LOCUS       NM_001411151            1986 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus acidic nuclear phosphoprotein 32 family member A
            (Anp32a), transcript variant 2, mRNA.
ACCESSION   NM_001411151 XM_006510778
VERSION     NM_001411151.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1986)
  AUTHORS   Zhang,M., Liu,M., Chen,H., Qiu,T., Jin,X., Fu,W., Teng,Q., Zhao,C.,
            Xu,J., Li,Z. and Zhang,X.
  TITLE     PB2 residue 473 contributes to the mammalian virulence of H7N9
            avian influenza virus by modulating viral polymerase activity via
            ANP32A
  JOURNAL   J Virol 98 (3), e0194423 (2024)
   PUBMED   38421166
  REMARK    GeneRIF: PB2 residue 473 contributes to the mammalian virulence of
            H7N9 avian influenza virus by modulating viral polymerase activity
            via ANP32A.
REFERENCE   2  (bases 1 to 1986)
  AUTHORS   Peacock,T.P., Sheppard,C.M., Lister,M.G., Staller,E., Frise,R.,
            Swann,O.C., Goldhill,D.H., Long,J.S. and Barclay,W.S.
  TITLE     Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase
            Adaptations in Avian Influenza Virus
  JOURNAL   J Virol 97 (5), e0021323 (2023)
   PUBMED   37074204
  REMARK    GeneRIF: Mammalian ANP32A and ANP32B Proteins Drive Differential
            Polymerase Adaptations in Avian Influenza Virus.
REFERENCE   3  (bases 1 to 1986)
  AUTHORS   Quintiens,J., De Roover,A., Cornelis,F.M.F., Escribano-Nunez,A.,
            Sermon,A., Pazmino,S., Monteagudo,S. and Lories,R.J.
  TITLE     Hypoxia and Wnt signaling inversely regulate expression of
            chondroprotective molecule ANP32A in articular cartilage
  JOURNAL   Osteoarthritis Cartilage 31 (4), 507-518 (2023)
   PUBMED   36370958
  REMARK    GeneRIF: Hypoxia and Wnt signaling inversely regulate expression of
            chondroprotective molecule ANP32A in articular cartilage.
REFERENCE   4  (bases 1 to 1986)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   5  (bases 1 to 1986)
  AUTHORS   Beck,S., Zickler,M., Pinho Dos Reis,V., Gunther,T., Grundhoff,A.,
            Reilly,P.T., Mak,T.W., Stanelle-Bertram,S. and Gabriel,G.
  TITLE     ANP32B Deficiency Protects Mice From Lethal Influenza A Virus
            Challenge by Dampening the Host Immune Response
  JOURNAL   Front Immunol 11, 450 (2020)
   PUBMED   32231671
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1986)
  AUTHORS   Matilla,A. and Radrizzani,M.
  TITLE     The Anp32 family of proteins containing leucine-rich repeats
  JOURNAL   Cerebellum 4 (1), 7-18 (2005)
   PUBMED   15895553
  REMARK    Review article
REFERENCE   7  (bases 1 to 1986)
  AUTHORS   Yang,W., Li,C. and Mansour,S.L.
  TITLE     Impaired motor coordination in mice that lack punc
  JOURNAL   Mol Cell Biol 21 (17), 6031-6043 (2001)
   PUBMED   11486040
REFERENCE   8  (bases 1 to 1986)
  AUTHORS   Turgeon,B., Saba-El-Leil,M.K. and Meloche,S.
  TITLE     Cloning and characterization of mouse
            extracellular-signal-regulated protein kinase 3 as a unique gene
            product of 100 kDa
  JOURNAL   Biochem J 346 Pt 1 (Pt 1), 169-175 (2000)
   PUBMED   10657254
REFERENCE   9  (bases 1 to 1986)
  AUTHORS   Matilla,A., Koshy,B.T., Cummings,C.J., Isobe,T., Orr,H.T. and
            Zoghbi,H.Y.
  TITLE     The cerebellar leucine-rich acidic nuclear protein interacts with
            ataxin-1
  JOURNAL   Nature 389 (6654), 974-978 (1997)
   PUBMED   9353121
  REMARK    Erratum:[Nature 1998 Feb 19;391(6669):818]
REFERENCE   10 (bases 1 to 1986)
  AUTHORS   Chen,T.H., Brody,J.R., Romantsev,F.E., Yu,J.G., Kayler,A.E.,
            Voneiff,E., Kuhajda,F.P. and Pasternack,G.R.
  TITLE     Structure of pp32, an acidic nuclear protein which inhibits
            oncogene-induced formation of transformed foci
  JOURNAL   Mol Biol Cell 7 (12), 2045-2056 (1996)
   PUBMED   8970164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113291.16 and AC121813.3.
            
            On Aug 22, 2022 this sequence version replaced XM_006510778.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.3970143.1,
                                           SRR13422603.540432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC113291.16        170527-170635
            110-193             AC113291.16        200345-200428
            194-259             AC121813.3         113504-113569       c
            260-382             AC121813.3         113189-113311       c
            383-575             AC121813.3         111696-111888       c
            576-673             AC121813.3         110622-110719       c
            674-737             AC121813.3         108010-108073       c
            738-1986            AC121813.3         106571-107819       c
FEATURES             Location/Qualifiers
     source          1..1986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.68 cM"
     gene            1..1986
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="acidic nuclear phosphoprotein 32 family member A"
                     /db_xref="GeneID:11737"
                     /db_xref="MGI:MGI:108447"
     exon            1..109
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..799
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="isoform 2 is encoded by transcript variant 2;
                     vacidic (leucine-rich) nuclear phosphoprotein 32 family,
                     member A; acidic nuclear phosphoprotein pp32; leucine-rich
                     acidic nuclear protein; potent heat-stable protein
                     phosphatase 2A inhibitor I1PP2A; acidic (leucine-rich)
                     nuclear phosphoprotein 32 family, member A; acidic nuclear
                     phosphoprotein 32"
                     /codon_start=1
                     /product="acidic leucine-rich nuclear phosphoprotein 32
                     family member A isoform 2"
                     /protein_id="NP_001398080.1"
                     /db_xref="GeneID:11737"
                     /db_xref="MGI:MGI:108447"
                     /translation="MEKMIEGRRRWAASWIKQQKGVKELVLDNCKSIEGKIEGLTDEF
                     EELEFLSTINVGLTSISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNK
                     IKDLSTIEPLKKLENLKSLDLFNCEVTNLNAYRENVFKLLPQVMYLDGYDRDNKEAPD
                     SDVEGYVEDDDEEDEDEEEYDEYAQLVEDEEEEDEEEEGEEEDVSGEEEEDEEGYNDG
                     EVDDEEDEEEAGEEEGSQKRKREPDDEGEEDD"
     exon            110..259
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            260..382
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            383..575
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            576..673
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            674..737
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1986
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      979..984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="hexamer: AATAAA"
     polyA_site      1002
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="major polyA site"
     regulatory      1049..1054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="hexamer: CATAAA"
     polyA_site      1077
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="hexamer: AATAAA"
     polyA_site      1986
                     /gene="Anp32a"
                     /gene_synonym="Anp32; I1PP2A; LANP; PHAP1; pp32"
                     /note="major polyA site"
ORIGIN      
        1 aatttcaccc tcgtccgagc tctcagctcc cacgacttgc atctggatgg aaaagatgat
       61 cgaggggagg agaagatggg ctgcctcctg gattaaacaa caaaaagggg tgaaagagct
      121 ggtcctggat aactgtaagt caattgaagg caaaatcgaa ggcctcacgg atgagtttga
      181 agaactggaa ttcctaagta caatcaacgt aggcctcacc tccatttcca acttaccaaa
      241 gttaaacaaa ctcaagaagc ttgaattaag cgaaaacaga atctcagggg acctggaagt
      301 attggcagag aaatgtccga accttaagca tctaaattta agtggcaaca aaataaaaga
      361 tctcagcaca atagagccgc tgaagaagtt agagaatctc aagagcctag acctgtttaa
      421 ctgtgaggtg accaacctga atgcctaccg agaaaacgtg ttcaagctcc tgccccaggt
      481 catgtacctc gatggctatg acagggacaa caaggaggcc cccgactccg atgttgaggg
      541 ctacgtggag gatgacgacg aggaagatga ggatgaggag gagtatgatg aatatgccca
      601 gctagtggaa gatgaagagg aagaggatga ggaggaagaa ggggaggaag aggatgtgag
      661 tggagaggag gaggaggatg aggaaggtta caatgacggg gaagtggatg acgaggaaga
      721 cgaagaagaa gctggtgaag aagaagggag tcagaagcga aaacgagaac cggacgatga
      781 gggcgaagag gatgactaag gaatgaacct gtttggggaa attcctattg tgatttgact
      841 gtttttaccc atatcccctc cccctcctat tcctgccccc cgaaacttat ttttttctga
      901 ttgtagcatt gctgtgggaa ggagagggga aaagtgtact gggggttgat ggggggtggg
      961 ggtggggggg aggggaggaa taaaatacta tttttactgc cacactttat ttccccccct
     1021 cctttttcct tgtgtctggt tttgtcccca taaatgcaat agcttagtgc acaccaagca
     1081 agtgtttgtt cttactctct ggagaggatg gcttggaggt ctaacatttt ctggtatgtc
     1141 ctacatcccc agagttgatc gggaggccgt ggctggcctc tgccaggtga ctcacagccc
     1201 ctgtcatctt cactaactcc tgttctggtt ccggttcgtg tggtcgctgc cagaggcacc
     1261 cagcaccccg gtttgtaaat agcaaccaaa aggcgtattt tggcactggt ttggggacag
     1321 tccccatctc gcatcccttt tccctccctc cacagatggc agtgggcttt gctttttgca
     1381 aagagaactc ttattactct ggggctatga tcccgagagc caaaaagaaa aaatcaaaat
     1441 aacaacaaca agaaaaaaac aaaaaacggc agggttagga gatacttgta aaatgggaaa
     1501 gaagtgaacc ttcatgtttc agcttcttaa aaacaaaaac aaacaaaaaa aactgttcta
     1561 tttggttctg taaaatatta gagcaactgg ttttgcagaa atgacaggag gacgcatctc
     1621 aggcgctcca gcttagaacc cttttacaaa tctacgctct ggagctccct ccaagagtcc
     1681 tctggggttt tgttctgctt gttttccttc tcacatacat tggagcacag gaaaggaatg
     1741 caaactcgta ttttcttacc cggtgggact ctgaaatggc cgcaggtttc tcctagggaa
     1801 tgctgtgtgc cttctgcatc cctcttccag atcgctttag aagtgacgtg ctgtgtccct
     1861 cctaccctgc gtctcattgg tacagaacaa ctgccactca tttttctccc gcccttgaga
     1921 agagccaaac tttgagtttt atgtctgttt gtcattgata aatttcaata aatctttttt
     1981 atacaa
//
