LOCUS       NM_145410                918 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus adenine nucleotide translocase lysine
            methyltransferase (Antkmt), transcript variant 1, mRNA.
ACCESSION   NM_145410
VERSION     NM_145410.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 918)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB855744.1, AK162337.1 and AC134908.5.
            
            On Oct 26, 2013 this sequence version replaced NM_145410.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146214.1, AK162337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                BB855744.1         2-89
            89-910              AK162337.1         65-886
            911-918             AC134908.5         164435-164442       c
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.89 cM"
     gene            1..918
                     /gene="Antkmt"
                     /gene_synonym="ANT-KMT; Fam173a"
                     /note="adenine nucleotide translocase lysine
                     methyltransferase"
                     /db_xref="GeneID:214917"
                     /db_xref="MGI:MGI:2384888"
     exon            1..342
                     /gene="Antkmt"
                     /gene_synonym="ANT-KMT; Fam173a"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..870
                     /gene="Antkmt"
                     /gene_synonym="ANT-KMT; Fam173a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM173A; protein N-lysine methyltransferase
                     FAM173A; adenine nucleotide translocase lysine
                     N-methyltransferase; family with sequence similarity 173,
                     member A"
                     /codon_start=1
                     /product="adenine nucleotide translocase lysine
                     N-methyltransferase isoform 1"
                     /protein_id="NP_663385.2"
                     /db_xref="CCDS:CCDS28528.1"
                     /db_xref="GeneID:214917"
                     /db_xref="MGI:MGI:2384888"
                     /translation="MDQDDPAEALTELREKRLGLLEIVQAAAGSGLAVYTIWALLLQP
                     GFRRVPLRLQVPYVGASARQVENVLSLLRGRPGKMVDLGSGDGRIVLAAHQCGLRPAM
                     GYELNPWLVGLARLHAWRAGCSASVCYHRKDLWKVSLRDCHNVSVFLAPSVLQLLEDK
                     LQAELPVGARVVSGRFPLPTWQPVAVVGEGTDRVWAYDVHGSGPTVSSCGVPIKAIPE
                     SSSTLVPRAPV"
     exon            343..447
                     /gene="Antkmt"
                     /gene_synonym="ANT-KMT; Fam173a"
                     /inference="alignment:Splign:2.1.0"
     exon            448..588
                     /gene="Antkmt"
                     /gene_synonym="ANT-KMT; Fam173a"
                     /inference="alignment:Splign:2.1.0"
     exon            589..639
                     /gene="Antkmt"
                     /gene_synonym="ANT-KMT; Fam173a"
                     /inference="alignment:Splign:2.1.0"
     exon            640..918
                     /gene="Antkmt"
                     /gene_synonym="ANT-KMT; Fam173a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      891..896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Antkmt"
                     /gene_synonym="ANT-KMT; Fam173a"
                     /note="hexamer: AATAAA"
     polyA_site      912
                     /gene="Antkmt"
                     /gene_synonym="ANT-KMT; Fam173a"
                     /note="major polyA site"
ORIGIN      
        1 cacttccggc gactgatcgc agcggatact tagatttctg cagttgcggc tgcggttggc
       61 tggcgtacgc tgcaagcgga tagagtttgg ctcaggctgg gggcagcggg gagggcaacc
      121 gcttccatta ccggccggga gccttgggaa gtaggacctg gaactgagtg tctgtcaatc
      181 atggatcagg acgacccagc cgaagcgttg actgagctac gcgagaagcg gctgggcttg
      241 ctggagatag tgcaagcggc ggcaggctcg ggattggccg tctatactat atgggcgctg
      301 ctgctgcagc cgggcttccg ccgggtgcct ctgaggctgc aggtgcccta cgttggcgcg
      361 agtgcccggc aggttgagaa cgtgctgtca ctgttgcgag gccgccctgg aaaaatggtg
      421 gatctaggct ctggtgatgg caggatcgtg ctggcggccc accaatgtgg tctccgtcca
      481 gctatgggat atgagctgaa cccgtggctt gtgggacttg cacggctgca tgcctggaga
      541 gccggttgtt ctgcgagtgt ctgctaccat cgaaaagatc tctggaaggt gagcctcagg
      601 gactgtcaca acgtgtctgt gttcctggct cccagtgtgc tccaactgct ggaggacaaa
      661 ctgcaagcag agctccctgt gggggcccgt gtggtatctg gacgattccc ccttcccacc
      721 tggcagcctg tagctgtggt gggcgagggc actgacagag tttgggccta tgatgtccat
      781 ggttctgggc caactgtgtc ttcttgtggg gtgcccatca aggccatccc agagtccagt
      841 tctaccttag tccctagagc ccctgtttga caaactggct gactggataa aataaagact
      901 ctgtgggttc aatcctga
//
