagt aggtgattac aggcaggaag
     4261 agctttgatg tggtttacaa agcccatcag ttctgtgtca ttccctgtaa gcaacaggag
     4321 atggtggttg tgattagcaa actgcatgtg ttatttgttt gactccttgt tattgtcctt
     4381 acggaggatt ttttttatat aagccaaatt ttgttgtata tattcatatt ccacgtgaca
     4441 gatggaagca cgtcctatca gtgtgaataa aaagaacagt tgtagtaaat tattaaagcc
     4501 agtgatttca tggcaggtta ccctaccaag ctgtgcttgt tgatctccca tgaccatact
     4561 gcttttacaa tgtacaaata gttcctaggt gacgagaccc tcctttacat aatgccgatg
     4621 acagccttgc tgggaactgc ggtccttctg ctgtgacagc cagctcgaaa acaggtcctg
     4681 cctggagctt gccacacact ttagggagac ataagagctg tctttcccca gcgtcaggga
     4741 caaagctacc ataaagaagt ggaaaagtct tggctctcca gcctgggaca gaggtctctc
     4801 tggaacccca aggaagagca gaaatgatcc ttgcctgcca ctgcacacaa tgtgatggtg
     4861 gaaaatccat caaggaataa ttgtgagata atgaccgaca gttcaggcgc aaagggaatt
     4921 catgctgtgt aaagtgggtg gaattcgttt gcaagctatg caaagcctga tcttactcac
     4981 caggaggatg gaaagggttt ttttagttat ctgagctcag ctgagttatc acgcttggag
     5041 aaccgattta aaggaattag aatatgattt ctgaatacac ataacattaa actcttctct
     5101 ttttctatgg taatttagtt atggacgttc agcgtctctg agttattgtt ataaaagact
     5161 tgtcatcacc gcactgtgct gtaggagact gggctgaacc tgtacaatgg tataccctgg
     5221 aagttgcttt tttaaaaaaa aataataata aacacctaaa atcaaaaaaa aaaaaaaaaa
//
