LOCUS       NM_008486               3813 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus alanyl aminopeptidase, membrane (Anpep), mRNA.
ACCESSION   NM_008486 XM_006540678
VERSION     NM_008486.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3813)
  AUTHORS   Guo,X., Xia,S., Ge,T., Lin,Y., Hu,S., Wu,H., Xie,X., Zhang,B.,
            Zhang,S., Zeng,J., Chen,J.F., Montagne,A., Gao,F., Ma,Q. and
            Zhao,Z.
  TITLE     Atp13a5 Marker Reveals Pericyte Specification in the Mouse Central
            Nervous System
  JOURNAL   J Neurosci 44 (43), e0727242024 (2024)
   PUBMED   39261008
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3813)
  AUTHORS   Lind,M.C.H., Naimi,W.A., Chiarelli,T.J., Sparrer,T., Ghosh,M.,
            Shapiro,L. and Carlyon,J.A.
  TITLE     Anaplasma phagocytophilum invasin AipA interacts with CD13 to
            elicit Src kinase signaling that promotes infection
  JOURNAL   mBio 15 (10), e0156124 (2024)
   PUBMED   39324816
  REMARK    GeneRIF: Anaplasma phagocytophilum invasin AipA interacts with CD13
            to elicit Src kinase signaling that promotes infection.
REFERENCE   3  (bases 1 to 3813)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3813)
  AUTHORS   Gupta,N., Soriano-Ubeda,C., Stein,P., Savy,V., Papas,B.N.,
            Ardestani,G., Carvacho,I., Alfandari,D., Williams,C.J. and
            Fissore,R.A.
  TITLE     Essential role of Mg2+ in mouse preimplantation embryo development
            revealed by TRPM7 chanzyme-deficient gametes
  JOURNAL   Cell Rep 42 (10), 113232 (2023)
   PUBMED   37824328
REFERENCE   5  (bases 1 to 3813)
  AUTHORS   Nguyen,J.N., Mohan,E.C., Pandya,G., Ali,U., Tan,C., Kofler,J.K.,
            Shapiro,L., Marrelli,S.P. and Chauhan,A.
  TITLE     CD13 facilitates immune cell migration and aggravates acute injury
            but promotes chronic post-stroke recovery
  JOURNAL   J Neuroinflammation 20 (1), 232 (2023)
   PUBMED   37817190
  REMARK    GeneRIF: CD13 facilitates immune cell migration and aggravates
            acute injury but promotes chronic post-stroke recovery.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3813)
  AUTHORS   Amiguet,P., D'Eustachio,P., Kristensen,T., Wetsel,R.A., Saris,C.J.,
            Hunter,T., Chaplin,D.D. and Tack,B.F.
  TITLE     Structure and chromosome assignment of the murine p36 (calpactin I
            heavy chain) gene
  JOURNAL   Biochemistry 29 (5), 1226-1232 (1990)
   PUBMED   2138915
REFERENCE   7  (bases 1 to 3813)
  AUTHORS   Ben-David,Y., Giddens,E.B. and Bernstein,A.
  TITLE     Identification and mapping of a common proviral integration site
            Fli-1 in erythroleukemia cells induced by Friend murine leukemia
            virus
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1332-1336 (1990)
   PUBMED   2304901
REFERENCE   8  (bases 1 to 3813)
  AUTHORS   Douglas,T.C. and Dawson,P.E.
  TITLE     Location of the gene for theta antigen in the mouse. III. The
            position of Thy-1 relative to Lap-1 and Mpi-1
  JOURNAL   J Hered 70 (4), 250-254 (1979)
   PUBMED   314952
REFERENCE   9  (bases 1 to 3813)
  AUTHORS   Womack,J.E., Taylor,B.A. and Barton,J.E.
  TITLE     Esterase 13, a new mouse esterase locus with recessive expression
            and its genetic location on chromosome 9
  JOURNAL   Biochem Genet 16 (11-12), 1107-1112 (1978)
   PUBMED   751643
REFERENCE   10 (bases 1 to 3813)
  AUTHORS   Womack,J.E., Lynes,M.A. and Taylor,B.A.
  TITLE     Genetic variation of an intestinal leucine arylaminopeptidase
            (Lap-1) in the mouse and its location on chromosome 9
  JOURNAL   Biochem Genet 13 (9-10), 511-518 (1975)
   PUBMED   1203051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY135516.1, AK171427.1, AK143746.1 and AI848985.1.
            
            On or before Oct 25, 2017 this sequence version replaced
            XM_006540678.3, NM_008486.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY135516.1         1-16
            17-619              AK171427.1         2-604
            620-3298            AK143746.1         189-2867
            3299-3792           AK171427.1         3287-3780
            3793-3813           AI848985.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..3813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.19 cM"
     gene            1..3813
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /note="alanyl aminopeptidase, membrane"
                     /db_xref="GeneID:16790"
                     /db_xref="MGI:MGI:5000466"
     exon            1..66
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            67..1089
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1232
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1369
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1496
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1651
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1765
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1909
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1975
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2041
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2217
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2291
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2425
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2481
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2629
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2721
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2832
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..3000
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3141
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3223
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3797
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3777..3782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /note="hexamer: AATAAA"
     polyA_site      3797
                     /gene="Anpep"
                     /gene_synonym="AP-M; AP-N; Apn; Cd13; P150"
                     /note="major polyA site"
ORIGIN      
        1 tttaacccgc cagagcaggc gggcggaggc gaggcaggag cagctcggag aagcgtgcag
       61 tcctaggtag attaccgtca ctgccttccc ccctgcctct aggtgccaag tctgcagcct
      121 gcccttcagc ccccgctcta gctgatttcc cacccccact cccccctctc catccaggcc
      181 acctgcagtc gtaaccacac actgtgttgg ttacagcagg catctcccct gcccaccccc
      241 atcccccatc ccttacccca agccagctct gcacactgtt tcatttctga tctctccaga
      301 gcctgggcag agcgtacccc tgtccagcct agtgaccttc gcctgagctc tggttaatat
      361 ttgtccgacc caaaggcagt ggggctccac cccctgtgag gatataagct ggccccgggg
      421 ctgctgttct ttcctcttgg cctgagctat tccgagctcc ctgtccaccg gcatcatggc
      481 caaggggttc tacatttcca agaccctggg catcttgggc atcctgttgg gtgtggcagc
      541 tgtgtgtacc atcatagctc tgtcggtggt ctacgctcag gagaagaata ggaatgcaga
      601 gaactctgcc acagccccca cgctcccggg cagcacctca gccaccaccg caaccaccac
      661 ccctgctgta gatgaaagca agccttggaa ccagtatcgc ttgcctaaga ctcttatacc
      721 tgactcctac cgggtgatcc tgagacccta cctcaccccc aacaatcagg gcctgtacat
      781 cttccaaggc aacagtactg ttcgctttac ctgcaaccag accacggatg tcattatcat
      841 ccacagcaaa aagctcaact acaccctcaa aggaaaccac agggtggtgt tgcgaaccct
      901 ggacggcact ccggcaccta acattgacaa aacggaactg gtagagcgta ctgagtacct
      961 ggtggtgcac ctgcaggggt ccctggtaga gggccgtcag tacgagatgg acagccagtt
     1021 ccagggggaa ctggctgatg acctggctgg cttctaccgc agcgagtaca tggaaggaga
     1081 cgtcaagaaa gtggtggcta caacgcagat gcaggctgct gatgctcgga aatcctttcc
     1141 atgttttgat gagccagcca tgaaggccat gttcaacatc acactcatct accccaacaa
     1201 cctcatagct ctgtctaata tgcttcccaa agagtccaag ccctatccgg aagacccttc
     1261 ctgcaccatg actgagttcc actccacccc taagatgtcc acatacctgc tggcctacat
     1321 cgtgagcgag ttcaaaaata taagctccgt ctcagccaat ggtgtccaga ttggaatctg
     1381 ggctcggccc agtgccattg atgagggcca gggtgattac gcactgaacg ttacaggccc
     1441 catcctaaat ttctttgccc aacattataa tacatcctac cctctaccaa agtctgacca
     1501 gattgccctg cctgacttca acgctggagc catggagaac tggggtctgg tgacctaccg
     1561 tgagagctcc ctggtctttg actctcagtc ctcctccatt agcaacaagg agcgggtggt
     1621 cactgtgatt gctcacgagc tggcccatca gtggtttggc aacctggtga ctgtggcttg
     1681 gtggaatgat ctgtggctga acgagggctt tgcctcctac gtggaatatc tgggtgctga
     1741 ctatgcagag cctacctgga atctgaaaga cctcatggta ctgaatgatg tgtaccgtgt
     1801 gatggccgtg gatgcccttg cctcctccca cccactgtcc agtcctgctg acgagatcaa
     1861 aacaccagac cagatcatgg agctgtttga cagcatcacc tacagcaagg gagcctcagt
     1921 catcaggatg ctgtccagtt tcctgacaga ggacctgttt aagaagggcc tttcatctta
     1981 tctccacacc taccagtact cgaacaccgt ttatctggac ctgtgggaac acctgcaaaa
     2041 ggccgtgaac caacagacag ctgtccaacc cccggccacg gtgcgcacta tcatggaccg
     2101 ctggattcta cagatgggct ttcccgttat cactgtgaac accaatacag gagaaatctc
     2161 ccagaaacac ttcctcctgg attccaagtc caacgttacc cgcccctccg agtttaatta
     2221 catctggatc gcgcccattc catttctcaa aagtggacag gaggatcact actggctgga
     2281 tgtcgagaaa aaccagagtg caaagttcca gacatcctcc aatgaatgga tcttactgaa
     2341 cattaacgta accggctact acctggttaa ctatgatgag aacaactgga agaagcttca
     2401 gaatcagctg caaacagacc tttctgttat ccctgtcatc aaccgagcac agattatcca
     2461 cgactccttc aacctggcca gtgctaaaat gatacccatc accctggcgc tggacaacac
     2521 cctcttcctg gtcaaagagg cggagtacat gccctggcag gctgccctga gcagcctcaa
     2581 ctacttcaca ctcatgttcg accgctcgga ggtctacggc cccatgaaga ggtatctgaa
     2641 gaagcaagtt acgcccctct tcttctactt ccaaaataga accaacaact gggtcaaccg
     2701 tcctccaacg ctgatggagc agtacaatga aattaacgcc atcagcaccg cctgttccag
     2761 tggtctcaaa gagtgtaggg acctggtcgt tgagctctat agtcagtgga tgaaaaaccc
     2821 taataataac acgatccacc ccaaccttcg gtctactgtc tactgcaatg ccattgcttt
     2881 cggtggcgaa gaagagtgga actttgcttg ggaacagttc cggaatgcaa ctctggtgaa
     2941 cgaagcggac aaactccggt cagccttggc ctgtagcaaa gatgtgtgga ttttgaacag
     3001 gtacctgagt tacactctga acccggacta catccggaag caggacacca cctccaccat
     3061 catcagcatt gccagcaacg tggctgggca ccctctggtt tgggactttg tccgaagcaa
     3121 ctggaagaaa ctgtttgaga attacggtgg aggatctttc tcctttgcca atctcatcca
     3181 gggagtgacc cggcgcttct cctctgagtt cgagctgcag cagctggagc agtttaaagc
     3241 ggataactca gccacaggct ttggcaccgg cactcgggct ctggagcaag ccctggagaa
     3301 gacgagagcc aacatcgact gggtgaagga gaacaaagat gcggtattca agtggttcac
     3361 agagaacagc agttagttcc tggttctgag aaccacttgt cccagtatga cacctcttac
     3421 tatctcagca gcctgtgcag ggtctctgtc ctcagagctc cagacaccag catcctactc
     3481 tcaaggatga agtctccagc ctgtggagcc agcctagctc ctaactgtca ggctgacgga
     3541 cacctcccag gtcttgcacc ctcatgccaa ctctgcccca ggtccaggcc tctggggctg
     3601 atctcaggga agcccagctc tgaagctaga tttactggac aaagggcagc ctggaaagag
     3661 actccctgaa tgctttacta tccctgcccc ctacccccac ccctaccccc cacgagatcc
     3721 agaaccaaag aatcaacagg gcacaagatc tatatatatt tttaagagaa aatgtaaata
     3781 aagaatttct aaaatgaaaa aaaaaaaaaa aaa
//
