LOCUS       NM_009672               2077 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus acidic nuclear phosphoprotein 32 family member A
            (Anp32a), transcript variant 1, mRNA.
ACCESSION   NM_009672
VERSION     NM_009672.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2077)
  AUTHORS   Zhang,M., Liu,M., Chen,H., Qiu,T., Jin,X., Fu,W., Teng,Q., Zhao,C.,
            Xu,J., Li,Z. and Zhang,X.
  TITLE     PB2 residue 473 contributes to the mammalian virulence of H7N9
            avian influenza virus by modulating viral polymerase activity via
            ANP32A
  JOURNAL   J Virol 98 (3), e0194423 (2024)
   PUBMED   38421166
  REMARK    GeneRIF: PB2 residue 473 contributes to the mammalian virulence of
            H7N9 avian influenza virus by modulating viral polymerase activity
            via ANP32A.
REFERENCE   2  (bases 1 to 2077)
  AUTHORS   Peacock,T.P., Sheppard,C.M., Lister,M.G., Staller,E., Frise,R.,
            Swann,O.C., Goldhill,D.H., Long,J.S. and Barclay,W.S.
  TITLE     Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase
            Adaptations in Avian Influenza Virus
  JOURNAL   J Virol 97 (5), e0021323 (2023)
   PUBMED   37074204
  REMARK    GeneRIF: Mammalian ANP32A and ANP32B Proteins Drive Differential
            Polymerase Adaptations in Avian Influenza Virus.
REFERENCE   3  (bases 1 to 2077)
  AUTHORS   Quintiens,J., De Roover,A., Cornelis,F.M.F., Escribano-Nunez,A.,
            Sermon,A., Pazmino,S., Monteagudo,S. and Lories,R.J.
  TITLE     Hypoxia and Wnt signaling inversely regulate expression of
            chondroprotective molecule ANP32A in articular cartilage
  JOURNAL   Osteoarthritis Cartilage 31 (4), 507-518 (2023)
   PUBMED   36370958
  REMARK    GeneRIF: Hypoxia and Wnt signaling inversely regulate expression of
            chondroprotective molecule ANP32A in articular cartilage.
REFERENCE   4  (bases 1 to 2077)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   5  (bases 1 to 2077)
  AUTHORS   Beck,S., Zickler,M., Pinho Dos Reis,V., Gunther,T., Grundhoff,A.,
            Reilly,P.T., Mak,T.W., Stanelle-Bertram,S. and Gabriel,G.
  TITLE     ANP32B Deficiency Protects Mice From Lethal Influenza A Virus
            Challenge by Dampening the Host Immune Response
  JOURNAL   Front Immunol 11, 450 (2020)
   PUBMED   32231671
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2077)
  AUTHORS   Matilla,A. and Radrizzani,M.
  TITLE     The Anp32 family of proteins containing leucine-rich repeats
  JOURNAL   Cerebellum 4 (1), 7-18 (2005)
   PUBMED   15895553
  REMARK    Review article
REFERENCE   7  (bases 1 to 2077)
  AUTHORS   Yang,W., Li,C. and Mansour,S.L.
  TITLE     Impaired motor coordination in mice that lack punc
  JOURNAL   Mol Cell Biol 21 (17), 6031-6043 (2001)
   PUBMED   11486040
REFERENCE   8  (bases 1 to 2077)
  AUTHORS   Turgeon,B., Saba-El-Leil,M.K. and Meloche,S.
  TITLE     Cloning and characterization of mouse
            extracellular-signal-regulated protein kinase 3 as a unique gene
            product of 100 kDa
  JOURNAL   Biochem J 346 Pt 1 (Pt 1), 169-175 (2000)
   PUBMED   10657254
REFERENCE   9  (bases 1 to 2077)
  AUTHORS   Matilla,A., Koshy,B.T., Cummings,C.J., Isobe,T., Orr,H.T. and
            Zoghbi,H.Y.
  TITLE     The cerebellar leucine-rich acidic nuclear protein interacts with
            ataxin-1
  JOURNAL   Nature 389 (6654), 974-978 (1997)
   PUBMED   9353121
  REMARK    Erratum:[Nature 1998 Feb 19;391(6669):818]
REFERENCE   10 (bases 1 to 2077)
  AUTHORS   Chen,T.H., Brody,J.R., Romantsev,F.E., Yu,J.G., Kayler,A.E.,
            Voneiff,E., Kuhajda,F.P. and Pasternack,G.R.
  TITLE     Structure of pp32, an acidic nuclear protein which inhibits
            oncogene-induced formation of transformed foci
  JOURNAL   Mol Biol Cell 7 (12), 2045-2056 (1996)
   PUBMED   8970164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113291.16 and AC121813.3.
            
            On Aug 22, 2022 this sequence version replaced NM_009672.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062899.1, SRR13422589.371118.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC113291.16        169980-170179
            201-284             AC113291.16        200345-200428
            285-350             AC121813.3         113504-113569       c
            351-473             AC121813.3         113189-113311       c
            474-666             AC121813.3         111696-111888       c
            667-764             AC121813.3         110622-110719       c
            765-828             AC121813.3         108010-108073       c
            829-2077            AC121813.3         106571-107819       c
FEATURES             Location/Qualifiers
     source          1..2077
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.68 cM"
     gene            1..2077
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="acidic nuclear phosphoprotein 32 family member A"
                     /db_xref="GeneID:11737"
                     /db_xref="MGI:MGI:108447"
     exon            1..200
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..890
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vacidic (leucine-rich) nuclear phosphoprotein 32 family,
                     member A; acidic nuclear phosphoprotein pp32; leucine-rich
                     acidic nuclear protein; potent heat-stable protein
                     phosphatase 2A inhibitor I1PP2A; acidic (leucine-rich)
                     nuclear phosphoprotein 32 family, member A; acidic nuclear
                     phosphoprotein 32"
                     /codon_start=1
                     /product="acidic leucine-rich nuclear phosphoprotein 32
                     family member A isoform 1"
                     /protein_id="NP_033802.2"
                     /db_xref="CCDS:CCDS40663.1"
                     /db_xref="GeneID:11737"
                     /db_xref="MGI:MGI:108447"
                     /translation="MEMDKRIYLELRNRTPSDVKELVLDNCKSIEGKIEGLTDEFEEL
                     EFLSTINVGLTSISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNKIKD
                     LSTIEPLKKLENLKSLDLFNCEVTNLNAYRENVFKLLPQVMYLDGYDRDNKEAPDSDV
                     EGYVEDDDEEDEDEEEYDEYAQLVEDEEEEDEEEEGEEEDVSGEEEEDEEGYNDGEVD
                     DEEDEEEAGEEEGSQKRKREPDDEGEEDD"
     exon            201..350
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            351..473
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            474..666
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            667..764
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            765..828
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            829..2077
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1070..1075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="hexamer: AATAAA"
     polyA_site      1093
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="major polyA site"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="hexamer: CATAAA"
     polyA_site      1168
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
     regulatory      2058..2063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="hexamer: AATAAA"
     polyA_site      2077
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgcgcc gcgggtgctg ggggctcgag aaccgagcgg agctggttga gccttcaaag
       61 tcctaaaacg cgcggccgtg ggttcggggt ttattgattg aattccgctg gcgcaggatc
      121 ctctgcagaa agagagagcg cgagagatgg agatggacaa acggatttat ttagagctgc
      181 ggaacaggac gccctctgat gtgaaagagc tggtcctgga taactgtaag tcaattgaag
      241 gcaaaatcga aggcctcacg gatgagtttg aagaactgga attcctaagt acaatcaacg
      301 taggcctcac ctccatttcc aacttaccaa agttaaacaa actcaagaag cttgaattaa
      361 gcgaaaacag aatctcaggg gacctggaag tattggcaga gaaatgtccg aaccttaagc
      421 atctaaattt aagtggcaac aaaataaaag atctcagcac aatagagccg ctgaagaagt
      481 tagagaatct caagagccta gacctgttta actgtgaggt gaccaacctg aatgcctacc
      541 gagaaaacgt gttcaagctc ctgccccagg tcatgtacct cgatggctat gacagggaca
      601 acaaggaggc ccccgactcc gatgttgagg gctacgtgga ggatgacgac gaggaagatg
      661 aggatgagga ggagtatgat gaatatgccc agctagtgga agatgaagag gaagaggatg
      721 aggaggaaga aggggaggaa gaggatgtga gtggagagga ggaggaggat gaggaaggtt
      781 acaatgacgg ggaagtggat gacgaggaag acgaagaaga agctggtgaa gaagaaggga
      841 gtcagaagcg aaaacgagaa ccggacgatg agggcgaaga ggatgactaa ggaatgaacc
      901 tgtttgggga aattcctatt gtgatttgac tgtttttacc catatcccct ccccctccta
      961 ttcctgcccc ccgaaactta tttttttctg attgtagcat tgctgtggga aggagagggg
     1021 aaaagtgtac tgggggttga tggggggtgg gggtgggggg gaggggagga ataaaatact
     1081 atttttactg ccacacttta tttccccccc tcctttttcc ttgtgtctgg ttttgtcccc
     1141 ataaatgcaa tagcttagtg cacaccaagc aagtgtttgt tcttactctc tggagaggat
     1201 ggcttggagg tctaacattt tctggtatgt cctacatccc cagagttgat cgggaggccg
     1261 tggctggcct ctgccaggtg actcacagcc cctgtcatct tcactaactc ctgttctggt
     1321 tccggttcgt gtggtcgctg ccagaggcac ccagcacccc ggtttgtaaa tagcaaccaa
     1381 aaggcgtatt ttggcactgg tttggggaca gtccccatct cgcatccctt ttccctccct
     1441 ccacagatgg cagtgggctt tgctttttgc aaagagaact cttattactc tggggctatg
     1501 atcccgagag ccaaaaagaa aaaatcaaaa taacaacaac aagaaaaaaa caaaaaacgg
     1561 cagggttagg agatacttgt aaaatgggaa agaagtgaac cttcatgttt cagcttctta
     1621 aaaacaaaaa caaacaaaaa aaactgttct atttggttct gtaaaatatt agagcaactg
     1681 gttttgcaga aatgacagga ggacgcatct caggcgctcc agcttagaac ccttttacaa
     1741 atctacgctc tggagctccc tccaagagtc ctctggggtt ttgttctgct tgttttcctt
     1801 ctcacataca ttggagcaca ggaaaggaat gcaaactcgt attttcttac ccggtgggac
     1861 tctgaaatgg ccgcaggttt ctcctaggga atgctgtgtg ccttctgcat ccctcttcca
     1921 gatcgcttta gaagtgacgt gctgtgtccc tcctaccctg cgtctcattg gtacagaaca
     1981 actgccactc atttttctcc cgcccttgag aagagccaaa ctttgagttt tatgtctgtt
     2041 tgtcattgat aaatttcaat aaatcttttt tatacaa
//
