LOCUS       NM_178381               3012 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus anoctamin 9 (Ano9), mRNA.
ACCESSION   NM_178381
VERSION     NM_178381.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3012)
  AUTHORS   Schreiber,R., Talbi,K., Ousingsawat,J. and Kunzelmann,K.
  TITLE     A TMEM16J variant leads to dysregulated cytosolic calcium which may
            lead to renal disease
  JOURNAL   FASEB J 37 (1), e22683 (2023)
   PUBMED   36520003
REFERENCE   2  (bases 1 to 3012)
  AUTHORS   Kim,H., Kim,H., Nguyen,L.T., Ha,T., Lim,S., Kim,K., Kim,S.H.,
            Han,K., Hyeon,S.J., Ryu,H., Park,Y.S., Kim,S.H., Kim,I.B.,
            Hong,G.S., Lee,S.E., Choi,Y., Cohen,L.B. and Oh,U.
  TITLE     Amplification of olfactory signals by Anoctamin 9 is important for
            mammalian olfaction
  JOURNAL   Prog Neurobiol 219, 102369 (2022)
   PUBMED   36330924
  REMARK    GeneRIF: Amplification of olfactory signals by Anoctamin 9 is
            important for mammalian olfaction.
REFERENCE   3  (bases 1 to 3012)
  AUTHORS   Kim,H., Kim,H., Lee,J., Lee,B., Kim,H.R., Jung,J., Lee,M.O. and
            Oh,U.
  TITLE     Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA
            signal
  JOURNAL   Cell Calcium 71, 75-85 (2018)
   PUBMED   29604966
  REMARK    GeneRIF: ANO9 is a cation channel activated by a cAMP/PKA pathway
            and could play a role in intestine function.
REFERENCE   4  (bases 1 to 3012)
  AUTHORS   Armfield,B.A., Seifert,A.W., Zheng,Z., Merton,E.M., Rock,J.R.,
            Lopez,M.C., Baker,H.V. and Cohn,M.J.
  TITLE     Molecular Characterization of the Genital Organizer: Gene
            Expression Profile of the Mouse Urethral Plate Epithelium
  JOURNAL   J Urol 196 (4), 1295-1302 (2016)
   PUBMED   27173853
REFERENCE   5  (bases 1 to 3012)
  AUTHORS   Suzuki,J., Fujii,T., Imao,T., Ishihara,K., Kuba,H. and Nagata,S.
  TITLE     Calcium-dependent phospholipid scramblase activity of TMEM16
            protein family members
  JOURNAL   J Biol Chem 288 (19), 13305-13316 (2013)
   PUBMED   23532839
REFERENCE   6  (bases 1 to 3012)
  AUTHORS   Schreiber,R., Uliyakina,I., Kongsuphol,P., Warth,R., Mirza,M.,
            Martins,J.R. and Kunzelmann,K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   7  (bases 1 to 3012)
  AUTHORS   Rock,J.R. and Harfe,B.D.
  TITLE     Expression of TMEM16 paralogs during murine embryogenesis
  JOURNAL   Dev Dyn 237 (9), 2566-2574 (2008)
   PUBMED   18729231
REFERENCE   8  (bases 1 to 3012)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human TP53I5 and mouse
            Tp53i5 genes in silico
  JOURNAL   Int J Oncol 25 (1), 225-230 (2004)
   PUBMED   15202010
REFERENCE   9  (bases 1 to 3012)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CF896275.1,
            AC109272.20, BY717147.1 and BB158112.1.
            
            On Oct 6, 2007 this sequence version replaced NM_178381.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by a combination of transcript alignments and orthologous
            data.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               CF896275.1         1-534
            535-537             AC109272.20        24448-24450
            538-611             AC109272.20        24544-24617
            612-746             AC109272.20        24850-24984
            747-843             AC109272.20        25093-25189
            844-904             AC109272.20        25378-25438
            905-987             AC109272.20        25552-25634
            988-1092            AC109272.20        25735-25839
            1093-1245           AC109272.20        25916-26068
            1246-1282           AC109272.20        26148-26184
            1283-1394           AC109272.20        26361-26472
            1395-1452           AC109272.20        28509-28566
            1453-1550           AC109272.20        28655-28752
            1551-1693           AC109272.20        28851-28993
            1694-1846           AC109272.20        29091-29243
            1847-1954           AC109272.20        30001-30108
            1955-2579           BY717147.1         1-625
            2580-2824           AC109272.20        31584-31828
            2825-3012           BB158112.1         87-274
FEATURES             Location/Qualifiers
     source          1..3012
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.37 cM"
     gene            1..3012
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /note="anoctamin 9"
                     /db_xref="GeneID:71345"
                     /db_xref="MGI:MGI:1918595"
     exon            1..93
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2331
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /note="Trp53 inducible protein 5; tumor protein p53
                     inducible protein 5; transformation related protein 53
                     inducible protein 5; transmembrane protein 16J"
                     /codon_start=1
                     /product="anoctamin-9"
                     /protein_id="NP_848468.2"
                     /db_xref="CCDS:CCDS52438.1"
                     /db_xref="GeneID:71345"
                     /db_xref="MGI:MGI:1918595"
                     /translation="MQDDESSQIFMGPEGDQLPLVEMGSCKPEASDQWDCVLVADLQT
                     LKIQKHAQKQLQFLENLESNGFHFKMLKDQKKVFFGIRADSDVIDKYRTLLMNPEDSG
                     SRDEQSFNIATTRIRIVSFVVNNKLKPGDTFEDLVKDGVFETMFLLHKGEQNLKNIWA
                     RWRNMFEPQPIDEIREYFGEKVALYFTWLGWYTYMLVPAAVVGLIVFLSGFALFDSSQ
                     ISKEICSANDIFMCPLGDHSHRYLRLSEMCTFAKLTHLFDNEGTVLFAIFMALWATVF
                     LEIWKRKRAHEVQSWKLYEWDEEEEEMALELINSPHYKLKDHRHSYLSSTIILILSLF
                     MICLMIGMAHVLVVYRVLAGALFSSLVKQQVTTAVVVTGAVVHYIIIVIMTKVNKYVA
                     LKLCKFEESGTFSEQERKFTVKFFILQFFAHFSSLIYIAFILGRINGHPGKSTRLAGL
                     WKLEECHLSGCMMDLFIQMAIIMGLKQTLSNCVEYLCPLLAHKWRLMWASKHGHMSKD
                     PELKEWQRNYYMNPINTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRL
                     DAIKMVRLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYHY
                     GPCRTNRTFTDDCLTNYVNHSLSVFYTKHFNDHSRMEGQENVTVCRYRDYRNEHDYNL
                     SEQFWFILAIRLTFVILFEHFALCIKLIAAWFVPDVPQKVKNEVLQEKYDRIRHRMRF
                     SSRSTDV"
     exon            94..168
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            169..294
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            295..431
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            432..478
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            479..537
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            538..611
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            612..746
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            747..843
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            844..904
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            905..987
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1092
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1245
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1282
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1394
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1452
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1550
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1693
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1846
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1994
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2096
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2190
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2303
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..3012
                     /gene="Ano9"
                     /gene_synonym="5430425C04Rik; Tmem16j; Tp53i5; Trp53i5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaccggga gcccgcaggc actctcacac ctgccagtgc cagccagcat ccagagcccc
       61 acattgaccg agggaccagc caccagcatg caggatgatg agagttccca gatctttatg
      121 gggccagaag gggaccagtt gccattggtg gaaatgggca gttgtaagcc tgaggcctct
      181 gatcaatggg actgtgtcct ggtggctgac ctccagaccc tgaaaatcca gaagcatgct
      241 cagaagcaac tgcagttcct agaaaacctc gagagcaatg gcttccactt caagatgtta
      301 aaggaccaga agaaggtgtt ctttgggatc cgagctgaca gtgacgtcat tgacaagtac
      361 cggactctcc tcatgaatcc tgaagattct ggctccagag acgagcagag cttcaacata
      421 gctaccacaa gaatccgaat tgtgagcttt gtcgtgaaca acaagctaaa acctggtgac
      481 acctttgagg acctggtgaa ggatggggtt tttgagacca tgtttcttct gcacaaggga
      541 gaacaaaacc tgaagaatat atgggctcgg tggagaaaca tgtttgaacc acagccaatt
      601 gatgaaatca gggaatactt tggcgagaag gtggctctgt acttcacctg gcttggctgg
      661 tacacctaca tgctggtgcc tgcggctgtg gtgggcctca tcgtctttct gagtggcttt
      721 gccctgtttg attccagcca gatcagcaaa gagatctgta gtgccaatga tatcttcatg
      781 tgccctcttg gcgaccacag tcacagatac ctgcgactct cagagatgtg cactttcgca
      841 aagctcactc atctctttga caacgagggc accgtgctat ttgccatctt catggcactg
      901 tgggctacgg tcttcctgga gatctggaag cgaaagcgtg cccatgaagt ccagagctgg
      961 aaactgtatg aatgggatga ggaagaggaa gagatggccc ttgagctcat taactctccg
     1021 cactataagc tgaaagacca ccgtcactcc tacctgagca gcaccatcat cctgatcctg
     1081 tccctgttca tgatctgttt aatgattggc atggctcatg tgctggttgt ctaccgtgtg
     1141 ctggctggag ccctcttcag cagcctcgtg aagcagcagg tgaccaccgc tgtggtggtg
     1201 actggggcag tggtacatta tataatcatt gtcatcatga ctaaggtcaa caaatatgta
     1261 gccctgaagc tttgtaaatt tgaggaatcc gggaccttct cagagcaaga gaggaagttc
     1321 actgtcaagt ttttcatcct gcagttcttc gcccacttct cctctctcat ctacattgcc
     1381 ttcattctgg gcaggatcaa tggtcaccct gggaaatcca cgcgcctggc tggcctgtgg
     1441 aagctggagg agtgccatct cagtggctgc atgatggacc tgtttatcca gatggccatc
     1501 atcatgggcc tgaagcaaac cctgagcaac tgcgttgagt acctgtgccc gttgttggcc
     1561 cataaatggc gcttaatgtg ggcttccaaa catggtcaca tgtccaaaga cccagaactg
     1621 aaggagtggc agcgtaacta ctacatgaat cccatcaaca ccttcagcct gtttgatgag
     1681 ttcatggaga tgatgatcca gtacggcttt accaccatct ttgtggctgc tttcccactc
     1741 gcacccctgt tggcgctctt cagcaacctt gtggaaatcc gtctggatgc catcaagatg
     1801 gtcagactac agcggcgcct ggttcctcgc aaggctaagg acatagggac ctggctgcag
     1861 gtgctagaga ccattggagt gctggcagtc attgccaatg gaatggttat cgccttcacc
     1921 tctgagttca tccccagggt agtctacaag taccactatg gcccgtgccg aacgaatcgg
     1981 accttcacag atgactgcct cacgaactat gtcaaccata gcttgtctgt cttctacacc
     2041 aaacacttca atgaccacag caggatggaa ggccaagaaa acgtgaccgt gtgcaggtac
     2101 cgggactacc gaaatgagca tgactacaac ttgtctgagc agttctggtt cattttggcc
     2161 atccgactga cctttgttat cctctttgag cattttgccc tgtgcatcaa actcattgct
     2221 gcgtggtttg tgcctgatgt gccccagaaa gtgaagaatg aggttctgca ggagaagtat
     2281 gacagaattc gccatagaat gcgcttcagt tccaggagca cggatgtata gacgacctgg
     2341 ggcaggtgga gaaatgccac tttccaggag cctggactag gaataagtcc ccacctctac
     2401 agcttgcccc tatccataac aatgtgtatg tatgtgttga gggaggctgt aaaatggccc
     2461 atgtatatgt aggatcctgg atggtctaca tatatgttaa tacatgaaga tcaaaggagg
     2521 gcctagacta tatgtaggtg tatatgggca tcctacgaag cccatgtgta tatgttaacc
     2581 acgggagact tgtatatgta gggatcattg aaatccatgt atatttaggg tatttatgaa
     2641 cggcacagat gtgcctgtgg ggtttgcttc aactttccta cggttcagat tggtacagac
     2701 ctgacttgag actcttgaat gaccctagta cctatagaac tgcaggttgc tcataaaacc
     2761 cccatgcagt aaaattagcc taaatgccat ggacctcctg gcttctgggc ctcagatcct
     2821 gctctgtggc ctcctgcttt gtgggaagcc atggacctcc tggcttctgg gcctcagatc
     2881 ctgctctgtg gcctcctgct ttgtgggaag cctagagagt aacttctgga tcccctccct
     2941 cccagttaac ctggatccgt acagcggcaa aactttttac aagcaaaata aacctgtgtg
     3001 tattgatttc tg
//
